Amino acid dipepetide frequency for Circovirus-like genome DCCV-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.617AlaAla: 11.617 ± 4.357
0.0AlaCys: 0.0 ± 0.0
1.936AlaAsp: 1.936 ± 0.728
4.84AlaGlu: 4.84 ± 2.342
5.808AlaPhe: 5.808 ± 0.645
4.84AlaGly: 4.84 ± 3.773
0.968AlaHis: 0.968 ± 0.654
2.904AlaIle: 2.904 ± 1.962
2.904AlaLys: 2.904 ± 1.152
9.681AlaLeu: 9.681 ± 1.597
0.0AlaMet: 0.0 ± 0.0
2.904AlaAsn: 2.904 ± 1.962
2.904AlaPro: 2.904 ± 1.152
0.968AlaGln: 0.968 ± 0.767
9.681AlaArg: 9.681 ± 1.995
3.872AlaSer: 3.872 ± 1.724
5.808AlaThr: 5.808 ± 1.859
1.936AlaVal: 1.936 ± 1.308
0.968AlaTrp: 0.968 ± 0.767
0.968AlaTyr: 0.968 ± 0.654
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.968CysAsp: 0.968 ± 1.175
1.936CysGlu: 1.936 ± 0.728
0.0CysPhe: 0.0 ± 0.0
0.968CysGly: 0.968 ± 0.767
0.968CysHis: 0.968 ± 0.767
0.968CysIle: 0.968 ± 0.767
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.968CysArg: 0.968 ± 1.234
0.968CysSer: 0.968 ± 0.767
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.936AspAla: 1.936 ± 1.534
0.0AspCys: 0.0 ± 0.0
5.808AspAsp: 5.808 ± 1.652
2.904AspGlu: 2.904 ± 1.794
0.968AspPhe: 0.968 ± 0.654
2.904AspGly: 2.904 ± 1.345
3.872AspHis: 3.872 ± 2.415
2.904AspIle: 2.904 ± 1.152
0.968AspLys: 0.968 ± 1.234
1.936AspLeu: 1.936 ± 1.028
0.0AspMet: 0.0 ± 0.0
2.904AspAsn: 2.904 ± 1.152
1.936AspPro: 1.936 ± 1.028
1.936AspGln: 1.936 ± 1.247
0.0AspArg: 0.0 ± 0.0
6.776AspSer: 6.776 ± 2.115
2.904AspThr: 2.904 ± 2.109
2.904AspVal: 2.904 ± 0.864
0.968AspTrp: 0.968 ± 1.234
2.904AspTyr: 2.904 ± 1.26
0.0AspXaa: 0.0 ± 0.0
Glu
0.968GluAla: 0.968 ± 1.234
0.968GluCys: 0.968 ± 1.175
0.968GluAsp: 0.968 ± 0.767
2.904GluGlu: 2.904 ± 1.328
0.968GluPhe: 0.968 ± 0.654
2.904GluGly: 2.904 ± 0.958
1.936GluHis: 1.936 ± 1.028
2.904GluIle: 2.904 ± 1.152
4.84GluLys: 4.84 ± 1.172
8.712GluLeu: 8.712 ± 3.751
0.0GluMet: 0.0 ± 0.0
1.936GluAsn: 1.936 ± 0.728
2.904GluPro: 2.904 ± 2.301
1.936GluGln: 1.936 ± 1.308
2.904GluArg: 2.904 ± 1.706
1.936GluSer: 1.936 ± 2.467
1.936GluThr: 1.936 ± 1.028
2.904GluVal: 2.904 ± 0.864
1.936GluTrp: 1.936 ± 1.335
2.904GluTyr: 2.904 ± 1.152
0.0GluXaa: 0.0 ± 0.0
Phe
1.936PheAla: 1.936 ± 1.028
0.968PheCys: 0.968 ± 0.767
0.968PheAsp: 0.968 ± 0.767
0.0PheGlu: 0.0 ± 0.0
0.0PhePhe: 0.0 ± 0.0
0.0PheGly: 0.0 ± 0.0
1.936PheHis: 1.936 ± 2.467
2.904PheIle: 2.904 ± 1.152
0.968PheLys: 0.968 ± 0.654
1.936PheLeu: 1.936 ± 0.728
0.968PheMet: 0.968 ± 0.767
3.872PheAsn: 3.872 ± 1.726
5.808PhePro: 5.808 ± 1.726
1.936PheGln: 1.936 ± 0.728
0.968PheArg: 0.968 ± 0.767
2.904PheSer: 2.904 ± 1.26
3.872PheThr: 3.872 ± 1.726
1.936PheVal: 1.936 ± 1.308
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.84GlyAla: 4.84 ± 1.325
0.968GlyCys: 0.968 ± 0.767
4.84GlyAsp: 4.84 ± 2.267
0.0GlyGlu: 0.0 ± 0.0
0.968GlyPhe: 0.968 ± 0.654
3.872GlyGly: 3.872 ± 1.726
0.968GlyHis: 0.968 ± 1.175
2.904GlyIle: 2.904 ± 1.152
3.872GlyLys: 3.872 ± 1.456
4.84GlyLeu: 4.84 ± 2.267
0.968GlyMet: 0.968 ± 0.911
3.872GlyAsn: 3.872 ± 2.065
0.968GlyPro: 0.968 ± 1.175
1.936GlyGln: 1.936 ± 1.07
6.776GlyArg: 6.776 ± 3.274
9.681GlySer: 9.681 ± 2.853
9.681GlyThr: 9.681 ± 1.046
2.904GlyVal: 2.904 ± 0.864
0.968GlyTrp: 0.968 ± 1.234
3.872GlyTyr: 3.872 ± 1.456
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.968HisAsp: 0.968 ± 1.234
0.968HisGlu: 0.968 ± 0.654
0.968HisPhe: 0.968 ± 1.234
0.0HisGly: 0.0 ± 0.0
0.968HisHis: 0.968 ± 0.654
0.0HisIle: 0.0 ± 0.0
0.968HisLys: 0.968 ± 0.654
2.904HisLeu: 2.904 ± 0.864
0.968HisMet: 0.968 ± 0.654
0.968HisAsn: 0.968 ± 0.767
0.0HisPro: 0.0 ± 0.0
1.936HisGln: 1.936 ± 2.467
2.904HisArg: 2.904 ± 0.958
3.872HisSer: 3.872 ± 2.268
3.872HisThr: 3.872 ± 0.953
2.904HisVal: 2.904 ± 1.345
0.0HisTrp: 0.0 ± 0.0
0.968HisTyr: 0.968 ± 0.767
0.0HisXaa: 0.0 ± 0.0
Ile
5.808IleAla: 5.808 ± 1.259
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
3.872IleGlu: 3.872 ± 1.06
0.968IlePhe: 0.968 ± 0.654
6.776IleGly: 6.776 ± 2.86
0.0IleHis: 0.0 ± 0.0
2.904IleIle: 2.904 ± 1.152
0.0IleLys: 0.0 ± 0.0
4.84IleLeu: 4.84 ± 1.88
0.0IleMet: 0.0 ± 0.0
2.904IleAsn: 2.904 ± 0.958
4.84IlePro: 4.84 ± 1.813
1.936IleGln: 1.936 ± 1.308
5.808IleArg: 5.808 ± 1.652
0.968IleSer: 0.968 ± 0.654
2.904IleThr: 2.904 ± 1.152
2.904IleVal: 2.904 ± 1.345
0.968IleTrp: 0.968 ± 0.767
3.872IleTyr: 3.872 ± 1.27
0.0IleXaa: 0.0 ± 0.0
Lys
4.84LysAla: 4.84 ± 3.269
0.0LysCys: 0.0 ± 0.0
5.808LysAsp: 5.808 ± 1.317
0.968LysGlu: 0.968 ± 0.767
1.936LysPhe: 1.936 ± 0.728
2.904LysGly: 2.904 ± 1.345
1.936LysHis: 1.936 ± 1.07
4.84LysIle: 4.84 ± 2.342
2.904LysLys: 2.904 ± 1.152
0.968LysLeu: 0.968 ± 0.654
0.968LysMet: 0.968 ± 1.234
1.936LysAsn: 1.936 ± 1.308
1.936LysPro: 1.936 ± 1.335
1.936LysGln: 1.936 ± 1.335
2.904LysArg: 2.904 ± 1.273
3.872LysSer: 3.872 ± 2.669
1.936LysThr: 1.936 ± 1.07
1.936LysVal: 1.936 ± 1.308
0.968LysTrp: 0.968 ± 0.767
1.936LysTyr: 1.936 ± 1.308
0.0LysXaa: 0.0 ± 0.0
Leu
5.808LeuAla: 5.808 ± 2.304
0.968LeuCys: 0.968 ± 1.234
4.84LeuAsp: 4.84 ± 2.044
4.84LeuGlu: 4.84 ± 2.229
3.872LeuPhe: 3.872 ± 1.456
5.808LeuGly: 5.808 ± 2.304
1.936LeuHis: 1.936 ± 1.335
3.872LeuIle: 3.872 ± 2.495
6.776LeuLys: 6.776 ± 2.115
7.744LeuLeu: 7.744 ± 0.699
0.0LeuMet: 0.0 ± 0.0
3.872LeuAsn: 3.872 ± 1.367
4.84LeuPro: 4.84 ± 2.659
2.904LeuGln: 2.904 ± 0.958
7.744LeuArg: 7.744 ± 4.289
3.872LeuSer: 3.872 ± 2.139
3.872LeuThr: 3.872 ± 3.73
5.808LeuVal: 5.808 ± 1.728
0.968LeuTrp: 0.968 ± 1.175
3.872LeuTyr: 3.872 ± 0.953
0.0LeuXaa: 0.0 ± 0.0
Met
2.904MetAla: 2.904 ± 1.26
0.0MetCys: 0.0 ± 0.0
0.968MetAsp: 0.968 ± 0.654
0.968MetGlu: 0.968 ± 0.654
0.0MetPhe: 0.0 ± 0.0
1.936MetGly: 1.936 ± 0.728
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.968MetLeu: 0.968 ± 1.234
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.968MetGln: 0.968 ± 1.234
2.904MetArg: 2.904 ± 1.655
0.0MetSer: 0.0 ± 0.0
2.904MetThr: 2.904 ± 1.328
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.84AsnAla: 4.84 ± 2.342
0.0AsnCys: 0.0 ± 0.0
3.872AsnAsp: 3.872 ± 1.456
2.904AsnGlu: 2.904 ± 0.958
2.904AsnPhe: 2.904 ± 1.152
3.872AsnGly: 3.872 ± 2.615
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
4.84AsnLys: 4.84 ± 1.172
4.84AsnLeu: 4.84 ± 1.301
0.0AsnMet: 0.0 ± 0.0
1.936AsnAsn: 1.936 ± 0.728
3.872AsnPro: 3.872 ± 1.27
3.872AsnGln: 3.872 ± 1.726
2.904AsnArg: 2.904 ± 1.152
0.0AsnSer: 0.0 ± 0.0
0.0AsnThr: 0.0 ± 0.0
2.904AsnVal: 2.904 ± 0.958
0.968AsnTrp: 0.968 ± 0.654
2.904AsnTyr: 2.904 ± 1.152
0.0AsnXaa: 0.0 ± 0.0
Pro
6.776ProAla: 6.776 ± 1.63
0.968ProCys: 0.968 ± 0.654
1.936ProAsp: 1.936 ± 1.028
3.872ProGlu: 3.872 ± 2.495
1.936ProPhe: 1.936 ± 1.335
5.808ProGly: 5.808 ± 3.31
0.968ProHis: 0.968 ± 0.767
1.936ProIle: 1.936 ± 0.728
3.872ProLys: 3.872 ± 1.367
9.681ProLeu: 9.681 ± 4.088
2.904ProMet: 2.904 ± 1.396
0.968ProAsn: 0.968 ± 1.175
6.776ProPro: 6.776 ± 4.736
0.968ProGln: 0.968 ± 1.234
2.904ProArg: 2.904 ± 1.962
8.712ProSer: 8.712 ± 3.894
1.936ProThr: 1.936 ± 0.728
4.84ProVal: 4.84 ± 3.102
1.936ProTrp: 1.936 ± 2.35
0.968ProTyr: 0.968 ± 1.234
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
2.904GlnGlu: 2.904 ± 3.701
0.0GlnPhe: 0.0 ± 0.0
2.904GlnGly: 2.904 ± 1.152
0.0GlnHis: 0.0 ± 0.0
1.936GlnIle: 1.936 ± 0.728
0.968GlnLys: 0.968 ± 0.654
2.904GlnLeu: 2.904 ± 1.328
0.0GlnMet: 0.0 ± 0.0
3.872GlnAsn: 3.872 ± 2.615
2.904GlnPro: 2.904 ± 1.328
4.84GlnGln: 4.84 ± 4.642
1.936GlnArg: 1.936 ± 0.728
2.904GlnSer: 2.904 ± 1.345
3.872GlnThr: 3.872 ± 2.139
0.968GlnVal: 0.968 ± 0.767
1.936GlnTrp: 1.936 ± 1.07
1.936GlnTyr: 1.936 ± 1.534
0.0GlnXaa: 0.0 ± 0.0
Arg
5.808ArgAla: 5.808 ± 2.051
0.0ArgCys: 0.0 ± 0.0
0.968ArgAsp: 0.968 ± 1.175
6.776ArgGlu: 6.776 ± 2.935
4.84ArgPhe: 4.84 ± 1.737
3.872ArgGly: 3.872 ± 1.456
2.904ArgHis: 2.904 ± 1.273
6.776ArgIle: 6.776 ± 1.796
0.968ArgLys: 0.968 ± 0.654
2.904ArgLeu: 2.904 ± 1.794
3.872ArgMet: 3.872 ± 1.762
1.936ArgAsn: 1.936 ± 1.07
2.904ArgPro: 2.904 ± 1.655
1.936ArgGln: 1.936 ± 1.07
10.649ArgArg: 10.649 ± 1.059
8.712ArgSer: 8.712 ± 2.211
7.744ArgThr: 7.744 ± 1.818
0.968ArgVal: 0.968 ± 0.654
2.904ArgTrp: 2.904 ± 1.345
2.904ArgTyr: 2.904 ± 0.958
0.0ArgXaa: 0.0 ± 0.0
Ser
4.84SerAla: 4.84 ± 1.88
0.0SerCys: 0.0 ± 0.0
2.904SerAsp: 2.904 ± 0.864
1.936SerGlu: 1.936 ± 1.701
3.872SerPhe: 3.872 ± 0.953
7.744SerGly: 7.744 ± 1.793
1.936SerHis: 1.936 ± 1.07
6.776SerIle: 6.776 ± 1.489
2.904SerLys: 2.904 ± 1.794
4.84SerLeu: 4.84 ± 2.229
0.0SerMet: 0.0 ± 0.0
3.872SerAsn: 3.872 ± 2.615
9.681SerPro: 9.681 ± 7.66
1.936SerGln: 1.936 ± 1.534
6.776SerArg: 6.776 ± 1.489
6.776SerSer: 6.776 ± 2.042
8.712SerThr: 8.712 ± 4.212
0.968SerVal: 0.968 ± 1.175
3.872SerTrp: 3.872 ± 0.89
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
7.744ThrAla: 7.744 ± 1.793
0.968ThrCys: 0.968 ± 0.767
3.872ThrAsp: 3.872 ± 2.085
1.936ThrGlu: 1.936 ± 1.308
0.0ThrPhe: 0.0 ± 0.0
6.776ThrGly: 6.776 ± 2.032
2.904ThrHis: 2.904 ± 0.864
1.936ThrIle: 1.936 ± 1.308
1.936ThrLys: 1.936 ± 1.07
4.84ThrLeu: 4.84 ± 3.508
0.968ThrMet: 0.968 ± 0.654
1.936ThrAsn: 1.936 ± 1.308
11.617ThrPro: 11.617 ± 3.433
2.904ThrGln: 2.904 ± 1.26
1.936ThrArg: 1.936 ± 1.247
6.776ThrSer: 6.776 ± 2.72
6.776ThrThr: 6.776 ± 2.2
3.872ThrVal: 3.872 ± 1.719
0.968ThrTrp: 0.968 ± 1.175
2.904ThrTyr: 2.904 ± 1.706
0.0ThrXaa: 0.0 ± 0.0
Val
0.968ValAla: 0.968 ± 0.767
0.0ValCys: 0.0 ± 0.0
1.936ValAsp: 1.936 ± 0.728
0.968ValGlu: 0.968 ± 0.767
0.968ValPhe: 0.968 ± 0.767
4.84ValGly: 4.84 ± 4.855
1.936ValHis: 1.936 ± 1.308
0.968ValIle: 0.968 ± 0.767
4.84ValLys: 4.84 ± 3.269
3.872ValLeu: 3.872 ± 1.456
1.936ValMet: 1.936 ± 1.333
4.84ValAsn: 4.84 ± 1.083
3.872ValPro: 3.872 ± 2.056
0.968ValGln: 0.968 ± 0.654
3.872ValArg: 3.872 ± 1.726
2.904ValSer: 2.904 ± 1.328
3.872ValThr: 3.872 ± 0.89
0.0ValVal: 0.0 ± 0.0
0.0ValTrp: 0.0 ± 0.0
1.936ValTyr: 1.936 ± 0.728
0.0ValXaa: 0.0 ± 0.0
Trp
0.968TrpAla: 0.968 ± 1.234
0.0TrpCys: 0.0 ± 0.0
1.936TrpAsp: 1.936 ± 1.247
1.936TrpGlu: 1.936 ± 1.247
0.968TrpPhe: 0.968 ± 0.654
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.936TrpIle: 1.936 ± 1.335
0.968TrpLys: 0.968 ± 0.654
3.872TrpLeu: 3.872 ± 1.27
0.0TrpMet: 0.0 ± 0.0
0.968TrpAsn: 0.968 ± 0.654
0.0TrpPro: 0.0 ± 0.0
0.968TrpGln: 0.968 ± 0.654
0.968TrpArg: 0.968 ± 1.234
2.904TrpSer: 2.904 ± 2.299
0.0TrpThr: 0.0 ± 0.0
2.904TrpVal: 2.904 ± 0.958
0.968TrpTrp: 0.968 ± 0.767
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.904TyrAla: 2.904 ± 1.152
1.936TyrCys: 1.936 ± 1.534
1.936TyrAsp: 1.936 ± 1.335
1.936TyrGlu: 1.936 ± 1.308
1.936TyrPhe: 1.936 ± 1.308
1.936TyrGly: 1.936 ± 1.308
0.0TyrHis: 0.0 ± 0.0
2.904TyrIle: 2.904 ± 1.345
1.936TyrLys: 1.936 ± 1.07
1.936TyrLeu: 1.936 ± 1.028
0.0TyrMet: 0.0 ± 0.0
1.936TyrAsn: 1.936 ± 1.534
2.904TyrPro: 2.904 ± 2.301
0.0TyrGln: 0.0 ± 0.0
4.84TyrArg: 4.84 ± 0.603
1.936TyrSer: 1.936 ± 0.728
0.968TyrThr: 0.968 ± 1.175
1.936TyrVal: 1.936 ± 0.728
0.968TyrTrp: 0.968 ± 0.654
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski