Amino acid dipepetide frequency for Klebsiella phage ST846-OXA48phi9.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.857AlaAla: 9.857 ± 0.923
0.939AlaCys: 0.939 ± 0.278
6.161AlaAsp: 6.161 ± 0.628
5.985AlaGlu: 5.985 ± 0.705
2.758AlaPhe: 2.758 ± 0.354
7.451AlaGly: 7.451 ± 0.719
1.115AlaHis: 1.115 ± 0.262
7.158AlaIle: 7.158 ± 0.787
4.342AlaLys: 4.342 ± 0.524
9.563AlaLeu: 9.563 ± 0.743
2.699AlaMet: 2.699 ± 0.421
4.224AlaAsn: 4.224 ± 0.473
3.52AlaPro: 3.52 ± 0.463
4.459AlaGln: 4.459 ± 0.657
5.691AlaArg: 5.691 ± 0.589
6.395AlaSer: 6.395 ± 0.677
5.398AlaThr: 5.398 ± 0.697
6.395AlaVal: 6.395 ± 0.637
1.643AlaTrp: 1.643 ± 0.315
2.112AlaTyr: 2.112 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.939CysAla: 0.939 ± 0.245
0.117CysCys: 0.117 ± 0.084
0.645CysAsp: 0.645 ± 0.21
0.997CysGlu: 0.997 ± 0.32
0.352CysPhe: 0.352 ± 0.174
1.232CysGly: 1.232 ± 0.287
0.235CysHis: 0.235 ± 0.121
0.763CysIle: 0.763 ± 0.218
0.587CysLys: 0.587 ± 0.191
0.645CysLeu: 0.645 ± 0.2
0.411CysMet: 0.411 ± 0.162
0.704CysAsn: 0.704 ± 0.203
0.645CysPro: 0.645 ± 0.18
0.352CysGln: 0.352 ± 0.127
1.232CysArg: 1.232 ± 0.239
1.232CysSer: 1.232 ± 0.333
0.235CysThr: 0.235 ± 0.11
0.645CysVal: 0.645 ± 0.19
0.235CysTrp: 0.235 ± 0.128
0.293CysTyr: 0.293 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
5.574AspAla: 5.574 ± 0.596
0.469AspCys: 0.469 ± 0.165
4.224AspAsp: 4.224 ± 0.604
4.694AspGlu: 4.694 ± 0.555
2.523AspPhe: 2.523 ± 0.381
5.28AspGly: 5.28 ± 0.578
0.997AspHis: 0.997 ± 0.259
3.872AspIle: 3.872 ± 0.418
3.051AspLys: 3.051 ± 0.502
4.576AspLeu: 4.576 ± 0.52
1.819AspMet: 1.819 ± 0.32
2.347AspAsn: 2.347 ± 0.305
3.051AspPro: 3.051 ± 0.419
2.23AspGln: 2.23 ± 0.384
2.464AspArg: 2.464 ± 0.368
3.168AspSer: 3.168 ± 0.429
3.344AspThr: 3.344 ± 0.359
4.459AspVal: 4.459 ± 0.435
0.997AspTrp: 0.997 ± 0.232
2.112AspTyr: 2.112 ± 0.414
0.0AspXaa: 0.0 ± 0.0
Glu
6.337GluAla: 6.337 ± 0.726
0.587GluCys: 0.587 ± 0.195
2.523GluAsp: 2.523 ± 0.465
2.934GluGlu: 2.934 ± 0.539
2.112GluPhe: 2.112 ± 0.308
4.576GluGly: 4.576 ± 0.573
0.763GluHis: 0.763 ± 0.187
4.107GluIle: 4.107 ± 0.41
3.755GluLys: 3.755 ± 0.497
6.454GluLeu: 6.454 ± 0.616
1.877GluMet: 1.877 ± 0.347
2.23GluAsn: 2.23 ± 0.4
2.347GluPro: 2.347 ± 0.393
3.051GluGln: 3.051 ± 0.512
3.696GluArg: 3.696 ± 0.502
3.227GluSer: 3.227 ± 0.442
3.579GluThr: 3.579 ± 0.548
3.579GluVal: 3.579 ± 0.491
1.525GluTrp: 1.525 ± 0.328
2.64GluTyr: 2.64 ± 0.503
0.0GluXaa: 0.0 ± 0.0
Phe
4.635PheAla: 4.635 ± 0.59
0.763PheCys: 0.763 ± 0.161
2.699PheAsp: 2.699 ± 0.386
1.525PheGlu: 1.525 ± 0.244
0.88PhePhe: 0.88 ± 0.198
2.406PheGly: 2.406 ± 0.318
0.645PheHis: 0.645 ± 0.161
1.467PheIle: 1.467 ± 0.281
1.467PheLys: 1.467 ± 0.251
2.406PheLeu: 2.406 ± 0.367
0.763PheMet: 0.763 ± 0.202
1.701PheAsn: 1.701 ± 0.314
1.525PhePro: 1.525 ± 0.344
1.232PheGln: 1.232 ± 0.265
2.112PheArg: 2.112 ± 0.367
2.288PheSer: 2.288 ± 0.297
2.816PheThr: 2.816 ± 0.389
1.936PheVal: 1.936 ± 0.331
0.528PheTrp: 0.528 ± 0.198
1.584PheTyr: 1.584 ± 0.312
0.0PheXaa: 0.0 ± 0.0
Gly
6.043GlyAla: 6.043 ± 0.843
0.939GlyCys: 0.939 ± 0.28
4.459GlyAsp: 4.459 ± 0.532
5.104GlyGlu: 5.104 ± 0.453
3.344GlyPhe: 3.344 ± 0.474
5.163GlyGly: 5.163 ± 0.755
1.525GlyHis: 1.525 ± 0.301
4.342GlyIle: 4.342 ± 0.476
4.283GlyLys: 4.283 ± 0.581
6.982GlyLeu: 6.982 ± 0.71
1.76GlyMet: 1.76 ± 0.3
2.992GlyAsn: 2.992 ± 0.43
1.877GlyPro: 1.877 ± 0.458
2.523GlyGln: 2.523 ± 0.441
3.579GlyArg: 3.579 ± 0.453
4.107GlySer: 4.107 ± 0.605
3.696GlyThr: 3.696 ± 0.468
5.808GlyVal: 5.808 ± 0.688
1.408GlyTrp: 1.408 ± 0.395
2.934GlyTyr: 2.934 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
1.349HisAla: 1.349 ± 0.293
0.411HisCys: 0.411 ± 0.163
1.232HisAsp: 1.232 ± 0.287
0.939HisGlu: 0.939 ± 0.236
0.88HisPhe: 0.88 ± 0.199
1.115HisGly: 1.115 ± 0.253
0.352HisHis: 0.352 ± 0.16
0.88HisIle: 0.88 ± 0.239
0.704HisLys: 0.704 ± 0.212
2.23HisLeu: 2.23 ± 0.342
0.176HisMet: 0.176 ± 0.104
0.411HisAsn: 0.411 ± 0.189
1.056HisPro: 1.056 ± 0.268
0.528HisGln: 0.528 ± 0.155
1.056HisArg: 1.056 ± 0.217
1.115HisSer: 1.115 ± 0.233
0.352HisThr: 0.352 ± 0.141
1.056HisVal: 1.056 ± 0.282
0.469HisTrp: 0.469 ± 0.187
0.469HisTyr: 0.469 ± 0.138
0.0HisXaa: 0.0 ± 0.0
Ile
6.278IleAla: 6.278 ± 0.69
1.232IleCys: 1.232 ± 0.27
4.459IleAsp: 4.459 ± 0.492
2.875IleGlu: 2.875 ± 0.381
1.584IlePhe: 1.584 ± 0.341
3.696IleGly: 3.696 ± 0.502
0.821IleHis: 0.821 ± 0.254
3.52IleIle: 3.52 ± 0.443
3.344IleLys: 3.344 ± 0.457
3.931IleLeu: 3.931 ± 0.471
0.528IleMet: 0.528 ± 0.217
2.699IleAsn: 2.699 ± 0.349
2.288IlePro: 2.288 ± 0.337
2.054IleGln: 2.054 ± 0.321
4.283IleArg: 4.283 ± 0.484
3.403IleSer: 3.403 ± 0.419
3.99IleThr: 3.99 ± 0.627
3.696IleVal: 3.696 ± 0.474
0.469IleTrp: 0.469 ± 0.163
1.995IleTyr: 1.995 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
5.456LysAla: 5.456 ± 0.732
0.997LysCys: 0.997 ± 0.276
3.11LysAsp: 3.11 ± 0.407
3.99LysGlu: 3.99 ± 0.587
1.349LysPhe: 1.349 ± 0.267
3.11LysGly: 3.11 ± 0.503
1.408LysHis: 1.408 ± 0.325
2.758LysIle: 2.758 ± 0.456
3.696LysLys: 3.696 ± 0.549
4.459LysLeu: 4.459 ± 0.476
1.643LysMet: 1.643 ± 0.236
2.054LysAsn: 2.054 ± 0.357
2.699LysPro: 2.699 ± 0.402
2.523LysGln: 2.523 ± 0.363
3.051LysArg: 3.051 ± 0.504
2.699LysSer: 2.699 ± 0.315
3.403LysThr: 3.403 ± 0.483
3.168LysVal: 3.168 ± 0.399
0.352LysTrp: 0.352 ± 0.154
1.467LysTyr: 1.467 ± 0.336
0.0LysXaa: 0.0 ± 0.0
Leu
7.686LeuAla: 7.686 ± 0.72
0.997LeuCys: 0.997 ± 0.277
5.456LeuAsp: 5.456 ± 0.552
5.222LeuGlu: 5.222 ± 0.549
2.64LeuPhe: 2.64 ± 0.411
6.454LeuGly: 6.454 ± 0.754
1.584LeuHis: 1.584 ± 0.304
5.691LeuIle: 5.691 ± 0.712
4.752LeuLys: 4.752 ± 0.735
8.507LeuLeu: 8.507 ± 1.017
1.584LeuMet: 1.584 ± 0.297
4.576LeuAsn: 4.576 ± 0.405
4.635LeuPro: 4.635 ± 0.656
3.168LeuGln: 3.168 ± 0.418
5.046LeuArg: 5.046 ± 0.601
5.926LeuSer: 5.926 ± 0.693
6.337LeuThr: 6.337 ± 0.545
5.574LeuVal: 5.574 ± 0.582
0.997LeuTrp: 0.997 ± 0.245
2.171LeuTyr: 2.171 ± 0.36
0.0LeuXaa: 0.0 ± 0.0
Met
2.992MetAla: 2.992 ± 0.377
0.293MetCys: 0.293 ± 0.138
1.232MetAsp: 1.232 ± 0.256
0.88MetGlu: 0.88 ± 0.237
0.88MetPhe: 0.88 ± 0.209
1.232MetGly: 1.232 ± 0.28
0.587MetHis: 0.587 ± 0.172
1.408MetIle: 1.408 ± 0.274
1.76MetLys: 1.76 ± 0.322
2.464MetLeu: 2.464 ± 0.409
0.469MetMet: 0.469 ± 0.137
0.587MetAsn: 0.587 ± 0.173
1.232MetPro: 1.232 ± 0.26
1.173MetGln: 1.173 ± 0.336
1.584MetArg: 1.584 ± 0.274
1.819MetSer: 1.819 ± 0.322
2.112MetThr: 2.112 ± 0.382
1.408MetVal: 1.408 ± 0.319
0.176MetTrp: 0.176 ± 0.099
0.763MetTyr: 0.763 ± 0.194
0.0MetXaa: 0.0 ± 0.0
Asn
4.107AsnAla: 4.107 ± 0.431
0.411AsnCys: 0.411 ± 0.145
2.288AsnAsp: 2.288 ± 0.35
2.523AsnGlu: 2.523 ± 0.369
0.763AsnPhe: 0.763 ± 0.225
3.696AsnGly: 3.696 ± 0.485
0.821AsnHis: 0.821 ± 0.21
2.23AsnIle: 2.23 ± 0.382
2.112AsnLys: 2.112 ± 0.341
2.992AsnLeu: 2.992 ± 0.366
1.115AsnMet: 1.115 ± 0.271
1.291AsnAsn: 1.291 ± 0.28
2.464AsnPro: 2.464 ± 0.458
1.701AsnGln: 1.701 ± 0.333
1.936AsnArg: 1.936 ± 0.424
2.054AsnSer: 2.054 ± 0.348
1.819AsnThr: 1.819 ± 0.349
2.816AsnVal: 2.816 ± 0.331
0.528AsnTrp: 0.528 ± 0.169
1.173AsnTyr: 1.173 ± 0.245
0.0AsnXaa: 0.0 ± 0.0
Pro
5.104ProAla: 5.104 ± 0.661
0.235ProCys: 0.235 ± 0.131
3.872ProAsp: 3.872 ± 0.605
3.52ProGlu: 3.52 ± 0.546
1.525ProPhe: 1.525 ± 0.267
3.11ProGly: 3.11 ± 0.523
1.349ProHis: 1.349 ± 0.297
1.349ProIle: 1.349 ± 0.22
1.701ProLys: 1.701 ± 0.315
3.286ProLeu: 3.286 ± 0.489
0.704ProMet: 0.704 ± 0.181
1.115ProAsn: 1.115 ± 0.239
1.643ProPro: 1.643 ± 0.378
0.997ProGln: 0.997 ± 0.228
2.347ProArg: 2.347 ± 0.413
2.347ProSer: 2.347 ± 0.427
2.64ProThr: 2.64 ± 0.428
3.462ProVal: 3.462 ± 0.459
0.821ProTrp: 0.821 ± 0.253
1.349ProTyr: 1.349 ± 0.365
0.0ProXaa: 0.0 ± 0.0
Gln
3.99GlnAla: 3.99 ± 0.57
0.176GlnCys: 0.176 ± 0.103
2.054GlnAsp: 2.054 ± 0.332
2.406GlnGlu: 2.406 ± 0.392
1.291GlnPhe: 1.291 ± 0.321
2.23GlnGly: 2.23 ± 0.341
0.352GlnHis: 0.352 ± 0.119
1.995GlnIle: 1.995 ± 0.38
2.758GlnLys: 2.758 ± 0.501
4.4GlnLeu: 4.4 ± 0.507
1.525GlnMet: 1.525 ± 0.265
1.525GlnAsn: 1.525 ± 0.383
1.584GlnPro: 1.584 ± 0.302
3.11GlnGln: 3.11 ± 0.6
3.344GlnArg: 3.344 ± 0.451
2.347GlnSer: 2.347 ± 0.514
2.523GlnThr: 2.523 ± 0.357
2.288GlnVal: 2.288 ± 0.377
0.411GlnTrp: 0.411 ± 0.142
0.939GlnTyr: 0.939 ± 0.205
0.0GlnXaa: 0.0 ± 0.0
Arg
5.808ArgAla: 5.808 ± 0.62
1.173ArgCys: 1.173 ± 0.289
2.464ArgAsp: 2.464 ± 0.38
3.931ArgGlu: 3.931 ± 0.478
1.877ArgPhe: 1.877 ± 0.306
3.227ArgGly: 3.227 ± 0.42
1.525ArgHis: 1.525 ± 0.294
3.168ArgIle: 3.168 ± 0.421
3.344ArgLys: 3.344 ± 0.434
6.63ArgLeu: 6.63 ± 0.854
1.819ArgMet: 1.819 ± 0.383
2.112ArgAsn: 2.112 ± 0.339
1.995ArgPro: 1.995 ± 0.285
3.11ArgGln: 3.11 ± 0.525
4.694ArgArg: 4.694 ± 0.791
3.051ArgSer: 3.051 ± 0.348
2.816ArgThr: 2.816 ± 0.361
4.283ArgVal: 4.283 ± 0.501
0.88ArgTrp: 0.88 ± 0.223
2.758ArgTyr: 2.758 ± 0.463
0.0ArgXaa: 0.0 ± 0.0
Ser
5.398SerAla: 5.398 ± 0.596
0.763SerCys: 0.763 ± 0.188
4.4SerAsp: 4.4 ± 0.413
3.755SerGlu: 3.755 ± 0.471
2.347SerPhe: 2.347 ± 0.421
5.574SerGly: 5.574 ± 0.626
0.587SerHis: 0.587 ± 0.192
3.344SerIle: 3.344 ± 0.377
3.11SerLys: 3.11 ± 0.438
4.342SerLeu: 4.342 ± 0.459
2.171SerMet: 2.171 ± 0.389
1.995SerAsn: 1.995 ± 0.408
2.464SerPro: 2.464 ± 0.403
2.464SerGln: 2.464 ± 0.34
3.52SerArg: 3.52 ± 0.443
3.638SerSer: 3.638 ± 0.502
4.107SerThr: 4.107 ± 0.552
4.048SerVal: 4.048 ± 0.528
1.232SerTrp: 1.232 ± 0.24
1.701SerTyr: 1.701 ± 0.336
0.0SerXaa: 0.0 ± 0.0
Thr
7.451ThrAla: 7.451 ± 0.769
0.411ThrCys: 0.411 ± 0.166
3.579ThrAsp: 3.579 ± 0.405
3.99ThrGlu: 3.99 ± 0.523
3.11ThrPhe: 3.11 ± 0.555
5.985ThrGly: 5.985 ± 0.708
0.645ThrHis: 0.645 ± 0.18
3.051ThrIle: 3.051 ± 0.46
2.171ThrLys: 2.171 ± 0.36
5.398ThrLeu: 5.398 ± 0.535
1.115ThrMet: 1.115 ± 0.221
1.467ThrAsn: 1.467 ± 0.273
2.699ThrPro: 2.699 ± 0.506
1.995ThrGln: 1.995 ± 0.38
2.875ThrArg: 2.875 ± 0.313
3.638ThrSer: 3.638 ± 0.463
3.579ThrThr: 3.579 ± 0.47
4.459ThrVal: 4.459 ± 0.604
1.115ThrTrp: 1.115 ± 0.271
1.467ThrTyr: 1.467 ± 0.297
0.0ThrXaa: 0.0 ± 0.0
Val
5.632ValAla: 5.632 ± 0.534
0.645ValCys: 0.645 ± 0.204
3.462ValAsp: 3.462 ± 0.402
4.283ValGlu: 4.283 ± 0.64
2.23ValPhe: 2.23 ± 0.402
4.928ValGly: 4.928 ± 0.558
0.88ValHis: 0.88 ± 0.219
3.462ValIle: 3.462 ± 0.443
4.459ValLys: 4.459 ± 0.527
5.926ValLeu: 5.926 ± 0.666
1.525ValMet: 1.525 ± 0.321
3.11ValAsn: 3.11 ± 0.462
2.64ValPro: 2.64 ± 0.375
1.877ValGln: 1.877 ± 0.301
3.872ValArg: 3.872 ± 0.436
5.28ValSer: 5.28 ± 0.587
4.459ValThr: 4.459 ± 0.704
4.459ValVal: 4.459 ± 0.606
0.939ValTrp: 0.939 ± 0.252
1.995ValTyr: 1.995 ± 0.268
0.0ValXaa: 0.0 ± 0.0
Trp
1.173TrpAla: 1.173 ± 0.286
0.176TrpCys: 0.176 ± 0.094
0.763TrpAsp: 0.763 ± 0.199
0.939TrpGlu: 0.939 ± 0.223
1.173TrpPhe: 1.173 ± 0.332
0.763TrpGly: 0.763 ± 0.206
0.176TrpHis: 0.176 ± 0.114
0.704TrpIle: 0.704 ± 0.212
0.645TrpLys: 0.645 ± 0.198
1.525TrpLeu: 1.525 ± 0.264
0.411TrpMet: 0.411 ± 0.192
0.821TrpAsn: 0.821 ± 0.193
0.528TrpPro: 0.528 ± 0.151
0.88TrpGln: 0.88 ± 0.228
1.408TrpArg: 1.408 ± 0.293
0.997TrpSer: 0.997 ± 0.204
1.115TrpThr: 1.115 ± 0.211
1.056TrpVal: 1.056 ± 0.246
0.176TrpTrp: 0.176 ± 0.107
0.176TrpTyr: 0.176 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.054TyrAla: 2.054 ± 0.41
0.763TyrCys: 0.763 ± 0.196
2.171TyrAsp: 2.171 ± 0.378
1.408TyrGlu: 1.408 ± 0.248
1.76TyrPhe: 1.76 ± 0.312
1.643TyrGly: 1.643 ± 0.365
0.411TyrHis: 0.411 ± 0.25
1.877TyrIle: 1.877 ± 0.326
1.349TyrLys: 1.349 ± 0.271
2.288TyrLeu: 2.288 ± 0.331
0.88TyrMet: 0.88 ± 0.226
0.88TyrAsn: 0.88 ± 0.261
1.584TyrPro: 1.584 ± 0.35
1.819TyrGln: 1.819 ± 0.265
2.875TyrArg: 2.875 ± 0.357
2.23TyrSer: 2.23 ± 0.318
1.877TyrThr: 1.877 ± 0.302
1.525TyrVal: 1.525 ± 0.298
0.704TyrTrp: 0.704 ± 0.174
0.704TyrTyr: 0.704 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 91 proteins (17045 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski