Amino acid dipepetide frequency for Equine herpesvirus 2 (strain 86/87) (EHV-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.683AlaAla: 9.683 ± 0.868
1.963AlaCys: 1.963 ± 0.25
3.35AlaAsp: 3.35 ± 0.357
4.214AlaGlu: 4.214 ± 0.574
3.114AlaPhe: 3.114 ± 0.296
7.014AlaGly: 7.014 ± 0.537
2.251AlaHis: 2.251 ± 0.247
2.826AlaIle: 2.826 ± 0.313
3.062AlaLys: 3.062 ± 0.279
7.145AlaLeu: 7.145 ± 0.515
1.361AlaMet: 1.361 ± 0.166
2.329AlaAsn: 2.329 ± 0.255
6.36AlaPro: 6.36 ± 0.892
2.879AlaGln: 2.879 ± 0.361
5.156AlaArg: 5.156 ± 0.619
6.517AlaSer: 6.517 ± 0.438
3.952AlaThr: 3.952 ± 0.412
5.862AlaVal: 5.862 ± 0.373
0.733AlaTrp: 0.733 ± 0.143
1.884AlaTyr: 1.884 ± 0.244
0.0AlaXaa: 0.0 ± 0.0
Cys
1.937CysAla: 1.937 ± 0.361
0.497CysCys: 0.497 ± 0.13
1.021CysAsp: 1.021 ± 0.176
1.727CysGlu: 1.727 ± 0.246
1.178CysPhe: 1.178 ± 0.227
1.518CysGly: 1.518 ± 0.187
0.497CysHis: 0.497 ± 0.118
0.864CysIle: 0.864 ± 0.128
0.785CysLys: 0.785 ± 0.168
3.088CysLeu: 3.088 ± 0.335
0.55CysMet: 0.55 ± 0.129
0.733CysAsn: 0.733 ± 0.13
1.256CysPro: 1.256 ± 0.202
1.125CysGln: 1.125 ± 0.201
1.413CysArg: 1.413 ± 0.259
1.439CysSer: 1.439 ± 0.229
1.178CysThr: 1.178 ± 0.159
1.675CysVal: 1.675 ± 0.233
0.314CysTrp: 0.314 ± 0.086
0.654CysTyr: 0.654 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
4.03AspAla: 4.03 ± 0.438
0.942AspCys: 0.942 ± 0.168
2.826AspAsp: 2.826 ± 0.336
3.245AspGlu: 3.245 ± 0.494
2.46AspPhe: 2.46 ± 0.244
4.161AspGly: 4.161 ± 0.543
1.021AspHis: 1.021 ± 0.184
1.858AspIle: 1.858 ± 0.265
1.57AspLys: 1.57 ± 0.201
5.077AspLeu: 5.077 ± 0.359
1.178AspMet: 1.178 ± 0.2
1.544AspAsn: 1.544 ± 0.163
3.507AspPro: 3.507 ± 0.804
1.282AspGln: 1.282 ± 0.169
2.696AspArg: 2.696 ± 0.275
3.402AspSer: 3.402 ± 0.319
2.172AspThr: 2.172 ± 0.254
3.402AspVal: 3.402 ± 0.296
0.707AspTrp: 0.707 ± 0.16
1.387AspTyr: 1.387 ± 0.175
0.0AspXaa: 0.0 ± 0.0
Glu
5.941GluAla: 5.941 ± 0.652
1.309GluCys: 1.309 ± 0.22
3.9GluAsp: 3.9 ± 0.493
5.444GluGlu: 5.444 ± 0.688
2.46GluPhe: 2.46 ± 0.295
6.281GluGly: 6.281 ± 1.023
0.837GluHis: 0.837 ± 0.137
2.408GluIle: 2.408 ± 0.271
2.382GluLys: 2.382 ± 0.315
4.894GluLeu: 4.894 ± 0.365
1.282GluMet: 1.282 ± 0.18
2.172GluAsn: 2.172 ± 0.26
4.214GluPro: 4.214 ± 1.585
1.492GluGln: 1.492 ± 0.227
3.769GluArg: 3.769 ± 0.46
4.266GluSer: 4.266 ± 0.543
3.062GluThr: 3.062 ± 0.318
4.161GluVal: 4.161 ± 0.357
0.393GluTrp: 0.393 ± 0.099
1.413GluTyr: 1.413 ± 0.186
0.0GluXaa: 0.0 ± 0.0
Phe
2.879PheAla: 2.879 ± 0.254
0.942PheCys: 0.942 ± 0.172
1.753PheAsp: 1.753 ± 0.244
2.225PheGlu: 2.225 ± 0.232
2.434PhePhe: 2.434 ± 0.314
2.643PheGly: 2.643 ± 0.262
0.968PheHis: 0.968 ± 0.133
2.329PheIle: 2.329 ± 0.287
2.774PheLys: 2.774 ± 0.374
5.313PheLeu: 5.313 ± 0.41
1.125PheMet: 1.125 ± 0.189
1.806PheAsn: 1.806 ± 0.257
2.329PhePro: 2.329 ± 0.203
1.544PheGln: 1.544 ± 0.178
1.963PheArg: 1.963 ± 0.254
3.821PheSer: 3.821 ± 0.377
2.172PheThr: 2.172 ± 0.338
2.905PheVal: 2.905 ± 0.359
0.707PheTrp: 0.707 ± 0.151
2.12PheTyr: 2.12 ± 0.246
0.0PheXaa: 0.0 ± 0.0
Gly
7.276GlyAla: 7.276 ± 0.627
1.675GlyCys: 1.675 ± 0.258
5.417GlyAsp: 5.417 ± 0.524
6.621GlyGlu: 6.621 ± 0.763
2.094GlyPhe: 2.094 ± 0.265
10.756GlyGly: 10.756 ± 1.081
1.439GlyHis: 1.439 ± 0.191
1.963GlyIle: 1.963 ± 0.192
2.198GlyLys: 2.198 ± 0.217
5.889GlyLeu: 5.889 ± 0.454
1.387GlyMet: 1.387 ± 0.183
1.989GlyAsn: 1.989 ± 0.226
5.103GlyPro: 5.103 ± 1.212
2.408GlyGln: 2.408 ± 0.264
5.574GlyArg: 5.574 ± 0.58
4.737GlySer: 4.737 ± 0.53
3.193GlyThr: 3.193 ± 0.232
5.784GlyVal: 5.784 ± 0.415
0.55GlyTrp: 0.55 ± 0.115
2.146GlyTyr: 2.146 ± 0.254
0.0GlyXaa: 0.0 ± 0.0
His
1.858HisAla: 1.858 ± 0.234
0.34HisCys: 0.34 ± 0.089
0.707HisAsp: 0.707 ± 0.149
1.204HisGlu: 1.204 ± 0.183
1.204HisPhe: 1.204 ± 0.18
1.727HisGly: 1.727 ± 0.231
0.471HisHis: 0.471 ± 0.111
0.864HisIle: 0.864 ± 0.174
1.021HisLys: 1.021 ± 0.143
2.722HisLeu: 2.722 ± 0.345
0.628HisMet: 0.628 ± 0.12
0.837HisAsn: 0.837 ± 0.153
1.78HisPro: 1.78 ± 0.276
0.628HisGln: 0.628 ± 0.123
1.439HisArg: 1.439 ± 0.174
1.492HisSer: 1.492 ± 0.221
1.309HisThr: 1.309 ± 0.16
2.041HisVal: 2.041 ± 0.231
0.209HisTrp: 0.209 ± 0.072
0.785HisTyr: 0.785 ± 0.14
0.0HisXaa: 0.0 ± 0.0
Ile
2.565IleAla: 2.565 ± 0.215
1.047IleCys: 1.047 ± 0.187
1.753IleAsp: 1.753 ± 0.218
1.989IleGlu: 1.989 ± 0.232
2.198IlePhe: 2.198 ± 0.314
1.492IleGly: 1.492 ± 0.172
1.047IleHis: 1.047 ± 0.158
1.884IleIle: 1.884 ± 0.242
1.727IleLys: 1.727 ± 0.252
4.397IleLeu: 4.397 ± 0.435
0.837IleMet: 0.837 ± 0.161
1.91IleAsn: 1.91 ± 0.231
2.015IlePro: 2.015 ± 0.244
1.361IleGln: 1.361 ± 0.205
1.91IleArg: 1.91 ± 0.201
3.01IleSer: 3.01 ± 0.292
2.146IleThr: 2.146 ± 0.289
2.172IleVal: 2.172 ± 0.256
0.471IleTrp: 0.471 ± 0.109
1.806IleTyr: 1.806 ± 0.22
0.0IleXaa: 0.0 ± 0.0
Lys
2.068LysAla: 2.068 ± 0.236
0.654LysCys: 0.654 ± 0.127
1.963LysAsp: 1.963 ± 0.202
2.198LysGlu: 2.198 ± 0.23
1.806LysPhe: 1.806 ± 0.246
2.251LysGly: 2.251 ± 0.297
1.387LysHis: 1.387 ± 0.203
2.12LysIle: 2.12 ± 0.239
3.324LysLys: 3.324 ± 0.394
3.978LysLeu: 3.978 ± 0.357
1.099LysMet: 1.099 ± 0.193
2.277LysAsn: 2.277 ± 0.3
3.455LysPro: 3.455 ± 1.329
1.387LysGln: 1.387 ± 0.164
2.591LysArg: 2.591 ± 0.302
3.245LysSer: 3.245 ± 0.307
3.167LysThr: 3.167 ± 0.269
2.565LysVal: 2.565 ± 0.264
0.314LysTrp: 0.314 ± 0.078
1.439LysTyr: 1.439 ± 0.206
0.0LysXaa: 0.0 ± 0.0
Leu
7.563LeuAla: 7.563 ± 0.468
2.617LeuCys: 2.617 ± 0.358
4.371LeuAsp: 4.371 ± 0.332
5.81LeuGlu: 5.81 ± 0.425
4.632LeuPhe: 4.632 ± 0.39
6.438LeuGly: 6.438 ± 0.463
2.46LeuHis: 2.46 ± 0.251
3.612LeuIle: 3.612 ± 0.37
4.606LeuLys: 4.606 ± 0.327
9.186LeuLeu: 9.186 ± 0.675
1.832LeuMet: 1.832 ± 0.223
4.214LeuAsn: 4.214 ± 0.383
5.522LeuPro: 5.522 ± 0.446
3.376LeuGln: 3.376 ± 0.352
6.752LeuArg: 6.752 ± 0.482
7.93LeuSer: 7.93 ± 0.549
5.313LeuThr: 5.313 ± 0.335
6.019LeuVal: 6.019 ± 0.593
1.256LeuTrp: 1.256 ± 0.193
3.585LeuTyr: 3.585 ± 0.296
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.298
0.419MetCys: 0.419 ± 0.14
0.811MetAsp: 0.811 ± 0.133
1.492MetGlu: 1.492 ± 0.23
1.204MetPhe: 1.204 ± 0.222
1.413MetGly: 1.413 ± 0.141
0.393MetHis: 0.393 ± 0.097
0.89MetIle: 0.89 ± 0.189
0.654MetLys: 0.654 ± 0.143
2.329MetLeu: 2.329 ± 0.256
0.55MetMet: 0.55 ± 0.122
0.471MetAsn: 0.471 ± 0.085
0.759MetPro: 0.759 ± 0.163
0.55MetGln: 0.55 ± 0.147
1.047MetArg: 1.047 ± 0.183
1.387MetSer: 1.387 ± 0.196
1.623MetThr: 1.623 ± 0.227
1.204MetVal: 1.204 ± 0.2
0.183MetTrp: 0.183 ± 0.08
0.89MetTyr: 0.89 ± 0.149
0.0MetXaa: 0.0 ± 0.0
Asn
1.989AsnAla: 1.989 ± 0.256
0.707AsnCys: 0.707 ± 0.168
0.811AsnAsp: 0.811 ± 0.127
1.335AsnGlu: 1.335 ± 0.175
1.361AsnPhe: 1.361 ± 0.203
2.225AsnGly: 2.225 ± 0.3
0.68AsnHis: 0.68 ± 0.15
2.146AsnIle: 2.146 ± 0.246
1.623AsnLys: 1.623 ± 0.23
4.109AsnLeu: 4.109 ± 0.376
0.811AsnMet: 0.811 ± 0.15
1.099AsnAsn: 1.099 ± 0.201
2.329AsnPro: 2.329 ± 0.22
1.099AsnGln: 1.099 ± 0.169
1.884AsnArg: 1.884 ± 0.26
2.957AsnSer: 2.957 ± 0.34
1.91AsnThr: 1.91 ± 0.235
2.957AsnVal: 2.957 ± 0.314
0.419AsnTrp: 0.419 ± 0.101
1.387AsnTyr: 1.387 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
5.47ProAla: 5.47 ± 0.65
1.361ProCys: 1.361 ± 0.218
3.036ProAsp: 3.036 ± 0.645
5.731ProGlu: 5.731 ± 1.745
2.355ProPhe: 2.355 ± 0.289
6.883ProGly: 6.883 ± 1.17
1.413ProHis: 1.413 ± 0.174
1.91ProIle: 1.91 ± 0.224
3.507ProLys: 3.507 ± 1.344
5.365ProLeu: 5.365 ± 0.325
1.021ProMet: 1.021 ± 0.19
1.256ProAsn: 1.256 ± 0.266
9.108ProPro: 9.108 ± 2.934
3.69ProGln: 3.69 ± 0.835
4.057ProArg: 4.057 ± 0.554
4.344ProSer: 4.344 ± 0.433
2.931ProThr: 2.931 ± 0.276
4.946ProVal: 4.946 ± 0.302
0.759ProTrp: 0.759 ± 0.171
1.57ProTyr: 1.57 ± 0.178
0.0ProXaa: 0.0 ± 0.0
Gln
3.219GlnAla: 3.219 ± 0.475
0.837GlnCys: 0.837 ± 0.135
1.125GlnAsp: 1.125 ± 0.186
1.884GlnGlu: 1.884 ± 0.232
1.649GlnPhe: 1.649 ± 0.212
2.8GlnGly: 2.8 ± 0.27
0.942GlnHis: 0.942 ± 0.189
1.544GlnIle: 1.544 ± 0.168
1.596GlnLys: 1.596 ± 0.253
3.167GlnLeu: 3.167 ± 0.352
0.602GlnMet: 0.602 ± 0.135
1.23GlnAsn: 1.23 ± 0.197
3.245GlnPro: 3.245 ± 0.71
3.402GlnGln: 3.402 ± 0.987
2.068GlnArg: 2.068 ± 0.246
2.068GlnSer: 2.068 ± 0.227
1.989GlnThr: 1.989 ± 0.249
2.094GlnVal: 2.094 ± 0.235
0.34GlnTrp: 0.34 ± 0.07
1.047GlnTyr: 1.047 ± 0.224
0.0GlnXaa: 0.0 ± 0.0
Arg
5.967ArgAla: 5.967 ± 0.41
1.806ArgCys: 1.806 ± 0.264
4.057ArgAsp: 4.057 ± 0.331
4.711ArgGlu: 4.711 ± 0.665
2.172ArgPhe: 2.172 ± 0.225
5.496ArgGly: 5.496 ± 0.612
1.544ArgHis: 1.544 ± 0.188
1.649ArgIle: 1.649 ± 0.191
2.146ArgLys: 2.146 ± 0.261
4.842ArgLeu: 4.842 ± 0.377
0.968ArgMet: 0.968 ± 0.168
1.518ArgAsn: 1.518 ± 0.187
4.004ArgPro: 4.004 ± 0.417
2.355ArgGln: 2.355 ± 0.283
4.554ArgArg: 4.554 ± 0.385
3.742ArgSer: 3.742 ± 0.341
2.172ArgThr: 2.172 ± 0.193
4.318ArgVal: 4.318 ± 0.478
0.576ArgTrp: 0.576 ± 0.092
1.858ArgTyr: 1.858 ± 0.26
0.0ArgXaa: 0.0 ± 0.0
Ser
4.789SerAla: 4.789 ± 0.464
1.858SerCys: 1.858 ± 0.29
4.214SerAsp: 4.214 ± 0.419
3.978SerGlu: 3.978 ± 0.462
3.245SerPhe: 3.245 ± 0.341
5.051SerGly: 5.051 ± 0.465
1.701SerHis: 1.701 ± 0.242
2.355SerIle: 2.355 ± 0.234
3.455SerLys: 3.455 ± 0.33
8.479SerLeu: 8.479 ± 0.455
1.623SerMet: 1.623 ± 0.26
2.015SerAsn: 2.015 ± 0.188
5.182SerPro: 5.182 ± 0.397
3.062SerGln: 3.062 ± 0.337
4.658SerArg: 4.658 ± 0.521
6.386SerSer: 6.386 ± 0.898
3.952SerThr: 3.952 ± 0.558
5.182SerVal: 5.182 ± 0.496
0.654SerTrp: 0.654 ± 0.124
1.937SerTyr: 1.937 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
3.873ThrAla: 3.873 ± 0.346
1.335ThrCys: 1.335 ± 0.205
2.565ThrAsp: 2.565 ± 0.292
2.696ThrGlu: 2.696 ± 0.272
2.879ThrPhe: 2.879 ± 0.426
3.324ThrGly: 3.324 ± 0.321
1.335ThrHis: 1.335 ± 0.16
1.937ThrIle: 1.937 ± 0.278
1.806ThrLys: 1.806 ± 0.237
5.758ThrLeu: 5.758 ± 0.309
1.152ThrMet: 1.152 ± 0.254
1.727ThrAsn: 1.727 ± 0.275
3.821ThrPro: 3.821 ± 0.32
1.858ThrGln: 1.858 ± 0.232
2.826ThrArg: 2.826 ± 0.231
4.449ThrSer: 4.449 ± 0.53
3.795ThrThr: 3.795 ± 0.633
3.69ThrVal: 3.69 ± 0.371
0.471ThrTrp: 0.471 ± 0.124
1.518ThrTyr: 1.518 ± 0.223
0.0ThrXaa: 0.0 ± 0.0
Val
5.182ValAla: 5.182 ± 0.445
1.91ValCys: 1.91 ± 0.254
3.088ValAsp: 3.088 ± 0.305
3.69ValGlu: 3.69 ± 0.402
4.292ValPhe: 4.292 ± 0.497
4.371ValGly: 4.371 ± 0.394
1.701ValHis: 1.701 ± 0.26
2.748ValIle: 2.748 ± 0.27
3.141ValLys: 3.141 ± 0.28
6.621ValLeu: 6.621 ± 0.529
1.544ValMet: 1.544 ± 0.239
2.512ValAsn: 2.512 ± 0.302
4.371ValPro: 4.371 ± 0.331
2.068ValGln: 2.068 ± 0.24
3.69ValArg: 3.69 ± 0.312
5.444ValSer: 5.444 ± 0.449
4.266ValThr: 4.266 ± 0.329
4.92ValVal: 4.92 ± 0.545
0.628ValTrp: 0.628 ± 0.158
2.722ValTyr: 2.722 ± 0.334
0.0ValXaa: 0.0 ± 0.0
Trp
0.811TrpAla: 0.811 ± 0.154
0.314TrpCys: 0.314 ± 0.1
0.366TrpAsp: 0.366 ± 0.106
0.628TrpGlu: 0.628 ± 0.123
0.471TrpPhe: 0.471 ± 0.123
0.759TrpGly: 0.759 ± 0.182
0.314TrpHis: 0.314 ± 0.082
0.34TrpIle: 0.34 ± 0.1
0.471TrpLys: 0.471 ± 0.118
1.152TrpLeu: 1.152 ± 0.19
0.157TrpMet: 0.157 ± 0.068
0.471TrpAsn: 0.471 ± 0.125
0.733TrpPro: 0.733 ± 0.18
0.393TrpGln: 0.393 ± 0.1
0.602TrpArg: 0.602 ± 0.149
0.55TrpSer: 0.55 ± 0.12
0.759TrpThr: 0.759 ± 0.145
0.523TrpVal: 0.523 ± 0.138
0.079TrpTrp: 0.079 ± 0.044
0.262TrpTyr: 0.262 ± 0.08
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.12TyrAla: 2.12 ± 0.247
0.916TyrCys: 0.916 ± 0.199
1.335TyrAsp: 1.335 ± 0.241
1.256TyrGlu: 1.256 ± 0.151
1.544TyrPhe: 1.544 ± 0.192
1.596TyrGly: 1.596 ± 0.178
0.864TyrHis: 0.864 ± 0.161
1.492TyrIle: 1.492 ± 0.217
1.439TyrLys: 1.439 ± 0.218
3.585TyrLeu: 3.585 ± 0.363
0.968TyrMet: 0.968 ± 0.148
1.727TyrAsn: 1.727 ± 0.265
1.623TyrPro: 1.623 ± 0.21
0.89TyrGln: 0.89 ± 0.174
1.806TyrArg: 1.806 ± 0.223
2.591TyrSer: 2.591 ± 0.278
1.78TyrThr: 1.78 ± 0.217
2.486TyrVal: 2.486 ± 0.329
0.393TyrTrp: 0.393 ± 0.095
1.387TyrTyr: 1.387 ± 0.231
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (38211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski