Amino acid dipepetide frequency for Paracoccus phage vB_PyeM_Pyei1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.108AlaAla: 22.108 ± 1.852
0.908AlaCys: 0.908 ± 0.224
9.336AlaAsp: 9.336 ± 0.941
8.817AlaGlu: 8.817 ± 0.816
4.538AlaPhe: 4.538 ± 0.616
12.448AlaGly: 12.448 ± 1.449
2.075AlaHis: 2.075 ± 0.345
5.122AlaIle: 5.122 ± 0.557
4.409AlaLys: 4.409 ± 0.693
12.254AlaLeu: 12.254 ± 0.93
4.474AlaMet: 4.474 ± 0.562
3.566AlaAsn: 3.566 ± 0.422
6.354AlaPro: 6.354 ± 0.642
5.252AlaGln: 5.252 ± 0.53
9.531AlaArg: 9.531 ± 0.65
7.261AlaSer: 7.261 ± 0.692
7.391AlaThr: 7.391 ± 0.638
7.65AlaVal: 7.65 ± 0.913
1.88AlaTrp: 1.88 ± 0.323
2.658AlaTyr: 2.658 ± 0.342
0.0AlaXaa: 0.0 ± 0.0
Cys
0.843CysAla: 0.843 ± 0.214
0.324CysCys: 0.324 ± 0.12
0.713CysAsp: 0.713 ± 0.208
0.324CysGlu: 0.324 ± 0.152
0.13CysPhe: 0.13 ± 0.081
0.908CysGly: 0.908 ± 0.259
0.195CysHis: 0.195 ± 0.113
0.454CysIle: 0.454 ± 0.155
0.259CysLys: 0.259 ± 0.122
0.778CysLeu: 0.778 ± 0.263
0.195CysMet: 0.195 ± 0.103
0.324CysAsn: 0.324 ± 0.182
0.584CysPro: 0.584 ± 0.172
0.195CysGln: 0.195 ± 0.111
1.621CysArg: 1.621 ± 0.316
0.324CysSer: 0.324 ± 0.155
0.259CysThr: 0.259 ± 0.131
0.324CysVal: 0.324 ± 0.126
0.065CysTrp: 0.065 ± 0.064
0.065CysTyr: 0.065 ± 0.061
0.0CysXaa: 0.0 ± 0.0
Asp
7.067AspAla: 7.067 ± 0.625
0.519AspCys: 0.519 ± 0.211
3.371AspAsp: 3.371 ± 0.558
3.696AspGlu: 3.696 ± 0.519
2.01AspPhe: 2.01 ± 0.39
6.872AspGly: 6.872 ± 0.677
1.297AspHis: 1.297 ± 0.288
2.529AspIle: 2.529 ± 0.316
2.01AspLys: 2.01 ± 0.331
7.132AspLeu: 7.132 ± 0.597
1.362AspMet: 1.362 ± 0.29
1.102AspAsn: 1.102 ± 0.289
3.436AspPro: 3.436 ± 0.459
2.593AspGln: 2.593 ± 0.445
5.187AspArg: 5.187 ± 0.495
1.362AspSer: 1.362 ± 0.274
2.788AspThr: 2.788 ± 0.69
3.825AspVal: 3.825 ± 0.462
1.815AspTrp: 1.815 ± 0.274
1.426AspTyr: 1.426 ± 0.324
0.0AspXaa: 0.0 ± 0.0
Glu
9.206GluAla: 9.206 ± 0.817
0.454GluCys: 0.454 ± 0.192
2.529GluAsp: 2.529 ± 0.397
3.307GluGlu: 3.307 ± 0.57
1.88GluPhe: 1.88 ± 0.372
5.122GluGly: 5.122 ± 0.785
1.102GluHis: 1.102 ± 0.267
2.853GluIle: 2.853 ± 0.445
1.621GluLys: 1.621 ± 0.338
3.955GluLeu: 3.955 ± 0.551
1.945GluMet: 1.945 ± 0.352
1.232GluAsn: 1.232 ± 0.274
3.436GluPro: 3.436 ± 0.523
1.945GluGln: 1.945 ± 0.371
4.085GluArg: 4.085 ± 0.529
2.01GluSer: 2.01 ± 0.366
3.89GluThr: 3.89 ± 0.427
4.733GluVal: 4.733 ± 0.533
0.973GluTrp: 0.973 ± 0.214
0.908GluTyr: 0.908 ± 0.238
0.0GluXaa: 0.0 ± 0.0
Phe
3.696PheAla: 3.696 ± 0.534
0.389PheCys: 0.389 ± 0.154
1.815PheAsp: 1.815 ± 0.373
1.362PheGlu: 1.362 ± 0.287
0.778PhePhe: 0.778 ± 0.227
2.529PheGly: 2.529 ± 0.404
0.389PheHis: 0.389 ± 0.207
1.167PheIle: 1.167 ± 0.271
1.167PheLys: 1.167 ± 0.289
1.815PheLeu: 1.815 ± 0.375
0.713PheMet: 0.713 ± 0.185
0.454PheAsn: 0.454 ± 0.17
1.362PhePro: 1.362 ± 0.301
1.037PheGln: 1.037 ± 0.266
1.815PheArg: 1.815 ± 0.357
2.01PheSer: 2.01 ± 0.477
1.297PheThr: 1.297 ± 0.305
1.426PheVal: 1.426 ± 0.383
0.584PheTrp: 0.584 ± 0.2
0.454PheTyr: 0.454 ± 0.165
0.0PheXaa: 0.0 ± 0.0
Gly
11.346GlyAla: 11.346 ± 1.348
0.713GlyCys: 0.713 ± 0.188
4.992GlyAsp: 4.992 ± 0.982
5.576GlyGlu: 5.576 ± 0.531
2.853GlyPhe: 2.853 ± 0.545
9.92GlyGly: 9.92 ± 2.407
1.88GlyHis: 1.88 ± 0.361
4.149GlyIle: 4.149 ± 0.619
3.436GlyLys: 3.436 ± 0.46
6.937GlyLeu: 6.937 ± 0.514
2.14GlyMet: 2.14 ± 0.404
2.01GlyAsn: 2.01 ± 0.519
2.853GlyPro: 2.853 ± 0.534
3.501GlyGln: 3.501 ± 0.528
7.067GlyArg: 7.067 ± 0.591
5.316GlySer: 5.316 ± 0.717
5.77GlyThr: 5.77 ± 0.764
6.872GlyVal: 6.872 ± 0.697
2.464GlyTrp: 2.464 ± 0.331
2.529GlyTyr: 2.529 ± 0.365
0.0GlyXaa: 0.0 ± 0.0
His
1.686HisAla: 1.686 ± 0.353
0.13HisCys: 0.13 ± 0.092
1.621HisAsp: 1.621 ± 0.45
0.778HisGlu: 0.778 ± 0.209
0.389HisPhe: 0.389 ± 0.147
2.204HisGly: 2.204 ± 0.422
0.843HisHis: 0.843 ± 0.241
0.778HisIle: 0.778 ± 0.234
0.324HisLys: 0.324 ± 0.134
1.945HisLeu: 1.945 ± 0.334
0.454HisMet: 0.454 ± 0.148
0.584HisAsn: 0.584 ± 0.192
0.973HisPro: 0.973 ± 0.303
0.713HisGln: 0.713 ± 0.268
1.556HisArg: 1.556 ± 0.252
0.843HisSer: 0.843 ± 0.191
1.037HisThr: 1.037 ± 0.318
0.908HisVal: 0.908 ± 0.248
0.389HisTrp: 0.389 ± 0.163
0.389HisTyr: 0.389 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
6.289IleAla: 6.289 ± 0.675
0.648IleCys: 0.648 ± 0.208
2.593IleAsp: 2.593 ± 0.363
3.825IleGlu: 3.825 ± 0.451
1.102IlePhe: 1.102 ± 0.325
4.02IleGly: 4.02 ± 0.569
0.908IleHis: 0.908 ± 0.256
2.464IleIle: 2.464 ± 0.466
1.362IleLys: 1.362 ± 0.299
3.76IleLeu: 3.76 ± 0.435
0.778IleMet: 0.778 ± 0.178
2.01IleAsn: 2.01 ± 0.383
2.14IlePro: 2.14 ± 0.345
1.102IleGln: 1.102 ± 0.207
3.955IleArg: 3.955 ± 0.489
2.658IleSer: 2.658 ± 0.39
3.242IleThr: 3.242 ± 0.528
4.02IleVal: 4.02 ± 0.487
0.973IleTrp: 0.973 ± 0.231
1.621IleTyr: 1.621 ± 0.322
0.0IleXaa: 0.0 ± 0.0
Lys
5.446LysAla: 5.446 ± 0.66
0.389LysCys: 0.389 ± 0.154
2.269LysAsp: 2.269 ± 0.339
1.362LysGlu: 1.362 ± 0.247
0.519LysPhe: 0.519 ± 0.217
2.788LysGly: 2.788 ± 0.372
0.713LysHis: 0.713 ± 0.256
1.362LysIle: 1.362 ± 0.285
0.908LysLys: 0.908 ± 0.247
2.464LysLeu: 2.464 ± 0.381
0.843LysMet: 0.843 ± 0.242
0.908LysAsn: 0.908 ± 0.245
1.815LysPro: 1.815 ± 0.363
1.037LysGln: 1.037 ± 0.238
2.788LysArg: 2.788 ± 0.363
1.88LysSer: 1.88 ± 0.357
1.945LysThr: 1.945 ± 0.427
2.334LysVal: 2.334 ± 0.416
0.584LysTrp: 0.584 ± 0.191
0.454LysTyr: 0.454 ± 0.167
0.0LysXaa: 0.0 ± 0.0
Leu
11.994LeuAla: 11.994 ± 0.963
0.908LeuCys: 0.908 ± 0.214
5.187LeuAsp: 5.187 ± 0.59
4.344LeuGlu: 4.344 ± 0.57
1.945LeuPhe: 1.945 ± 0.387
7.197LeuGly: 7.197 ± 0.754
1.426LeuHis: 1.426 ± 0.285
3.696LeuIle: 3.696 ± 0.48
3.047LeuLys: 3.047 ± 0.487
4.992LeuLeu: 4.992 ± 0.741
2.075LeuMet: 2.075 ± 0.408
1.945LeuAsn: 1.945 ± 0.342
5.381LeuPro: 5.381 ± 0.577
2.853LeuGln: 2.853 ± 0.513
6.678LeuArg: 6.678 ± 0.622
4.798LeuSer: 4.798 ± 0.751
6.094LeuThr: 6.094 ± 0.721
4.992LeuVal: 4.992 ± 0.653
1.167LeuTrp: 1.167 ± 0.244
1.167LeuTyr: 1.167 ± 0.32
0.0LeuXaa: 0.0 ± 0.0
Met
3.696MetAla: 3.696 ± 0.535
0.13MetCys: 0.13 ± 0.092
1.556MetAsp: 1.556 ± 0.326
1.426MetGlu: 1.426 ± 0.279
0.584MetPhe: 0.584 ± 0.162
2.204MetGly: 2.204 ± 0.313
0.324MetHis: 0.324 ± 0.136
1.037MetIle: 1.037 ± 0.298
1.426MetLys: 1.426 ± 0.289
1.88MetLeu: 1.88 ± 0.29
0.908MetMet: 0.908 ± 0.216
0.648MetAsn: 0.648 ± 0.215
1.426MetPro: 1.426 ± 0.336
1.102MetGln: 1.102 ± 0.281
2.204MetArg: 2.204 ± 0.368
1.751MetSer: 1.751 ± 0.356
2.658MetThr: 2.658 ± 0.414
2.01MetVal: 2.01 ± 0.301
0.0MetTrp: 0.0 ± 0.0
0.259MetTyr: 0.259 ± 0.131
0.0MetXaa: 0.0 ± 0.0
Asn
4.085AsnAla: 4.085 ± 0.599
0.259AsnCys: 0.259 ± 0.112
1.621AsnAsp: 1.621 ± 0.471
1.167AsnGlu: 1.167 ± 0.264
0.13AsnPhe: 0.13 ± 0.098
2.918AsnGly: 2.918 ± 0.445
0.648AsnHis: 0.648 ± 0.212
1.102AsnIle: 1.102 ± 0.281
0.454AsnLys: 0.454 ± 0.148
2.334AsnLeu: 2.334 ± 0.33
0.454AsnMet: 0.454 ± 0.158
0.584AsnAsn: 0.584 ± 0.225
0.908AsnPro: 0.908 ± 0.246
0.713AsnGln: 0.713 ± 0.228
1.815AsnArg: 1.815 ± 0.328
1.426AsnSer: 1.426 ± 0.303
1.426AsnThr: 1.426 ± 0.365
1.491AsnVal: 1.491 ± 0.39
0.519AsnTrp: 0.519 ± 0.184
0.389AsnTyr: 0.389 ± 0.136
0.0AsnXaa: 0.0 ± 0.0
Pro
8.234ProAla: 8.234 ± 0.78
0.519ProCys: 0.519 ± 0.158
3.177ProAsp: 3.177 ± 0.412
2.853ProGlu: 2.853 ± 0.35
1.167ProPhe: 1.167 ± 0.256
4.798ProGly: 4.798 ± 0.697
0.973ProHis: 0.973 ± 0.329
2.788ProIle: 2.788 ± 0.406
1.621ProLys: 1.621 ± 0.414
3.566ProLeu: 3.566 ± 0.516
1.88ProMet: 1.88 ± 0.338
1.037ProAsn: 1.037 ± 0.282
2.334ProPro: 2.334 ± 0.441
1.102ProGln: 1.102 ± 0.232
3.112ProArg: 3.112 ± 0.453
3.242ProSer: 3.242 ± 0.401
2.788ProThr: 2.788 ± 0.383
4.409ProVal: 4.409 ± 0.504
1.167ProTrp: 1.167 ± 0.327
1.102ProTyr: 1.102 ± 0.217
0.0ProXaa: 0.0 ± 0.0
Gln
4.927GlnAla: 4.927 ± 0.553
0.065GlnCys: 0.065 ± 0.07
1.945GlnAsp: 1.945 ± 0.363
1.037GlnGlu: 1.037 ± 0.406
1.362GlnPhe: 1.362 ± 0.298
3.112GlnGly: 3.112 ± 0.409
0.519GlnHis: 0.519 ± 0.191
2.334GlnIle: 2.334 ± 0.39
1.167GlnLys: 1.167 ± 0.309
2.01GlnLeu: 2.01 ± 0.369
1.102GlnMet: 1.102 ± 0.259
0.973GlnAsn: 0.973 ± 0.301
2.788GlnPro: 2.788 ± 0.401
1.362GlnGln: 1.362 ± 0.289
2.593GlnArg: 2.593 ± 0.467
1.362GlnSer: 1.362 ± 0.285
2.14GlnThr: 2.14 ± 0.404
3.112GlnVal: 3.112 ± 0.402
0.648GlnTrp: 0.648 ± 0.176
0.454GlnTyr: 0.454 ± 0.163
0.0GlnXaa: 0.0 ± 0.0
Arg
9.336ArgAla: 9.336 ± 0.757
0.778ArgCys: 0.778 ± 0.204
4.668ArgAsp: 4.668 ± 0.512
4.149ArgGlu: 4.149 ± 0.602
2.334ArgPhe: 2.334 ± 0.334
6.03ArgGly: 6.03 ± 0.64
1.751ArgHis: 1.751 ± 0.344
4.733ArgIle: 4.733 ± 0.664
3.047ArgLys: 3.047 ± 0.381
7.132ArgLeu: 7.132 ± 0.755
1.621ArgMet: 1.621 ± 0.303
2.269ArgAsn: 2.269 ± 0.36
4.214ArgPro: 4.214 ± 0.514
3.371ArgGln: 3.371 ± 0.591
6.937ArgArg: 6.937 ± 0.844
3.436ArgSer: 3.436 ± 0.506
3.696ArgThr: 3.696 ± 0.603
4.149ArgVal: 4.149 ± 0.567
1.945ArgTrp: 1.945 ± 0.357
1.751ArgTyr: 1.751 ± 0.294
0.0ArgXaa: 0.0 ± 0.0
Ser
6.354SerAla: 6.354 ± 0.834
0.389SerCys: 0.389 ± 0.151
3.631SerAsp: 3.631 ± 0.393
2.658SerGlu: 2.658 ± 0.424
1.102SerPhe: 1.102 ± 0.271
6.159SerGly: 6.159 ± 0.615
0.713SerHis: 0.713 ± 0.28
2.982SerIle: 2.982 ± 0.447
1.167SerLys: 1.167 ± 0.218
4.863SerLeu: 4.863 ± 0.505
1.686SerMet: 1.686 ± 0.25
1.102SerAsn: 1.102 ± 0.258
2.399SerPro: 2.399 ± 0.429
1.621SerGln: 1.621 ± 0.28
3.825SerArg: 3.825 ± 0.531
3.371SerSer: 3.371 ± 0.595
2.788SerThr: 2.788 ± 0.372
3.501SerVal: 3.501 ± 0.456
0.713SerTrp: 0.713 ± 0.213
0.973SerTyr: 0.973 ± 0.295
0.0SerXaa: 0.0 ± 0.0
Thr
7.326ThrAla: 7.326 ± 0.827
0.389ThrCys: 0.389 ± 0.146
3.76ThrAsp: 3.76 ± 0.532
4.085ThrGlu: 4.085 ± 0.665
1.297ThrPhe: 1.297 ± 0.306
5.381ThrGly: 5.381 ± 0.514
1.037ThrHis: 1.037 ± 0.294
4.538ThrIle: 4.538 ± 0.521
1.751ThrLys: 1.751 ± 0.405
3.501ThrLeu: 3.501 ± 0.484
1.945ThrMet: 1.945 ± 0.36
1.491ThrAsn: 1.491 ± 0.29
3.242ThrPro: 3.242 ± 0.405
1.556ThrGln: 1.556 ± 0.266
4.279ThrArg: 4.279 ± 0.572
2.918ThrSer: 2.918 ± 0.409
2.853ThrThr: 2.853 ± 0.382
4.992ThrVal: 4.992 ± 0.517
0.908ThrTrp: 0.908 ± 0.252
1.491ThrTyr: 1.491 ± 0.336
0.0ThrXaa: 0.0 ± 0.0
Val
9.595ValAla: 9.595 ± 0.782
0.584ValCys: 0.584 ± 0.164
3.955ValAsp: 3.955 ± 0.493
4.538ValGlu: 4.538 ± 0.684
0.778ValPhe: 0.778 ± 0.237
4.538ValGly: 4.538 ± 0.535
1.167ValHis: 1.167 ± 0.241
3.566ValIle: 3.566 ± 0.466
2.658ValLys: 2.658 ± 0.359
6.548ValLeu: 6.548 ± 0.762
1.621ValMet: 1.621 ± 0.344
1.232ValAsn: 1.232 ± 0.23
3.436ValPro: 3.436 ± 0.59
2.529ValGln: 2.529 ± 0.399
4.992ValArg: 4.992 ± 0.494
3.89ValSer: 3.89 ± 0.458
4.863ValThr: 4.863 ± 0.648
5.057ValVal: 5.057 ± 0.523
1.102ValTrp: 1.102 ± 0.315
1.297ValTyr: 1.297 ± 0.243
0.0ValXaa: 0.0 ± 0.0
Trp
2.01TrpAla: 2.01 ± 0.432
0.324TrpCys: 0.324 ± 0.118
1.491TrpAsp: 1.491 ± 0.287
0.843TrpGlu: 0.843 ± 0.248
0.713TrpPhe: 0.713 ± 0.249
1.362TrpGly: 1.362 ± 0.323
0.195TrpHis: 0.195 ± 0.101
0.908TrpIle: 0.908 ± 0.237
0.324TrpLys: 0.324 ± 0.123
2.01TrpLeu: 2.01 ± 0.341
0.519TrpMet: 0.519 ± 0.166
0.519TrpAsn: 0.519 ± 0.22
1.167TrpPro: 1.167 ± 0.27
0.843TrpGln: 0.843 ± 0.174
1.751TrpArg: 1.751 ± 0.33
1.426TrpSer: 1.426 ± 0.25
0.843TrpThr: 0.843 ± 0.222
0.778TrpVal: 0.778 ± 0.184
0.324TrpTrp: 0.324 ± 0.227
0.259TrpTyr: 0.259 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.788TyrAla: 2.788 ± 0.52
0.065TyrCys: 0.065 ± 0.064
1.167TyrAsp: 1.167 ± 0.233
1.037TyrGlu: 1.037 ± 0.268
0.648TyrPhe: 0.648 ± 0.253
1.815TyrGly: 1.815 ± 0.342
0.389TyrHis: 0.389 ± 0.163
0.908TyrIle: 0.908 ± 0.267
0.648TyrLys: 0.648 ± 0.19
2.01TyrLeu: 2.01 ± 0.316
0.454TyrMet: 0.454 ± 0.199
0.454TyrAsn: 0.454 ± 0.17
1.621TyrPro: 1.621 ± 0.444
0.584TyrGln: 0.584 ± 0.155
1.556TyrArg: 1.556 ± 0.354
0.713TyrSer: 0.713 ± 0.285
0.973TyrThr: 0.973 ± 0.266
1.426TyrVal: 1.426 ± 0.302
0.389TyrTrp: 0.389 ± 0.151
0.389TyrTyr: 0.389 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (15425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski