Amino acid dipepetide frequency for Peniophora sp. CONT

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.397AlaAla: 10.397 ± 0.059
1.298AlaCys: 1.298 ± 0.014
4.669AlaAsp: 4.669 ± 0.027
5.202AlaGlu: 5.202 ± 0.035
3.56AlaPhe: 3.56 ± 0.024
6.246AlaGly: 6.246 ± 0.029
2.579AlaHis: 2.579 ± 0.019
4.26AlaIle: 4.26 ± 0.031
3.503AlaLys: 3.503 ± 0.028
10.254AlaLeu: 10.254 ± 0.046
2.1AlaMet: 2.1 ± 0.016
2.757AlaAsn: 2.757 ± 0.021
6.377AlaPro: 6.377 ± 0.049
3.68AlaGln: 3.68 ± 0.024
6.779AlaArg: 6.779 ± 0.035
8.244AlaSer: 8.244 ± 0.047
5.645AlaThr: 5.645 ± 0.031
6.196AlaVal: 6.196 ± 0.032
1.373AlaTrp: 1.373 ± 0.014
2.531AlaTyr: 2.531 ± 0.019
0.0AlaXaa: 0.0 ± 0.0
Cys
1.251CysAla: 1.251 ± 0.014
0.272CysCys: 0.272 ± 0.007
0.733CysAsp: 0.733 ± 0.011
0.639CysGlu: 0.639 ± 0.01
0.525CysPhe: 0.525 ± 0.008
0.92CysGly: 0.92 ± 0.013
0.367CysHis: 0.367 ± 0.007
0.728CysIle: 0.728 ± 0.011
0.498CysLys: 0.498 ± 0.009
1.303CysLeu: 1.303 ± 0.013
0.313CysMet: 0.313 ± 0.006
0.405CysAsn: 0.405 ± 0.007
0.752CysPro: 0.752 ± 0.012
0.433CysGln: 0.433 ± 0.008
0.904CysArg: 0.904 ± 0.012
1.073CysSer: 1.073 ± 0.011
0.856CysThr: 0.856 ± 0.012
0.891CysVal: 0.891 ± 0.011
0.209CysTrp: 0.209 ± 0.005
0.324CysTyr: 0.324 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
6.0AspAla: 6.0 ± 0.034
0.68AspCys: 0.68 ± 0.01
4.182AspAsp: 4.182 ± 0.032
4.559AspGlu: 4.559 ± 0.034
2.06AspPhe: 2.06 ± 0.017
4.149AspGly: 4.149 ± 0.03
1.203AspHis: 1.203 ± 0.011
3.04AspIle: 3.04 ± 0.02
1.956AspLys: 1.956 ± 0.019
5.105AspLeu: 5.105 ± 0.03
1.277AspMet: 1.277 ± 0.014
1.586AspAsn: 1.586 ± 0.014
3.191AspPro: 3.191 ± 0.02
1.374AspGln: 1.374 ± 0.014
2.922AspArg: 2.922 ± 0.023
3.773AspSer: 3.773 ± 0.022
2.997AspThr: 2.997 ± 0.019
4.431AspVal: 4.431 ± 0.026
0.972AspTrp: 0.972 ± 0.012
1.468AspTyr: 1.468 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
5.176GluAla: 5.176 ± 0.036
0.675GluCys: 0.675 ± 0.01
4.173GluAsp: 4.173 ± 0.029
4.756GluGlu: 4.756 ± 0.039
1.677GluPhe: 1.677 ± 0.014
3.772GluGly: 3.772 ± 0.023
1.629GluHis: 1.629 ± 0.017
2.502GluIle: 2.502 ± 0.018
2.683GluLys: 2.683 ± 0.024
5.764GluLeu: 5.764 ± 0.032
1.308GluMet: 1.308 ± 0.014
1.696GluAsn: 1.696 ± 0.014
2.905GluPro: 2.905 ± 0.021
2.082GluGln: 2.082 ± 0.02
4.506GluArg: 4.506 ± 0.028
3.698GluSer: 3.698 ± 0.023
2.864GluThr: 2.864 ± 0.019
3.549GluVal: 3.549 ± 0.027
0.915GluTrp: 0.915 ± 0.012
1.488GluTyr: 1.488 ± 0.015
0.0GluXaa: 0.0 ± 0.0
Phe
3.425PheAla: 3.425 ± 0.023
0.554PheCys: 0.554 ± 0.008
2.234PheAsp: 2.234 ± 0.02
2.054PheGlu: 2.054 ± 0.017
1.465PhePhe: 1.465 ± 0.015
2.744PheGly: 2.744 ± 0.023
0.851PheHis: 0.851 ± 0.011
1.695PheIle: 1.695 ± 0.017
1.318PheLys: 1.318 ± 0.014
3.282PheLeu: 3.282 ± 0.023
0.778PheMet: 0.778 ± 0.01
1.28PheAsn: 1.28 ± 0.013
1.977PhePro: 1.977 ± 0.017
1.059PheGln: 1.059 ± 0.012
1.906PheArg: 1.906 ± 0.016
2.851PheSer: 2.851 ± 0.021
2.139PheThr: 2.139 ± 0.017
2.57PheVal: 2.57 ± 0.019
0.621PheTrp: 0.621 ± 0.009
1.018PheTyr: 1.018 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
6.01GlyAla: 6.01 ± 0.035
0.886GlyCys: 0.886 ± 0.011
3.53GlyAsp: 3.53 ± 0.022
3.64GlyGlu: 3.64 ± 0.028
2.433GlyPhe: 2.433 ± 0.019
5.336GlyGly: 5.336 ± 0.046
1.78GlyHis: 1.78 ± 0.017
2.965GlyIle: 2.965 ± 0.02
2.915GlyLys: 2.915 ± 0.026
5.854GlyLeu: 5.854 ± 0.031
1.494GlyMet: 1.494 ± 0.018
2.026GlyAsn: 2.026 ± 0.02
3.459GlyPro: 3.459 ± 0.025
2.19GlyGln: 2.19 ± 0.018
4.22GlyArg: 4.22 ± 0.025
5.514GlySer: 5.514 ± 0.037
3.892GlyThr: 3.892 ± 0.024
4.451GlyVal: 4.451 ± 0.026
1.224GlyTrp: 1.224 ± 0.014
1.819GlyTyr: 1.819 ± 0.016
0.0GlyXaa: 0.0 ± 0.0
His
2.576HisAla: 2.576 ± 0.02
0.389HisCys: 0.389 ± 0.006
1.442HisAsp: 1.442 ± 0.014
1.357HisGlu: 1.357 ± 0.014
0.999HisPhe: 0.999 ± 0.012
1.755HisGly: 1.755 ± 0.015
0.824HisHis: 0.824 ± 0.013
1.353HisIle: 1.353 ± 0.016
0.838HisLys: 0.838 ± 0.011
2.722HisLeu: 2.722 ± 0.023
0.511HisMet: 0.511 ± 0.009
0.776HisAsn: 0.776 ± 0.01
1.876HisPro: 1.876 ± 0.019
0.763HisGln: 0.763 ± 0.01
1.752HisArg: 1.752 ± 0.019
2.017HisSer: 2.017 ± 0.019
1.562HisThr: 1.562 ± 0.013
1.813HisVal: 1.813 ± 0.017
0.403HisTrp: 0.403 ± 0.007
0.67HisTyr: 0.67 ± 0.009
0.0HisXaa: 0.0 ± 0.0
Ile
4.281IleAla: 4.281 ± 0.024
0.698IleCys: 0.698 ± 0.01
2.628IleAsp: 2.628 ± 0.021
2.527IleGlu: 2.527 ± 0.02
1.806IlePhe: 1.806 ± 0.018
2.738IleGly: 2.738 ± 0.019
1.15IleHis: 1.15 ± 0.013
2.146IleIle: 2.146 ± 0.02
1.555IleLys: 1.555 ± 0.014
4.319IleLeu: 4.319 ± 0.028
0.896IleMet: 0.896 ± 0.011
1.347IleAsn: 1.347 ± 0.013
2.908IlePro: 2.908 ± 0.021
1.499IleGln: 1.499 ± 0.015
2.704IleArg: 2.704 ± 0.017
3.448IleSer: 3.448 ± 0.024
2.546IleThr: 2.546 ± 0.021
3.292IleVal: 3.292 ± 0.024
0.757IleTrp: 0.757 ± 0.011
1.259IleTyr: 1.259 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
3.854LysAla: 3.854 ± 0.027
0.436LysCys: 0.436 ± 0.008
2.223LysAsp: 2.223 ± 0.02
2.504LysGlu: 2.504 ± 0.022
1.065LysPhe: 1.065 ± 0.012
2.495LysGly: 2.495 ± 0.02
1.03LysHis: 1.03 ± 0.011
1.541LysIle: 1.541 ± 0.017
2.287LysLys: 2.287 ± 0.031
3.518LysLeu: 3.518 ± 0.022
0.752LysMet: 0.752 ± 0.011
1.124LysAsn: 1.124 ± 0.013
2.325LysPro: 2.325 ± 0.021
1.303LysGln: 1.303 ± 0.014
3.179LysArg: 3.179 ± 0.024
2.565LysSer: 2.565 ± 0.021
2.167LysThr: 2.167 ± 0.021
2.221LysVal: 2.221 ± 0.019
0.538LysTrp: 0.538 ± 0.008
1.006LysTyr: 1.006 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
9.319LeuAla: 9.319 ± 0.042
1.422LeuCys: 1.422 ± 0.016
5.648LeuAsp: 5.648 ± 0.034
5.686LeuGlu: 5.686 ± 0.033
3.402LeuPhe: 3.402 ± 0.026
5.957LeuGly: 5.957 ± 0.032
2.796LeuHis: 2.796 ± 0.02
3.579LeuIle: 3.579 ± 0.024
3.556LeuLys: 3.556 ± 0.025
9.136LeuLeu: 9.136 ± 0.05
1.667LeuMet: 1.667 ± 0.015
3.034LeuAsn: 3.034 ± 0.018
6.603LeuPro: 6.603 ± 0.036
3.587LeuGln: 3.587 ± 0.025
7.086LeuArg: 7.086 ± 0.041
8.246LeuSer: 8.246 ± 0.041
5.237LeuThr: 5.237 ± 0.03
6.096LeuVal: 6.096 ± 0.033
1.444LeuTrp: 1.444 ± 0.013
2.551LeuTyr: 2.551 ± 0.022
0.0LeuXaa: 0.0 ± 0.0
Met
1.914MetAla: 1.914 ± 0.017
0.264MetCys: 0.264 ± 0.007
1.2MetAsp: 1.2 ± 0.012
1.017MetGlu: 1.017 ± 0.012
0.751MetPhe: 0.751 ± 0.01
1.237MetGly: 1.237 ± 0.013
0.631MetHis: 0.631 ± 0.011
0.815MetIle: 0.815 ± 0.01
0.783MetLys: 0.783 ± 0.011
2.028MetLeu: 2.028 ± 0.014
0.481MetMet: 0.481 ± 0.009
0.716MetAsn: 0.716 ± 0.008
1.457MetPro: 1.457 ± 0.014
0.827MetGln: 0.827 ± 0.012
1.534MetArg: 1.534 ± 0.016
2.002MetSer: 2.002 ± 0.017
1.166MetThr: 1.166 ± 0.012
1.094MetVal: 1.094 ± 0.013
0.274MetTrp: 0.274 ± 0.006
0.554MetTyr: 0.554 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.297AsnAla: 3.297 ± 0.019
0.38AsnCys: 0.38 ± 0.007
1.685AsnAsp: 1.685 ± 0.012
1.638AsnGlu: 1.638 ± 0.016
1.109AsnPhe: 1.109 ± 0.011
2.39AsnGly: 2.39 ± 0.019
0.7AsnHis: 0.7 ± 0.01
1.662AsnIle: 1.662 ± 0.016
1.113AsnLys: 1.113 ± 0.014
2.892AsnLeu: 2.892 ± 0.02
0.706AsnMet: 0.706 ± 0.009
1.077AsnAsn: 1.077 ± 0.012
1.911AsnPro: 1.911 ± 0.018
0.885AsnGln: 0.885 ± 0.012
1.573AsnArg: 1.573 ± 0.016
2.181AsnSer: 2.181 ± 0.017
1.896AsnThr: 1.896 ± 0.015
2.294AsnVal: 2.294 ± 0.02
0.482AsnTrp: 0.482 ± 0.008
0.773AsnTyr: 0.773 ± 0.009
0.0AsnXaa: 0.0 ± 0.0
Pro
6.561ProAla: 6.561 ± 0.04
0.581ProCys: 0.581 ± 0.011
3.447ProAsp: 3.447 ± 0.023
3.686ProGlu: 3.686 ± 0.025
2.144ProPhe: 2.144 ± 0.017
3.969ProGly: 3.969 ± 0.027
1.633ProHis: 1.633 ± 0.015
2.543ProIle: 2.543 ± 0.02
2.078ProLys: 2.078 ± 0.02
5.456ProLeu: 5.456 ± 0.027
1.131ProMet: 1.131 ± 0.013
1.942ProAsn: 1.942 ± 0.015
6.281ProPro: 6.281 ± 0.082
2.202ProGln: 2.202 ± 0.023
4.005ProArg: 4.005 ± 0.031
6.708ProSer: 6.708 ± 0.046
4.308ProThr: 4.308 ± 0.029
4.082ProVal: 4.082 ± 0.026
0.754ProTrp: 0.754 ± 0.01
1.507ProTyr: 1.507 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
3.395GlnAla: 3.395 ± 0.025
0.456GlnCys: 0.456 ± 0.009
1.822GlnAsp: 1.822 ± 0.015
1.843GlnGlu: 1.843 ± 0.016
1.086GlnPhe: 1.086 ± 0.013
2.014GlnGly: 2.014 ± 0.018
1.037GlnHis: 1.037 ± 0.012
1.414GlnIle: 1.414 ± 0.014
1.22GlnLys: 1.22 ± 0.015
3.323GlnLeu: 3.323 ± 0.026
0.717GlnMet: 0.717 ± 0.01
1.083GlnAsn: 1.083 ± 0.011
2.373GlnPro: 2.373 ± 0.026
1.719GlnGln: 1.719 ± 0.033
2.577GlnArg: 2.577 ± 0.021
2.758GlnSer: 2.758 ± 0.018
2.107GlnThr: 2.107 ± 0.016
1.931GlnVal: 1.931 ± 0.018
0.516GlnTrp: 0.516 ± 0.009
0.992GlnTyr: 0.992 ± 0.012
0.0GlnXaa: 0.0 ± 0.0
Arg
6.88ArgAla: 6.88 ± 0.036
0.917ArgCys: 0.917 ± 0.015
3.646ArgAsp: 3.646 ± 0.026
4.043ArgGlu: 4.043 ± 0.031
2.317ArgPhe: 2.317 ± 0.02
3.872ArgGly: 3.872 ± 0.03
1.745ArgHis: 1.745 ± 0.017
2.987ArgIle: 2.987 ± 0.021
2.895ArgLys: 2.895 ± 0.023
6.479ArgLeu: 6.479 ± 0.035
1.462ArgMet: 1.462 ± 0.014
1.9ArgAsn: 1.9 ± 0.015
3.869ArgPro: 3.869 ± 0.028
2.279ArgGln: 2.279 ± 0.02
5.902ArgArg: 5.902 ± 0.039
5.315ArgSer: 5.315 ± 0.035
3.987ArgThr: 3.987 ± 0.025
4.259ArgVal: 4.259 ± 0.023
1.103ArgTrp: 1.103 ± 0.013
1.721ArgTyr: 1.721 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
7.981SerAla: 7.981 ± 0.043
1.004SerCys: 1.004 ± 0.012
4.298SerAsp: 4.298 ± 0.025
3.814SerGlu: 3.814 ± 0.021
2.986SerPhe: 2.986 ± 0.021
5.517SerGly: 5.517 ± 0.031
1.962SerHis: 1.962 ± 0.018
3.698SerIle: 3.698 ± 0.026
2.708SerLys: 2.708 ± 0.019
7.863SerLeu: 7.863 ± 0.038
1.645SerMet: 1.645 ± 0.015
2.461SerAsn: 2.461 ± 0.018
5.736SerPro: 5.736 ± 0.044
2.718SerGln: 2.718 ± 0.022
5.295SerArg: 5.295 ± 0.034
9.102SerSer: 9.102 ± 0.05
5.775SerThr: 5.775 ± 0.036
5.1SerVal: 5.1 ± 0.03
1.147SerTrp: 1.147 ± 0.014
1.979SerTyr: 1.979 ± 0.016
0.0SerXaa: 0.0 ± 0.0
Thr
5.449ThrAla: 5.449 ± 0.029
0.786ThrCys: 0.786 ± 0.012
2.752ThrAsp: 2.752 ± 0.019
2.601ThrGlu: 2.601 ± 0.016
2.352ThrPhe: 2.352 ± 0.017
3.888ThrGly: 3.888 ± 0.027
1.548ThrHis: 1.548 ± 0.015
2.784ThrIle: 2.784 ± 0.021
1.937ThrLys: 1.937 ± 0.017
6.176ThrLeu: 6.176 ± 0.031
1.202ThrMet: 1.202 ± 0.013
1.788ThrAsn: 1.788 ± 0.016
4.663ThrPro: 4.663 ± 0.034
1.946ThrGln: 1.946 ± 0.016
3.707ThrArg: 3.707 ± 0.025
5.509ThrSer: 5.509 ± 0.032
3.948ThrThr: 3.948 ± 0.03
3.937ThrVal: 3.937 ± 0.022
0.836ThrTrp: 0.836 ± 0.011
1.571ThrTyr: 1.571 ± 0.016
0.0ThrXaa: 0.0 ± 0.0
Val
6.03ValAla: 6.03 ± 0.03
1.013ValCys: 1.013 ± 0.014
3.978ValAsp: 3.978 ± 0.026
3.958ValGlu: 3.958 ± 0.025
2.508ValPhe: 2.508 ± 0.021
3.931ValGly: 3.931 ± 0.025
1.879ValHis: 1.879 ± 0.016
2.774ValIle: 2.774 ± 0.019
2.62ValLys: 2.62 ± 0.021
6.668ValLeu: 6.668 ± 0.033
1.301ValMet: 1.301 ± 0.014
2.117ValAsn: 2.117 ± 0.017
4.119ValPro: 4.119 ± 0.023
2.506ValGln: 2.506 ± 0.019
4.192ValArg: 4.192 ± 0.026
4.734ValSer: 4.734 ± 0.026
3.538ValThr: 3.538 ± 0.021
4.678ValVal: 4.678 ± 0.029
1.021ValTrp: 1.021 ± 0.011
1.889ValTyr: 1.889 ± 0.015
0.0ValXaa: 0.0 ± 0.0
Trp
1.339TrpAla: 1.339 ± 0.013
0.226TrpCys: 0.226 ± 0.005
0.984TrpAsp: 0.984 ± 0.014
0.822TrpGlu: 0.822 ± 0.01
0.524TrpPhe: 0.524 ± 0.008
0.848TrpGly: 0.848 ± 0.012
0.385TrpHis: 0.385 ± 0.007
0.719TrpIle: 0.719 ± 0.009
0.732TrpLys: 0.732 ± 0.01
1.417TrpLeu: 1.417 ± 0.014
0.399TrpMet: 0.399 ± 0.008
0.601TrpAsn: 0.601 ± 0.009
0.704TrpPro: 0.704 ± 0.009
0.522TrpGln: 0.522 ± 0.009
1.25TrpArg: 1.25 ± 0.014
1.181TrpSer: 1.181 ± 0.013
1.064TrpThr: 1.064 ± 0.013
0.895TrpVal: 0.895 ± 0.01
0.298TrpTrp: 0.298 ± 0.007
0.41TrpTyr: 0.41 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.518TyrAla: 2.518 ± 0.017
0.457TyrCys: 0.457 ± 0.008
1.649TyrAsp: 1.649 ± 0.016
1.473TyrGlu: 1.473 ± 0.015
1.053TyrPhe: 1.053 ± 0.013
1.858TyrGly: 1.858 ± 0.02
0.671TyrHis: 0.671 ± 0.009
1.299TyrIle: 1.299 ± 0.014
0.938TyrLys: 0.938 ± 0.011
2.492TyrLeu: 2.492 ± 0.019
0.606TyrMet: 0.606 ± 0.009
0.925TyrAsn: 0.925 ± 0.013
1.53TyrPro: 1.53 ± 0.017
0.809TyrGln: 0.809 ± 0.011
1.586TyrArg: 1.586 ± 0.015
1.871TyrSer: 1.871 ± 0.016
1.682TyrThr: 1.682 ± 0.017
1.675TyrVal: 1.675 ± 0.016
0.435TyrTrp: 0.435 ± 0.007
0.827TyrTyr: 0.827 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18912 proteins (7847246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski