Amino acid dipepetide frequency for Vibrio sp. UCD-FRSSP16_10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.687AlaAla: 6.687 ± 0.11
0.869AlaCys: 0.869 ± 0.029
4.534AlaAsp: 4.534 ± 0.115
4.92AlaGlu: 4.92 ± 0.076
3.36AlaPhe: 3.36 ± 0.07
5.779AlaGly: 5.779 ± 0.115
1.581AlaHis: 1.581 ± 0.05
6.103AlaIle: 6.103 ± 0.097
5.075AlaLys: 5.075 ± 0.089
9.366AlaLeu: 9.366 ± 0.131
2.509AlaMet: 2.509 ± 0.059
3.624AlaAsn: 3.624 ± 0.06
2.725AlaPro: 2.725 ± 0.062
3.927AlaGln: 3.927 ± 0.073
3.407AlaArg: 3.407 ± 0.067
5.348AlaSer: 5.348 ± 0.096
4.71AlaThr: 4.71 ± 0.094
5.688AlaVal: 5.688 ± 0.09
0.898AlaTrp: 0.898 ± 0.031
2.268AlaTyr: 2.268 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.822CysAla: 0.822 ± 0.033
0.157CysCys: 0.157 ± 0.013
0.621CysAsp: 0.621 ± 0.026
0.585CysGlu: 0.585 ± 0.027
0.419CysPhe: 0.419 ± 0.021
0.923CysGly: 0.923 ± 0.031
0.371CysHis: 0.371 ± 0.023
0.633CysIle: 0.633 ± 0.027
0.429CysLys: 0.429 ± 0.021
0.959CysLeu: 0.959 ± 0.03
0.232CysMet: 0.232 ± 0.016
0.391CysAsn: 0.391 ± 0.021
0.404CysPro: 0.404 ± 0.02
0.422CysGln: 0.422 ± 0.02
0.434CysArg: 0.434 ± 0.025
0.71CysSer: 0.71 ± 0.03
0.511CysThr: 0.511 ± 0.022
0.658CysVal: 0.658 ± 0.032
0.123CysTrp: 0.123 ± 0.01
0.307CysTyr: 0.307 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.665AspAla: 4.665 ± 0.114
0.532AspCys: 0.532 ± 0.027
3.313AspAsp: 3.313 ± 0.13
3.908AspGlu: 3.908 ± 0.074
2.439AspPhe: 2.439 ± 0.058
4.04AspGly: 4.04 ± 0.17
1.173AspHis: 1.173 ± 0.064
4.215AspIle: 4.215 ± 0.091
3.537AspLys: 3.537 ± 0.071
5.504AspLeu: 5.504 ± 0.095
1.368AspMet: 1.368 ± 0.043
2.731AspAsn: 2.731 ± 0.094
2.087AspPro: 2.087 ± 0.068
1.976AspGln: 1.976 ± 0.054
2.122AspArg: 2.122 ± 0.047
3.92AspSer: 3.92 ± 0.132
3.004AspThr: 3.004 ± 0.127
4.084AspVal: 4.084 ± 0.096
0.806AspTrp: 0.806 ± 0.034
2.035AspTyr: 2.035 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.925GluAla: 4.925 ± 0.077
0.551GluCys: 0.551 ± 0.027
2.855GluAsp: 2.855 ± 0.064
3.564GluGlu: 3.564 ± 0.073
2.467GluPhe: 2.467 ± 0.049
3.554GluGly: 3.554 ± 0.06
1.591GluHis: 1.591 ± 0.048
3.8GluIle: 3.8 ± 0.068
3.501GluLys: 3.501 ± 0.075
6.954GluLeu: 6.954 ± 0.091
1.639GluMet: 1.639 ± 0.045
2.475GluAsn: 2.475 ± 0.054
1.921GluPro: 1.921 ± 0.045
3.866GluGln: 3.866 ± 0.072
3.056GluArg: 3.056 ± 0.07
3.767GluSer: 3.767 ± 0.074
2.978GluThr: 2.978 ± 0.068
4.26GluVal: 4.26 ± 0.073
0.666GluTrp: 0.666 ± 0.027
1.793GluTyr: 1.793 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.583PheAla: 3.583 ± 0.058
0.484PheCys: 0.484 ± 0.023
2.916PheAsp: 2.916 ± 0.055
2.55PheGlu: 2.55 ± 0.049
1.61PhePhe: 1.61 ± 0.055
3.191PheGly: 3.191 ± 0.063
0.793PheHis: 0.793 ± 0.026
2.937PheIle: 2.937 ± 0.053
2.08PheLys: 2.08 ± 0.048
3.279PheLeu: 3.279 ± 0.076
1.03PheMet: 1.03 ± 0.038
2.162PheAsn: 2.162 ± 0.046
1.338PhePro: 1.338 ± 0.039
1.193PheGln: 1.193 ± 0.033
1.389PheArg: 1.389 ± 0.033
3.378PheSer: 3.378 ± 0.064
2.542PheThr: 2.542 ± 0.067
2.96PheVal: 2.96 ± 0.067
0.506PheTrp: 0.506 ± 0.023
1.265PheTyr: 1.265 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.275GlyAla: 5.275 ± 0.108
0.885GlyCys: 0.885 ± 0.034
3.824GlyAsp: 3.824 ± 0.139
4.126GlyGlu: 4.126 ± 0.071
3.343GlyPhe: 3.343 ± 0.067
4.769GlyGly: 4.769 ± 0.123
1.61GlyHis: 1.61 ± 0.054
4.885GlyIle: 4.885 ± 0.083
3.975GlyLys: 3.975 ± 0.076
6.895GlyLeu: 6.895 ± 0.103
2.011GlyMet: 2.011 ± 0.054
2.741GlyAsn: 2.741 ± 0.078
1.574GlyPro: 1.574 ± 0.05
2.865GlyGln: 2.865 ± 0.078
3.054GlyArg: 3.054 ± 0.063
4.307GlySer: 4.307 ± 0.119
3.585GlyThr: 3.585 ± 0.104
5.155GlyVal: 5.155 ± 0.095
0.903GlyTrp: 0.903 ± 0.031
2.547GlyTyr: 2.547 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.655HisAla: 1.655 ± 0.041
0.323HisCys: 0.323 ± 0.017
1.142HisAsp: 1.142 ± 0.048
1.045HisGlu: 1.045 ± 0.041
1.122HisPhe: 1.122 ± 0.034
1.577HisGly: 1.577 ± 0.063
0.668HisHis: 0.668 ± 0.03
1.483HisIle: 1.483 ± 0.056
1.16HisLys: 1.16 ± 0.036
2.305HisLeu: 2.305 ± 0.058
0.469HisMet: 0.469 ± 0.024
0.981HisAsn: 0.981 ± 0.04
1.128HisPro: 1.128 ± 0.035
1.226HisGln: 1.226 ± 0.042
1.005HisArg: 1.005 ± 0.035
1.558HisSer: 1.558 ± 0.044
1.236HisThr: 1.236 ± 0.047
1.327HisVal: 1.327 ± 0.039
0.375HisTrp: 0.375 ± 0.021
0.879HisTyr: 0.879 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.701IleAla: 6.701 ± 0.091
0.687IleCys: 0.687 ± 0.031
4.544IleAsp: 4.544 ± 0.111
4.923IleGlu: 4.923 ± 0.083
2.305IlePhe: 2.305 ± 0.055
4.861IleGly: 4.861 ± 0.082
1.324IleHis: 1.324 ± 0.041
4.145IleIle: 4.145 ± 0.071
3.512IleLys: 3.512 ± 0.061
5.475IleLeu: 5.475 ± 0.075
1.386IleMet: 1.386 ± 0.043
3.182IleAsn: 3.182 ± 0.068
2.675IlePro: 2.675 ± 0.066
2.425IleGln: 2.425 ± 0.053
2.733IleArg: 2.733 ± 0.061
4.821IleSer: 4.821 ± 0.081
3.993IleThr: 3.993 ± 0.115
4.453IleVal: 4.453 ± 0.075
0.61IleTrp: 0.61 ± 0.023
1.758IleTyr: 1.758 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.816LysAla: 4.816 ± 0.083
0.314LysCys: 0.314 ± 0.017
2.99LysAsp: 2.99 ± 0.064
3.459LysGlu: 3.459 ± 0.078
1.642LysPhe: 1.642 ± 0.048
3.627LysGly: 3.627 ± 0.071
1.382LysHis: 1.382 ± 0.033
3.094LysIle: 3.094 ± 0.059
3.141LysLys: 3.141 ± 0.071
5.47LysLeu: 5.47 ± 0.099
1.53LysMet: 1.53 ± 0.041
2.315LysAsn: 2.315 ± 0.054
2.365LysPro: 2.365 ± 0.056
3.189LysGln: 3.189 ± 0.075
2.665LysArg: 2.665 ± 0.066
3.432LysSer: 3.432 ± 0.063
2.947LysThr: 2.947 ± 0.057
4.043LysVal: 4.043 ± 0.06
0.6LysTrp: 0.6 ± 0.026
1.416LysTyr: 1.416 ± 0.04
0.001LysXaa: 0.001 ± 0.001
Leu
8.977LeuAla: 8.977 ± 0.118
1.15LeuCys: 1.15 ± 0.037
6.048LeuAsp: 6.048 ± 0.108
5.926LeuGlu: 5.926 ± 0.08
4.337LeuPhe: 4.337 ± 0.084
6.992LeuGly: 6.992 ± 0.118
2.049LeuHis: 2.049 ± 0.061
6.526LeuIle: 6.526 ± 0.104
5.449LeuLys: 5.449 ± 0.098
10.263LeuLeu: 10.263 ± 0.158
2.625LeuMet: 2.625 ± 0.074
4.752LeuAsn: 4.752 ± 0.065
4.464LeuPro: 4.464 ± 0.076
3.918LeuGln: 3.918 ± 0.075
4.185LeuArg: 4.185 ± 0.083
8.082LeuSer: 8.082 ± 0.107
6.151LeuThr: 6.151 ± 0.113
6.92LeuVal: 6.92 ± 0.089
1.006LeuTrp: 1.006 ± 0.035
2.587LeuTyr: 2.587 ± 0.058
0.001LeuXaa: 0.001 ± 0.001
Met
2.305MetAla: 2.305 ± 0.053
0.218MetCys: 0.218 ± 0.015
1.224MetAsp: 1.224 ± 0.032
1.208MetGlu: 1.208 ± 0.038
0.928MetPhe: 0.928 ± 0.031
1.786MetGly: 1.786 ± 0.055
0.507MetHis: 0.507 ± 0.023
1.51MetIle: 1.51 ± 0.045
1.478MetLys: 1.478 ± 0.041
2.776MetLeu: 2.776 ± 0.066
0.761MetMet: 0.761 ± 0.031
1.173MetAsn: 1.173 ± 0.036
1.189MetPro: 1.189 ± 0.041
1.23MetGln: 1.23 ± 0.038
1.193MetArg: 1.193 ± 0.035
1.973MetSer: 1.973 ± 0.048
1.622MetThr: 1.622 ± 0.039
1.799MetVal: 1.799 ± 0.05
0.231MetTrp: 0.231 ± 0.015
0.567MetTyr: 0.567 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.341AsnAla: 3.341 ± 0.071
0.422AsnCys: 0.422 ± 0.019
2.557AsnAsp: 2.557 ± 0.107
2.456AsnGlu: 2.456 ± 0.05
1.626AsnPhe: 1.626 ± 0.041
2.999AsnGly: 2.999 ± 0.069
1.084AsnHis: 1.084 ± 0.045
3.005AsnIle: 3.005 ± 0.067
2.526AsnLys: 2.526 ± 0.056
4.176AsnLeu: 4.176 ± 0.065
1.009AsnMet: 1.009 ± 0.03
2.211AsnAsn: 2.211 ± 0.069
2.214AsnPro: 2.214 ± 0.059
2.11AsnGln: 2.11 ± 0.05
1.861AsnArg: 1.861 ± 0.047
2.924AsnSer: 2.924 ± 0.064
2.483AsnThr: 2.483 ± 0.068
2.779AsnVal: 2.779 ± 0.062
0.592AsnTrp: 0.592 ± 0.024
1.359AsnTyr: 1.359 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.866ProAla: 2.866 ± 0.061
0.332ProCys: 0.332 ± 0.018
2.19ProAsp: 2.19 ± 0.049
2.858ProGlu: 2.858 ± 0.06
1.617ProPhe: 1.617 ± 0.045
1.994ProGly: 1.994 ± 0.057
0.866ProHis: 0.866 ± 0.032
2.659ProIle: 2.659 ± 0.06
2.057ProLys: 2.057 ± 0.051
3.895ProLeu: 3.895 ± 0.075
1.081ProMet: 1.081 ± 0.032
1.712ProAsn: 1.712 ± 0.044
0.993ProPro: 0.993 ± 0.035
1.691ProGln: 1.691 ± 0.045
1.276ProArg: 1.276 ± 0.039
2.543ProSer: 2.543 ± 0.056
2.324ProThr: 2.324 ± 0.06
2.925ProVal: 2.925 ± 0.088
0.457ProTrp: 0.457 ± 0.025
1.229ProTyr: 1.229 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.215GlnAla: 4.215 ± 0.082
0.398GlnCys: 0.398 ± 0.021
2.336GlnAsp: 2.336 ± 0.056
2.339GlnGlu: 2.339 ± 0.056
1.863GlnPhe: 1.863 ± 0.042
3.025GlnGly: 3.025 ± 0.065
1.255GlnHis: 1.255 ± 0.04
2.657GlnIle: 2.657 ± 0.049
2.299GlnLys: 2.299 ± 0.052
5.058GlnLeu: 5.058 ± 0.091
1.136GlnMet: 1.136 ± 0.035
1.645GlnAsn: 1.645 ± 0.049
1.643GlnPro: 1.643 ± 0.048
3.363GlnGln: 3.363 ± 0.092
2.216GlnArg: 2.216 ± 0.054
3.052GlnSer: 3.052 ± 0.064
2.315GlnThr: 2.315 ± 0.055
3.247GlnVal: 3.247 ± 0.059
0.738GlnTrp: 0.738 ± 0.026
1.534GlnTyr: 1.534 ± 0.044
0.001GlnXaa: 0.001 ± 0.001
Arg
3.128ArgAla: 3.128 ± 0.066
0.441ArgCys: 0.441 ± 0.022
2.232ArgAsp: 2.232 ± 0.053
2.685ArgGlu: 2.685 ± 0.061
2.161ArgPhe: 2.161 ± 0.049
2.475ArgGly: 2.475 ± 0.055
1.032ArgHis: 1.032 ± 0.034
3.023ArgIle: 3.023 ± 0.059
2.286ArgLys: 2.286 ± 0.055
4.614ArgLeu: 4.614 ± 0.091
1.114ArgMet: 1.114 ± 0.034
1.811ArgAsn: 1.811 ± 0.047
1.5ArgPro: 1.5 ± 0.05
1.982ArgGln: 1.982 ± 0.05
2.213ArgArg: 2.213 ± 0.068
2.69ArgSer: 2.69 ± 0.053
2.111ArgThr: 2.111 ± 0.055
3.005ArgVal: 3.005 ± 0.06
0.561ArgTrp: 0.561 ± 0.023
1.598ArgTyr: 1.598 ± 0.04
0.001ArgXaa: 0.001 ± 0.001
Ser
5.459SerAla: 5.459 ± 0.086
0.556SerCys: 0.556 ± 0.023
4.13SerAsp: 4.13 ± 0.138
3.959SerGlu: 3.959 ± 0.071
2.952SerPhe: 2.952 ± 0.061
5.107SerGly: 5.107 ± 0.134
1.658SerHis: 1.658 ± 0.051
4.745SerIle: 4.745 ± 0.092
3.648SerLys: 3.648 ± 0.066
7.2SerLeu: 7.2 ± 0.086
1.746SerMet: 1.746 ± 0.04
3.056SerAsn: 3.056 ± 0.071
2.367SerPro: 2.367 ± 0.055
3.202SerGln: 3.202 ± 0.055
2.764SerArg: 2.764 ± 0.061
4.817SerSer: 4.817 ± 0.099
3.722SerThr: 3.722 ± 0.082
4.927SerVal: 4.927 ± 0.097
0.798SerTrp: 0.798 ± 0.027
2.169SerTyr: 2.169 ± 0.046
0.001SerXaa: 0.001 ± 0.001
Thr
4.565ThrAla: 4.565 ± 0.092
0.472ThrCys: 0.472 ± 0.023
3.367ThrAsp: 3.367 ± 0.155
3.213ThrGlu: 3.213 ± 0.064
2.194ThrPhe: 2.194 ± 0.062
4.094ThrGly: 4.094 ± 0.085
1.359ThrHis: 1.359 ± 0.036
3.607ThrIle: 3.607 ± 0.095
2.603ThrLys: 2.603 ± 0.059
6.551ThrLeu: 6.551 ± 0.124
1.204ThrMet: 1.204 ± 0.038
2.116ThrAsn: 2.116 ± 0.063
2.655ThrPro: 2.655 ± 0.053
2.709ThrGln: 2.709 ± 0.063
2.102ThrArg: 2.102 ± 0.052
3.591ThrSer: 3.591 ± 0.087
3.163ThrThr: 3.163 ± 0.066
4.192ThrVal: 4.192 ± 0.134
0.628ThrTrp: 0.628 ± 0.026
1.507ThrTyr: 1.507 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
6.356ValAla: 6.356 ± 0.092
0.767ValCys: 0.767 ± 0.03
4.372ValAsp: 4.372 ± 0.112
4.524ValGlu: 4.524 ± 0.087
2.828ValPhe: 2.828 ± 0.056
4.749ValGly: 4.749 ± 0.084
1.229ValHis: 1.229 ± 0.037
5.059ValIle: 5.059 ± 0.098
3.681ValLys: 3.681 ± 0.065
6.806ValLeu: 6.806 ± 0.096
1.879ValMet: 1.879 ± 0.05
2.943ValAsn: 2.943 ± 0.06
2.575ValPro: 2.575 ± 0.054
2.353ValGln: 2.353 ± 0.045
2.819ValArg: 2.819 ± 0.057
5.177ValSer: 5.177 ± 0.081
4.397ValThr: 4.397 ± 0.125
5.534ValVal: 5.534 ± 0.094
0.695ValTrp: 0.695 ± 0.026
1.855ValTyr: 1.855 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.794TrpAla: 0.794 ± 0.029
0.151TrpCys: 0.151 ± 0.01
0.574TrpAsp: 0.574 ± 0.029
0.501TrpGlu: 0.501 ± 0.027
0.569TrpPhe: 0.569 ± 0.027
0.765TrpGly: 0.765 ± 0.03
0.362TrpHis: 0.362 ± 0.019
0.686TrpIle: 0.686 ± 0.029
0.527TrpLys: 0.527 ± 0.024
1.595TrpLeu: 1.595 ± 0.053
0.326TrpMet: 0.326 ± 0.021
0.517TrpAsn: 0.517 ± 0.023
0.432TrpPro: 0.432 ± 0.021
0.835TrpGln: 0.835 ± 0.03
0.595TrpArg: 0.595 ± 0.025
0.724TrpSer: 0.724 ± 0.026
0.51TrpThr: 0.51 ± 0.023
0.821TrpVal: 0.821 ± 0.032
0.191TrpTrp: 0.191 ± 0.014
0.351TrpTyr: 0.351 ± 0.023
0.001TrpXaa: 0.001 ± 0.001
Tyr
2.241TyrAla: 2.241 ± 0.058
0.402TyrCys: 0.402 ± 0.021
1.695TyrAsp: 1.695 ± 0.049
1.433TyrGlu: 1.433 ± 0.041
1.403TyrPhe: 1.403 ± 0.043
2.02TyrGly: 2.02 ± 0.045
0.77TyrHis: 0.77 ± 0.03
1.739TyrIle: 1.739 ± 0.048
1.473TyrLys: 1.473 ± 0.042
3.269TyrLeu: 3.269 ± 0.068
0.621TyrMet: 0.621 ± 0.032
1.195TyrAsn: 1.195 ± 0.041
1.314TyrPro: 1.314 ± 0.04
1.854TyrGln: 1.854 ± 0.059
1.571TyrArg: 1.571 ± 0.042
2.17TyrSer: 2.17 ± 0.054
1.589TyrThr: 1.589 ± 0.05
1.819TyrVal: 1.819 ± 0.044
0.443TyrTrp: 0.443 ± 0.021
1.029TyrTyr: 1.029 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3062 proteins (1010657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski