Amino acid dipepetide frequency for Methyloligella halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.805AlaAla: 14.805 ± 0.177	1.07AlaCys: 1.07 ± 0.039	6.658AlaAsp: 6.658 ± 0.102	8.411AlaGlu: 8.411 ± 0.114	4.167AlaPhe: 4.167 ± 0.074	9.884AlaGly: 9.884 ± 0.122	2.017AlaHis: 2.017 ± 0.051	5.982AlaIle: 5.982 ± 0.091	4.921AlaLys: 4.921 ± 0.09	12.3AlaLeu: 12.3 ± 0.135	3.223AlaMet: 3.223 ± 0.059	2.779AlaAsn: 2.779 ± 0.059	5.6AlaPro: 5.6 ± 0.096	3.694AlaGln: 3.694 ± 0.066	7.091AlaArg: 7.091 ± 0.097	6.229AlaSer: 6.229 ± 0.092	5.245AlaThr: 5.245 ± 0.082	7.744AlaVal: 7.744 ± 0.097	1.38AlaTrp: 1.38 ± 0.041	2.668AlaTyr: 2.668 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.944CysAla: 0.944 ± 0.033	0.135CysCys: 0.135 ± 0.012	0.519CysAsp: 0.519 ± 0.024	0.527CysGlu: 0.527 ± 0.02	0.343CysPhe: 0.343 ± 0.018	0.972CysGly: 0.972 ± 0.039	0.236CysHis: 0.236 ± 0.02	0.375CysIle: 0.375 ± 0.022	0.243CysLys: 0.243 ± 0.016	0.825CysLeu: 0.825 ± 0.032	0.193CysMet: 0.193 ± 0.012	0.245CysAsn: 0.245 ± 0.016	0.468CysPro: 0.468 ± 0.025	0.237CysGln: 0.237 ± 0.016	0.63CysArg: 0.63 ± 0.021	0.548CysSer: 0.548 ± 0.024	0.423CysThr: 0.423 ± 0.023	0.584CysVal: 0.584 ± 0.026	0.126CysTrp: 0.126 ± 0.012	0.229CysTyr: 0.229 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.719AspAla: 6.719 ± 0.104	0.543AspCys: 0.543 ± 0.024	3.738AspAsp: 3.738 ± 0.074	4.475AspGlu: 4.475 ± 0.079	2.323AspPhe: 2.323 ± 0.059	5.564AspGly: 5.564 ± 0.088	1.226AspHis: 1.226 ± 0.035	3.038AspIle: 3.038 ± 0.063	2.133AspLys: 2.133 ± 0.057	5.898AspLeu: 5.898 ± 0.089	1.355AspMet: 1.355 ± 0.041	1.355AspAsn: 1.355 ± 0.04	3.5AspPro: 3.5 ± 0.059	1.994AspGln: 1.994 ± 0.051	4.311AspArg: 4.311 ± 0.079	2.625AspSer: 2.625 ± 0.049	2.779AspThr: 2.779 ± 0.065	4.122AspVal: 4.122 ± 0.067	1.012AspTrp: 1.012 ± 0.036	1.655AspTyr: 1.655 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.402GluAla: 8.402 ± 0.125	0.383GluCys: 0.383 ± 0.019	3.765GluAsp: 3.765 ± 0.068	4.713GluGlu: 4.713 ± 0.1	1.855GluPhe: 1.855 ± 0.047	5.13GluGly: 5.13 ± 0.078	1.3GluHis: 1.3 ± 0.042	3.952GluIle: 3.952 ± 0.065	2.925GluLys: 2.925 ± 0.065	5.842GluLeu: 5.842 ± 0.091	1.687GluMet: 1.687 ± 0.049	1.959GluAsn: 1.959 ± 0.05	3.242GluPro: 3.242 ± 0.06	2.392GluGln: 2.392 ± 0.054	5.101GluArg: 5.101 ± 0.091	3.218GluSer: 3.218 ± 0.064	4.249GluThr: 4.249 ± 0.069	4.212GluVal: 4.212 ± 0.084	0.766GluTrp: 0.766 ± 0.028	1.18GluTyr: 1.18 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.554PheAla: 4.554 ± 0.082	0.407PheCys: 0.407 ± 0.021	2.751PheAsp: 2.751 ± 0.061	2.346PheGlu: 2.346 ± 0.055	1.559PhePhe: 1.559 ± 0.046	3.795PheGly: 3.795 ± 0.059	0.722PheHis: 0.722 ± 0.027	1.631PheIle: 1.631 ± 0.044	1.181PheLys: 1.181 ± 0.037	3.45PheLeu: 3.45 ± 0.07	0.84PheMet: 0.84 ± 0.032	1.083PheAsn: 1.083 ± 0.036	1.6PhePro: 1.6 ± 0.043	1.037PheGln: 1.037 ± 0.031	2.19PheArg: 2.19 ± 0.049	2.196PheSer: 2.196 ± 0.053	2.029PheThr: 2.029 ± 0.043	2.647PheVal: 2.647 ± 0.053	0.561PheTrp: 0.561 ± 0.022	0.923PheTyr: 0.923 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.855GlyAla: 8.855 ± 0.118	0.857GlyCys: 0.857 ± 0.033	5.135GlyAsp: 5.135 ± 0.102	5.657GlyGlu: 5.657 ± 0.088	3.699GlyPhe: 3.699 ± 0.07	7.68GlyGly: 7.68 ± 0.137	1.841GlyHis: 1.841 ± 0.051	4.304GlyIle: 4.304 ± 0.071	3.638GlyLys: 3.638 ± 0.069	8.618GlyLeu: 8.618 ± 0.121	2.255GlyMet: 2.255 ± 0.05	2.24GlyAsn: 2.24 ± 0.069	3.719GlyPro: 3.719 ± 0.067	2.771GlyGln: 2.771 ± 0.063	5.793GlyArg: 5.793 ± 0.088	4.957GlySer: 4.957 ± 0.082	4.655GlyThr: 4.655 ± 0.12	5.849GlyVal: 5.849 ± 0.09	1.406GlyTrp: 1.406 ± 0.038	2.364GlyTyr: 2.364 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.068HisAla: 2.068 ± 0.047	0.245HisCys: 0.245 ± 0.018	1.189HisAsp: 1.189 ± 0.042	1.132HisGlu: 1.132 ± 0.036	0.845HisPhe: 0.845 ± 0.032	1.851HisGly: 1.851 ± 0.047	0.545HisHis: 0.545 ± 0.03	0.942HisIle: 0.942 ± 0.035	0.541HisLys: 0.541 ± 0.024	2.007HisLeu: 2.007 ± 0.042	0.448HisMet: 0.448 ± 0.024	0.492HisAsn: 0.492 ± 0.021	1.304HisPro: 1.304 ± 0.037	0.608HisGln: 0.608 ± 0.025	1.374HisArg: 1.374 ± 0.044	0.942HisSer: 0.942 ± 0.031	0.815HisThr: 0.815 ± 0.033	1.358HisVal: 1.358 ± 0.039	0.318HisTrp: 0.318 ± 0.02	0.596HisTyr: 0.596 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.896IleAla: 6.896 ± 0.095	0.557IleCys: 0.557 ± 0.027	3.541IleAsp: 3.541 ± 0.061	3.616IleGlu: 3.616 ± 0.062	1.806IlePhe: 1.806 ± 0.051	4.988IleGly: 4.988 ± 0.077	0.845IleHis: 0.845 ± 0.029	2.087IleIle: 2.087 ± 0.056	1.491IleLys: 1.491 ± 0.046	4.399IleLeu: 4.399 ± 0.062	0.874IleMet: 0.874 ± 0.034	1.282IleAsn: 1.282 ± 0.045	2.355IlePro: 2.355 ± 0.049	1.311IleGln: 1.311 ± 0.037	2.894IleArg: 2.894 ± 0.055	2.977IleSer: 2.977 ± 0.056	2.544IleThr: 2.544 ± 0.051	4.188IleVal: 4.188 ± 0.071	0.6IleTrp: 0.6 ± 0.028	1.185IleTyr: 1.185 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.475LysAla: 4.475 ± 0.089	0.207LysCys: 0.207 ± 0.015	2.3LysAsp: 2.3 ± 0.053	2.396LysGlu: 2.396 ± 0.061	0.917LysPhe: 0.917 ± 0.031	3.074LysGly: 3.074 ± 0.076	0.709LysHis: 0.709 ± 0.025	1.826LysIle: 1.826 ± 0.044	1.654LysLys: 1.654 ± 0.057	3.888LysLeu: 3.888 ± 0.071	0.858LysMet: 0.858 ± 0.033	0.942LysAsn: 0.942 ± 0.033	2.566LysPro: 2.566 ± 0.064	1.265LysGln: 1.265 ± 0.037	2.914LysArg: 2.914 ± 0.062	2.257LysSer: 2.257 ± 0.056	2.224LysThr: 2.224 ± 0.055	2.618LysVal: 2.618 ± 0.058	0.388LysTrp: 0.388 ± 0.02	0.705LysTyr: 0.705 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.188LeuAla: 12.188 ± 0.145	0.874LeuCys: 0.874 ± 0.032	5.91LeuAsp: 5.91 ± 0.084	5.938LeuGlu: 5.938 ± 0.09	3.594LeuPhe: 3.594 ± 0.062	8.101LeuGly: 8.101 ± 0.102	1.838LeuHis: 1.838 ± 0.053	5.0LeuIle: 5.0 ± 0.083	4.299LeuLys: 4.299 ± 0.064	9.409LeuLeu: 9.409 ± 0.129	2.245LeuMet: 2.245 ± 0.057	2.631LeuAsn: 2.631 ± 0.065	5.288LeuPro: 5.288 ± 0.075	2.978LeuGln: 2.978 ± 0.065	6.257LeuArg: 6.257 ± 0.095	6.282LeuSer: 6.282 ± 0.081	5.71LeuThr: 5.71 ± 0.09	6.951LeuVal: 6.951 ± 0.088	1.139LeuTrp: 1.139 ± 0.04	2.273LeuTyr: 2.273 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.946MetAla: 2.946 ± 0.056	0.14MetCys: 0.14 ± 0.012	1.168MetAsp: 1.168 ± 0.038	1.354MetGlu: 1.354 ± 0.043	0.719MetPhe: 0.719 ± 0.03	1.829MetGly: 1.829 ± 0.046	0.456MetHis: 0.456 ± 0.024	1.269MetIle: 1.269 ± 0.04	1.011MetLys: 1.011 ± 0.034	2.491MetLeu: 2.491 ± 0.057	0.599MetMet: 0.599 ± 0.025	0.713MetAsn: 0.713 ± 0.028	1.472MetPro: 1.472 ± 0.046	0.814MetGln: 0.814 ± 0.035	1.808MetArg: 1.808 ± 0.046	1.643MetSer: 1.643 ± 0.041	1.629MetThr: 1.629 ± 0.037	1.558MetVal: 1.558 ± 0.045	0.207MetTrp: 0.207 ± 0.016	0.299MetTyr: 0.299 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.052AsnAla: 3.052 ± 0.071	0.269AsnCys: 0.269 ± 0.019	1.534AsnAsp: 1.534 ± 0.051	1.546AsnGlu: 1.546 ± 0.041	0.985AsnPhe: 0.985 ± 0.038	2.349AsnGly: 2.349 ± 0.07	0.514AsnHis: 0.514 ± 0.023	1.343AsnIle: 1.343 ± 0.042	0.814AsnLys: 0.814 ± 0.032	2.617AsnLeu: 2.617 ± 0.058	0.578AsnMet: 0.578 ± 0.023	0.709AsnAsn: 0.709 ± 0.031	1.811AsnPro: 1.811 ± 0.046	0.841AsnGln: 0.841 ± 0.032	1.769AsnArg: 1.769 ± 0.047	1.299AsnSer: 1.299 ± 0.048	1.268AsnThr: 1.268 ± 0.042	1.959AsnVal: 1.959 ± 0.053	0.413AsnTrp: 0.413 ± 0.021	0.732AsnTyr: 0.732 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.893ProAla: 5.893 ± 0.094	0.385ProCys: 0.385 ± 0.024	3.95ProAsp: 3.95 ± 0.079	4.441ProGlu: 4.441 ± 0.074	2.05ProPhe: 2.05 ± 0.05	4.546ProGly: 4.546 ± 0.081	1.028ProHis: 1.028 ± 0.031	2.443ProIle: 2.443 ± 0.045	2.279ProLys: 2.279 ± 0.052	4.619ProLeu: 4.619 ± 0.074	1.198ProMet: 1.198 ± 0.037	1.483ProAsn: 1.483 ± 0.04	2.86ProPro: 2.86 ± 0.077	1.709ProGln: 1.709 ± 0.043	2.875ProArg: 2.875 ± 0.059	3.008ProSer: 3.008 ± 0.063	2.448ProThr: 2.448 ± 0.051	3.869ProVal: 3.869 ± 0.071	0.667ProTrp: 0.667 ± 0.032	1.347ProTyr: 1.347 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.822GlnAla: 3.822 ± 0.066	0.206GlnCys: 0.206 ± 0.016	1.679GlnAsp: 1.679 ± 0.047	1.968GlnGlu: 1.968 ± 0.053	1.117GlnPhe: 1.117 ± 0.035	2.587GlnGly: 2.587 ± 0.058	0.584GlnHis: 0.584 ± 0.028	1.763GlnIle: 1.763 ± 0.044	1.196GlnLys: 1.196 ± 0.035	2.983GlnLeu: 2.983 ± 0.059	0.828GlnMet: 0.828 ± 0.031	0.862GlnAsn: 0.862 ± 0.035	1.769GlnPro: 1.769 ± 0.053	1.126GlnGln: 1.126 ± 0.048	2.243GlnArg: 2.243 ± 0.051	1.879GlnSer: 1.879 ± 0.049	1.776GlnThr: 1.776 ± 0.043	2.153GlnVal: 2.153 ± 0.048	0.371GlnTrp: 0.371 ± 0.02	0.636GlnTyr: 0.636 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.71ArgAla: 6.71 ± 0.103	0.566ArgCys: 0.566 ± 0.025	3.906ArgAsp: 3.906 ± 0.07	4.244ArgGlu: 4.244 ± 0.074	2.892ArgPhe: 2.892 ± 0.058	4.647ArgGly: 4.647 ± 0.07	1.619ArgHis: 1.619 ± 0.048	3.632ArgIle: 3.632 ± 0.065	2.431ArgLys: 2.431 ± 0.054	7.171ArgLeu: 7.171 ± 0.111	1.772ArgMet: 1.772 ± 0.046	1.887ArgAsn: 1.887 ± 0.053	3.497ArgPro: 3.497 ± 0.074	2.344ArgGln: 2.344 ± 0.058	5.224ArgArg: 5.224 ± 0.104	3.786ArgSer: 3.786 ± 0.069	3.041ArgThr: 3.041 ± 0.054	4.145ArgVal: 4.145 ± 0.068	0.977ArgTrp: 0.977 ± 0.036	1.968ArgTyr: 1.968 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.007SerAla: 6.007 ± 0.082	0.495SerCys: 0.495 ± 0.026	3.429SerAsp: 3.429 ± 0.068	3.543SerGlu: 3.543 ± 0.066	2.35SerPhe: 2.35 ± 0.048	5.686SerGly: 5.686 ± 0.107	1.074SerHis: 1.074 ± 0.033	2.644SerIle: 2.644 ± 0.052	1.968SerLys: 1.968 ± 0.051	5.645SerLeu: 5.645 ± 0.086	1.398SerMet: 1.398 ± 0.043	1.491SerAsn: 1.491 ± 0.047	3.035SerPro: 3.035 ± 0.069	1.721SerGln: 1.721 ± 0.046	3.705SerArg: 3.705 ± 0.063	3.256SerSer: 3.256 ± 0.067	2.659SerThr: 2.659 ± 0.058	3.929SerVal: 3.929 ± 0.062	0.846SerTrp: 0.846 ± 0.032	1.434SerTyr: 1.434 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.789ThrAla: 5.789 ± 0.082	0.466ThrCys: 0.466 ± 0.022	2.889ThrAsp: 2.889 ± 0.055	3.175ThrGlu: 3.175 ± 0.058	1.999ThrPhe: 1.999 ± 0.054	5.222ThrGly: 5.222 ± 0.084	0.961ThrHis: 0.961 ± 0.034	2.644ThrIle: 2.644 ± 0.054	1.684ThrLys: 1.684 ± 0.047	5.591ThrLeu: 5.591 ± 0.088	1.109ThrMet: 1.109 ± 0.035	1.267ThrAsn: 1.267 ± 0.044	3.371ThrPro: 3.371 ± 0.06	1.387ThrGln: 1.387 ± 0.04	3.027ThrArg: 3.027 ± 0.055	2.767ThrSer: 2.767 ± 0.066	2.625ThrThr: 2.625 ± 0.063	4.316ThrVal: 4.316 ± 0.074	0.624ThrTrp: 0.624 ± 0.029	1.351ThrTyr: 1.351 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.074ValAla: 8.074 ± 0.101	0.581ValCys: 0.581 ± 0.026	3.988ValAsp: 3.988 ± 0.064	4.714ValGlu: 4.714 ± 0.087	2.689ValPhe: 2.689 ± 0.055	5.094ValGly: 5.094 ± 0.085	1.24ValHis: 1.24 ± 0.039	3.922ValIle: 3.922 ± 0.065	2.572ValLys: 2.572 ± 0.061	7.038ValLeu: 7.038 ± 0.091	1.795ValMet: 1.795 ± 0.051	1.962ValAsn: 1.962 ± 0.05	3.746ValPro: 3.746 ± 0.065	1.99ValGln: 1.99 ± 0.042	4.173ValArg: 4.173 ± 0.064	4.298ValSer: 4.298 ± 0.079	4.305ValThr: 4.305 ± 0.067	5.41ValVal: 5.41 ± 0.091	0.886ValTrp: 0.886 ± 0.032	1.622ValTyr: 1.622 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.189TrpAla: 1.189 ± 0.035	0.15TrpCys: 0.15 ± 0.013	0.648TrpAsp: 0.648 ± 0.033	0.623TrpGlu: 0.623 ± 0.027	0.517TrpPhe: 0.517 ± 0.024	0.944TrpGly: 0.944 ± 0.037	0.341TrpHis: 0.341 ± 0.019	0.651TrpIle: 0.651 ± 0.028	0.474TrpLys: 0.474 ± 0.022	1.657TrpLeu: 1.657 ± 0.046	0.384TrpMet: 0.384 ± 0.026	0.397TrpAsn: 0.397 ± 0.02	0.73TrpPro: 0.73 ± 0.03	0.548TrpGln: 0.548 ± 0.023	1.199TrpArg: 1.199 ± 0.033	0.843TrpSer: 0.843 ± 0.028	0.725TrpThr: 0.725 ± 0.028	0.806TrpVal: 0.806 ± 0.029	0.238TrpTrp: 0.238 ± 0.018	0.276TrpTyr: 0.276 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.045	0.266TyrCys: 0.266 ± 0.014	1.666TyrAsp: 1.666 ± 0.048	1.454TyrGlu: 1.454 ± 0.037	1.077TyrPhe: 1.077 ± 0.037	2.346TyrGly: 2.346 ± 0.048	0.526TyrHis: 0.526 ± 0.028	0.989TyrIle: 0.989 ± 0.036	0.726TyrLys: 0.726 ± 0.031	2.454TyrLeu: 2.454 ± 0.055	0.483TyrMet: 0.483 ± 0.024	0.625TyrAsn: 0.625 ± 0.027	1.164TyrPro: 1.164 ± 0.036	0.783TyrGln: 0.783 ± 0.036	1.882TyrArg: 1.882 ± 0.045	1.304TyrSer: 1.304 ± 0.036	1.117TyrThr: 1.117 ± 0.039	1.681TyrVal: 1.681 ± 0.043	0.418TyrTrp: 0.418 ± 0.021	0.667TyrTyr: 0.667 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3174 proteins (933872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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