Amino acid dipepetide frequency for CRESS virus sp. ctin15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.778AlaAla: 4.778 ± 1.054
1.365AlaCys: 1.365 ± 1.142
2.048AlaAsp: 2.048 ± 0.971
0.0AlaGlu: 0.0 ± 0.0
4.096AlaPhe: 4.096 ± 1.619
4.096AlaGly: 4.096 ± 0.8
2.048AlaHis: 2.048 ± 2.229
2.048AlaIle: 2.048 ± 0.481
3.413AlaLys: 3.413 ± 2.401
4.096AlaLeu: 4.096 ± 1.315
2.73AlaMet: 2.73 ± 1.131
1.365AlaAsn: 1.365 ± 1.07
5.461AlaPro: 5.461 ± 1.367
0.683AlaGln: 0.683 ± 0.493
1.365AlaArg: 1.365 ± 0.615
3.413AlaSer: 3.413 ± 1.447
4.096AlaThr: 4.096 ± 1.942
0.0AlaVal: 0.0 ± 0.0
0.0AlaTrp: 0.0 ± 0.0
0.683AlaTyr: 0.683 ± 0.743
0.0AlaXaa: 0.0 ± 0.0
Cys
0.683CysAla: 0.683 ± 0.571
0.0CysCys: 0.0 ± 0.0
0.683CysAsp: 0.683 ± 0.571
0.0CysGlu: 0.0 ± 0.0
2.73CysPhe: 2.73 ± 1.14
0.683CysGly: 0.683 ± 0.571
0.0CysHis: 0.0 ± 0.0
1.365CysIle: 1.365 ± 0.841
3.413CysLys: 3.413 ± 2.029
0.683CysLeu: 0.683 ± 0.493
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.683CysGln: 0.683 ± 0.743
0.0CysArg: 0.0 ± 0.0
1.365CysSer: 1.365 ± 0.517
2.048CysThr: 2.048 ± 0.971
1.365CysVal: 1.365 ± 1.07
0.0CysTrp: 0.0 ± 0.0
1.365CysTyr: 1.365 ± 0.517
0.0CysXaa: 0.0 ± 0.0
Asp
2.73AspAla: 2.73 ± 1.449
1.365AspCys: 1.365 ± 0.986
4.096AspAsp: 4.096 ± 0.985
4.096AspGlu: 4.096 ± 1.668
2.73AspPhe: 2.73 ± 2.187
2.73AspGly: 2.73 ± 1.507
0.683AspHis: 0.683 ± 1.095
4.778AspIle: 4.778 ± 2.102
3.413AspLys: 3.413 ± 1.375
2.048AspLeu: 2.048 ± 1.231
2.048AspMet: 2.048 ± 1.271
4.096AspAsn: 4.096 ± 1.335
2.048AspPro: 2.048 ± 0.834
1.365AspGln: 1.365 ± 2.191
2.73AspArg: 2.73 ± 1.99
6.143AspSer: 6.143 ± 2.918
0.683AspThr: 0.683 ± 0.571
3.413AspVal: 3.413 ± 2.291
0.0AspTrp: 0.0 ± 0.0
2.73AspTyr: 2.73 ± 1.269
0.0AspXaa: 0.0 ± 0.0
Glu
3.413GluAla: 3.413 ± 0.667
0.683GluCys: 0.683 ± 0.493
2.048GluAsp: 2.048 ± 1.481
4.096GluGlu: 4.096 ± 3.211
2.048GluPhe: 2.048 ± 1.271
2.73GluGly: 2.73 ± 0.491
2.048GluHis: 2.048 ± 1.226
5.461GluIle: 5.461 ± 2.147
3.413GluLys: 3.413 ± 1.278
4.096GluLeu: 4.096 ± 3.211
2.73GluMet: 2.73 ± 1.581
0.683GluAsn: 0.683 ± 0.493
4.096GluPro: 4.096 ± 2.021
0.683GluGln: 0.683 ± 0.743
0.683GluArg: 0.683 ± 1.095
2.73GluSer: 2.73 ± 1.14
2.048GluThr: 2.048 ± 2.176
3.413GluVal: 3.413 ± 2.232
0.683GluTrp: 0.683 ± 0.743
3.413GluTyr: 3.413 ± 1.278
0.0GluXaa: 0.0 ± 0.0
Phe
1.365PheAla: 1.365 ± 0.841
1.365PheCys: 1.365 ± 0.841
3.413PheAsp: 3.413 ± 1.297
2.048PheGlu: 2.048 ± 1.231
1.365PhePhe: 1.365 ± 0.841
1.365PheGly: 1.365 ± 0.615
1.365PheHis: 1.365 ± 1.07
4.778PheIle: 4.778 ± 1.519
4.778PheLys: 4.778 ± 2.11
4.096PheLeu: 4.096 ± 1.627
0.0PheMet: 0.0 ± 0.0
6.143PheAsn: 6.143 ± 1.023
0.683PhePro: 0.683 ± 0.493
1.365PheGln: 1.365 ± 0.517
0.683PheArg: 0.683 ± 0.493
4.096PheSer: 4.096 ± 0.962
4.096PheThr: 4.096 ± 1.312
4.096PheVal: 4.096 ± 1.627
0.683PheTrp: 0.683 ± 0.493
2.048PheTyr: 2.048 ± 0.83
0.0PheXaa: 0.0 ± 0.0
Gly
1.365GlyAla: 1.365 ± 1.142
1.365GlyCys: 1.365 ± 0.841
0.683GlyAsp: 0.683 ± 0.743
2.73GlyGlu: 2.73 ± 1.22
6.826GlyPhe: 6.826 ± 1.431
2.73GlyGly: 2.73 ± 1.22
0.0GlyHis: 0.0 ± 0.0
2.048GlyIle: 2.048 ± 0.971
4.778GlyLys: 4.778 ± 2.11
2.73GlyLeu: 2.73 ± 1.22
1.365GlyMet: 1.365 ± 0.517
4.096GlyAsn: 4.096 ± 0.962
2.048GlyPro: 2.048 ± 0.834
1.365GlyGln: 1.365 ± 1.142
1.365GlyArg: 1.365 ± 0.841
6.143GlySer: 6.143 ± 1.31
6.826GlyThr: 6.826 ± 1.712
4.096GlyVal: 4.096 ± 0.8
0.683GlyTrp: 0.683 ± 0.571
4.096GlyTyr: 4.096 ± 1.312
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
1.365HisAsp: 1.365 ± 1.486
0.683HisGlu: 0.683 ± 0.571
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.365HisIle: 1.365 ± 0.615
2.73HisLys: 2.73 ± 1.682
2.048HisLeu: 2.048 ± 1.226
1.365HisMet: 1.365 ± 1.142
0.683HisAsn: 0.683 ± 0.571
4.096HisPro: 4.096 ± 0.962
2.048HisGln: 2.048 ± 3.286
0.0HisArg: 0.0 ± 0.0
0.683HisSer: 0.683 ± 0.743
0.683HisThr: 0.683 ± 0.571
1.365HisVal: 1.365 ± 0.615
0.683HisTrp: 0.683 ± 0.571
1.365HisTyr: 1.365 ± 0.615
0.0HisXaa: 0.0 ± 0.0
Ile
2.73IleAla: 2.73 ± 1.449
0.683IleCys: 0.683 ± 0.571
3.413IleAsp: 3.413 ± 1.735
7.509IleGlu: 7.509 ± 3.584
2.73IlePhe: 2.73 ± 1.269
6.143IleGly: 6.143 ± 1.023
0.683IleHis: 0.683 ± 0.743
8.191IleIle: 8.191 ± 4.224
2.73IleLys: 2.73 ± 1.052
3.413IleLeu: 3.413 ± 1.133
1.365IleMet: 1.365 ± 1.306
4.096IleAsn: 4.096 ± 2.058
5.461IlePro: 5.461 ± 2.538
1.365IleGln: 1.365 ± 0.517
4.778IleArg: 4.778 ± 1.587
4.096IleSer: 4.096 ± 2.213
2.048IleThr: 2.048 ± 0.971
2.048IleVal: 2.048 ± 1.226
0.683IleTrp: 0.683 ± 1.095
2.048IleTyr: 2.048 ± 0.834
0.0IleXaa: 0.0 ± 0.0
Lys
2.048LysAla: 2.048 ± 1.271
2.048LysCys: 2.048 ± 0.971
3.413LysAsp: 3.413 ± 0.667
3.413LysGlu: 3.413 ± 2.058
1.365LysPhe: 1.365 ± 1.142
2.048LysGly: 2.048 ± 1.481
2.73LysHis: 2.73 ± 1.667
4.096LysIle: 4.096 ± 1.415
7.509LysLys: 7.509 ± 0.862
5.461LysLeu: 5.461 ± 1.367
1.365LysMet: 1.365 ± 0.841
4.778LysAsn: 4.778 ± 2.064
2.048LysPro: 2.048 ± 0.834
3.413LysGln: 3.413 ± 0.665
3.413LysArg: 3.413 ± 2.373
5.461LysSer: 5.461 ± 2.908
5.461LysThr: 5.461 ± 2.768
2.73LysVal: 2.73 ± 0.858
0.683LysTrp: 0.683 ± 0.571
2.73LysTyr: 2.73 ± 1.229
0.0LysXaa: 0.0 ± 0.0
Leu
2.048LeuAla: 2.048 ± 1.226
2.73LeuCys: 2.73 ± 0.854
3.413LeuAsp: 3.413 ± 1.303
4.778LeuGlu: 4.778 ± 3.461
2.73LeuPhe: 2.73 ± 1.22
4.096LeuGly: 4.096 ± 0.8
3.413LeuHis: 3.413 ± 1.447
2.048LeuIle: 2.048 ± 0.481
4.096LeuLys: 4.096 ± 0.802
2.73LeuLeu: 2.73 ± 2.04
0.683LeuMet: 0.683 ± 0.493
10.239LeuAsn: 10.239 ± 4.943
2.73LeuPro: 2.73 ± 1.22
1.365LeuGln: 1.365 ± 0.841
6.826LeuArg: 6.826 ± 2.91
5.461LeuSer: 5.461 ± 0.841
5.461LeuThr: 5.461 ± 2.068
2.048LeuVal: 2.048 ± 0.987
0.0LeuTrp: 0.0 ± 0.0
1.365LeuTyr: 1.365 ± 0.615
0.0LeuXaa: 0.0 ± 0.0
Met
1.365MetAla: 1.365 ± 0.841
0.0MetCys: 0.0 ± 0.0
2.73MetAsp: 2.73 ± 2.141
0.683MetGlu: 0.683 ± 0.493
1.365MetPhe: 1.365 ± 0.517
0.683MetGly: 0.683 ± 0.493
0.0MetHis: 0.0 ± 0.0
0.683MetIle: 0.683 ± 0.571
1.365MetLys: 1.365 ± 1.153
2.048MetLeu: 2.048 ± 1.271
0.0MetMet: 0.0 ± 0.0
2.73MetAsn: 2.73 ± 1.042
1.365MetPro: 1.365 ± 0.986
0.683MetGln: 0.683 ± 0.493
0.683MetArg: 0.683 ± 0.493
0.683MetSer: 0.683 ± 0.743
1.365MetThr: 1.365 ± 1.153
3.413MetVal: 3.413 ± 1.02
0.0MetTrp: 0.0 ± 0.0
1.365MetTyr: 1.365 ± 0.615
0.0MetXaa: 0.0 ± 0.0
Asn
2.73AsnAla: 2.73 ± 0.858
1.365AsnCys: 1.365 ± 1.142
2.73AsnAsp: 2.73 ± 1.14
4.096AsnGlu: 4.096 ± 3.013
2.048AsnPhe: 2.048 ± 1.256
4.778AsnGly: 4.778 ± 1.786
1.365AsnHis: 1.365 ± 1.142
3.413AsnIle: 3.413 ± 2.466
1.365AsnLys: 1.365 ± 1.153
6.826AsnLeu: 6.826 ± 1.721
2.048AsnMet: 2.048 ± 1.226
4.778AsnAsn: 4.778 ± 1.092
3.413AsnPro: 3.413 ± 1.735
2.048AsnGln: 2.048 ± 1.035
3.413AsnArg: 3.413 ± 1.375
7.509AsnSer: 7.509 ± 1.287
4.096AsnThr: 4.096 ± 0.8
3.413AsnVal: 3.413 ± 1.297
0.683AsnTrp: 0.683 ± 0.493
4.096AsnTyr: 4.096 ± 2.132
0.0AsnXaa: 0.0 ± 0.0
Pro
1.365ProAla: 1.365 ± 1.486
0.683ProCys: 0.683 ± 0.743
4.778ProAsp: 4.778 ± 1.24
1.365ProGlu: 1.365 ± 1.153
5.461ProPhe: 5.461 ± 2.118
2.73ProGly: 2.73 ± 0.491
1.365ProHis: 1.365 ± 0.615
4.778ProIle: 4.778 ± 2.697
0.0ProLys: 0.0 ± 0.0
4.096ProLeu: 4.096 ± 1.605
2.73ProMet: 2.73 ± 1.973
3.413ProAsn: 3.413 ± 1.976
9.556ProPro: 9.556 ± 6.125
1.365ProGln: 1.365 ± 0.517
2.048ProArg: 2.048 ± 1.271
7.509ProSer: 7.509 ± 2.959
6.143ProThr: 6.143 ± 1.902
4.096ProVal: 4.096 ± 1.605
0.683ProTrp: 0.683 ± 0.493
0.683ProTyr: 0.683 ± 0.493
0.0ProXaa: 0.0 ± 0.0
Gln
1.365GlnAla: 1.365 ± 0.517
0.0GlnCys: 0.0 ± 0.0
0.683GlnAsp: 0.683 ± 0.571
2.048GlnGlu: 2.048 ± 2.109
0.683GlnPhe: 0.683 ± 0.493
3.413GlnGly: 3.413 ± 2.058
0.0GlnHis: 0.0 ± 0.0
2.048GlnIle: 2.048 ± 0.971
0.683GlnLys: 0.683 ± 1.095
2.048GlnLeu: 2.048 ± 0.987
0.683GlnMet: 0.683 ± 1.095
1.365GlnAsn: 1.365 ± 0.517
0.683GlnPro: 0.683 ± 1.095
1.365GlnGln: 1.365 ± 0.841
2.73GlnArg: 2.73 ± 1.581
0.0GlnSer: 0.0 ± 0.0
2.73GlnThr: 2.73 ± 0.491
3.413GlnVal: 3.413 ± 1.795
0.0GlnTrp: 0.0 ± 0.0
2.73GlnTyr: 2.73 ± 1.22
0.0GlnXaa: 0.0 ± 0.0
Arg
2.048ArgAla: 2.048 ± 1.453
0.0ArgCys: 0.0 ± 0.0
2.73ArgAsp: 2.73 ± 0.858
2.73ArgGlu: 2.73 ± 1.449
3.413ArgPhe: 3.413 ± 1.375
2.73ArgGly: 2.73 ± 1.22
0.0ArgHis: 0.0 ± 0.0
2.73ArgIle: 2.73 ± 2.167
2.048ArgLys: 2.048 ± 1.453
2.048ArgLeu: 2.048 ± 1.035
0.683ArgMet: 0.683 ± 0.571
2.048ArgAsn: 2.048 ± 0.83
2.048ArgPro: 2.048 ± 0.834
2.73ArgGln: 2.73 ± 1.454
2.73ArgArg: 2.73 ± 2.02
5.461ArgSer: 5.461 ± 1.101
4.096ArgThr: 4.096 ± 0.94
3.413ArgVal: 3.413 ± 0.859
0.0ArgTrp: 0.0 ± 0.0
2.73ArgTyr: 2.73 ± 1.229
0.0ArgXaa: 0.0 ± 0.0
Ser
7.509SerAla: 7.509 ± 2.072
1.365SerCys: 1.365 ± 0.517
8.191SerAsp: 8.191 ± 2.596
4.096SerGlu: 4.096 ± 1.619
1.365SerPhe: 1.365 ± 0.615
5.461SerGly: 5.461 ± 1.716
2.048SerHis: 2.048 ± 1.481
5.461SerIle: 5.461 ± 1.042
8.874SerLys: 8.874 ± 4.405
2.73SerLeu: 2.73 ± 1.206
0.0SerMet: 0.0 ± 0.0
4.096SerAsn: 4.096 ± 0.8
6.826SerPro: 6.826 ± 1.947
2.048SerGln: 2.048 ± 1.48
3.413SerArg: 3.413 ± 0.667
10.922SerSer: 10.922 ± 4.581
4.778SerThr: 4.778 ± 1.092
2.73SerVal: 2.73 ± 0.491
2.048SerTrp: 2.048 ± 1.481
4.778SerTyr: 4.778 ± 2.09
0.0SerXaa: 0.0 ± 0.0
Thr
4.096ThrAla: 4.096 ± 1.942
0.683ThrCys: 0.683 ± 0.571
1.365ThrAsp: 1.365 ± 0.841
2.048ThrGlu: 2.048 ± 0.83
3.413ThrPhe: 3.413 ± 2.029
6.826ThrGly: 6.826 ± 1.718
0.683ThrHis: 0.683 ± 0.493
6.143ThrIle: 6.143 ± 2.639
3.413ThrLys: 3.413 ± 1.133
6.826ThrLeu: 6.826 ± 1.721
0.683ThrMet: 0.683 ± 0.423
4.778ThrAsn: 4.778 ± 1.459
5.461ThrPro: 5.461 ± 1.568
0.0ThrGln: 0.0 ± 0.0
4.778ThrArg: 4.778 ± 1.979
4.096ThrSer: 4.096 ± 1.14
8.191ThrThr: 8.191 ± 2.596
5.461ThrVal: 5.461 ± 1.042
0.683ThrTrp: 0.683 ± 0.493
2.73ThrTyr: 2.73 ± 1.269
0.0ThrXaa: 0.0 ± 0.0
Val
2.048ValAla: 2.048 ± 1.256
0.0ValCys: 0.0 ± 0.0
3.413ValAsp: 3.413 ± 1.303
2.73ValGlu: 2.73 ± 2.02
2.73ValPhe: 2.73 ± 1.14
2.73ValGly: 2.73 ± 1.724
2.048ValHis: 2.048 ± 1.231
2.048ValIle: 2.048 ± 0.481
4.778ValLys: 4.778 ± 1.584
4.778ValLeu: 4.778 ± 1.054
1.365ValMet: 1.365 ± 0.903
5.461ValAsn: 5.461 ± 1.042
2.048ValPro: 2.048 ± 0.481
3.413ValGln: 3.413 ± 1.976
3.413ValArg: 3.413 ± 0.944
6.826ValSer: 6.826 ± 1.334
2.73ValThr: 2.73 ± 0.854
5.461ValVal: 5.461 ± 1.367
0.0ValTrp: 0.0 ± 0.0
0.683ValTyr: 0.683 ± 0.743
0.0ValXaa: 0.0 ± 0.0
Trp
0.683TrpAla: 0.683 ± 0.571
0.683TrpCys: 0.683 ± 0.743
1.365TrpAsp: 1.365 ± 0.986
0.0TrpGlu: 0.0 ± 0.0
1.365TrpPhe: 1.365 ± 0.841
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.683TrpIle: 0.683 ± 0.493
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.683TrpMet: 0.683 ± 1.095
1.365TrpAsn: 1.365 ± 0.986
0.0TrpPro: 0.0 ± 0.0
0.683TrpGln: 0.683 ± 0.743
0.683TrpArg: 0.683 ± 0.571
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.683TrpVal: 0.683 ± 0.571
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.413TyrAla: 3.413 ± 1.375
0.683TyrCys: 0.683 ± 0.743
1.365TyrAsp: 1.365 ± 0.841
2.048TyrGlu: 2.048 ± 0.83
1.365TyrPhe: 1.365 ± 0.615
1.365TyrGly: 1.365 ± 0.986
0.683TyrHis: 0.683 ± 0.571
2.048TyrIle: 2.048 ± 0.834
3.413TyrLys: 3.413 ± 0.944
5.461TyrLeu: 5.461 ± 2.44
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
4.778TyrPro: 4.778 ± 2.608
0.0TyrGln: 0.0 ± 0.0
0.683TyrArg: 0.683 ± 0.493
6.143TyrSer: 6.143 ± 1.562
4.778TyrThr: 4.778 ± 2.028
2.73TyrVal: 2.73 ± 0.858
0.683TyrTrp: 0.683 ± 0.493
1.365TyrTyr: 1.365 ± 0.615
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1466 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski