Amino acid dipepetide frequency for Kingella denitrificans ATCC 33394

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.83AlaAla: 15.83 ± 0.234
1.704AlaCys: 1.704 ± 0.064
6.022AlaAsp: 6.022 ± 0.108
7.403AlaGlu: 7.403 ± 0.14
4.106AlaPhe: 4.106 ± 0.098
7.549AlaGly: 7.549 ± 0.11
2.443AlaHis: 2.443 ± 0.069
4.598AlaIle: 4.598 ± 0.096
5.014AlaLys: 5.014 ± 0.105
11.051AlaLeu: 11.051 ± 0.189
2.714AlaMet: 2.714 ± 0.068
3.335AlaAsn: 3.335 ± 0.077
4.255AlaPro: 4.255 ± 0.096
6.445AlaGln: 6.445 ± 0.138
5.344AlaArg: 5.344 ± 0.105
4.278AlaSer: 4.278 ± 0.111
4.086AlaThr: 4.086 ± 0.088
7.944AlaVal: 7.944 ± 0.141
1.419AlaTrp: 1.419 ± 0.055
2.741AlaTyr: 2.741 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
1.228CysAla: 1.228 ± 0.044
0.212CysCys: 0.212 ± 0.019
0.524CysAsp: 0.524 ± 0.03
0.548CysGlu: 0.548 ± 0.027
0.618CysPhe: 0.618 ± 0.029
1.083CysGly: 1.083 ± 0.046
0.311CysHis: 0.311 ± 0.022
0.58CysIle: 0.58 ± 0.029
0.417CysLys: 0.417 ± 0.026
1.209CysLeu: 1.209 ± 0.045
0.209CysMet: 0.209 ± 0.019
0.373CysAsn: 0.373 ± 0.019
0.583CysPro: 0.583 ± 0.031
0.474CysGln: 0.474 ± 0.026
1.014CysArg: 1.014 ± 0.043
0.644CysSer: 0.644 ± 0.029
0.865CysThr: 0.865 ± 0.043
0.698CysVal: 0.698 ± 0.029
0.14CysTrp: 0.14 ± 0.015
0.355CysTyr: 0.355 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.774AspAla: 4.774 ± 0.079
0.535AspCys: 0.535 ± 0.029
2.706AspAsp: 2.706 ± 0.087
3.6AspGlu: 3.6 ± 0.083
2.391AspPhe: 2.391 ± 0.066
3.873AspGly: 3.873 ± 0.084
0.86AspHis: 0.86 ± 0.039
3.233AspIle: 3.233 ± 0.07
2.817AspLys: 2.817 ± 0.076
4.829AspLeu: 4.829 ± 0.094
1.409AspMet: 1.409 ± 0.049
2.237AspAsn: 2.237 ± 0.065
1.756AspPro: 1.756 ± 0.052
1.244AspGln: 1.244 ± 0.046
2.131AspArg: 2.131 ± 0.061
2.67AspSer: 2.67 ± 0.062
2.778AspThr: 2.778 ± 0.074
3.404AspVal: 3.404 ± 0.066
0.996AspTrp: 0.996 ± 0.044
2.004AspTyr: 2.004 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
5.513GluAla: 5.513 ± 0.112
0.606GluCys: 0.606 ± 0.029
2.415GluAsp: 2.415 ± 0.07
3.227GluGlu: 3.227 ± 0.091
2.077GluPhe: 2.077 ± 0.054
3.142GluGly: 3.142 ± 0.075
1.748GluHis: 1.748 ± 0.054
3.728GluIle: 3.728 ± 0.072
3.386GluLys: 3.386 ± 0.076
5.469GluLeu: 5.469 ± 0.106
1.722GluMet: 1.722 ± 0.048
2.865GluAsn: 2.865 ± 0.068
2.074GluPro: 2.074 ± 0.065
3.539GluGln: 3.539 ± 0.085
3.763GluArg: 3.763 ± 0.082
2.834GluSer: 2.834 ± 0.069
3.291GluThr: 3.291 ± 0.082
3.125GluVal: 3.125 ± 0.087
0.888GluTrp: 0.888 ± 0.033
1.843GluTyr: 1.843 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
4.808PheAla: 4.808 ± 0.088
0.675PheCys: 0.675 ± 0.034
2.44PheAsp: 2.44 ± 0.055
2.056PheGlu: 2.056 ± 0.048
1.863PhePhe: 1.863 ± 0.059
3.433PheGly: 3.433 ± 0.085
0.926PheHis: 0.926 ± 0.037
2.277PheIle: 2.277 ± 0.065
1.697PheLys: 1.697 ± 0.048
3.716PheLeu: 3.716 ± 0.084
1.049PheMet: 1.049 ± 0.041
1.695PheAsn: 1.695 ± 0.051
1.595PhePro: 1.595 ± 0.049
1.456PheGln: 1.456 ± 0.05
1.952PheArg: 1.952 ± 0.058
2.65PheSer: 2.65 ± 0.063
2.082PheThr: 2.082 ± 0.064
2.886PheVal: 2.886 ± 0.063
0.69PheTrp: 0.69 ± 0.034
1.441PheTyr: 1.441 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
6.134GlyAla: 6.134 ± 0.127
1.185GlyCys: 1.185 ± 0.044
3.293GlyAsp: 3.293 ± 0.082
4.117GlyGlu: 4.117 ± 0.088
3.255GlyPhe: 3.255 ± 0.073
5.55GlyGly: 5.55 ± 0.118
1.5GlyHis: 1.5 ± 0.051
4.5GlyIle: 4.5 ± 0.086
4.584GlyLys: 4.584 ± 0.108
6.555GlyLeu: 6.555 ± 0.113
2.118GlyMet: 2.118 ± 0.062
2.932GlyAsn: 2.932 ± 0.088
0.993GlyPro: 0.993 ± 0.043
2.909GlyGln: 2.909 ± 0.073
4.004GlyArg: 4.004 ± 0.099
4.441GlySer: 4.441 ± 0.102
3.588GlyThr: 3.588 ± 0.088
5.014GlyVal: 5.014 ± 0.099
1.08GlyTrp: 1.08 ± 0.049
2.306GlyTyr: 2.306 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.403HisAla: 2.403 ± 0.065
0.343HisCys: 0.343 ± 0.023
1.253HisAsp: 1.253 ± 0.047
1.339HisGlu: 1.339 ± 0.05
1.197HisPhe: 1.197 ± 0.044
1.951HisGly: 1.951 ± 0.05
0.758HisHis: 0.758 ± 0.04
1.849HisIle: 1.849 ± 0.054
0.924HisLys: 0.924 ± 0.037
2.376HisLeu: 2.376 ± 0.062
0.528HisMet: 0.528 ± 0.028
0.999HisAsn: 0.999 ± 0.039
1.398HisPro: 1.398 ± 0.048
1.017HisGln: 1.017 ± 0.041
1.462HisArg: 1.462 ± 0.049
1.281HisSer: 1.281 ± 0.051
1.515HisThr: 1.515 ± 0.051
1.331HisVal: 1.331 ± 0.041
0.381HisTrp: 0.381 ± 0.024
0.946HisTyr: 0.946 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.398IleAla: 6.398 ± 0.098
0.666IleCys: 0.666 ± 0.032
3.287IleAsp: 3.287 ± 0.08
3.28IleGlu: 3.28 ± 0.082
2.128IlePhe: 2.128 ± 0.058
4.426IleGly: 4.426 ± 0.105
1.299IleHis: 1.299 ± 0.051
3.06IleIle: 3.06 ± 0.079
2.304IleLys: 2.304 ± 0.059
5.011IleLeu: 5.011 ± 0.095
1.313IleMet: 1.313 ± 0.048
2.141IleAsn: 2.141 ± 0.066
2.525IlePro: 2.525 ± 0.063
2.077IleGln: 2.077 ± 0.065
3.419IleArg: 3.419 ± 0.074
3.099IleSer: 3.099 ± 0.083
3.178IleThr: 3.178 ± 0.066
3.788IleVal: 3.788 ± 0.086
0.612IleTrp: 0.612 ± 0.032
1.477IleTyr: 1.477 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.685LysAla: 4.685 ± 0.097
0.338LysCys: 0.338 ± 0.025
2.222LysAsp: 2.222 ± 0.065
2.514LysGlu: 2.514 ± 0.077
1.425LysPhe: 1.425 ± 0.055
2.833LysGly: 2.833 ± 0.079
1.157LysHis: 1.157 ± 0.047
3.264LysIle: 3.264 ± 0.083
2.673LysLys: 2.673 ± 0.081
4.513LysLeu: 4.513 ± 0.083
1.537LysMet: 1.537 ± 0.052
2.268LysAsn: 2.268 ± 0.076
2.525LysPro: 2.525 ± 0.06
2.912LysGln: 2.912 ± 0.076
2.749LysArg: 2.749 ± 0.063
2.697LysSer: 2.697 ± 0.069
3.133LysThr: 3.133 ± 0.08
2.711LysVal: 2.711 ± 0.073
0.583LysTrp: 0.583 ± 0.036
1.339LysTyr: 1.339 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
11.163LeuAla: 11.163 ± 0.175
1.253LeuCys: 1.253 ± 0.048
5.193LeuAsp: 5.193 ± 0.096
4.66LeuGlu: 4.66 ± 0.103
4.403LeuPhe: 4.403 ± 0.095
6.704LeuGly: 6.704 ± 0.12
3.145LeuHis: 3.145 ± 0.085
4.832LeuIle: 4.832 ± 0.085
4.637LeuLys: 4.637 ± 0.094
10.985LeuLeu: 10.985 ± 0.209
2.525LeuMet: 2.525 ± 0.07
4.1LeuAsn: 4.1 ± 0.077
6.367LeuPro: 6.367 ± 0.113
4.723LeuGln: 4.723 ± 0.109
5.495LeuArg: 5.495 ± 0.094
6.223LeuSer: 6.223 ± 0.109
5.155LeuThr: 5.155 ± 0.089
5.802LeuVal: 5.802 ± 0.108
1.313LeuTrp: 1.313 ± 0.052
2.656LeuTyr: 2.656 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.612MetAla: 2.612 ± 0.072
0.259MetCys: 0.259 ± 0.021
1.109MetAsp: 1.109 ± 0.042
1.125MetGlu: 1.125 ± 0.046
0.895MetPhe: 0.895 ± 0.038
1.739MetGly: 1.739 ± 0.053
0.55MetHis: 0.55 ± 0.028
1.252MetIle: 1.252 ± 0.046
1.652MetLys: 1.652 ± 0.049
2.545MetLeu: 2.545 ± 0.066
0.867MetMet: 0.867 ± 0.035
1.269MetAsn: 1.269 ± 0.045
1.425MetPro: 1.425 ± 0.044
1.486MetGln: 1.486 ± 0.05
1.476MetArg: 1.476 ± 0.044
1.509MetSer: 1.509 ± 0.05
1.4MetThr: 1.4 ± 0.051
1.71MetVal: 1.71 ± 0.053
0.245MetTrp: 0.245 ± 0.021
0.647MetTyr: 0.647 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
4.132AsnAla: 4.132 ± 0.087
0.356AsnCys: 0.356 ± 0.027
1.852AsnAsp: 1.852 ± 0.056
2.109AsnGlu: 2.109 ± 0.064
1.313AsnPhe: 1.313 ± 0.048
3.407AsnGly: 3.407 ± 0.089
1.011AsnHis: 1.011 ± 0.038
2.556AsnIle: 2.556 ± 0.067
1.799AsnLys: 1.799 ± 0.058
3.523AsnLeu: 3.523 ± 0.076
0.943AsnMet: 0.943 ± 0.043
1.531AsnAsn: 1.531 ± 0.065
2.438AsnPro: 2.438 ± 0.064
1.713AsnGln: 1.713 ± 0.056
2.396AsnArg: 2.396 ± 0.06
1.879AsnSer: 1.879 ± 0.066
2.207AsnThr: 2.207 ± 0.064
2.588AsnVal: 2.588 ± 0.063
0.519AsnTrp: 0.519 ± 0.033
1.084AsnTyr: 1.084 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
5.26ProAla: 5.26 ± 0.115
0.446ProCys: 0.446 ± 0.032
2.84ProAsp: 2.84 ± 0.08
4.001ProGlu: 4.001 ± 0.088
1.969ProPhe: 1.969 ± 0.049
1.64ProGly: 1.64 ± 0.054
1.255ProHis: 1.255 ± 0.042
2.15ProIle: 2.15 ± 0.061
2.316ProLys: 2.316 ± 0.063
4.165ProLeu: 4.165 ± 0.077
1.167ProMet: 1.167 ± 0.035
2.048ProAsn: 2.048 ± 0.057
1.928ProPro: 1.928 ± 0.069
2.339ProGln: 2.339 ± 0.068
1.939ProArg: 1.939 ± 0.063
2.225ProSer: 2.225 ± 0.065
2.182ProThr: 2.182 ± 0.06
3.376ProVal: 3.376 ± 0.074
0.422ProTrp: 0.422 ± 0.027
1.317ProTyr: 1.317 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
6.206GlnAla: 6.206 ± 0.104
0.457GlnCys: 0.457 ± 0.029
1.992GlnAsp: 1.992 ± 0.065
2.457GlnGlu: 2.457 ± 0.078
1.672GlnPhe: 1.672 ± 0.048
3.04GlnGly: 3.04 ± 0.081
1.479GlnHis: 1.479 ± 0.055
2.936GlnIle: 2.936 ± 0.071
2.647GlnLys: 2.647 ± 0.07
4.295GlnLeu: 4.295 ± 0.103
1.282GlnMet: 1.282 ± 0.046
2.256GlnAsn: 2.256 ± 0.071
2.877GlnPro: 2.877 ± 0.08
3.009GlnGln: 3.009 ± 0.111
2.821GlnArg: 2.821 ± 0.072
2.757GlnSer: 2.757 ± 0.072
2.862GlnThr: 2.862 ± 0.065
2.566GlnVal: 2.566 ± 0.068
0.793GlnTrp: 0.793 ± 0.041
1.584GlnTyr: 1.584 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
4.918ArgAla: 4.918 ± 0.096
0.525ArgCys: 0.525 ± 0.027
2.621ArgAsp: 2.621 ± 0.073
3.59ArgGlu: 3.59 ± 0.07
2.758ArgPhe: 2.758 ± 0.068
3.279ArgGly: 3.279 ± 0.068
1.73ArgHis: 1.73 ± 0.057
3.5ArgIle: 3.5 ± 0.075
2.63ArgLys: 2.63 ± 0.066
6.354ArgLeu: 6.354 ± 0.115
1.558ArgMet: 1.558 ± 0.049
2.167ArgAsn: 2.167 ± 0.065
2.297ArgPro: 2.297 ± 0.053
3.736ArgGln: 3.736 ± 0.101
3.678ArgArg: 3.678 ± 0.092
2.658ArgSer: 2.658 ± 0.062
2.6ArgThr: 2.6 ± 0.07
3.43ArgVal: 3.43 ± 0.085
0.76ArgTrp: 0.76 ± 0.034
1.966ArgTyr: 1.966 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.594SerAla: 5.594 ± 0.11
0.608SerCys: 0.608 ± 0.035
2.723SerAsp: 2.723 ± 0.067
2.877SerGlu: 2.877 ± 0.076
2.21SerPhe: 2.21 ± 0.061
4.899SerGly: 4.899 ± 0.089
1.253SerHis: 1.253 ± 0.04
2.804SerIle: 2.804 ± 0.065
2.147SerLys: 2.147 ± 0.064
6.0SerLeu: 6.0 ± 0.106
1.27SerMet: 1.27 ± 0.049
1.841SerAsn: 1.841 ± 0.065
2.481SerPro: 2.481 ± 0.078
2.173SerGln: 2.173 ± 0.06
2.941SerArg: 2.941 ± 0.071
3.331SerSer: 3.331 ± 0.096
2.505SerThr: 2.505 ± 0.068
3.849SerVal: 3.849 ± 0.078
0.722SerTrp: 0.722 ± 0.036
1.448SerTyr: 1.448 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.871ThrAla: 5.871 ± 0.112
0.449ThrCys: 0.449 ± 0.028
2.789ThrAsp: 2.789 ± 0.064
2.912ThrGlu: 2.912 ± 0.07
1.934ThrPhe: 1.934 ± 0.055
3.905ThrGly: 3.905 ± 0.096
1.243ThrHis: 1.243 ± 0.046
2.522ThrIle: 2.522 ± 0.053
1.759ThrLys: 1.759 ± 0.053
5.909ThrLeu: 5.909 ± 0.089
1.03ThrMet: 1.03 ± 0.042
1.538ThrAsn: 1.538 ± 0.056
3.11ThrPro: 3.11 ± 0.075
2.335ThrGln: 2.335 ± 0.056
2.67ThrArg: 2.67 ± 0.057
2.175ThrSer: 2.175 ± 0.065
2.251ThrThr: 2.251 ± 0.074
4.363ThrVal: 4.363 ± 0.091
0.6ThrTrp: 0.6 ± 0.034
1.234ThrTyr: 1.234 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
6.553ValAla: 6.553 ± 0.112
0.873ValCys: 0.873 ± 0.031
2.884ValAsp: 2.884 ± 0.074
3.475ValGlu: 3.475 ± 0.088
2.964ValPhe: 2.964 ± 0.061
4.372ValGly: 4.372 ± 0.096
1.383ValHis: 1.383 ± 0.046
3.579ValIle: 3.579 ± 0.079
3.078ValLys: 3.078 ± 0.078
7.51ValLeu: 7.51 ± 0.132
1.706ValMet: 1.706 ± 0.056
2.287ValAsn: 2.287 ± 0.06
2.686ValPro: 2.686 ± 0.064
3.654ValGln: 3.654 ± 0.079
4.042ValArg: 4.042 ± 0.091
4.244ValSer: 4.244 ± 0.081
2.616ValThr: 2.616 ± 0.07
4.592ValVal: 4.592 ± 0.096
1.007ValTrp: 1.007 ± 0.042
2.105ValTyr: 2.105 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
1.171TrpAla: 1.171 ± 0.046
0.178TrpCys: 0.178 ± 0.018
0.565TrpAsp: 0.565 ± 0.031
0.538TrpGlu: 0.538 ± 0.031
0.711TrpPhe: 0.711 ± 0.037
0.897TrpGly: 0.897 ± 0.04
0.425TrpHis: 0.425 ± 0.029
0.725TrpIle: 0.725 ± 0.038
0.576TrpLys: 0.576 ± 0.03
2.115TrpLeu: 2.115 ± 0.072
0.27TrpMet: 0.27 ± 0.019
0.448TrpAsn: 0.448 ± 0.027
0.263TrpPro: 0.263 ± 0.022
1.339TrpGln: 1.339 ± 0.055
1.097TrpArg: 1.097 ± 0.042
0.516TrpSer: 0.516 ± 0.029
0.589TrpThr: 0.589 ± 0.035
0.839TrpVal: 0.839 ± 0.041
0.21TrpTrp: 0.21 ± 0.018
0.414TrpTyr: 0.414 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.029TyrAla: 3.029 ± 0.076
0.417TyrCys: 0.417 ± 0.025
1.518TyrAsp: 1.518 ± 0.043
1.429TyrGlu: 1.429 ± 0.044
1.496TyrPhe: 1.496 ± 0.045
2.335TyrGly: 2.335 ± 0.055
0.775TyrHis: 0.775 ± 0.035
1.543TyrIle: 1.543 ± 0.052
1.019TyrLys: 1.019 ± 0.039
3.207TyrLeu: 3.207 ± 0.071
0.556TyrMet: 0.556 ± 0.028
1.025TyrAsn: 1.025 ± 0.046
1.41TyrPro: 1.41 ± 0.047
1.406TyrGln: 1.406 ± 0.056
2.362TyrArg: 2.362 ± 0.07
1.566TyrSer: 1.566 ± 0.055
1.713TyrThr: 1.713 ± 0.059
1.596TyrVal: 1.596 ± 0.044
0.506TyrTrp: 0.506 ± 0.027
1.002TyrTyr: 1.002 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2517 proteins (656618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski