Amino acid dipepetide frequency for Alteromonas australica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.694AlaAla: 7.694 ± 0.117	1.022AlaCys: 1.022 ± 0.03	4.94AlaAsp: 4.94 ± 0.081	5.334AlaGlu: 5.334 ± 0.095	3.868AlaPhe: 3.868 ± 0.069	5.981AlaGly: 5.981 ± 0.079	1.958AlaHis: 1.958 ± 0.051	6.014AlaIle: 6.014 ± 0.078	4.879AlaLys: 4.879 ± 0.088	10.61AlaLeu: 10.61 ± 0.11	2.799AlaMet: 2.799 ± 0.054	3.955AlaAsn: 3.955 ± 0.053	3.242AlaPro: 3.242 ± 0.06	4.152AlaGln: 4.152 ± 0.07	3.868AlaArg: 3.868 ± 0.068	6.026AlaSer: 6.026 ± 0.087	4.912AlaThr: 4.912 ± 0.095	5.929AlaVal: 5.929 ± 0.081	0.943AlaTrp: 0.943 ± 0.031	2.723AlaTyr: 2.723 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.853CysAla: 0.853 ± 0.025	0.147CysCys: 0.147 ± 0.013	0.572CysAsp: 0.572 ± 0.024	0.655CysGlu: 0.655 ± 0.023	0.435CysPhe: 0.435 ± 0.018	0.787CysGly: 0.787 ± 0.028	0.323CysHis: 0.323 ± 0.018	0.579CysIle: 0.579 ± 0.024	0.41CysLys: 0.41 ± 0.02	0.893CysLeu: 0.893 ± 0.028	0.228CysMet: 0.228 ± 0.013	0.337CysAsn: 0.337 ± 0.017	0.4CysPro: 0.4 ± 0.019	0.397CysGln: 0.397 ± 0.018	0.41CysArg: 0.41 ± 0.02	0.638CysSer: 0.638 ± 0.022	0.458CysThr: 0.458 ± 0.022	0.667CysVal: 0.667 ± 0.022	0.113CysTrp: 0.113 ± 0.01	0.304CysTyr: 0.304 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.581AspAla: 5.581 ± 0.09	0.458AspCys: 0.458 ± 0.023	3.739AspAsp: 3.739 ± 0.079	4.209AspGlu: 4.209 ± 0.058	2.612AspPhe: 2.612 ± 0.053	4.032AspGly: 4.032 ± 0.088	1.009AspHis: 1.009 ± 0.032	4.436AspIle: 4.436 ± 0.063	3.266AspLys: 3.266 ± 0.056	4.72AspLeu: 4.72 ± 0.07	1.479AspMet: 1.479 ± 0.037	2.831AspAsn: 2.831 ± 0.066	2.064AspPro: 2.064 ± 0.046	1.434AspGln: 1.434 ± 0.037	2.05AspArg: 2.05 ± 0.04	3.469AspSer: 3.469 ± 0.064	3.614AspThr: 3.614 ± 0.088	4.595AspVal: 4.595 ± 0.076	0.817AspTrp: 0.817 ± 0.031	2.14AspTyr: 2.14 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.68GluAla: 5.68 ± 0.069	0.427GluCys: 0.427 ± 0.022	3.457GluAsp: 3.457 ± 0.057	3.964GluGlu: 3.964 ± 0.071	2.364GluPhe: 2.364 ± 0.047	4.144GluGly: 4.144 ± 0.065	1.51GluHis: 1.51 ± 0.035	3.517GluIle: 3.517 ± 0.058	3.876GluLys: 3.876 ± 0.072	5.921GluLeu: 5.921 ± 0.067	1.606GluMet: 1.606 ± 0.04	3.053GluAsn: 3.053 ± 0.051	1.821GluPro: 1.821 ± 0.049	3.324GluGln: 3.324 ± 0.059	3.152GluArg: 3.152 ± 0.057	3.757GluSer: 3.757 ± 0.053	3.314GluThr: 3.314 ± 0.054	4.269GluVal: 4.269 ± 0.062	0.703GluTrp: 0.703 ± 0.026	1.794GluTyr: 1.794 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.771PheAla: 3.771 ± 0.057	0.5PheCys: 0.5 ± 0.022	2.966PheAsp: 2.966 ± 0.06	2.559PheGlu: 2.559 ± 0.044	1.775PhePhe: 1.775 ± 0.044	3.098PheGly: 3.098 ± 0.059	0.871PheHis: 0.871 ± 0.028	2.785PheIle: 2.785 ± 0.056	1.901PheLys: 1.901 ± 0.044	3.343PheLeu: 3.343 ± 0.065	1.007PheMet: 1.007 ± 0.032	2.153PheAsn: 2.153 ± 0.045	1.448PhePro: 1.448 ± 0.032	1.129PheGln: 1.129 ± 0.035	1.508PheArg: 1.508 ± 0.039	3.646PheSer: 3.646 ± 0.071	2.737PheThr: 2.737 ± 0.057	2.968PheVal: 2.968 ± 0.058	0.533PheTrp: 0.533 ± 0.023	1.442PheTyr: 1.442 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.583GlyAla: 5.583 ± 0.072	0.781GlyCys: 0.781 ± 0.026	3.945GlyAsp: 3.945 ± 0.079	4.571GlyGlu: 4.571 ± 0.07	3.463GlyPhe: 3.463 ± 0.062	4.775GlyGly: 4.775 ± 0.082	1.489GlyHis: 1.489 ± 0.038	4.445GlyIle: 4.445 ± 0.076	4.013GlyLys: 4.013 ± 0.072	6.694GlyLeu: 6.694 ± 0.09	1.988GlyMet: 1.988 ± 0.052	2.896GlyAsn: 2.896 ± 0.133	1.682GlyPro: 1.682 ± 0.04	2.554GlyGln: 2.554 ± 0.046	2.788GlyArg: 2.788 ± 0.049	4.054GlySer: 4.054 ± 0.078	3.651GlyThr: 3.651 ± 0.086	5.417GlyVal: 5.417 ± 0.074	0.917GlyTrp: 0.917 ± 0.031	2.554GlyTyr: 2.554 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.905HisAla: 1.905 ± 0.042	0.322HisCys: 0.322 ± 0.018	1.138HisAsp: 1.138 ± 0.029	1.198HisGlu: 1.198 ± 0.029	1.161HisPhe: 1.161 ± 0.032	1.618HisGly: 1.618 ± 0.045	0.766HisHis: 0.766 ± 0.027	1.507HisIle: 1.507 ± 0.037	1.084HisLys: 1.084 ± 0.036	2.268HisLeu: 2.268 ± 0.048	0.525HisMet: 0.525 ± 0.022	0.926HisAsn: 0.926 ± 0.027	1.152HisPro: 1.152 ± 0.035	1.0HisGln: 1.0 ± 0.027	1.034HisArg: 1.034 ± 0.028	1.433HisSer: 1.433 ± 0.038	1.226HisThr: 1.226 ± 0.035	1.479HisVal: 1.479 ± 0.037	0.391HisTrp: 0.391 ± 0.018	0.923HisTyr: 0.923 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.383IleAla: 6.383 ± 0.087	0.606IleCys: 0.606 ± 0.023	4.316IleAsp: 4.316 ± 0.067	4.36IleGlu: 4.36 ± 0.065	2.097IlePhe: 2.097 ± 0.043	4.34IleGly: 4.34 ± 0.062	1.25IleHis: 1.25 ± 0.034	3.248IleIle: 3.248 ± 0.056	2.979IleLys: 2.979 ± 0.054	4.731IleLeu: 4.731 ± 0.085	1.277IleMet: 1.277 ± 0.033	2.989IleAsn: 2.989 ± 0.05	2.473IlePro: 2.473 ± 0.05	2.098IleGln: 2.098 ± 0.042	2.657IleArg: 2.657 ± 0.054	4.412IleSer: 4.412 ± 0.065	3.681IleThr: 3.681 ± 0.062	4.224IleVal: 4.224 ± 0.065	0.588IleTrp: 0.588 ± 0.025	1.62IleTyr: 1.62 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.991LysAla: 4.991 ± 0.087	0.318LysCys: 0.318 ± 0.018	2.717LysAsp: 2.717 ± 0.052	3.064LysGlu: 3.064 ± 0.065	1.484LysPhe: 1.484 ± 0.038	3.579LysGly: 3.579 ± 0.061	1.311LysHis: 1.311 ± 0.038	2.573LysIle: 2.573 ± 0.056	2.693LysLys: 2.693 ± 0.059	4.863LysLeu: 4.863 ± 0.08	1.259LysMet: 1.259 ± 0.031	2.05LysAsn: 2.05 ± 0.039	2.314LysPro: 2.314 ± 0.051	2.782LysGln: 2.782 ± 0.056	2.916LysArg: 2.916 ± 0.056	3.091LysSer: 3.091 ± 0.053	2.729LysThr: 2.729 ± 0.056	3.8LysVal: 3.8 ± 0.062	0.568LysTrp: 0.568 ± 0.025	1.333LysTyr: 1.333 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.833LeuAla: 9.833 ± 0.103	1.103LeuCys: 1.103 ± 0.031	5.853LeuAsp: 5.853 ± 0.064	5.523LeuGlu: 5.523 ± 0.066	4.212LeuPhe: 4.212 ± 0.066	6.522LeuGly: 6.522 ± 0.079	2.212LeuHis: 2.212 ± 0.049	5.684LeuIle: 5.684 ± 0.074	4.793LeuLys: 4.793 ± 0.072	9.869LeuLeu: 9.869 ± 0.132	2.429LeuMet: 2.429 ± 0.054	4.587LeuAsn: 4.587 ± 0.067	4.675LeuPro: 4.675 ± 0.066	3.53LeuGln: 3.53 ± 0.052	4.22LeuArg: 4.22 ± 0.068	8.087LeuSer: 8.087 ± 0.106	6.272LeuThr: 6.272 ± 0.076	6.769LeuVal: 6.769 ± 0.082	1.008LeuTrp: 1.008 ± 0.031	2.729LeuTyr: 2.729 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.532MetAla: 2.532 ± 0.055	0.203MetCys: 0.203 ± 0.012	1.215MetAsp: 1.215 ± 0.03	1.237MetGlu: 1.237 ± 0.036	0.899MetPhe: 0.899 ± 0.026	1.761MetGly: 1.761 ± 0.042	0.525MetHis: 0.525 ± 0.023	1.254MetIle: 1.254 ± 0.036	1.411MetLys: 1.411 ± 0.037	2.634MetLeu: 2.634 ± 0.055	0.724MetMet: 0.724 ± 0.027	0.998MetAsn: 0.998 ± 0.029	1.268MetPro: 1.268 ± 0.032	1.177MetGln: 1.177 ± 0.031	1.252MetArg: 1.252 ± 0.037	1.862MetSer: 1.862 ± 0.039	1.52MetThr: 1.52 ± 0.037	1.751MetVal: 1.751 ± 0.041	0.237MetTrp: 0.237 ± 0.015	0.55MetTyr: 0.55 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	4.211AsnAla: 4.211 ± 0.065	0.363AsnCys: 0.363 ± 0.02	2.655AsnAsp: 2.655 ± 0.064	2.627AsnGlu: 2.627 ± 0.047	1.62AsnPhe: 1.62 ± 0.041	3.105AsnGly: 3.105 ± 0.073	0.934AsnHis: 0.934 ± 0.03	2.824AsnIle: 2.824 ± 0.059	2.251AsnLys: 2.251 ± 0.05	3.874AsnLeu: 3.874 ± 0.063	1.006AsnMet: 1.006 ± 0.03	1.99AsnAsn: 1.99 ± 0.049	2.038AsnPro: 2.038 ± 0.053	1.849AsnGln: 1.849 ± 0.04	2.005AsnArg: 2.005 ± 0.041	2.503AsnSer: 2.503 ± 0.052	2.713AsnThr: 2.713 ± 0.068	3.116AsnVal: 3.116 ± 0.056	0.592AsnTrp: 0.592 ± 0.023	1.411AsnTyr: 1.411 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.111ProAla: 3.111 ± 0.06	0.304ProCys: 0.304 ± 0.019	2.504ProAsp: 2.504 ± 0.044	2.969ProGlu: 2.969 ± 0.047	1.803ProPhe: 1.803 ± 0.042	2.493ProGly: 2.493 ± 0.049	0.918ProHis: 0.918 ± 0.03	2.391ProIle: 2.391 ± 0.049	1.834ProLys: 1.834 ± 0.043	4.104ProLeu: 4.104 ± 0.064	0.948ProMet: 0.948 ± 0.028	1.749ProAsn: 1.749 ± 0.042	1.314ProPro: 1.314 ± 0.04	1.651ProGln: 1.651 ± 0.036	1.445ProArg: 1.445 ± 0.037	2.805ProSer: 2.805 ± 0.05	2.274ProThr: 2.274 ± 0.055	3.169ProVal: 3.169 ± 0.051	0.483ProTrp: 0.483 ± 0.023	1.266ProTyr: 1.266 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.149GlnAla: 4.149 ± 0.073	0.391GlnCys: 0.391 ± 0.019	2.01GlnAsp: 2.01 ± 0.04	2.288GlnGlu: 2.288 ± 0.049	1.728GlnPhe: 1.728 ± 0.036	2.771GlnGly: 2.771 ± 0.052	1.172GlnHis: 1.172 ± 0.031	2.15GlnIle: 2.15 ± 0.041	2.012GlnLys: 2.012 ± 0.047	4.557GlnLeu: 4.557 ± 0.069	0.948GlnMet: 0.948 ± 0.031	1.579GlnAsn: 1.579 ± 0.035	1.586GlnPro: 1.586 ± 0.035	2.735GlnGln: 2.735 ± 0.057	2.326GlnArg: 2.326 ± 0.047	2.704GlnSer: 2.704 ± 0.049	2.225GlnThr: 2.225 ± 0.051	3.011GlnVal: 3.011 ± 0.053	0.661GlnTrp: 0.661 ± 0.024	1.367GlnTyr: 1.367 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.581ArgAla: 3.581 ± 0.066	0.388ArgCys: 0.388 ± 0.018	2.493ArgAsp: 2.493 ± 0.054	2.968ArgGlu: 2.968 ± 0.053	2.235ArgPhe: 2.235 ± 0.045	2.63ArgGly: 2.63 ± 0.051	1.199ArgHis: 1.199 ± 0.034	2.909ArgIle: 2.909 ± 0.049	2.272ArgLys: 2.272 ± 0.051	4.738ArgLeu: 4.738 ± 0.077	1.125ArgMet: 1.125 ± 0.03	1.816ArgAsn: 1.816 ± 0.043	1.601ArgPro: 1.601 ± 0.044	2.086ArgGln: 2.086 ± 0.045	2.222ArgArg: 2.222 ± 0.051	2.429ArgSer: 2.429 ± 0.045	2.147ArgThr: 2.147 ± 0.044	3.278ArgVal: 3.278 ± 0.054	0.585ArgTrp: 0.585 ± 0.021	1.86ArgTyr: 1.86 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.14SerAla: 6.14 ± 0.083	0.57SerCys: 0.57 ± 0.024	3.955SerAsp: 3.955 ± 0.08	4.133SerGlu: 4.133 ± 0.056	2.831SerPhe: 2.831 ± 0.053	4.827SerGly: 4.827 ± 0.073	1.691SerHis: 1.691 ± 0.041	3.977SerIle: 3.977 ± 0.068	2.963SerLys: 2.963 ± 0.05	7.341SerLeu: 7.341 ± 0.092	1.69SerMet: 1.69 ± 0.042	2.608SerAsn: 2.608 ± 0.051	2.711SerPro: 2.711 ± 0.052	3.032SerGln: 3.032 ± 0.054	3.018SerArg: 3.018 ± 0.053	4.505SerSer: 4.505 ± 0.075	3.661SerThr: 3.661 ± 0.068	4.898SerVal: 4.898 ± 0.076	0.794SerTrp: 0.794 ± 0.026	2.102SerTyr: 2.102 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.829ThrAla: 4.829 ± 0.112	0.46ThrCys: 0.46 ± 0.022	3.273ThrAsp: 3.273 ± 0.096	3.085ThrGlu: 3.085 ± 0.052	2.429ThrPhe: 2.429 ± 0.049	4.191ThrGly: 4.191 ± 0.074	1.466ThrHis: 1.466 ± 0.031	3.267ThrIle: 3.267 ± 0.082	2.214ThrLys: 2.214 ± 0.046	7.168ThrLeu: 7.168 ± 0.097	1.189ThrMet: 1.189 ± 0.034	2.015ThrAsn: 2.015 ± 0.048	3.098ThrPro: 3.098 ± 0.054	2.724ThrGln: 2.724 ± 0.053	2.39ThrArg: 2.39 ± 0.048	3.702ThrSer: 3.702 ± 0.063	3.253ThrThr: 3.253 ± 0.101	4.146ThrVal: 4.146 ± 0.139	0.654ThrTrp: 0.654 ± 0.025	1.78ThrTyr: 1.78 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	6.574ValAla: 6.574 ± 0.079	0.744ValCys: 0.744 ± 0.023	4.384ValAsp: 4.384 ± 0.077	4.521ValGlu: 4.521 ± 0.053	3.021ValPhe: 3.021 ± 0.05	4.618ValGly: 4.618 ± 0.07	1.303ValHis: 1.303 ± 0.038	4.539ValIle: 4.539 ± 0.069	3.766ValLys: 3.766 ± 0.06	6.761ValLeu: 6.761 ± 0.079	1.845ValMet: 1.845 ± 0.044	3.5ValAsn: 3.5 ± 0.054	2.824ValPro: 2.824 ± 0.057	2.233ValGln: 2.233 ± 0.047	2.875ValArg: 2.875 ± 0.049	5.539ValSer: 5.539 ± 0.077	4.629ValThr: 4.629 ± 0.107	5.491ValVal: 5.491 ± 0.073	0.748ValTrp: 0.748 ± 0.029	1.967ValTyr: 1.967 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.816TrpAla: 0.816 ± 0.029	0.154TrpCys: 0.154 ± 0.011	0.578TrpAsp: 0.578 ± 0.024	0.628TrpGlu: 0.628 ± 0.025	0.577TrpPhe: 0.577 ± 0.028	0.779TrpGly: 0.779 ± 0.029	0.333TrpHis: 0.333 ± 0.017	0.606TrpIle: 0.606 ± 0.024	0.488TrpLys: 0.488 ± 0.021	1.53TrpLeu: 1.53 ± 0.039	0.328TrpMet: 0.328 ± 0.018	0.428TrpAsn: 0.428 ± 0.018	0.474TrpPro: 0.474 ± 0.022	0.885TrpGln: 0.885 ± 0.029	0.694TrpArg: 0.694 ± 0.024	0.691TrpSer: 0.691 ± 0.026	0.489TrpThr: 0.489 ± 0.02	0.911TrpVal: 0.911 ± 0.026	0.183TrpTrp: 0.183 ± 0.015	0.395TrpTyr: 0.395 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.632TyrAla: 2.632 ± 0.055	0.345TyrCys: 0.345 ± 0.018	1.847TyrAsp: 1.847 ± 0.043	1.76TyrGlu: 1.76 ± 0.048	1.526TyrPhe: 1.526 ± 0.04	2.208TyrGly: 2.208 ± 0.048	0.814TyrHis: 0.814 ± 0.027	1.625TyrIle: 1.625 ± 0.038	1.33TyrLys: 1.33 ± 0.037	3.291TyrLeu: 3.291 ± 0.052	0.606TyrMet: 0.606 ± 0.024	1.23TyrAsn: 1.23 ± 0.034	1.351TyrPro: 1.351 ± 0.033	1.597TyrGln: 1.597 ± 0.038	1.732TyrArg: 1.732 ± 0.039	2.096TyrSer: 2.096 ± 0.047	1.83TyrThr: 1.83 ± 0.044	1.993TyrVal: 1.993 ± 0.042	0.449TyrTrp: 0.449 ± 0.02	1.15TyrTyr: 1.15 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3445 proteins (1183837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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