Amino acid dipepetide frequency for Littorina sp. associated circular virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.937AlaAla: 7.937 ± 0.204
1.587AlaCys: 1.587 ± 1.192
7.937AlaAsp: 7.937 ± 2.259
6.349AlaGlu: 6.349 ± 3.451
0.0AlaPhe: 0.0 ± 0.0
3.175AlaGly: 3.175 ± 0.329
0.0AlaHis: 0.0 ± 0.0
6.349AlaIle: 6.349 ± 0.659
6.349AlaLys: 6.349 ± 1.396
0.0AlaLeu: 0.0 ± 0.0
1.587AlaMet: 1.587 ± 1.192
4.762AlaAsn: 4.762 ± 1.521
4.762AlaPro: 4.762 ± 1.521
1.587AlaGln: 1.587 ± 0.863
6.349AlaArg: 6.349 ± 0.659
3.175AlaSer: 3.175 ± 0.329
4.762AlaThr: 4.762 ± 0.533
6.349AlaVal: 6.349 ± 0.659
1.587AlaTrp: 1.587 ± 0.863
1.587AlaTyr: 1.587 ± 0.863
0.0AlaXaa: 0.0 ± 0.0
Cys
4.762CysAla: 4.762 ± 0.533
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
3.175CysPhe: 3.175 ± 1.725
0.0CysGly: 0.0 ± 0.0
3.175CysHis: 3.175 ± 0.329
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
1.587CysMet: 1.587 ± 0.863
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
1.587CysGln: 1.587 ± 0.863
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.587AspAla: 1.587 ± 1.192
3.175AspCys: 3.175 ± 0.329
1.587AspAsp: 1.587 ± 0.863
1.587AspGlu: 1.587 ± 0.863
0.0AspPhe: 0.0 ± 0.0
3.175AspGly: 3.175 ± 0.329
1.587AspHis: 1.587 ± 0.863
3.175AspIle: 3.175 ± 1.725
1.587AspLys: 1.587 ± 1.192
6.349AspLeu: 6.349 ± 3.451
4.762AspMet: 4.762 ± 2.588
3.175AspAsn: 3.175 ± 2.384
4.762AspPro: 4.762 ± 0.533
1.587AspGln: 1.587 ± 0.863
4.762AspArg: 4.762 ± 0.533
9.524AspSer: 9.524 ± 1.067
6.349AspThr: 6.349 ± 0.659
3.175AspVal: 3.175 ± 1.725
1.587AspTrp: 1.587 ± 0.863
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
4.762GluAla: 4.762 ± 2.588
0.0GluCys: 0.0 ± 0.0
3.175GluAsp: 3.175 ± 1.725
1.587GluGlu: 1.587 ± 0.863
0.0GluPhe: 0.0 ± 0.0
3.175GluGly: 3.175 ± 1.725
0.0GluHis: 0.0 ± 0.0
3.175GluIle: 3.175 ± 2.384
4.762GluLys: 4.762 ± 2.588
3.175GluLeu: 3.175 ± 1.725
4.762GluMet: 4.762 ± 1.106
3.175GluAsn: 3.175 ± 1.725
3.175GluPro: 3.175 ± 1.725
0.0GluGln: 0.0 ± 0.0
4.762GluArg: 4.762 ± 0.533
6.349GluSer: 6.349 ± 1.396
0.0GluThr: 0.0 ± 0.0
3.175GluVal: 3.175 ± 1.725
1.587GluTrp: 1.587 ± 0.863
1.587GluTyr: 1.587 ± 0.863
0.0GluXaa: 0.0 ± 0.0
Phe
4.762PheAla: 4.762 ± 2.588
0.0PheCys: 0.0 ± 0.0
3.175PheAsp: 3.175 ± 1.725
1.587PheGlu: 1.587 ± 0.863
0.0PhePhe: 0.0 ± 0.0
1.587PheGly: 1.587 ± 1.192
0.0PheHis: 0.0 ± 0.0
3.175PheIle: 3.175 ± 0.329
3.175PheLys: 3.175 ± 2.384
1.587PheLeu: 1.587 ± 1.192
1.587PheMet: 1.587 ± 1.192
3.175PheAsn: 3.175 ± 0.329
0.0PhePro: 0.0 ± 0.0
1.587PheGln: 1.587 ± 1.192
0.0PheArg: 0.0 ± 0.0
1.587PheSer: 1.587 ± 0.863
7.937PheThr: 7.937 ± 3.906
1.587PheVal: 1.587 ± 0.863
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
11.111GlyAla: 11.111 ± 0.126
0.0GlyCys: 0.0 ± 0.0
7.937GlyAsp: 7.937 ± 4.313
4.762GlyGlu: 4.762 ± 0.533
1.587GlyPhe: 1.587 ± 0.863
11.111GlyGly: 11.111 ± 0.126
1.587GlyHis: 1.587 ± 0.863
3.175GlyIle: 3.175 ± 0.329
7.937GlyLys: 7.937 ± 4.313
3.175GlyLeu: 3.175 ± 0.329
0.0GlyMet: 0.0 ± 0.0
4.762GlyAsn: 4.762 ± 0.533
3.175GlyPro: 3.175 ± 0.329
4.762GlyGln: 4.762 ± 3.576
3.175GlyArg: 3.175 ± 0.329
1.587GlySer: 1.587 ± 0.863
3.175GlyThr: 3.175 ± 1.725
1.587GlyVal: 1.587 ± 0.863
0.0GlyTrp: 0.0 ± 0.0
1.587GlyTyr: 1.587 ± 0.863
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.587HisPhe: 1.587 ± 0.863
4.762HisGly: 4.762 ± 0.533
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
4.762HisLeu: 4.762 ± 2.588
0.0HisMet: 0.0 ± 0.0
3.175HisAsn: 3.175 ± 0.329
0.0HisPro: 0.0 ± 0.0
1.587HisGln: 1.587 ± 0.863
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
4.762HisVal: 4.762 ± 0.533
3.175HisTrp: 3.175 ± 0.329
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.175IleAla: 3.175 ± 0.329
0.0IleCys: 0.0 ± 0.0
1.587IleAsp: 1.587 ± 0.863
4.762IleGlu: 4.762 ± 0.533
3.175IlePhe: 3.175 ± 0.329
1.587IleGly: 1.587 ± 0.863
1.587IleHis: 1.587 ± 0.863
0.0IleIle: 0.0 ± 0.0
1.587IleLys: 1.587 ± 0.863
3.175IleLeu: 3.175 ± 1.725
3.175IleMet: 3.175 ± 1.725
0.0IleAsn: 0.0 ± 0.0
3.175IlePro: 3.175 ± 2.384
3.175IleGln: 3.175 ± 2.384
3.175IleArg: 3.175 ± 2.384
3.175IleSer: 3.175 ± 2.384
0.0IleThr: 0.0 ± 0.0
6.349IleVal: 6.349 ± 3.451
0.0IleTrp: 0.0 ± 0.0
3.175IleTyr: 3.175 ± 2.384
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
1.587LysCys: 1.587 ± 0.863
1.587LysAsp: 1.587 ± 0.863
3.175LysGlu: 3.175 ± 1.725
6.349LysPhe: 6.349 ± 2.714
3.175LysGly: 3.175 ± 1.725
1.587LysHis: 1.587 ± 0.863
4.762LysIle: 4.762 ± 0.533
1.587LysLys: 1.587 ± 0.863
3.175LysLeu: 3.175 ± 1.725
4.762LysMet: 4.762 ± 1.521
1.587LysAsn: 1.587 ± 0.863
0.0LysPro: 0.0 ± 0.0
3.175LysGln: 3.175 ± 1.725
7.937LysArg: 7.937 ± 0.204
7.937LysSer: 7.937 ± 0.204
4.762LysThr: 4.762 ± 1.521
3.175LysVal: 3.175 ± 1.725
0.0LysTrp: 0.0 ± 0.0
3.175LysTyr: 3.175 ± 1.725
0.0LysXaa: 0.0 ± 0.0
Leu
7.937LeuAla: 7.937 ± 2.259
3.175LeuCys: 3.175 ± 1.725
1.587LeuAsp: 1.587 ± 1.192
4.762LeuGlu: 4.762 ± 0.533
0.0LeuPhe: 0.0 ± 0.0
7.937LeuGly: 7.937 ± 4.313
0.0LeuHis: 0.0 ± 0.0
3.175LeuIle: 3.175 ± 1.725
1.587LeuLys: 1.587 ± 0.863
1.587LeuLeu: 1.587 ± 0.863
0.0LeuMet: 0.0 ± 0.0
1.587LeuAsn: 1.587 ± 0.863
0.0LeuPro: 0.0 ± 0.0
3.175LeuGln: 3.175 ± 1.725
3.175LeuArg: 3.175 ± 0.329
6.349LeuSer: 6.349 ± 0.659
1.587LeuThr: 1.587 ± 1.192
3.175LeuVal: 3.175 ± 1.725
1.587LeuTrp: 1.587 ± 0.863
4.762LeuTyr: 4.762 ± 3.576
0.0LeuXaa: 0.0 ± 0.0
Met
6.349MetAla: 6.349 ± 0.659
0.0MetCys: 0.0 ± 0.0
1.587MetAsp: 1.587 ± 0.863
1.587MetGlu: 1.587 ± 0.863
1.587MetPhe: 1.587 ± 0.863
1.587MetGly: 1.587 ± 0.863
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
3.175MetLys: 3.175 ± 0.329
0.0MetLeu: 0.0 ± 0.0
1.587MetMet: 1.587 ± 1.192
0.0MetAsn: 0.0 ± 0.0
3.175MetPro: 3.175 ± 0.329
0.0MetGln: 0.0 ± 0.0
1.587MetArg: 1.587 ± 0.863
3.175MetSer: 3.175 ± 0.329
4.762MetThr: 4.762 ± 0.533
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
3.175MetTyr: 3.175 ± 0.329
0.0MetXaa: 0.0 ± 0.0
Asn
1.587AsnAla: 1.587 ± 1.192
0.0AsnCys: 0.0 ± 0.0
3.175AsnAsp: 3.175 ± 0.329
0.0AsnGlu: 0.0 ± 0.0
1.587AsnPhe: 1.587 ± 1.192
7.937AsnGly: 7.937 ± 0.204
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
1.587AsnLys: 1.587 ± 1.192
0.0AsnLeu: 0.0 ± 0.0
1.587AsnMet: 1.587 ± 0.863
6.349AsnAsn: 6.349 ± 2.714
1.587AsnPro: 1.587 ± 1.192
3.175AsnGln: 3.175 ± 2.384
3.175AsnArg: 3.175 ± 0.329
1.587AsnSer: 1.587 ± 0.863
1.587AsnThr: 1.587 ± 1.192
3.175AsnVal: 3.175 ± 1.725
3.175AsnTrp: 3.175 ± 0.329
6.349AsnTyr: 6.349 ± 0.659
0.0AsnXaa: 0.0 ± 0.0
Pro
4.762ProAla: 4.762 ± 1.521
0.0ProCys: 0.0 ± 0.0
3.175ProAsp: 3.175 ± 0.329
3.175ProGlu: 3.175 ± 1.725
1.587ProPhe: 1.587 ± 1.192
0.0ProGly: 0.0 ± 0.0
3.175ProHis: 3.175 ± 1.725
1.587ProIle: 1.587 ± 0.863
1.587ProLys: 1.587 ± 0.863
0.0ProLeu: 0.0 ± 0.0
0.0ProMet: 0.0 ± 0.0
1.587ProAsn: 1.587 ± 1.192
0.0ProPro: 0.0 ± 0.0
0.0ProGln: 0.0 ± 0.0
3.175ProArg: 3.175 ± 2.384
4.762ProSer: 4.762 ± 3.576
1.587ProThr: 1.587 ± 1.192
4.762ProVal: 4.762 ± 0.533
1.587ProTrp: 1.587 ± 1.192
3.175ProTyr: 3.175 ± 2.384
0.0ProXaa: 0.0 ± 0.0
Gln
1.587GlnAla: 1.587 ± 0.863
0.0GlnCys: 0.0 ± 0.0
3.175GlnAsp: 3.175 ± 0.329
4.762GlnGlu: 4.762 ± 0.533
1.587GlnPhe: 1.587 ± 1.192
4.762GlnGly: 4.762 ± 0.533
3.175GlnHis: 3.175 ± 1.725
1.587GlnIle: 1.587 ± 1.192
0.0GlnLys: 0.0 ± 0.0
6.349GlnLeu: 6.349 ± 0.659
0.0GlnMet: 0.0 ± 0.0
1.587GlnAsn: 1.587 ± 1.192
1.587GlnPro: 1.587 ± 1.192
3.175GlnGln: 3.175 ± 0.329
1.587GlnArg: 1.587 ± 0.863
0.0GlnSer: 0.0 ± 0.0
0.0GlnThr: 0.0 ± 0.0
4.762GlnVal: 4.762 ± 1.521
0.0GlnTrp: 0.0 ± 0.0
1.587GlnTyr: 1.587 ± 0.863
0.0GlnXaa: 0.0 ± 0.0
Arg
6.349ArgAla: 6.349 ± 0.659
1.587ArgCys: 1.587 ± 0.863
4.762ArgAsp: 4.762 ± 1.521
3.175ArgGlu: 3.175 ± 1.725
4.762ArgPhe: 4.762 ± 1.521
6.349ArgGly: 6.349 ± 0.659
1.587ArgHis: 1.587 ± 0.863
4.762ArgIle: 4.762 ± 1.521
4.762ArgLys: 4.762 ± 0.533
0.0ArgLeu: 0.0 ± 0.0
1.587ArgMet: 1.587 ± 1.192
3.175ArgAsn: 3.175 ± 2.384
3.175ArgPro: 3.175 ± 2.384
0.0ArgGln: 0.0 ± 0.0
20.635ArgArg: 20.635 ± 15.497
1.587ArgSer: 1.587 ± 0.863
6.349ArgThr: 6.349 ± 2.714
3.175ArgVal: 3.175 ± 0.329
3.175ArgTrp: 3.175 ± 1.725
3.175ArgTyr: 3.175 ± 2.384
0.0ArgXaa: 0.0 ± 0.0
Ser
1.587SerAla: 1.587 ± 0.863
0.0SerCys: 0.0 ± 0.0
4.762SerAsp: 4.762 ± 0.533
1.587SerGlu: 1.587 ± 1.192
0.0SerPhe: 0.0 ± 0.0
1.587SerGly: 1.587 ± 0.863
1.587SerHis: 1.587 ± 1.192
3.175SerIle: 3.175 ± 0.329
11.111SerLys: 11.111 ± 1.929
4.762SerLeu: 4.762 ± 0.533
0.0SerMet: 0.0 ± 0.0
1.587SerAsn: 1.587 ± 0.863
4.762SerPro: 4.762 ± 1.521
1.587SerGln: 1.587 ± 0.863
9.524SerArg: 9.524 ± 3.043
0.0SerSer: 0.0 ± 0.0
6.349SerThr: 6.349 ± 2.714
4.762SerVal: 4.762 ± 1.521
0.0SerTrp: 0.0 ± 0.0
3.175SerTyr: 3.175 ± 0.329
0.0SerXaa: 0.0 ± 0.0
Thr
3.175ThrAla: 3.175 ± 2.384
0.0ThrCys: 0.0 ± 0.0
4.762ThrAsp: 4.762 ± 2.588
4.762ThrGlu: 4.762 ± 0.533
0.0ThrPhe: 0.0 ± 0.0
6.349ThrGly: 6.349 ± 0.659
0.0ThrHis: 0.0 ± 0.0
0.0ThrIle: 0.0 ± 0.0
0.0ThrLys: 0.0 ± 0.0
6.349ThrLeu: 6.349 ± 0.659
0.0ThrMet: 0.0 ± 0.0
3.175ThrAsn: 3.175 ± 2.384
4.762ThrPro: 4.762 ± 1.521
1.587ThrGln: 1.587 ± 0.863
6.349ThrArg: 6.349 ± 2.714
6.349ThrSer: 6.349 ± 4.768
3.175ThrThr: 3.175 ± 2.384
3.175ThrVal: 3.175 ± 2.384
1.587ThrTrp: 1.587 ± 0.863
1.587ThrTyr: 1.587 ± 1.192
0.0ThrXaa: 0.0 ± 0.0
Val
3.175ValAla: 3.175 ± 0.329
0.0ValCys: 0.0 ± 0.0
1.587ValAsp: 1.587 ± 1.192
3.175ValGlu: 3.175 ± 1.725
7.937ValPhe: 7.937 ± 0.204
4.762ValGly: 4.762 ± 2.588
3.175ValHis: 3.175 ± 0.329
4.762ValIle: 4.762 ± 0.533
6.349ValLys: 6.349 ± 3.451
9.524ValLeu: 9.524 ± 1.067
1.587ValMet: 1.587 ± 0.863
0.0ValAsn: 0.0 ± 0.0
1.587ValPro: 1.587 ± 0.863
1.587ValGln: 1.587 ± 0.863
1.587ValArg: 1.587 ± 0.863
1.587ValSer: 1.587 ± 0.863
1.587ValThr: 1.587 ± 1.192
4.762ValVal: 4.762 ± 2.588
0.0ValTrp: 0.0 ± 0.0
4.762ValTyr: 4.762 ± 1.521
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.587TrpCys: 1.587 ± 0.863
3.175TrpAsp: 3.175 ± 0.329
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.587TrpGly: 1.587 ± 0.863
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
3.175TrpLys: 3.175 ± 0.329
0.0TrpLeu: 0.0 ± 0.0
3.175TrpMet: 3.175 ± 1.725
1.587TrpAsn: 1.587 ± 0.863
0.0TrpPro: 0.0 ± 0.0
1.587TrpGln: 1.587 ± 0.863
1.587TrpArg: 1.587 ± 1.192
1.587TrpSer: 1.587 ± 0.863
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.587TyrAla: 1.587 ± 0.863
1.587TyrCys: 1.587 ± 0.863
4.762TyrAsp: 4.762 ± 1.521
1.587TyrGlu: 1.587 ± 0.863
1.587TyrPhe: 1.587 ± 1.192
1.587TyrGly: 1.587 ± 1.192
1.587TyrHis: 1.587 ± 1.192
3.175TyrIle: 3.175 ± 0.329
3.175TyrLys: 3.175 ± 2.384
3.175TyrLeu: 3.175 ± 0.329
0.0TyrMet: 0.0 ± 0.743
3.175TyrAsn: 3.175 ± 0.329
0.0TyrPro: 0.0 ± 0.0
6.349TyrGln: 6.349 ± 2.714
1.587TyrArg: 1.587 ± 1.192
1.587TyrSer: 1.587 ± 1.192
3.175TyrThr: 3.175 ± 0.329
1.587TyrVal: 1.587 ± 0.863
0.0TyrTrp: 0.0 ± 0.0
1.587TyrTyr: 1.587 ± 1.192
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski