Amino acid dipepetide frequency for Lentimicrobium saccharophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.525AlaAla: 6.525 ± 0.106	0.762AlaCys: 0.762 ± 0.028	4.33AlaAsp: 4.33 ± 0.073	4.76AlaGlu: 4.76 ± 0.075	3.674AlaPhe: 3.674 ± 0.061	7.743AlaGly: 7.743 ± 0.106	1.119AlaHis: 1.119 ± 0.031	5.063AlaIle: 5.063 ± 0.073	2.936AlaLys: 2.936 ± 0.064	7.045AlaLeu: 7.045 ± 0.093	1.994AlaMet: 1.994 ± 0.051	3.091AlaAsn: 3.091 ± 0.073	2.66AlaPro: 2.66 ± 0.08	2.224AlaGln: 2.224 ± 0.048	3.622AlaArg: 3.622 ± 0.058	4.792AlaSer: 4.792 ± 0.08	3.969AlaThr: 3.969 ± 0.156	5.101AlaVal: 5.101 ± 0.075	0.974AlaTrp: 0.974 ± 0.026	2.741AlaTyr: 2.741 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.606CysAla: 0.606 ± 0.04	0.119CysCys: 0.119 ± 0.011	0.48CysAsp: 0.48 ± 0.021	0.548CysGlu: 0.548 ± 0.036	0.431CysPhe: 0.431 ± 0.021	0.879CysGly: 0.879 ± 0.041	0.249CysHis: 0.249 ± 0.02	0.63CysIle: 0.63 ± 0.026	0.38CysLys: 0.38 ± 0.018	0.748CysLeu: 0.748 ± 0.026	0.192CysMet: 0.192 ± 0.011	0.52CysAsn: 0.52 ± 0.029	0.474CysPro: 0.474 ± 0.025	0.263CysGln: 0.263 ± 0.02	0.52CysArg: 0.52 ± 0.021	0.648CysSer: 0.648 ± 0.028	0.531CysThr: 0.531 ± 0.023	0.452CysVal: 0.452 ± 0.026	0.116CysTrp: 0.116 ± 0.009	0.313CysTyr: 0.313 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.088AspAla: 4.088 ± 0.099	0.472AspCys: 0.472 ± 0.022	2.526AspAsp: 2.526 ± 0.059	3.439AspGlu: 3.439 ± 0.057	3.268AspPhe: 3.268 ± 0.061	4.014AspGly: 4.014 ± 0.087	0.992AspHis: 0.992 ± 0.027	3.97AspIle: 3.97 ± 0.068	2.925AspLys: 2.925 ± 0.053	4.917AspLeu: 4.917 ± 0.071	1.249AspMet: 1.249 ± 0.034	2.791AspAsn: 2.791 ± 0.066	2.498AspPro: 2.498 ± 0.045	1.675AspGln: 1.675 ± 0.035	2.283AspArg: 2.283 ± 0.05	2.928AspSer: 2.928 ± 0.057	2.635AspThr: 2.635 ± 0.051	3.005AspVal: 3.005 ± 0.05	0.699AspTrp: 0.699 ± 0.025	2.623AspTyr: 2.623 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.547GluAla: 4.547 ± 0.083	0.388GluCys: 0.388 ± 0.02	2.679GluAsp: 2.679 ± 0.048	3.88GluGlu: 3.88 ± 0.075	2.622GluPhe: 2.622 ± 0.052	3.952GluGly: 3.952 ± 0.064	1.022GluHis: 1.022 ± 0.03	5.037GluIle: 5.037 ± 0.077	4.623GluLys: 4.623 ± 0.08	5.497GluLeu: 5.497 ± 0.081	1.741GluMet: 1.741 ± 0.039	3.543GluAsn: 3.543 ± 0.06	2.121GluPro: 2.121 ± 0.052	2.057GluGln: 2.057 ± 0.046	2.566GluArg: 2.566 ± 0.048	3.292GluSer: 3.292 ± 0.052	3.478GluThr: 3.478 ± 0.055	4.02GluVal: 4.02 ± 0.06	0.702GluTrp: 0.702 ± 0.027	2.299GluTyr: 2.299 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.369PheAla: 3.369 ± 0.054	0.479PheCys: 0.479 ± 0.02	2.918PheAsp: 2.918 ± 0.048	2.848PheGlu: 2.848 ± 0.053	2.445PhePhe: 2.445 ± 0.061	3.591PheGly: 3.591 ± 0.058	0.867PheHis: 0.867 ± 0.028	3.553PheIle: 3.553 ± 0.063	1.999PheLys: 1.999 ± 0.043	4.106PheLeu: 4.106 ± 0.08	1.203PheMet: 1.203 ± 0.035	2.839PheAsn: 2.839 ± 0.053	2.002PhePro: 2.002 ± 0.044	1.248PheGln: 1.248 ± 0.034	2.885PheArg: 2.885 ± 0.063	4.22PheSer: 4.22 ± 0.073	3.547PheThr: 3.547 ± 0.07	2.864PheVal: 2.864 ± 0.053	0.606PheTrp: 0.606 ± 0.025	2.018PheTyr: 2.018 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.836GlyAla: 4.836 ± 0.087	0.873GlyCys: 0.873 ± 0.059	3.782GlyAsp: 3.782 ± 0.067	4.127GlyGlu: 4.127 ± 0.067	4.048GlyPhe: 4.048 ± 0.068	5.39GlyGly: 5.39 ± 0.109	1.276GlyHis: 1.276 ± 0.032	6.241GlyIle: 6.241 ± 0.077	4.703GlyLys: 4.703 ± 0.079	6.798GlyLeu: 6.798 ± 0.082	2.032GlyMet: 2.032 ± 0.045	4.502GlyAsn: 4.502 ± 0.088	2.087GlyPro: 2.087 ± 0.049	2.382GlyGln: 2.382 ± 0.046	3.283GlyArg: 3.283 ± 0.057	5.245GlySer: 5.245 ± 0.13	4.679GlyThr: 4.679 ± 0.135	4.44GlyVal: 4.44 ± 0.066	0.985GlyTrp: 0.985 ± 0.03	3.337GlyTyr: 3.337 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.22HisAla: 1.22 ± 0.034	0.233HisCys: 0.233 ± 0.013	0.894HisAsp: 0.894 ± 0.03	0.989HisGlu: 0.989 ± 0.027	1.035HisPhe: 1.035 ± 0.029	1.234HisGly: 1.234 ± 0.034	0.503HisHis: 0.503 ± 0.022	1.273HisIle: 1.273 ± 0.034	0.895HisLys: 0.895 ± 0.024	1.829HisLeu: 1.829 ± 0.046	0.368HisMet: 0.368 ± 0.018	0.959HisAsn: 0.959 ± 0.031	1.105HisPro: 1.105 ± 0.032	0.644HisGln: 0.644 ± 0.026	0.915HisArg: 0.915 ± 0.029	1.085HisSer: 1.085 ± 0.032	1.008HisThr: 1.008 ± 0.032	0.902HisVal: 0.902 ± 0.029	0.225HisTrp: 0.225 ± 0.016	0.807HisTyr: 0.807 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.584IleAla: 5.584 ± 0.066	0.713IleCys: 0.713 ± 0.041	4.189IleAsp: 4.189 ± 0.056	4.357IleGlu: 4.357 ± 0.056	3.307IlePhe: 3.307 ± 0.064	4.561IleGly: 4.561 ± 0.077	1.329IleHis: 1.329 ± 0.035	5.268IleIle: 5.268 ± 0.091	3.395IleLys: 3.395 ± 0.063	6.36IleLeu: 6.36 ± 0.101	1.508IleMet: 1.508 ± 0.033	3.955IleAsn: 3.955 ± 0.062	3.56IlePro: 3.56 ± 0.062	2.076IleGln: 2.076 ± 0.04	4.315IleArg: 4.315 ± 0.065	5.924IleSer: 5.924 ± 0.073	4.859IleThr: 4.859 ± 0.083	4.076IleVal: 4.076 ± 0.066	0.676IleTrp: 0.676 ± 0.024	2.842IleTyr: 2.842 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.196LysAla: 4.196 ± 0.078	0.328LysCys: 0.328 ± 0.014	2.671LysAsp: 2.671 ± 0.051	3.562LysGlu: 3.562 ± 0.074	2.114LysPhe: 2.114 ± 0.044	3.694LysGly: 3.694 ± 0.068	0.992LysHis: 0.992 ± 0.029	4.051LysIle: 4.051 ± 0.068	3.625LysLys: 3.625 ± 0.071	5.017LysLeu: 5.017 ± 0.075	1.472LysMet: 1.472 ± 0.035	2.79LysAsn: 2.79 ± 0.058	2.448LysPro: 2.448 ± 0.052	1.916LysGln: 1.916 ± 0.045	2.362LysArg: 2.362 ± 0.049	3.408LysSer: 3.408 ± 0.071	3.268LysThr: 3.268 ± 0.061	3.522LysVal: 3.522 ± 0.065	0.605LysTrp: 0.605 ± 0.024	2.21LysTyr: 2.21 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.716LeuAla: 6.716 ± 0.088	0.804LeuCys: 0.804 ± 0.033	4.411LeuAsp: 4.411 ± 0.075	5.086LeuGlu: 5.086 ± 0.084	4.627LeuPhe: 4.627 ± 0.085	5.673LeuGly: 5.673 ± 0.078	1.695LeuHis: 1.695 ± 0.044	7.0LeuIle: 7.0 ± 0.102	6.078LeuLys: 6.078 ± 0.1	9.819LeuLeu: 9.819 ± 0.139	2.465LeuMet: 2.465 ± 0.052	5.174LeuAsn: 5.174 ± 0.074	4.467LeuPro: 4.467 ± 0.066	3.049LeuGln: 3.049 ± 0.053	4.414LeuArg: 4.414 ± 0.07	7.052LeuSer: 7.052 ± 0.084	5.848LeuThr: 5.848 ± 0.135	5.353LeuVal: 5.353 ± 0.077	1.023LeuTrp: 1.023 ± 0.042	3.207LeuTyr: 3.207 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.023MetAla: 2.023 ± 0.05	0.131MetCys: 0.131 ± 0.01	1.182MetAsp: 1.182 ± 0.031	1.471MetGlu: 1.471 ± 0.04	0.901MetPhe: 0.901 ± 0.026	1.566MetGly: 1.566 ± 0.042	0.47MetHis: 0.47 ± 0.022	1.857MetIle: 1.857 ± 0.045	2.033MetLys: 2.033 ± 0.039	2.576MetLeu: 2.576 ± 0.053	0.735MetMet: 0.735 ± 0.025	1.399MetAsn: 1.399 ± 0.033	1.15MetPro: 1.15 ± 0.031	0.975MetGln: 0.975 ± 0.029	1.091MetArg: 1.091 ± 0.029	1.319MetSer: 1.319 ± 0.032	1.282MetThr: 1.282 ± 0.04	1.664MetVal: 1.664 ± 0.039	0.185MetTrp: 0.185 ± 0.013	0.655MetTyr: 0.655 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.749AsnAla: 3.749 ± 0.077	0.535AsnCys: 0.535 ± 0.032	2.636AsnAsp: 2.636 ± 0.05	2.878AsnGlu: 2.878 ± 0.057	2.388AsnPhe: 2.388 ± 0.046	4.181AsnGly: 4.181 ± 0.101	1.015AsnHis: 1.015 ± 0.021	3.818AsnIle: 3.818 ± 0.062	2.478AsnLys: 2.478 ± 0.052	4.9AsnLeu: 4.9 ± 0.071	1.156AsnMet: 1.156 ± 0.027	2.861AsnAsn: 2.861 ± 0.073	3.266AsnPro: 3.266 ± 0.073	1.897AsnGln: 1.897 ± 0.043	2.656AsnArg: 2.656 ± 0.053	3.093AsnSer: 3.093 ± 0.06	3.079AsnThr: 3.079 ± 0.083	2.783AsnVal: 2.783 ± 0.053	0.737AsnTrp: 0.737 ± 0.035	2.42AsnTyr: 2.42 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	4.351ProAla: 4.351 ± 0.092	0.377ProCys: 0.377 ± 0.048	3.291ProAsp: 3.291 ± 0.056	3.909ProGlu: 3.909 ± 0.067	2.071ProPhe: 2.071 ± 0.041	4.188ProGly: 4.188 ± 0.071	0.654ProHis: 0.654 ± 0.022	1.606ProIle: 1.606 ± 0.04	1.419ProLys: 1.419 ± 0.042	3.763ProLeu: 3.763 ± 0.05	0.863ProMet: 0.863 ± 0.027	1.56ProAsn: 1.56 ± 0.048	1.458ProPro: 1.458 ± 0.044	1.283ProGln: 1.283 ± 0.034	1.396ProArg: 1.396 ± 0.042	2.474ProSer: 2.474 ± 0.063	1.635ProThr: 1.635 ± 0.06	4.502ProVal: 4.502 ± 0.087	0.488ProTrp: 0.488 ± 0.019	1.534ProTyr: 1.534 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.54GlnAla: 2.54 ± 0.051	0.225GlnCys: 0.225 ± 0.018	1.432GlnAsp: 1.432 ± 0.033	1.852GlnGlu: 1.852 ± 0.043	1.352GlnPhe: 1.352 ± 0.032	2.039GlnGly: 2.039 ± 0.041	0.668GlnHis: 0.668 ± 0.025	2.255GlnIle: 2.255 ± 0.04	1.923GlnLys: 1.923 ± 0.044	3.212GlnLeu: 3.212 ± 0.048	0.871GlnMet: 0.871 ± 0.031	1.592GlnAsn: 1.592 ± 0.042	1.469GlnPro: 1.469 ± 0.035	1.549GlnGln: 1.549 ± 0.045	1.455GlnArg: 1.455 ± 0.038	1.862GlnSer: 1.862 ± 0.048	1.85GlnThr: 1.85 ± 0.049	2.205GlnVal: 2.205 ± 0.044	0.452GlnTrp: 0.452 ± 0.021	1.214GlnTyr: 1.214 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.701ArgAla: 2.701 ± 0.051	0.323ArgCys: 0.323 ± 0.017	2.365ArgAsp: 2.365 ± 0.048	3.22ArgGlu: 3.22 ± 0.064	2.605ArgPhe: 2.605 ± 0.047	2.522ArgGly: 2.522 ± 0.053	0.963ArgHis: 0.963 ± 0.028	3.894ArgIle: 3.894 ± 0.063	3.443ArgLys: 3.443 ± 0.06	4.834ArgLeu: 4.834 ± 0.085	1.448ArgMet: 1.448 ± 0.037	2.706ArgAsn: 2.706 ± 0.05	1.722ArgPro: 1.722 ± 0.04	1.833ArgGln: 1.833 ± 0.043	2.217ArgArg: 2.217 ± 0.056	2.599ArgSer: 2.599 ± 0.054	2.187ArgThr: 2.187 ± 0.042	2.676ArgVal: 2.676 ± 0.05	0.61ArgTrp: 0.61 ± 0.021	2.028ArgTyr: 2.028 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.241SerAla: 5.241 ± 0.094	0.69SerCys: 0.69 ± 0.029	3.558SerAsp: 3.558 ± 0.054	3.556SerGlu: 3.556 ± 0.056	3.47SerPhe: 3.47 ± 0.058	6.897SerGly: 6.897 ± 0.125	1.084SerHis: 1.084 ± 0.033	4.493SerIle: 4.493 ± 0.078	2.936SerLys: 2.936 ± 0.055	6.403SerLeu: 6.403 ± 0.085	1.51SerMet: 1.51 ± 0.035	2.987SerAsn: 2.987 ± 0.072	2.789SerPro: 2.789 ± 0.054	1.912SerGln: 1.912 ± 0.039	3.069SerArg: 3.069 ± 0.062	4.137SerSer: 4.137 ± 0.085	3.447SerThr: 3.447 ± 0.083	4.598SerVal: 4.598 ± 0.074	0.889SerTrp: 0.889 ± 0.032	2.587SerTyr: 2.587 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.833ThrAla: 4.833 ± 0.119	0.465ThrCys: 0.465 ± 0.021	3.479ThrAsp: 3.479 ± 0.069	3.154ThrGlu: 3.154 ± 0.059	2.842ThrPhe: 2.842 ± 0.062	6.327ThrGly: 6.327 ± 0.119	0.95ThrHis: 0.95 ± 0.027	4.32ThrIle: 4.32 ± 0.102	1.919ThrLys: 1.919 ± 0.037	5.529ThrLeu: 5.529 ± 0.133	1.091ThrMet: 1.091 ± 0.029	2.502ThrAsn: 2.502 ± 0.069	2.708ThrPro: 2.708 ± 0.068	1.4ThrGln: 1.4 ± 0.037	2.42ThrArg: 2.42 ± 0.045	3.707ThrSer: 3.707 ± 0.092	3.302ThrThr: 3.302 ± 0.092	3.983ThrVal: 3.983 ± 0.102	0.82ThrTrp: 0.82 ± 0.05	2.296ThrTyr: 2.296 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	4.498ValAla: 4.498 ± 0.084	0.641ValCys: 0.641 ± 0.024	3.224ValAsp: 3.224 ± 0.056	3.591ValGlu: 3.591 ± 0.057	3.518ValPhe: 3.518 ± 0.06	3.031ValGly: 3.031 ± 0.062	1.091ValHis: 1.091 ± 0.032	5.077ValIle: 5.077 ± 0.067	3.849ValLys: 3.849 ± 0.074	5.595ValLeu: 5.595 ± 0.072	1.634ValMet: 1.634 ± 0.041	3.636ValAsn: 3.636 ± 0.061	2.573ValPro: 2.573 ± 0.053	1.728ValGln: 1.728 ± 0.037	2.725ValArg: 2.725 ± 0.046	4.885ValSer: 4.885 ± 0.087	4.03ValThr: 4.03 ± 0.11	4.388ValVal: 4.388 ± 0.081	0.717ValTrp: 0.717 ± 0.027	2.723ValTyr: 2.723 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.025	0.122TrpCys: 0.122 ± 0.012	0.737TrpAsp: 0.737 ± 0.028	0.72TrpGlu: 0.72 ± 0.026	0.635TrpPhe: 0.635 ± 0.026	0.822TrpGly: 0.822 ± 0.027	0.27TrpHis: 0.27 ± 0.014	0.845TrpIle: 0.845 ± 0.029	0.719TrpLys: 0.719 ± 0.027	1.159TrpLeu: 1.159 ± 0.032	0.345TrpMet: 0.345 ± 0.014	0.716TrpAsn: 0.716 ± 0.027	0.381TrpPro: 0.381 ± 0.016	0.5TrpGln: 0.5 ± 0.026	0.432TrpArg: 0.432 ± 0.018	0.805TrpSer: 0.805 ± 0.035	0.785TrpThr: 0.785 ± 0.062	0.699TrpVal: 0.699 ± 0.025	0.179TrpTrp: 0.179 ± 0.011	0.515TrpTyr: 0.515 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.736TyrAla: 2.736 ± 0.055	0.417TyrCys: 0.417 ± 0.021	2.214TyrAsp: 2.214 ± 0.053	2.117TyrGlu: 2.117 ± 0.047	2.255TyrPhe: 2.255 ± 0.048	2.742TyrGly: 2.742 ± 0.048	0.917TyrHis: 0.917 ± 0.028	2.604TyrIle: 2.604 ± 0.047	1.973TyrLys: 1.973 ± 0.047	3.854TyrLeu: 3.854 ± 0.06	0.787TyrMet: 0.787 ± 0.027	2.403TyrAsn: 2.403 ± 0.058	1.884TyrPro: 1.884 ± 0.042	1.406TyrGln: 1.406 ± 0.034	2.271TyrArg: 2.271 ± 0.049	2.777TyrSer: 2.777 ± 0.056	2.629TyrThr: 2.629 ± 0.097	1.919TyrVal: 1.919 ± 0.042	0.462TyrTrp: 0.462 ± 0.021	1.972TyrTyr: 1.972 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3377 proteins (1291125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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