Amino acid dipepetide frequency for Rhodococcus coprophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.66AlaAla: 18.66 ± 0.188
0.899AlaCys: 0.899 ± 0.029
8.121AlaAsp: 8.121 ± 0.094
8.027AlaGlu: 8.027 ± 0.082
3.524AlaPhe: 3.524 ± 0.05
11.646AlaGly: 11.646 ± 0.11
2.563AlaHis: 2.563 ± 0.054
4.487AlaIle: 4.487 ± 0.06
2.597AlaLys: 2.597 ± 0.054
13.334AlaLeu: 13.334 ± 0.118
2.495AlaMet: 2.495 ± 0.046
2.046AlaAsn: 2.046 ± 0.047
6.197AlaPro: 6.197 ± 0.085
3.637AlaGln: 3.637 ± 0.06
9.084AlaArg: 9.084 ± 0.096
6.146AlaSer: 6.146 ± 0.074
7.152AlaThr: 7.152 ± 0.077
12.143AlaVal: 12.143 ± 0.128
1.524AlaTrp: 1.524 ± 0.036
2.213AlaTyr: 2.213 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.973CysAla: 0.973 ± 0.032
0.093CysCys: 0.093 ± 0.008
0.482CysAsp: 0.482 ± 0.019
0.394CysGlu: 0.394 ± 0.018
0.223CysPhe: 0.223 ± 0.012
0.879CysGly: 0.879 ± 0.025
0.182CysHis: 0.182 ± 0.011
0.266CysIle: 0.266 ± 0.013
0.115CysLys: 0.115 ± 0.01
0.607CysLeu: 0.607 ± 0.019
0.104CysMet: 0.104 ± 0.008
0.154CysAsn: 0.154 ± 0.011
0.44CysPro: 0.44 ± 0.018
0.126CysGln: 0.126 ± 0.008
0.542CysArg: 0.542 ± 0.019
0.475CysSer: 0.475 ± 0.017
0.496CysThr: 0.496 ± 0.019
0.597CysVal: 0.597 ± 0.02
0.097CysTrp: 0.097 ± 0.009
0.145CysTyr: 0.145 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
8.131AspAla: 8.131 ± 0.09
0.362AspCys: 0.362 ± 0.016
4.422AspAsp: 4.422 ± 0.064
4.58AspGlu: 4.58 ± 0.068
1.779AspPhe: 1.779 ± 0.039
6.109AspGly: 6.109 ± 0.073
1.407AspHis: 1.407 ± 0.036
2.539AspIle: 2.539 ± 0.04
1.228AspLys: 1.228 ± 0.035
6.854AspLeu: 6.854 ± 0.085
0.967AspMet: 0.967 ± 0.027
1.121AspAsn: 1.121 ± 0.035
4.798AspPro: 4.798 ± 0.075
1.395AspGln: 1.395 ± 0.037
5.204AspArg: 5.204 ± 0.077
3.075AspSer: 3.075 ± 0.05
3.624AspThr: 3.624 ± 0.065
5.483AspVal: 5.483 ± 0.072
0.843AspTrp: 0.843 ± 0.028
1.284AspTyr: 1.284 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
6.375GluAla: 6.375 ± 0.067
0.407GluCys: 0.407 ± 0.018
2.88GluAsp: 2.88 ± 0.046
3.127GluGlu: 3.127 ± 0.063
1.971GluPhe: 1.971 ± 0.041
3.948GluGly: 3.948 ± 0.065
1.658GluHis: 1.658 ± 0.037
3.049GluIle: 3.049 ± 0.044
1.583GluLys: 1.583 ± 0.04
6.63GluLeu: 6.63 ± 0.083
1.111GluMet: 1.111 ± 0.033
1.403GluAsn: 1.403 ± 0.034
3.246GluPro: 3.246 ± 0.045
2.285GluGln: 2.285 ± 0.043
5.047GluArg: 5.047 ± 0.073
3.237GluSer: 3.237 ± 0.051
3.158GluThr: 3.158 ± 0.05
4.842GluVal: 4.842 ± 0.074
0.859GluTrp: 0.859 ± 0.028
1.315GluTyr: 1.315 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.055PheAla: 4.055 ± 0.06
0.292PheCys: 0.292 ± 0.015
2.504PheAsp: 2.504 ± 0.047
1.761PheGlu: 1.761 ± 0.038
0.978PhePhe: 0.978 ± 0.031
3.48PheGly: 3.48 ± 0.058
0.631PheHis: 0.631 ± 0.023
0.822PheIle: 0.822 ± 0.026
0.44PheLys: 0.44 ± 0.017
2.63PheLeu: 2.63 ± 0.047
0.451PheMet: 0.451 ± 0.019
0.564PheAsn: 0.564 ± 0.02
1.433PhePro: 1.433 ± 0.032
0.604PheGln: 0.604 ± 0.025
1.862PheArg: 1.862 ± 0.04
1.641PheSer: 1.641 ± 0.04
2.011PheThr: 2.011 ± 0.035
2.982PheVal: 2.982 ± 0.054
0.395PheTrp: 0.395 ± 0.02
0.674PheTyr: 0.674 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.26GlyAla: 10.26 ± 0.105
0.732GlyCys: 0.732 ± 0.025
5.34GlyAsp: 5.34 ± 0.078
4.797GlyGlu: 4.797 ± 0.059
3.05GlyPhe: 3.05 ± 0.048
7.866GlyGly: 7.866 ± 0.091
1.949GlyHis: 1.949 ± 0.042
4.368GlyIle: 4.368 ± 0.069
2.283GlyLys: 2.283 ± 0.046
8.632GlyLeu: 8.632 ± 0.086
2.062GlyMet: 2.062 ± 0.039
1.967GlyAsn: 1.967 ± 0.038
4.458GlyPro: 4.458 ± 0.057
2.332GlyGln: 2.332 ± 0.045
6.828GlyArg: 6.828 ± 0.075
5.594GlySer: 5.594 ± 0.071
5.979GlyThr: 5.979 ± 0.067
7.715GlyVal: 7.715 ± 0.091
1.521GlyTrp: 1.521 ± 0.035
2.287GlyTyr: 2.287 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.372HisAla: 2.372 ± 0.045
0.179HisCys: 0.179 ± 0.011
1.409HisAsp: 1.409 ± 0.034
1.13HisGlu: 1.13 ± 0.031
0.634HisPhe: 0.634 ± 0.021
2.116HisGly: 2.116 ± 0.042
0.652HisHis: 0.652 ± 0.024
0.806HisIle: 0.806 ± 0.025
0.327HisLys: 0.327 ± 0.016
2.229HisLeu: 2.229 ± 0.047
0.346HisMet: 0.346 ± 0.017
0.421HisAsn: 0.421 ± 0.017
1.599HisPro: 1.599 ± 0.036
0.504HisGln: 0.504 ± 0.02
1.911HisArg: 1.911 ± 0.046
1.107HisSer: 1.107 ± 0.028
1.252HisThr: 1.252 ± 0.035
1.714HisVal: 1.714 ± 0.04
0.319HisTrp: 0.319 ± 0.016
0.472HisTyr: 0.472 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.954IleAla: 5.954 ± 0.079
0.313IleCys: 0.313 ± 0.016
3.298IleAsp: 3.298 ± 0.043
2.646IleGlu: 2.646 ± 0.045
0.984IlePhe: 0.984 ± 0.034
4.272IleGly: 4.272 ± 0.061
0.728IleHis: 0.728 ± 0.025
1.229IleIle: 1.229 ± 0.036
0.705IleLys: 0.705 ± 0.026
3.321IleLeu: 3.321 ± 0.055
0.621IleMet: 0.621 ± 0.024
0.827IleAsn: 0.827 ± 0.027
2.206IlePro: 2.206 ± 0.042
0.81IleGln: 0.81 ± 0.022
2.672IleArg: 2.672 ± 0.043
2.123IleSer: 2.123 ± 0.046
2.524IleThr: 2.524 ± 0.048
3.995IleVal: 3.995 ± 0.057
0.398IleTrp: 0.398 ± 0.018
0.696IleTyr: 0.696 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.422LysAla: 2.422 ± 0.06
0.117LysCys: 0.117 ± 0.01
1.093LysAsp: 1.093 ± 0.033
1.022LysGlu: 1.022 ± 0.032
0.634LysPhe: 0.634 ± 0.023
1.529LysGly: 1.529 ± 0.04
0.426LysHis: 0.426 ± 0.017
1.066LysIle: 1.066 ± 0.032
0.743LysLys: 0.743 ± 0.033
1.948LysLeu: 1.948 ± 0.035
0.452LysMet: 0.452 ± 0.018
0.532LysAsn: 0.532 ± 0.018
1.176LysPro: 1.176 ± 0.032
0.628LysGln: 0.628 ± 0.023
1.389LysArg: 1.389 ± 0.03
1.196LysSer: 1.196 ± 0.033
1.245LysThr: 1.245 ± 0.03
1.9LysVal: 1.9 ± 0.04
0.306LysTrp: 0.306 ± 0.015
0.502LysTyr: 0.502 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
13.688LeuAla: 13.688 ± 0.115
0.774LeuCys: 0.774 ± 0.022
7.417LeuAsp: 7.417 ± 0.101
5.432LeuGlu: 5.432 ± 0.073
2.835LeuPhe: 2.835 ± 0.051
9.26LeuGly: 9.26 ± 0.098
2.105LeuHis: 2.105 ± 0.045
3.442LeuIle: 3.442 ± 0.059
1.461LeuLys: 1.461 ± 0.04
9.758LeuLeu: 9.758 ± 0.103
1.586LeuMet: 1.586 ± 0.038
1.656LeuAsn: 1.656 ± 0.034
5.808LeuPro: 5.808 ± 0.08
2.273LeuGln: 2.273 ± 0.041
7.789LeuArg: 7.789 ± 0.085
5.576LeuSer: 5.576 ± 0.067
6.313LeuThr: 6.313 ± 0.065
9.521LeuVal: 9.521 ± 0.089
1.207LeuTrp: 1.207 ± 0.027
1.712LeuTyr: 1.712 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.147MetAla: 2.147 ± 0.041
0.177MetCys: 0.177 ± 0.012
0.839MetAsp: 0.839 ± 0.025
0.679MetGlu: 0.679 ± 0.022
0.66MetPhe: 0.66 ± 0.021
1.371MetGly: 1.371 ± 0.031
0.407MetHis: 0.407 ± 0.019
0.886MetIle: 0.886 ± 0.025
0.428MetLys: 0.428 ± 0.02
2.059MetLeu: 2.059 ± 0.041
0.362MetMet: 0.362 ± 0.017
0.495MetAsn: 0.495 ± 0.018
1.154MetPro: 1.154 ± 0.032
0.551MetGln: 0.551 ± 0.018
1.492MetArg: 1.492 ± 0.032
1.543MetSer: 1.543 ± 0.034
1.769MetThr: 1.769 ± 0.038
1.505MetVal: 1.505 ± 0.033
0.254MetTrp: 0.254 ± 0.016
0.336MetTyr: 0.336 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.41AsnAla: 2.41 ± 0.047
0.155AsnCys: 0.155 ± 0.012
1.09AsnAsp: 1.09 ± 0.03
0.961AsnGlu: 0.961 ± 0.027
0.567AsnPhe: 0.567 ± 0.021
1.83AsnGly: 1.83 ± 0.041
0.388AsnHis: 0.388 ± 0.017
0.912AsnIle: 0.912 ± 0.028
0.405AsnLys: 0.405 ± 0.019
1.962AsnLeu: 1.962 ± 0.041
0.384AsnMet: 0.384 ± 0.017
0.481AsnAsn: 0.481 ± 0.021
1.611AsnPro: 1.611 ± 0.039
0.497AsnGln: 0.497 ± 0.024
1.372AsnArg: 1.372 ± 0.033
1.102AsnSer: 1.102 ± 0.027
1.234AsnThr: 1.234 ± 0.033
1.581AsnVal: 1.581 ± 0.035
0.316AsnTrp: 0.316 ± 0.016
0.464AsnTyr: 0.464 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.234ProAla: 7.234 ± 0.097
0.28ProCys: 0.28 ± 0.016
4.604ProAsp: 4.604 ± 0.073
4.242ProGlu: 4.242 ± 0.059
1.625ProPhe: 1.625 ± 0.03
5.809ProGly: 5.809 ± 0.075
1.22ProHis: 1.22 ± 0.03
1.993ProIle: 1.993 ± 0.039
1.171ProLys: 1.171 ± 0.03
4.836ProLeu: 4.836 ± 0.062
1.076ProMet: 1.076 ± 0.03
1.019ProAsn: 1.019 ± 0.026
2.95ProPro: 2.95 ± 0.065
1.535ProGln: 1.535 ± 0.045
3.62ProArg: 3.62 ± 0.054
3.219ProSer: 3.219 ± 0.052
3.313ProThr: 3.313 ± 0.057
5.398ProVal: 5.398 ± 0.076
0.782ProTrp: 0.782 ± 0.026
1.138ProTyr: 1.138 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
2.948GlnAla: 2.948 ± 0.052
0.165GlnCys: 0.165 ± 0.009
1.236GlnAsp: 1.236 ± 0.035
1.223GlnGlu: 1.223 ± 0.03
0.848GlnPhe: 0.848 ± 0.026
1.875GlnGly: 1.875 ± 0.039
0.592GlnHis: 0.592 ± 0.021
1.396GlnIle: 1.396 ± 0.031
0.581GlnLys: 0.581 ± 0.021
2.918GlnLeu: 2.918 ± 0.046
0.574GlnMet: 0.574 ± 0.021
0.594GlnAsn: 0.594 ± 0.026
1.431GlnPro: 1.431 ± 0.04
1.124GlnGln: 1.124 ± 0.046
2.329GlnArg: 2.329 ± 0.044
1.343GlnSer: 1.343 ± 0.035
1.29GlnThr: 1.29 ± 0.035
2.447GlnVal: 2.447 ± 0.04
0.474GlnTrp: 0.474 ± 0.019
0.609GlnTyr: 0.609 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.485ArgAla: 8.485 ± 0.094
0.545ArgCys: 0.545 ± 0.023
4.564ArgAsp: 4.564 ± 0.062
4.428ArgGlu: 4.428 ± 0.061
2.462ArgPhe: 2.462 ± 0.043
5.479ArgGly: 5.479 ± 0.068
1.706ArgHis: 1.706 ± 0.04
3.809ArgIle: 3.809 ± 0.047
1.757ArgLys: 1.757 ± 0.038
7.397ArgLeu: 7.397 ± 0.094
1.907ArgMet: 1.907 ± 0.034
1.696ArgAsn: 1.696 ± 0.043
4.059ArgPro: 4.059 ± 0.066
1.838ArgGln: 1.838 ± 0.041
6.853ArgArg: 6.853 ± 0.099
4.373ArgSer: 4.373 ± 0.064
4.96ArgThr: 4.96 ± 0.067
6.012ArgVal: 6.012 ± 0.061
1.328ArgTrp: 1.328 ± 0.026
1.862ArgTyr: 1.862 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.784SerAla: 6.784 ± 0.084
0.394SerCys: 0.394 ± 0.017
3.513SerAsp: 3.513 ± 0.046
3.0SerGlu: 3.0 ± 0.055
1.726SerPhe: 1.726 ± 0.035
5.985SerGly: 5.985 ± 0.064
0.993SerHis: 0.993 ± 0.031
2.157SerIle: 2.157 ± 0.044
1.113SerLys: 1.113 ± 0.031
5.145SerLeu: 5.145 ± 0.069
1.297SerMet: 1.297 ± 0.032
1.088SerAsn: 1.088 ± 0.032
3.149SerPro: 3.149 ± 0.048
1.336SerGln: 1.336 ± 0.037
3.909SerArg: 3.909 ± 0.059
3.299SerSer: 3.299 ± 0.059
3.531SerThr: 3.531 ± 0.059
4.833SerVal: 4.833 ± 0.064
0.884SerTrp: 0.884 ± 0.027
1.16SerTyr: 1.16 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
7.819ThrAla: 7.819 ± 0.107
0.39ThrCys: 0.39 ± 0.017
4.007ThrAsp: 4.007 ± 0.06
3.625ThrGlu: 3.625 ± 0.051
1.79ThrPhe: 1.79 ± 0.04
6.192ThrGly: 6.192 ± 0.07
1.213ThrHis: 1.213 ± 0.03
2.342ThrIle: 2.342 ± 0.046
1.18ThrLys: 1.18 ± 0.032
5.846ThrLeu: 5.846 ± 0.063
1.112ThrMet: 1.112 ± 0.028
1.104ThrAsn: 1.104 ± 0.031
3.993ThrPro: 3.993 ± 0.053
1.343ThrGln: 1.343 ± 0.032
4.008ThrArg: 4.008 ± 0.055
3.33ThrSer: 3.33 ± 0.053
4.088ThrThr: 4.088 ± 0.072
6.518ThrVal: 6.518 ± 0.087
0.832ThrTrp: 0.832 ± 0.026
1.223ThrTyr: 1.223 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
11.968ValAla: 11.968 ± 0.111
0.784ValCys: 0.784 ± 0.023
6.233ValAsp: 6.233 ± 0.073
5.247ValGlu: 5.247 ± 0.072
2.67ValPhe: 2.67 ± 0.046
7.303ValGly: 7.303 ± 0.082
1.987ValHis: 1.987 ± 0.039
3.393ValIle: 3.393 ± 0.052
1.512ValLys: 1.512 ± 0.039
9.767ValLeu: 9.767 ± 0.098
1.563ValMet: 1.563 ± 0.041
1.721ValAsn: 1.721 ± 0.037
5.44ValPro: 5.44 ± 0.071
2.156ValGln: 2.156 ± 0.041
6.715ValArg: 6.715 ± 0.076
4.834ValSer: 4.834 ± 0.065
5.922ValThr: 5.922 ± 0.068
9.697ValVal: 9.697 ± 0.104
1.118ValTrp: 1.118 ± 0.032
1.569ValTyr: 1.569 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.487TrpAla: 1.487 ± 0.031
0.144TrpCys: 0.144 ± 0.011
0.773TrpAsp: 0.773 ± 0.022
0.691TrpGlu: 0.691 ± 0.025
0.534TrpPhe: 0.534 ± 0.022
0.999TrpGly: 0.999 ± 0.031
0.319TrpHis: 0.319 ± 0.014
0.683TrpIle: 0.683 ± 0.023
0.338TrpLys: 0.338 ± 0.014
1.524TrpLeu: 1.524 ± 0.033
0.335TrpMet: 0.335 ± 0.016
0.4TrpAsn: 0.4 ± 0.018
0.69TrpPro: 0.69 ± 0.021
0.507TrpGln: 0.507 ± 0.018
1.11TrpArg: 1.11 ± 0.032
0.941TrpSer: 0.941 ± 0.027
0.915TrpThr: 0.915 ± 0.027
1.091TrpVal: 1.091 ± 0.028
0.335TrpTrp: 0.335 ± 0.016
0.304TrpTyr: 0.304 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.32TyrAla: 2.32 ± 0.041
0.187TyrCys: 0.187 ± 0.011
1.379TyrAsp: 1.379 ± 0.035
1.12TyrGlu: 1.12 ± 0.028
0.714TyrPhe: 0.714 ± 0.026
2.072TyrGly: 2.072 ± 0.036
0.37TyrHis: 0.37 ± 0.018
0.677TyrIle: 0.677 ± 0.025
0.359TyrLys: 0.359 ± 0.017
2.215TyrLeu: 2.215 ± 0.038
0.309TyrMet: 0.309 ± 0.016
0.434TyrAsn: 0.434 ± 0.019
1.229TyrPro: 1.229 ± 0.031
0.517TyrGln: 0.517 ± 0.018
1.785TyrArg: 1.785 ± 0.036
1.142TyrSer: 1.142 ± 0.026
1.177TyrThr: 1.177 ± 0.034
1.626TyrVal: 1.626 ± 0.037
0.332TyrTrp: 0.332 ± 0.016
0.437TyrTyr: 0.437 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4163 proteins (1371707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski