Amino acid dipepetide frequency for bacterium A37T11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.45AlaAla: 6.45 ± 0.088	0.634AlaCys: 0.634 ± 0.021	4.483AlaAsp: 4.483 ± 0.051	4.218AlaGlu: 4.218 ± 0.049	3.47AlaPhe: 3.47 ± 0.05	5.793AlaGly: 5.793 ± 0.071	1.313AlaHis: 1.313 ± 0.031	5.195AlaIle: 5.195 ± 0.068	4.147AlaLys: 4.147 ± 0.054	7.264AlaLeu: 7.264 ± 0.088	1.577AlaMet: 1.577 ± 0.037	3.821AlaAsn: 3.821 ± 0.054	2.314AlaPro: 2.314 ± 0.037	2.844AlaGln: 2.844 ± 0.042	2.9AlaArg: 2.9 ± 0.045	4.967AlaSer: 4.967 ± 0.053	3.965AlaThr: 3.965 ± 0.05	4.596AlaVal: 4.596 ± 0.056	0.93AlaTrp: 0.93 ± 0.026	3.224AlaTyr: 3.224 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.454CysAla: 0.454 ± 0.019	0.116CysCys: 0.116 ± 0.008	0.293CysAsp: 0.293 ± 0.014	0.29CysGlu: 0.29 ± 0.015	0.371CysPhe: 0.371 ± 0.016	0.574CysGly: 0.574 ± 0.024	0.176CysHis: 0.176 ± 0.012	0.555CysIle: 0.555 ± 0.02	0.375CysLys: 0.375 ± 0.017	0.843CysLeu: 0.843 ± 0.024	0.176CysMet: 0.176 ± 0.011	0.305CysAsn: 0.305 ± 0.015	0.263CysPro: 0.263 ± 0.015	0.249CysGln: 0.249 ± 0.013	0.329CysArg: 0.329 ± 0.015	0.48CysSer: 0.48 ± 0.017	0.403CysThr: 0.403 ± 0.019	0.385CysVal: 0.385 ± 0.015	0.103CysTrp: 0.103 ± 0.009	0.313CysTyr: 0.313 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.981AspAla: 3.981 ± 0.056	0.303AspCys: 0.303 ± 0.014	2.687AspAsp: 2.687 ± 0.044	3.452AspGlu: 3.452 ± 0.054	2.835AspPhe: 2.835 ± 0.039	3.984AspGly: 3.984 ± 0.058	1.209AspHis: 1.209 ± 0.03	3.673AspIle: 3.673 ± 0.053	3.419AspLys: 3.419 ± 0.05	5.325AspLeu: 5.325 ± 0.07	1.103AspMet: 1.103 ± 0.028	2.577AspAsn: 2.577 ± 0.041	2.509AspPro: 2.509 ± 0.045	2.186AspGln: 2.186 ± 0.04	2.439AspArg: 2.439 ± 0.035	3.132AspSer: 3.132 ± 0.056	2.551AspThr: 2.551 ± 0.044	3.33AspVal: 3.33 ± 0.046	0.858AspTrp: 0.858 ± 0.024	2.617AspTyr: 2.617 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.305GluAla: 4.305 ± 0.066	0.307GluCys: 0.307 ± 0.016	2.548GluAsp: 2.548 ± 0.041	3.483GluGlu: 3.483 ± 0.071	2.049GluPhe: 2.049 ± 0.041	3.527GluGly: 3.527 ± 0.049	1.105GluHis: 1.105 ± 0.025	3.956GluIle: 3.956 ± 0.061	4.322GluLys: 4.322 ± 0.063	5.544GluLeu: 5.544 ± 0.071	1.268GluMet: 1.268 ± 0.03	3.031GluAsn: 3.031 ± 0.048	1.722GluPro: 1.722 ± 0.036	2.495GluGln: 2.495 ± 0.043	2.721GluArg: 2.721 ± 0.04	2.906GluSer: 2.906 ± 0.046	2.754GluThr: 2.754 ± 0.043	3.876GluVal: 3.876 ± 0.06	0.664GluTrp: 0.664 ± 0.022	1.95GluTyr: 1.95 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.065PheAla: 3.065 ± 0.052	0.42PheCys: 0.42 ± 0.016	2.679PheAsp: 2.679 ± 0.044	2.482PheGlu: 2.482 ± 0.043	2.395PhePhe: 2.395 ± 0.055	3.424PheGly: 3.424 ± 0.047	0.834PheHis: 0.834 ± 0.024	3.056PheIle: 3.056 ± 0.053	2.798PheLys: 2.798 ± 0.042	4.419PheLeu: 4.419 ± 0.058	1.182PheMet: 1.182 ± 0.026	2.823PheAsn: 2.823 ± 0.041	1.855PhePro: 1.855 ± 0.035	1.565PheGln: 1.565 ± 0.029	2.177PheArg: 2.177 ± 0.039	3.801PheSer: 3.801 ± 0.049	2.866PheThr: 2.866 ± 0.046	2.613PheVal: 2.613 ± 0.044	0.651PheTrp: 0.651 ± 0.021	2.184PheTyr: 2.184 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.543GlyAla: 4.543 ± 0.06	0.533GlyCys: 0.533 ± 0.022	3.461GlyAsp: 3.461 ± 0.048	3.344GlyGlu: 3.344 ± 0.049	3.621GlyPhe: 3.621 ± 0.052	4.989GlyGly: 4.989 ± 0.07	1.361GlyHis: 1.361 ± 0.029	5.537GlyIle: 5.537 ± 0.064	5.068GlyLys: 5.068 ± 0.063	6.821GlyLeu: 6.821 ± 0.074	1.651GlyMet: 1.651 ± 0.04	3.823GlyAsn: 3.823 ± 0.053	1.782GlyPro: 1.782 ± 0.035	2.81GlyGln: 2.81 ± 0.042	3.004GlyArg: 3.004 ± 0.049	4.692GlySer: 4.692 ± 0.064	4.131GlyThr: 4.131 ± 0.059	4.333GlyVal: 4.333 ± 0.062	1.017GlyTrp: 1.017 ± 0.027	3.567GlyTyr: 3.567 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.304HisAla: 1.304 ± 0.033	0.185HisCys: 0.185 ± 0.01	0.929HisAsp: 0.929 ± 0.027	0.994HisGlu: 0.994 ± 0.025	1.141HisPhe: 1.141 ± 0.025	1.188HisGly: 1.188 ± 0.028	0.559HisHis: 0.559 ± 0.024	1.523HisIle: 1.523 ± 0.034	1.01HisLys: 1.01 ± 0.024	2.06HisLeu: 2.06 ± 0.039	0.429HisMet: 0.429 ± 0.016	0.9HisAsn: 0.9 ± 0.027	1.12HisPro: 1.12 ± 0.03	0.886HisGln: 0.886 ± 0.027	0.925HisArg: 0.925 ± 0.027	1.142HisSer: 1.142 ± 0.027	1.088HisThr: 1.088 ± 0.028	1.053HisVal: 1.053 ± 0.028	0.311HisTrp: 0.311 ± 0.014	0.984HisTyr: 0.984 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.189IleAla: 5.189 ± 0.065	0.609IleCys: 0.609 ± 0.021	3.958IleAsp: 3.958 ± 0.048	3.335IleGlu: 3.335 ± 0.05	2.935IlePhe: 2.935 ± 0.052	4.711IleGly: 4.711 ± 0.058	1.494IleHis: 1.494 ± 0.036	4.454IleIle: 4.454 ± 0.061	4.12IleLys: 4.12 ± 0.059	6.165IleLeu: 6.165 ± 0.064	1.244IleMet: 1.244 ± 0.031	3.891IleAsn: 3.891 ± 0.066	3.27IlePro: 3.27 ± 0.04	2.568IleGln: 2.568 ± 0.037	3.549IleArg: 3.549 ± 0.049	5.321IleSer: 5.321 ± 0.063	4.123IleThr: 4.123 ± 0.054	3.803IleVal: 3.803 ± 0.06	0.845IleTrp: 0.845 ± 0.024	2.733IleTyr: 2.733 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.752LysAla: 4.752 ± 0.062	0.248LysCys: 0.248 ± 0.012	3.645LysAsp: 3.645 ± 0.054	4.322LysGlu: 4.322 ± 0.06	2.228LysPhe: 2.228 ± 0.043	4.354LysGly: 4.354 ± 0.058	1.126LysHis: 1.126 ± 0.026	4.04LysIle: 4.04 ± 0.052	4.708LysLys: 4.708 ± 0.068	5.84LysLeu: 5.84 ± 0.071	1.487LysMet: 1.487 ± 0.029	3.701LysAsn: 3.701 ± 0.044	2.681LysPro: 2.681 ± 0.047	2.682LysGln: 2.682 ± 0.035	2.9LysArg: 2.9 ± 0.047	3.583LysSer: 3.583 ± 0.051	3.608LysThr: 3.608 ± 0.05	3.882LysVal: 3.882 ± 0.049	0.77LysTrp: 0.77 ± 0.022	2.495LysTyr: 2.495 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.486LeuAla: 7.486 ± 0.09	0.766LeuCys: 0.766 ± 0.023	5.379LeuAsp: 5.379 ± 0.048	5.115LeuGlu: 5.115 ± 0.069	4.889LeuPhe: 4.889 ± 0.064	6.125LeuGly: 6.125 ± 0.066	1.934LeuHis: 1.934 ± 0.043	6.267LeuIle: 6.267 ± 0.065	6.752LeuLys: 6.752 ± 0.074	10.407LeuLeu: 10.407 ± 0.118	2.141LeuMet: 2.141 ± 0.035	5.482LeuAsn: 5.482 ± 0.059	4.408LeuPro: 4.408 ± 0.052	4.117LeuGln: 4.117 ± 0.062	4.478LeuArg: 4.478 ± 0.06	7.558LeuSer: 7.558 ± 0.08	5.608LeuThr: 5.608 ± 0.06	5.685LeuVal: 5.685 ± 0.069	1.132LeuTrp: 1.132 ± 0.029	3.781LeuTyr: 3.781 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.923MetAla: 1.923 ± 0.043	0.125MetCys: 0.125 ± 0.009	1.35MetAsp: 1.35 ± 0.031	1.35MetGlu: 1.35 ± 0.033	0.701MetPhe: 0.701 ± 0.022	1.531MetGly: 1.531 ± 0.035	0.41MetHis: 0.41 ± 0.016	1.247MetIle: 1.247 ± 0.031	1.599MetLys: 1.599 ± 0.035	2.132MetLeu: 2.132 ± 0.042	0.503MetMet: 0.503 ± 0.02	1.211MetAsn: 1.211 ± 0.029	0.985MetPro: 0.985 ± 0.024	0.957MetGln: 0.957 ± 0.024	1.055MetArg: 1.055 ± 0.026	1.24MetSer: 1.24 ± 0.03	1.064MetThr: 1.064 ± 0.029	1.386MetVal: 1.386 ± 0.032	0.184MetTrp: 0.184 ± 0.011	0.67MetTyr: 0.67 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.698AsnAla: 3.698 ± 0.05	0.275AsnCys: 0.275 ± 0.016	2.663AsnAsp: 2.663 ± 0.039	2.714AsnGlu: 2.714 ± 0.042	2.537AsnPhe: 2.537 ± 0.046	4.049AsnGly: 4.049 ± 0.064	1.006AsnHis: 1.006 ± 0.027	3.661AsnIle: 3.661 ± 0.056	3.235AsnLys: 3.235 ± 0.052	5.115AsnLeu: 5.115 ± 0.061	1.133AsnMet: 1.133 ± 0.028	2.994AsnAsn: 2.994 ± 0.055	2.727AsnPro: 2.727 ± 0.043	2.287AsnGln: 2.287 ± 0.045	2.57AsnArg: 2.57 ± 0.036	3.325AsnSer: 3.325 ± 0.054	3.235AsnThr: 3.235 ± 0.056	3.038AsnVal: 3.038 ± 0.054	0.743AsnTrp: 0.743 ± 0.024	2.697AsnTyr: 2.697 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.219ProAla: 3.219 ± 0.05	0.243ProCys: 0.243 ± 0.014	2.805ProAsp: 2.805 ± 0.045	2.816ProGlu: 2.816 ± 0.041	1.945ProPhe: 1.945 ± 0.035	3.094ProGly: 3.094 ± 0.049	0.767ProHis: 0.767 ± 0.025	2.675ProIle: 2.675 ± 0.041	2.069ProLys: 2.069 ± 0.037	3.874ProLeu: 3.874 ± 0.05	0.779ProMet: 0.779 ± 0.023	1.956ProAsn: 1.956 ± 0.037	1.174ProPro: 1.174 ± 0.033	1.462ProGln: 1.462 ± 0.03	1.3ProArg: 1.3 ± 0.029	2.631ProSer: 2.631 ± 0.043	2.048ProThr: 2.048 ± 0.041	2.999ProVal: 2.999 ± 0.046	0.449ProTrp: 0.449 ± 0.016	1.83ProTyr: 1.83 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.104GlnAla: 3.104 ± 0.05	0.19GlnCys: 0.19 ± 0.012	1.87GlnAsp: 1.87 ± 0.037	2.338GlnGlu: 2.338 ± 0.04	1.686GlnPhe: 1.686 ± 0.033	2.464GlnGly: 2.464 ± 0.043	0.95GlnHis: 0.95 ± 0.026	2.699GlnIle: 2.699 ± 0.041	2.519GlnLys: 2.519 ± 0.038	4.618GlnLeu: 4.618 ± 0.056	0.852GlnMet: 0.852 ± 0.026	1.98GlnAsn: 1.98 ± 0.035	1.592GlnPro: 1.592 ± 0.037	2.49GlnGln: 2.49 ± 0.04	1.835GlnArg: 1.835 ± 0.035	2.257GlnSer: 2.257 ± 0.036	2.262GlnThr: 2.262 ± 0.038	2.794GlnVal: 2.794 ± 0.041	0.534GlnTrp: 0.534 ± 0.016	1.762GlnTyr: 1.762 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.9ArgAla: 2.9 ± 0.048	0.255ArgCys: 0.255 ± 0.014	2.222ArgAsp: 2.222 ± 0.041	2.553ArgGlu: 2.553 ± 0.045	2.356ArgPhe: 2.356 ± 0.039	2.515ArgGly: 2.515 ± 0.042	0.869ArgHis: 0.869 ± 0.028	3.529ArgIle: 3.529 ± 0.048	3.035ArgLys: 3.035 ± 0.05	4.541ArgLeu: 4.541 ± 0.062	1.237ArgMet: 1.237 ± 0.027	2.411ArgAsn: 2.411 ± 0.039	1.568ArgPro: 1.568 ± 0.041	1.898ArgGln: 1.898 ± 0.035	1.958ArgArg: 1.958 ± 0.04	2.674ArgSer: 2.674 ± 0.046	2.224ArgThr: 2.224 ± 0.036	2.737ArgVal: 2.737 ± 0.04	0.792ArgTrp: 0.792 ± 0.021	2.246ArgTyr: 2.246 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.899SerAla: 4.899 ± 0.059	0.559SerCys: 0.559 ± 0.02	3.184SerAsp: 3.184 ± 0.053	3.072SerGlu: 3.072 ± 0.047	3.518SerPhe: 3.518 ± 0.057	5.238SerGly: 5.238 ± 0.069	1.166SerHis: 1.166 ± 0.028	4.687SerIle: 4.687 ± 0.058	3.611SerLys: 3.611 ± 0.05	7.013SerLeu: 7.013 ± 0.076	1.35SerMet: 1.35 ± 0.03	3.315SerAsn: 3.315 ± 0.051	2.61SerPro: 2.61 ± 0.043	2.381SerGln: 2.381 ± 0.041	2.846SerArg: 2.846 ± 0.043	4.603SerSer: 4.603 ± 0.068	3.782SerThr: 3.782 ± 0.057	4.262SerVal: 4.262 ± 0.057	0.913SerTrp: 0.913 ± 0.025	3.284SerTyr: 3.284 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.422ThrAla: 4.422 ± 0.059	0.339ThrCys: 0.339 ± 0.014	3.447ThrAsp: 3.447 ± 0.043	2.783ThrGlu: 2.783 ± 0.048	2.74ThrPhe: 2.74 ± 0.043	4.659ThrGly: 4.659 ± 0.056	1.024ThrHis: 1.024 ± 0.029	3.87ThrIle: 3.87 ± 0.052	2.869ThrLys: 2.869 ± 0.047	5.596ThrLeu: 5.596 ± 0.056	0.964ThrMet: 0.964 ± 0.025	2.767ThrAsn: 2.767 ± 0.052	2.51ThrPro: 2.51 ± 0.037	1.916ThrGln: 1.916 ± 0.034	2.043ThrArg: 2.043 ± 0.034	3.649ThrSer: 3.649 ± 0.054	3.313ThrThr: 3.313 ± 0.056	3.677ThrVal: 3.677 ± 0.049	0.697ThrTrp: 0.697 ± 0.022	2.7ThrTyr: 2.7 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.41ValAla: 4.41 ± 0.06	0.477ValCys: 0.477 ± 0.018	3.325ValAsp: 3.325 ± 0.044	2.982ValGlu: 2.982 ± 0.045	2.962ValPhe: 2.962 ± 0.046	3.834ValGly: 3.834 ± 0.055	1.137ValHis: 1.137 ± 0.028	4.424ValIle: 4.424 ± 0.058	3.936ValLys: 3.936 ± 0.052	6.176ValLeu: 6.176 ± 0.063	1.35ValMet: 1.35 ± 0.033	3.472ValAsn: 3.472 ± 0.053	2.643ValPro: 2.643 ± 0.041	2.225ValGln: 2.225 ± 0.037	2.64ValArg: 2.64 ± 0.047	4.615ValSer: 4.615 ± 0.058	3.61ValThr: 3.61 ± 0.054	4.151ValVal: 4.151 ± 0.06	0.728ValTrp: 0.728 ± 0.025	2.561ValTyr: 2.561 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.823TrpAla: 0.823 ± 0.026	0.129TrpCys: 0.129 ± 0.011	0.783TrpAsp: 0.783 ± 0.024	0.767TrpGlu: 0.767 ± 0.022	0.597TrpPhe: 0.597 ± 0.019	0.954TrpGly: 0.954 ± 0.027	0.256TrpHis: 0.256 ± 0.013	0.804TrpIle: 0.804 ± 0.022	0.907TrpLys: 0.907 ± 0.025	1.395TrpLeu: 1.395 ± 0.032	0.38TrpMet: 0.38 ± 0.017	0.724TrpAsn: 0.724 ± 0.022	0.447TrpPro: 0.447 ± 0.017	0.633TrpGln: 0.633 ± 0.023	0.583TrpArg: 0.583 ± 0.019	0.766TrpSer: 0.766 ± 0.023	0.652TrpThr: 0.652 ± 0.022	0.746TrpVal: 0.746 ± 0.021	0.213TrpTrp: 0.213 ± 0.013	0.569TrpTyr: 0.569 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.178TyrAla: 3.178 ± 0.051	0.34TyrCys: 0.34 ± 0.015	2.459TyrAsp: 2.459 ± 0.046	2.122TyrGlu: 2.122 ± 0.04	2.311TyrPhe: 2.311 ± 0.045	3.083TyrGly: 3.083 ± 0.048	1.036TyrHis: 1.036 ± 0.025	2.466TyrIle: 2.466 ± 0.047	2.551TyrLys: 2.551 ± 0.041	4.366TyrLeu: 4.366 ± 0.059	0.817TyrMet: 0.817 ± 0.024	2.517TyrAsn: 2.517 ± 0.049	1.953TyrPro: 1.953 ± 0.034	2.145TyrGln: 2.145 ± 0.038	2.267TyrArg: 2.267 ± 0.035	2.953TyrSer: 2.953 ± 0.052	2.7TyrThr: 2.7 ± 0.045	2.311TyrVal: 2.311 ± 0.038	0.594TyrTrp: 0.594 ± 0.022	2.144TyrTyr: 2.144 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4337 proteins (1547353 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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