Amino acid dipepetide frequency for Bifidobacterium primatium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.434AlaAla: 14.434 ± 0.264	0.96AlaCys: 0.96 ± 0.041	7.902AlaAsp: 7.902 ± 0.116	6.367AlaGlu: 6.367 ± 0.114	3.57AlaPhe: 3.57 ± 0.078	9.242AlaGly: 9.242 ± 0.136	2.0AlaHis: 2.0 ± 0.059	5.576AlaIle: 5.576 ± 0.102	5.105AlaLys: 5.105 ± 0.134	9.732AlaLeu: 9.732 ± 0.153	3.132AlaMet: 3.132 ± 0.077	3.44AlaAsn: 3.44 ± 0.082	3.837AlaPro: 3.837 ± 0.091	3.727AlaGln: 3.727 ± 0.092	6.025AlaArg: 6.025 ± 0.109	6.424AlaSer: 6.424 ± 0.12	6.086AlaThr: 6.086 ± 0.106	9.258AlaVal: 9.258 ± 0.142	1.37AlaTrp: 1.37 ± 0.048	2.788AlaTyr: 2.788 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.035	0.123CysCys: 0.123 ± 0.013	0.552CysAsp: 0.552 ± 0.027	0.497CysGlu: 0.497 ± 0.025	0.327CysPhe: 0.327 ± 0.023	0.979CysGly: 0.979 ± 0.041	0.216CysHis: 0.216 ± 0.018	0.422CysIle: 0.422 ± 0.028	0.221CysLys: 0.221 ± 0.015	0.715CysLeu: 0.715 ± 0.031	0.228CysMet: 0.228 ± 0.015	0.203CysAsn: 0.203 ± 0.017	0.43CysPro: 0.43 ± 0.029	0.204CysGln: 0.204 ± 0.018	0.551CysArg: 0.551 ± 0.032	0.52CysSer: 0.52 ± 0.025	0.468CysThr: 0.468 ± 0.025	0.772CysVal: 0.772 ± 0.034	0.109CysTrp: 0.109 ± 0.011	0.225CysTyr: 0.225 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	7.937AspAla: 7.937 ± 0.152	0.527AspCys: 0.527 ± 0.029	5.573AspAsp: 5.573 ± 0.134	4.897AspGlu: 4.897 ± 0.102	2.303AspPhe: 2.303 ± 0.065	6.615AspGly: 6.615 ± 0.136	1.343AspHis: 1.343 ± 0.044	3.451AspIle: 3.451 ± 0.058	2.44AspLys: 2.44 ± 0.068	5.165AspLeu: 5.165 ± 0.112	1.607AspMet: 1.607 ± 0.054	1.826AspAsn: 1.826 ± 0.056	3.377AspPro: 3.377 ± 0.071	1.576AspGln: 1.576 ± 0.04	3.701AspArg: 3.701 ± 0.078	3.722AspSer: 3.722 ± 0.076	3.329AspThr: 3.329 ± 0.071	5.547AspVal: 5.547 ± 0.107	0.933AspTrp: 0.933 ± 0.036	2.067AspTyr: 2.067 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.847GluAla: 5.847 ± 0.115	0.468GluCys: 0.468 ± 0.027	3.107GluAsp: 3.107 ± 0.077	3.303GluGlu: 3.303 ± 0.083	1.972GluPhe: 1.972 ± 0.049	3.958GluGly: 3.958 ± 0.077	1.619GluHis: 1.619 ± 0.05	2.751GluIle: 2.751 ± 0.076	2.391GluLys: 2.391 ± 0.064	5.191GluLeu: 5.191 ± 0.101	1.377GluMet: 1.377 ± 0.041	1.979GluAsn: 1.979 ± 0.048	2.593GluPro: 2.593 ± 0.056	2.331GluGln: 2.331 ± 0.062	4.319GluArg: 4.319 ± 0.106	3.356GluSer: 3.356 ± 0.07	3.353GluThr: 3.353 ± 0.066	3.448GluVal: 3.448 ± 0.073	0.682GluTrp: 0.682 ± 0.031	1.764GluTyr: 1.764 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	4.088PheAla: 4.088 ± 0.095	0.364PheCys: 0.364 ± 0.023	2.756PheAsp: 2.756 ± 0.065	1.742PheGlu: 1.742 ± 0.056	1.299PhePhe: 1.299 ± 0.054	3.474PheGly: 3.474 ± 0.076	0.727PheHis: 0.727 ± 0.032	1.817PheIle: 1.817 ± 0.062	1.109PheLys: 1.109 ± 0.038	2.804PheLeu: 2.804 ± 0.083	0.727PheMet: 0.727 ± 0.033	1.186PheAsn: 1.186 ± 0.042	1.443PhePro: 1.443 ± 0.044	0.848PheGln: 0.848 ± 0.033	1.74PheArg: 1.74 ± 0.044	2.266PheSer: 2.266 ± 0.066	2.158PheThr: 2.158 ± 0.056	2.768PheVal: 2.768 ± 0.069	0.403PheTrp: 0.403 ± 0.026	0.962PheTyr: 0.962 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	7.651GlyAla: 7.651 ± 0.126	0.779GlyCys: 0.779 ± 0.033	5.213GlyAsp: 5.213 ± 0.094	4.722GlyGlu: 4.722 ± 0.092	3.315GlyPhe: 3.315 ± 0.067	6.73GlyGly: 6.73 ± 0.131	1.829GlyHis: 1.829 ± 0.053	4.959GlyIle: 4.959 ± 0.087	3.978GlyLys: 3.978 ± 0.092	7.136GlyLeu: 7.136 ± 0.114	2.292GlyMet: 2.292 ± 0.049	2.843GlyAsn: 2.843 ± 0.085	2.748GlyPro: 2.748 ± 0.064	2.339GlyGln: 2.339 ± 0.056	5.275GlyArg: 5.275 ± 0.092	5.407GlySer: 5.407 ± 0.118	5.271GlyThr: 5.271 ± 0.097	6.819GlyVal: 6.819 ± 0.108	1.154GlyTrp: 1.154 ± 0.045	2.758GlyTyr: 2.758 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	2.211HisAla: 2.211 ± 0.066	0.203HisCys: 0.203 ± 0.019	1.71HisAsp: 1.71 ± 0.055	1.262HisGlu: 1.262 ± 0.045	0.615HisPhe: 0.615 ± 0.028	1.938HisGly: 1.938 ± 0.047	0.57HisHis: 0.57 ± 0.029	1.157HisIle: 1.157 ± 0.041	0.618HisLys: 0.618 ± 0.031	1.617HisLeu: 1.617 ± 0.051	0.578HisMet: 0.578 ± 0.025	0.603HisAsn: 0.603 ± 0.03	1.311HisPro: 1.311 ± 0.042	0.572HisGln: 0.572 ± 0.025	1.48HisArg: 1.48 ± 0.051	1.008HisSer: 1.008 ± 0.037	1.183HisThr: 1.183 ± 0.036	1.739HisVal: 1.739 ± 0.058	0.282HisTrp: 0.282 ± 0.02	0.618HisTyr: 0.618 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.547IleAla: 6.547 ± 0.111	0.585IleCys: 0.585 ± 0.031	4.274IleAsp: 4.274 ± 0.082	3.05IleGlu: 3.05 ± 0.071	1.44IlePhe: 1.44 ± 0.057	4.815IleGly: 4.815 ± 0.105	1.008IleHis: 1.008 ± 0.039	3.01IleIle: 3.01 ± 0.084	1.672IleLys: 1.672 ± 0.052	3.869IleLeu: 3.869 ± 0.08	1.246IleMet: 1.246 ± 0.038	1.635IleAsn: 1.635 ± 0.05	2.735IlePro: 2.735 ± 0.063	1.278IleGln: 1.278 ± 0.043	3.144IleArg: 3.144 ± 0.072	3.01IleSer: 3.01 ± 0.079	3.274IleThr: 3.274 ± 0.069	4.806IleVal: 4.806 ± 0.098	0.589IleTrp: 0.589 ± 0.03	1.155IleTyr: 1.155 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	5.125LysAla: 5.125 ± 0.122	0.186LysCys: 0.186 ± 0.016	2.557LysAsp: 2.557 ± 0.078	2.187LysGlu: 2.187 ± 0.061	1.012LysPhe: 1.012 ± 0.041	2.858LysGly: 2.858 ± 0.076	0.8LysHis: 0.8 ± 0.033	1.847LysIle: 1.847 ± 0.063	1.91LysLys: 1.91 ± 0.064	3.128LysLeu: 3.128 ± 0.077	0.862LysMet: 0.862 ± 0.036	1.549LysAsn: 1.549 ± 0.052	2.348LysPro: 2.348 ± 0.061	1.374LysGln: 1.374 ± 0.044	2.416LysArg: 2.416 ± 0.059	2.419LysSer: 2.419 ± 0.069	2.841LysThr: 2.841 ± 0.087	2.92LysVal: 2.92 ± 0.073	0.452LysTrp: 0.452 ± 0.025	1.149LysTyr: 1.149 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	10.121LeuAla: 10.121 ± 0.139	0.831LeuCys: 0.831 ± 0.035	6.026LeuAsp: 6.026 ± 0.104	4.371LeuGlu: 4.371 ± 0.08	3.039LeuPhe: 3.039 ± 0.082	7.219LeuGly: 7.219 ± 0.121	1.863LeuHis: 1.863 ± 0.046	4.465LeuIle: 4.465 ± 0.094	3.47LeuLys: 3.47 ± 0.074	7.694LeuLeu: 7.694 ± 0.144	2.229LeuMet: 2.229 ± 0.063	2.821LeuAsn: 2.821 ± 0.064	4.375LeuPro: 4.375 ± 0.083	2.116LeuGln: 2.116 ± 0.06	5.39LeuArg: 5.39 ± 0.1	5.304LeuSer: 5.304 ± 0.09	5.42LeuThr: 5.42 ± 0.091	6.504LeuVal: 6.504 ± 0.105	1.016LeuTrp: 1.016 ± 0.045	2.03LeuTyr: 2.03 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.966MetAla: 2.966 ± 0.061	0.242MetCys: 0.242 ± 0.018	1.353MetAsp: 1.353 ± 0.044	1.076MetGlu: 1.076 ± 0.034	0.9MetPhe: 0.9 ± 0.039	1.872MetGly: 1.872 ± 0.047	0.526MetHis: 0.526 ± 0.027	1.271MetIle: 1.271 ± 0.044	0.996MetLys: 0.996 ± 0.038	2.512MetLeu: 2.512 ± 0.066	0.752MetMet: 0.752 ± 0.039	0.964MetAsn: 0.964 ± 0.041	1.455MetPro: 1.455 ± 0.044	0.787MetGln: 0.787 ± 0.036	1.632MetArg: 1.632 ± 0.056	1.636MetSer: 1.636 ± 0.046	2.099MetThr: 2.099 ± 0.046	1.843MetVal: 1.843 ± 0.047	0.292MetTrp: 0.292 ± 0.018	0.549MetTyr: 0.549 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.659AsnAla: 3.659 ± 0.071	0.22AsnCys: 0.22 ± 0.017	2.356AsnAsp: 2.356 ± 0.065	1.656AsnGlu: 1.656 ± 0.041	0.917AsnPhe: 0.917 ± 0.036	3.506AsnGly: 3.506 ± 0.112	0.663AsnHis: 0.663 ± 0.028	1.697AsnIle: 1.697 ± 0.053	1.148AsnLys: 1.148 ± 0.04	2.675AsnLeu: 2.675 ± 0.061	0.752AsnMet: 0.752 ± 0.029	1.083AsnAsn: 1.083 ± 0.052	2.148AsnPro: 2.148 ± 0.054	0.922AsnGln: 0.922 ± 0.036	1.992AsnArg: 1.992 ± 0.059	1.628AsnSer: 1.628 ± 0.052	2.047AsnThr: 2.047 ± 0.057	2.58AsnVal: 2.58 ± 0.062	0.436AsnTrp: 0.436 ± 0.028	0.859AsnTyr: 0.859 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	4.996ProAla: 4.996 ± 0.086	0.327ProCys: 0.327 ± 0.022	3.403ProAsp: 3.403 ± 0.077	3.325ProGlu: 3.325 ± 0.067	1.601ProPhe: 1.601 ± 0.045	3.508ProGly: 3.508 ± 0.075	0.997ProHis: 0.997 ± 0.039	2.182ProIle: 2.182 ± 0.067	1.98ProLys: 1.98 ± 0.06	3.74ProLeu: 3.74 ± 0.075	1.08ProMet: 1.08 ± 0.039	1.617ProAsn: 1.617 ± 0.04	1.261ProPro: 1.261 ± 0.049	1.686ProGln: 1.686 ± 0.051	2.353ProArg: 2.353 ± 0.052	2.876ProSer: 2.876 ± 0.071	2.956ProThr: 2.956 ± 0.063	3.933ProVal: 3.933 ± 0.076	0.719ProTrp: 0.719 ± 0.028	1.412ProTyr: 1.412 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.306GlnAla: 3.306 ± 0.085	0.252GlnCys: 0.252 ± 0.02	1.47GlnAsp: 1.47 ± 0.044	1.394GlnGlu: 1.394 ± 0.04	0.96GlnPhe: 0.96 ± 0.036	2.157GlnGly: 2.157 ± 0.058	0.682GlnHis: 0.682 ± 0.03	1.806GlnIle: 1.806 ± 0.055	1.125GlnLys: 1.125 ± 0.042	2.976GlnLeu: 2.976 ± 0.067	0.822GlnMet: 0.822 ± 0.033	0.971GlnAsn: 0.971 ± 0.039	1.536GlnPro: 1.536 ± 0.051	1.415GlnGln: 1.415 ± 0.055	2.14GlnArg: 2.14 ± 0.063	1.916GlnSer: 1.916 ± 0.052	1.751GlnThr: 1.751 ± 0.051	2.244GlnVal: 2.244 ± 0.053	0.547GlnTrp: 0.547 ± 0.028	1.028GlnTyr: 1.028 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	5.219ArgAla: 5.219 ± 0.101	0.518ArgCys: 0.518 ± 0.029	3.719ArgAsp: 3.719 ± 0.09	3.686ArgGlu: 3.686 ± 0.077	2.535ArgPhe: 2.535 ± 0.063	4.101ArgGly: 4.101 ± 0.089	1.607ArgHis: 1.607 ± 0.049	3.756ArgIle: 3.756 ± 0.065	2.574ArgLys: 2.574 ± 0.066	5.709ArgLeu: 5.709 ± 0.096	1.909ArgMet: 1.909 ± 0.045	2.187ArgAsn: 2.187 ± 0.059	2.813ArgPro: 2.813 ± 0.077	2.145ArgGln: 2.145 ± 0.051	5.553ArgArg: 5.553 ± 0.124	3.397ArgSer: 3.397 ± 0.071	3.464ArgThr: 3.464 ± 0.068	3.989ArgVal: 3.989 ± 0.086	0.817ArgTrp: 0.817 ± 0.034	1.855ArgTyr: 1.855 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.544SerAla: 6.544 ± 0.117	0.478SerCys: 0.478 ± 0.024	3.86SerAsp: 3.86 ± 0.084	2.971SerGlu: 2.971 ± 0.07	2.078SerPhe: 2.078 ± 0.057	5.798SerGly: 5.798 ± 0.107	1.245SerHis: 1.245 ± 0.044	3.136SerIle: 3.136 ± 0.063	2.246SerLys: 2.246 ± 0.058	5.208SerLeu: 5.208 ± 0.104	1.619SerMet: 1.619 ± 0.048	1.834SerAsn: 1.834 ± 0.055	2.561SerPro: 2.561 ± 0.063	1.989SerGln: 1.989 ± 0.055	3.494SerArg: 3.494 ± 0.068	4.439SerSer: 4.439 ± 0.136	3.682SerThr: 3.682 ± 0.078	4.628SerVal: 4.628 ± 0.086	0.846SerTrp: 0.846 ± 0.035	1.68SerTyr: 1.68 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.701ThrAla: 6.701 ± 0.13	0.457ThrCys: 0.457 ± 0.024	3.946ThrAsp: 3.946 ± 0.08	2.729ThrGlu: 2.729 ± 0.06	2.223ThrPhe: 2.223 ± 0.054	5.29ThrGly: 5.29 ± 0.113	1.149ThrHis: 1.149 ± 0.043	3.503ThrIle: 3.503 ± 0.071	2.311ThrLys: 2.311 ± 0.065	5.581ThrLeu: 5.581 ± 0.092	1.469ThrMet: 1.469 ± 0.046	2.003ThrAsn: 2.003 ± 0.059	3.327ThrPro: 3.327 ± 0.079	1.742ThrGln: 1.742 ± 0.046	2.981ThrArg: 2.981 ± 0.061	3.433ThrSer: 3.433 ± 0.067	3.893ThrThr: 3.893 ± 0.093	5.694ThrVal: 5.694 ± 0.115	0.798ThrTrp: 0.798 ± 0.044	1.68ThrTyr: 1.68 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	8.49ValAla: 8.49 ± 0.146	0.829ValCys: 0.829 ± 0.04	5.316ValAsp: 5.316 ± 0.089	4.425ValGlu: 4.425 ± 0.086	3.026ValPhe: 3.026 ± 0.08	5.622ValGly: 5.622 ± 0.101	1.535ValHis: 1.535 ± 0.049	4.478ValIle: 4.478 ± 0.096	3.142ValLys: 3.142 ± 0.084	7.039ValLeu: 7.039 ± 0.108	2.046ValMet: 2.046 ± 0.061	2.717ValAsn: 2.717 ± 0.055	3.914ValPro: 3.914 ± 0.083	1.968ValGln: 1.968 ± 0.051	4.559ValArg: 4.559 ± 0.085	5.115ValSer: 5.115 ± 0.088	5.195ValThr: 5.195 ± 0.115	6.808ValVal: 6.808 ± 0.111	0.963ValTrp: 0.963 ± 0.038	1.958ValTyr: 1.958 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	1.146TrpAla: 1.146 ± 0.035	0.137TrpCys: 0.137 ± 0.013	0.738TrpAsp: 0.738 ± 0.032	0.549TrpGlu: 0.549 ± 0.028	0.531TrpPhe: 0.531 ± 0.035	0.918TrpGly: 0.918 ± 0.033	0.365TrpHis: 0.365 ± 0.027	0.664TrpIle: 0.664 ± 0.032	0.594TrpLys: 0.594 ± 0.03	1.395TrpLeu: 1.395 ± 0.043	0.378TrpMet: 0.378 ± 0.022	0.613TrpAsn: 0.613 ± 0.03	0.498TrpPro: 0.498 ± 0.029	0.564TrpGln: 0.564 ± 0.028	0.964TrpArg: 0.964 ± 0.039	0.843TrpSer: 0.843 ± 0.035	0.785TrpThr: 0.785 ± 0.03	0.763TrpVal: 0.763 ± 0.034	0.25TrpTrp: 0.25 ± 0.018	0.39TrpTyr: 0.39 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.993TyrAla: 2.993 ± 0.07	0.274TyrCys: 0.274 ± 0.019	2.101TyrAsp: 2.101 ± 0.058	1.597TyrGlu: 1.597 ± 0.053	1.018TyrPhe: 1.018 ± 0.041	2.617TyrGly: 2.617 ± 0.064	0.531TyrHis: 0.531 ± 0.027	1.196TyrIle: 1.196 ± 0.042	0.906TyrLys: 0.906 ± 0.039	2.42TyrLeu: 2.42 ± 0.057	0.617TyrMet: 0.617 ± 0.031	0.87TyrAsn: 0.87 ± 0.037	1.246TyrPro: 1.246 ± 0.045	0.914TyrGln: 0.914 ± 0.038	1.846TyrArg: 1.846 ± 0.052	1.618TyrSer: 1.618 ± 0.051	1.653TyrThr: 1.653 ± 0.056	2.082TyrVal: 2.082 ± 0.055	0.427TyrTrp: 0.427 ± 0.024	0.881TyrTyr: 0.881 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2029 proteins (759016 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---