Amino acid dipepetide frequency for Aestuariisphingobium litorale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.905AlaAla: 18.905 ± 0.216	0.998AlaCys: 0.998 ± 0.035	7.742AlaAsp: 7.742 ± 0.081	7.736AlaGlu: 7.736 ± 0.107	4.515AlaPhe: 4.515 ± 0.068	11.113AlaGly: 11.113 ± 0.135	2.487AlaHis: 2.487 ± 0.056	6.244AlaIle: 6.244 ± 0.078	4.664AlaLys: 4.664 ± 0.09	13.635AlaLeu: 13.635 ± 0.14	3.959AlaMet: 3.959 ± 0.068	3.233AlaAsn: 3.233 ± 0.07	6.4AlaPro: 6.4 ± 0.103	4.436AlaGln: 4.436 ± 0.064	9.414AlaArg: 9.414 ± 0.119	6.482AlaSer: 6.482 ± 0.1	6.683AlaThr: 6.683 ± 0.092	8.89AlaVal: 8.89 ± 0.097	1.596AlaTrp: 1.596 ± 0.04	2.617AlaTyr: 2.617 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.017CysAla: 1.017 ± 0.032	0.102CysCys: 0.102 ± 0.01	0.509CysAsp: 0.509 ± 0.023	0.383CysGlu: 0.383 ± 0.018	0.277CysPhe: 0.277 ± 0.016	0.881CysGly: 0.881 ± 0.034	0.211CysHis: 0.211 ± 0.02	0.38CysIle: 0.38 ± 0.017	0.188CysLys: 0.188 ± 0.013	0.669CysLeu: 0.669 ± 0.027	0.155CysMet: 0.155 ± 0.013	0.21CysAsn: 0.21 ± 0.015	0.46CysPro: 0.46 ± 0.024	0.213CysGln: 0.213 ± 0.014	0.53CysArg: 0.53 ± 0.024	0.424CysSer: 0.424 ± 0.021	0.399CysThr: 0.399 ± 0.019	0.586CysVal: 0.586 ± 0.024	0.119CysTrp: 0.119 ± 0.01	0.182CysTyr: 0.182 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.152AspAla: 8.152 ± 0.095	0.465AspCys: 0.465 ± 0.02	3.131AspAsp: 3.131 ± 0.056	3.153AspGlu: 3.153 ± 0.062	2.253AspPhe: 2.253 ± 0.047	5.589AspGly: 5.589 ± 0.076	1.337AspHis: 1.337 ± 0.041	3.09AspIle: 3.09 ± 0.059	1.838AspLys: 1.838 ± 0.045	5.814AspLeu: 5.814 ± 0.081	1.565AspMet: 1.565 ± 0.043	1.354AspAsn: 1.354 ± 0.034	3.605AspPro: 3.605 ± 0.061	1.801AspGln: 1.801 ± 0.046	4.583AspArg: 4.583 ± 0.068	2.234AspSer: 2.234 ± 0.044	2.582AspThr: 2.582 ± 0.048	4.544AspVal: 4.544 ± 0.062	1.193AspTrp: 1.193 ± 0.035	1.624AspTyr: 1.624 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.82GluAla: 7.82 ± 0.114	0.303GluCys: 0.303 ± 0.019	2.939GluAsp: 2.939 ± 0.049	2.913GluGlu: 2.913 ± 0.063	1.56GluPhe: 1.56 ± 0.04	4.348GluGly: 4.348 ± 0.076	1.053GluHis: 1.053 ± 0.032	3.007GluIle: 3.007 ± 0.049	2.038GluLys: 2.038 ± 0.051	4.732GluLeu: 4.732 ± 0.073	1.469GluMet: 1.469 ± 0.034	1.431GluAsn: 1.431 ± 0.038	2.312GluPro: 2.312 ± 0.048	1.921GluGln: 1.921 ± 0.049	4.392GluArg: 4.392 ± 0.074	2.174GluSer: 2.174 ± 0.042	3.317GluThr: 3.317 ± 0.048	3.595GluVal: 3.595 ± 0.057	0.677GluTrp: 0.677 ± 0.026	0.921GluTyr: 0.921 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.618PheAla: 4.618 ± 0.065	0.331PheCys: 0.331 ± 0.02	2.719PheAsp: 2.719 ± 0.048	2.046PheGlu: 2.046 ± 0.045	1.283PhePhe: 1.283 ± 0.04	3.833PheGly: 3.833 ± 0.059	0.685PheHis: 0.685 ± 0.022	1.545PheIle: 1.545 ± 0.041	1.003PheLys: 1.003 ± 0.029	3.079PheLeu: 3.079 ± 0.056	0.806PheMet: 0.806 ± 0.028	1.171PheAsn: 1.171 ± 0.038	1.511PhePro: 1.511 ± 0.042	1.01PheGln: 1.01 ± 0.03	2.151PheArg: 2.151 ± 0.047	2.11PheSer: 2.11 ± 0.046	2.024PheThr: 2.024 ± 0.048	2.675PheVal: 2.675 ± 0.058	0.528PheTrp: 0.528 ± 0.024	0.907PheTyr: 0.907 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.106GlyAla: 10.106 ± 0.122	0.81GlyCys: 0.81 ± 0.029	4.839GlyAsp: 4.839 ± 0.065	4.451GlyGlu: 4.451 ± 0.06	3.659GlyPhe: 3.659 ± 0.055	8.057GlyGly: 8.057 ± 0.148	1.864GlyHis: 1.864 ± 0.043	4.3GlyIle: 4.3 ± 0.065	3.528GlyLys: 3.528 ± 0.066	9.058GlyLeu: 9.058 ± 0.101	2.271GlyMet: 2.271 ± 0.053	2.376GlyAsn: 2.376 ± 0.084	3.718GlyPro: 3.718 ± 0.057	3.153GlyGln: 3.153 ± 0.056	6.212GlyArg: 6.212 ± 0.078	4.605GlySer: 4.605 ± 0.107	4.955GlyThr: 4.955 ± 0.154	6.541GlyVal: 6.541 ± 0.086	1.638GlyTrp: 1.638 ± 0.039	2.36GlyTyr: 2.36 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.312HisAla: 2.312 ± 0.053	0.225HisCys: 0.225 ± 0.016	1.208HisAsp: 1.208 ± 0.035	0.952HisGlu: 0.952 ± 0.029	0.835HisPhe: 0.835 ± 0.029	1.929HisGly: 1.929 ± 0.042	0.545HisHis: 0.545 ± 0.023	0.999HisIle: 0.999 ± 0.036	0.553HisLys: 0.553 ± 0.024	1.91HisLeu: 1.91 ± 0.045	0.52HisMet: 0.52 ± 0.024	0.456HisAsn: 0.456 ± 0.021	1.368HisPro: 1.368 ± 0.037	0.534HisGln: 0.534 ± 0.024	1.401HisArg: 1.401 ± 0.034	0.876HisSer: 0.876 ± 0.031	0.689HisThr: 0.689 ± 0.026	1.568HisVal: 1.568 ± 0.042	0.369HisTrp: 0.369 ± 0.019	0.567HisTyr: 0.567 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.251IleAla: 7.251 ± 0.077	0.497IleCys: 0.497 ± 0.021	3.742IleAsp: 3.742 ± 0.066	3.282IleGlu: 3.282 ± 0.053	1.527IlePhe: 1.527 ± 0.04	4.924IleGly: 4.924 ± 0.068	0.896IleHis: 0.896 ± 0.029	2.267IleIle: 2.267 ± 0.049	1.444IleLys: 1.444 ± 0.042	4.188IleLeu: 4.188 ± 0.062	0.957IleMet: 0.957 ± 0.032	1.452IleAsn: 1.452 ± 0.037	2.263IlePro: 2.263 ± 0.053	1.213IleGln: 1.213 ± 0.033	3.142IleArg: 3.142 ± 0.053	2.822IleSer: 2.822 ± 0.077	2.696IleThr: 2.696 ± 0.081	4.028IleVal: 4.028 ± 0.065	0.667IleTrp: 0.667 ± 0.025	0.973IleTyr: 0.973 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.899LysAla: 4.899 ± 0.091	0.169LysCys: 0.169 ± 0.012	1.893LysAsp: 1.893 ± 0.05	1.405LysGlu: 1.405 ± 0.042	1.002LysPhe: 1.002 ± 0.032	2.964LysGly: 2.964 ± 0.056	0.579LysHis: 0.579 ± 0.026	1.614LysIle: 1.614 ± 0.04	1.321LysLys: 1.321 ± 0.051	3.378LysLeu: 3.378 ± 0.063	0.877LysMet: 0.877 ± 0.026	0.786LysAsn: 0.786 ± 0.026	2.075LysPro: 2.075 ± 0.049	0.969LysGln: 0.969 ± 0.027	2.34LysArg: 2.34 ± 0.058	1.793LysSer: 1.793 ± 0.046	1.94LysThr: 1.94 ± 0.037	2.463LysVal: 2.463 ± 0.052	0.433LysTrp: 0.433 ± 0.018	0.626LysTyr: 0.626 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.439LeuAla: 13.439 ± 0.136	0.733LeuCys: 0.733 ± 0.026	6.071LeuAsp: 6.071 ± 0.093	4.708LeuGlu: 4.708 ± 0.071	3.448LeuPhe: 3.448 ± 0.064	8.256LeuGly: 8.256 ± 0.09	1.753LeuHis: 1.753 ± 0.041	4.86LeuIle: 4.86 ± 0.069	3.538LeuLys: 3.538 ± 0.061	8.834LeuLeu: 8.834 ± 0.127	2.274LeuMet: 2.274 ± 0.051	2.646LeuAsn: 2.646 ± 0.062	5.326LeuPro: 5.326 ± 0.084	2.557LeuGln: 2.557 ± 0.046	6.31LeuArg: 6.31 ± 0.091	6.392LeuSer: 6.392 ± 0.093	5.873LeuThr: 5.873 ± 0.121	6.858LeuVal: 6.858 ± 0.088	1.239LeuTrp: 1.239 ± 0.037	1.994LeuTyr: 1.994 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.373MetAla: 3.373 ± 0.06	0.155MetCys: 0.155 ± 0.012	1.258MetAsp: 1.258 ± 0.036	1.158MetGlu: 1.158 ± 0.034	0.707MetPhe: 0.707 ± 0.026	2.059MetGly: 2.059 ± 0.045	0.464MetHis: 0.464 ± 0.02	1.339MetIle: 1.339 ± 0.037	1.091MetLys: 1.091 ± 0.034	2.489MetLeu: 2.489 ± 0.05	0.696MetMet: 0.696 ± 0.028	0.72MetAsn: 0.72 ± 0.024	1.434MetPro: 1.434 ± 0.036	0.796MetGln: 0.796 ± 0.025	1.822MetArg: 1.822 ± 0.047	1.588MetSer: 1.588 ± 0.04	1.986MetThr: 1.986 ± 0.047	1.705MetVal: 1.705 ± 0.039	0.252MetTrp: 0.252 ± 0.017	0.288MetTyr: 0.288 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.364AsnAla: 3.364 ± 0.074	0.268AsnCys: 0.268 ± 0.015	1.444AsnAsp: 1.444 ± 0.037	1.185AsnGlu: 1.185 ± 0.036	0.961AsnPhe: 0.961 ± 0.035	2.597AsnGly: 2.597 ± 0.063	0.445AsnHis: 0.445 ± 0.022	1.466AsnIle: 1.466 ± 0.048	0.722AsnLys: 0.722 ± 0.029	2.527AsnLeu: 2.527 ± 0.054	0.628AsnMet: 0.628 ± 0.026	0.735AsnAsn: 0.735 ± 0.039	1.802AsnPro: 1.802 ± 0.044	0.797AsnGln: 0.797 ± 0.031	1.898AsnArg: 1.898 ± 0.04	1.288AsnSer: 1.288 ± 0.04	1.281AsnThr: 1.281 ± 0.047	2.096AsnVal: 2.096 ± 0.053	0.445AsnTrp: 0.445 ± 0.02	0.741AsnTyr: 0.741 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.786ProAla: 6.786 ± 0.091	0.35ProCys: 0.35 ± 0.017	3.873ProAsp: 3.873 ± 0.07	3.529ProGlu: 3.529 ± 0.063	1.999ProPhe: 1.999 ± 0.046	4.527ProGly: 4.527 ± 0.066	1.064ProHis: 1.064 ± 0.034	2.29ProIle: 2.29 ± 0.049	1.804ProLys: 1.804 ± 0.049	4.667ProLeu: 4.667 ± 0.072	1.225ProMet: 1.225 ± 0.035	1.348ProAsn: 1.348 ± 0.039	2.537ProPro: 2.537 ± 0.062	1.643ProGln: 1.643 ± 0.043	2.804ProArg: 2.804 ± 0.055	2.644ProSer: 2.644 ± 0.055	2.668ProThr: 2.668 ± 0.054	4.485ProVal: 4.485 ± 0.068	0.683ProTrp: 0.683 ± 0.027	1.113ProTyr: 1.113 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.144GlnAla: 4.144 ± 0.067	0.222GlnCys: 0.222 ± 0.013	1.5GlnAsp: 1.5 ± 0.04	1.262GlnGlu: 1.262 ± 0.036	1.12GlnPhe: 1.12 ± 0.033	2.496GlnGly: 2.496 ± 0.05	0.592GlnHis: 0.592 ± 0.025	1.757GlnIle: 1.757 ± 0.038	1.091GlnLys: 1.091 ± 0.034	3.02GlnLeu: 3.02 ± 0.056	0.93GlnMet: 0.93 ± 0.028	0.827GlnAsn: 0.827 ± 0.028	1.767GlnPro: 1.767 ± 0.043	1.158GlnGln: 1.158 ± 0.033	2.267GlnArg: 2.267 ± 0.051	1.766GlnSer: 1.766 ± 0.044	1.76GlnThr: 1.76 ± 0.046	2.319GlnVal: 2.319 ± 0.044	0.426GlnTrp: 0.426 ± 0.019	0.612GlnTyr: 0.612 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.554ArgAla: 8.554 ± 0.111	0.492ArgCys: 0.492 ± 0.022	4.123ArgAsp: 4.123 ± 0.066	3.606ArgGlu: 3.606 ± 0.062	2.835ArgPhe: 2.835 ± 0.052	4.741ArgGly: 4.741 ± 0.073	1.567ArgHis: 1.567 ± 0.04	3.969ArgIle: 3.969 ± 0.068	2.215ArgLys: 2.215 ± 0.047	7.883ArgLeu: 7.883 ± 0.115	1.979ArgMet: 1.979 ± 0.041	1.825ArgAsn: 1.825 ± 0.042	3.525ArgPro: 3.525 ± 0.075	2.357ArgGln: 2.357 ± 0.042	5.158ArgArg: 5.158 ± 0.093	3.209ArgSer: 3.209 ± 0.053	3.679ArgThr: 3.679 ± 0.065	4.769ArgVal: 4.769 ± 0.069	1.143ArgTrp: 1.143 ± 0.035	1.734ArgTyr: 1.734 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.444SerAla: 6.444 ± 0.091	0.43SerCys: 0.43 ± 0.022	3.069SerAsp: 3.069 ± 0.051	2.499SerGlu: 2.499 ± 0.039	2.194SerPhe: 2.194 ± 0.045	5.599SerGly: 5.599 ± 0.127	1.008SerHis: 1.008 ± 0.034	2.733SerIle: 2.733 ± 0.057	1.542SerLys: 1.542 ± 0.036	5.053SerLeu: 5.053 ± 0.071	1.256SerMet: 1.256 ± 0.034	1.413SerAsn: 1.413 ± 0.049	2.715SerPro: 2.715 ± 0.055	1.511SerGln: 1.511 ± 0.038	3.307SerArg: 3.307 ± 0.058	2.846SerSer: 2.846 ± 0.095	2.75SerThr: 2.75 ± 0.102	4.0SerVal: 4.0 ± 0.085	0.808SerTrp: 0.808 ± 0.025	1.351SerTyr: 1.351 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.737ThrAla: 6.737 ± 0.11	0.403ThrCys: 0.403 ± 0.02	3.009ThrAsp: 3.009 ± 0.053	2.465ThrGlu: 2.465 ± 0.047	1.906ThrPhe: 1.906 ± 0.047	5.611ThrGly: 5.611 ± 0.141	1.04ThrHis: 1.04 ± 0.031	2.863ThrIle: 2.863 ± 0.07	1.53ThrLys: 1.53 ± 0.044	5.842ThrLeu: 5.842 ± 0.146	1.187ThrMet: 1.187 ± 0.029	1.514ThrAsn: 1.514 ± 0.048	3.672ThrPro: 3.672 ± 0.068	1.636ThrGln: 1.636 ± 0.046	3.458ThrArg: 3.458 ± 0.058	2.924ThrSer: 2.924 ± 0.1	3.059ThrThr: 3.059 ± 0.128	4.435ThrVal: 4.435 ± 0.089	0.611ThrTrp: 0.611 ± 0.026	1.202ThrTyr: 1.202 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.574ValAla: 9.574 ± 0.108	0.576ValCys: 0.576 ± 0.025	4.495ValAsp: 4.495 ± 0.066	4.423ValGlu: 4.423 ± 0.064	2.499ValPhe: 2.499 ± 0.05	5.76ValGly: 5.76 ± 0.096	1.397ValHis: 1.397 ± 0.035	3.927ValIle: 3.927 ± 0.061	2.253ValLys: 2.253 ± 0.05	6.629ValLeu: 6.629 ± 0.089	1.8ValMet: 1.8 ± 0.042	2.144ValAsn: 2.144 ± 0.056	3.849ValPro: 3.849 ± 0.06	2.098ValGln: 2.098 ± 0.044	5.145ValArg: 5.145 ± 0.078	4.282ValSer: 4.282 ± 0.088	4.831ValThr: 4.831 ± 0.104	5.474ValVal: 5.474 ± 0.078	1.001ValTrp: 1.001 ± 0.032	1.431ValTyr: 1.431 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.51TrpAla: 1.51 ± 0.039	0.137TrpCys: 0.137 ± 0.012	0.762TrpAsp: 0.762 ± 0.029	0.624TrpGlu: 0.624 ± 0.026	0.589TrpPhe: 0.589 ± 0.027	1.02TrpGly: 1.02 ± 0.031	0.339TrpHis: 0.339 ± 0.018	0.713TrpIle: 0.713 ± 0.027	0.515TrpLys: 0.515 ± 0.024	1.672TrpLeu: 1.672 ± 0.043	0.41TrpMet: 0.41 ± 0.019	0.412TrpAsn: 0.412 ± 0.017	0.712TrpPro: 0.712 ± 0.028	0.545TrpGln: 0.545 ± 0.026	1.268TrpArg: 1.268 ± 0.034	0.917TrpSer: 0.917 ± 0.033	0.889TrpThr: 0.889 ± 0.031	0.872TrpVal: 0.872 ± 0.027	0.243TrpTrp: 0.243 ± 0.015	0.293TrpTyr: 0.293 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.747TyrAla: 2.747 ± 0.053	0.226TyrCys: 0.226 ± 0.015	1.581TyrAsp: 1.581 ± 0.043	1.141TyrGlu: 1.141 ± 0.037	0.866TyrPhe: 0.866 ± 0.023	2.197TyrGly: 2.197 ± 0.058	0.492TyrHis: 0.492 ± 0.019	0.871TyrIle: 0.871 ± 0.03	0.651TyrLys: 0.651 ± 0.025	2.03TyrLeu: 2.03 ± 0.042	0.415TyrMet: 0.415 ± 0.023	0.636TyrAsn: 0.636 ± 0.026	0.987TyrPro: 0.987 ± 0.031	0.688TyrGln: 0.688 ± 0.025	1.761TyrArg: 1.761 ± 0.039	1.155TyrSer: 1.155 ± 0.034	1.045TyrThr: 1.045 ± 0.035	1.684TyrVal: 1.684 ± 0.037	0.366TyrTrp: 0.366 ± 0.02	0.607TyrTyr: 0.607 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3475 proteins (1112920 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---