Amino acid dipepetide frequency for Solobacterium moorei F0204

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.946AlaAla: 4.946 ± 0.129
1.13AlaCys: 1.13 ± 0.039
3.704AlaAsp: 3.704 ± 0.078
4.316AlaGlu: 4.316 ± 0.093
2.882AlaPhe: 2.882 ± 0.073
4.744AlaGly: 4.744 ± 0.097
1.202AlaHis: 1.202 ± 0.047
6.083AlaIle: 6.083 ± 0.129
5.397AlaLys: 5.397 ± 0.108
6.478AlaLeu: 6.478 ± 0.124
2.257AlaMet: 2.257 ± 0.065
3.122AlaAsn: 3.122 ± 0.08
1.514AlaPro: 1.514 ± 0.054
2.146AlaGln: 2.146 ± 0.057
2.543AlaArg: 2.543 ± 0.067
3.998AlaSer: 3.998 ± 0.074
3.55AlaThr: 3.55 ± 0.09
4.923AlaVal: 4.923 ± 0.106
0.58AlaTrp: 0.58 ± 0.03
2.946AlaTyr: 2.946 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.874CysAla: 0.874 ± 0.043
0.171CysCys: 0.171 ± 0.022
0.759CysAsp: 0.759 ± 0.038
0.701CysGlu: 0.701 ± 0.032
0.581CysPhe: 0.581 ± 0.032
1.086CysGly: 1.086 ± 0.046
0.33CysHis: 0.33 ± 0.026
1.106CysIle: 1.106 ± 0.045
0.844CysLys: 0.844 ± 0.037
0.991CysLeu: 0.991 ± 0.04
0.459CysMet: 0.459 ± 0.026
0.542CysAsn: 0.542 ± 0.03
0.456CysPro: 0.456 ± 0.031
0.302CysGln: 0.302 ± 0.021
0.492CysArg: 0.492 ± 0.029
0.725CysSer: 0.725 ± 0.039
0.676CysThr: 0.676 ± 0.035
0.839CysVal: 0.839 ± 0.039
0.091CysTrp: 0.091 ± 0.013
0.483CysTyr: 0.483 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.94AspAla: 3.94 ± 0.094
0.709AspCys: 0.709 ± 0.037
3.222AspAsp: 3.222 ± 0.09
5.012AspGlu: 5.012 ± 0.116
2.654AspPhe: 2.654 ± 0.059
4.089AspGly: 4.089 ± 0.102
1.076AspHis: 1.076 ± 0.043
5.0AspIle: 5.0 ± 0.094
3.847AspLys: 3.847 ± 0.095
4.808AspLeu: 4.808 ± 0.078
1.672AspMet: 1.672 ± 0.056
2.338AspAsn: 2.338 ± 0.065
1.801AspPro: 1.801 ± 0.058
1.573AspGln: 1.573 ± 0.046
2.071AspArg: 2.071 ± 0.063
2.786AspSer: 2.786 ± 0.08
3.246AspThr: 3.246 ± 0.083
4.03AspVal: 4.03 ± 0.095
0.599AspTrp: 0.599 ± 0.036
2.623AspTyr: 2.623 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
4.473GluAla: 4.473 ± 0.099
0.684GluCys: 0.684 ± 0.035
3.811GluAsp: 3.811 ± 0.092
5.949GluGlu: 5.949 ± 0.12
2.427GluPhe: 2.427 ± 0.065
3.753GluGly: 3.753 ± 0.085
1.391GluHis: 1.391 ± 0.05
5.742GluIle: 5.742 ± 0.106
6.367GluLys: 6.367 ± 0.124
6.227GluLeu: 6.227 ± 0.116
2.18GluMet: 2.18 ± 0.055
4.22GluAsn: 4.22 ± 0.085
1.623GluPro: 1.623 ± 0.052
2.417GluGln: 2.417 ± 0.073
2.81GluArg: 2.81 ± 0.073
3.222GluSer: 3.222 ± 0.087
3.619GluThr: 3.619 ± 0.073
4.59GluVal: 4.59 ± 0.114
0.585GluTrp: 0.585 ± 0.034
3.114GluTyr: 3.114 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
3.083PheAla: 3.083 ± 0.071
0.508PheCys: 0.508 ± 0.028
2.832PheAsp: 2.832 ± 0.075
2.717PheGlu: 2.717 ± 0.066
1.964PhePhe: 1.964 ± 0.071
3.003PheGly: 3.003 ± 0.068
0.919PheHis: 0.919 ± 0.042
3.514PheIle: 3.514 ± 0.09
2.368PheLys: 2.368 ± 0.069
3.761PheLeu: 3.761 ± 0.091
1.293PheMet: 1.293 ± 0.042
2.183PheAsn: 2.183 ± 0.063
1.269PhePro: 1.269 ± 0.045
1.333PheGln: 1.333 ± 0.054
1.538PheArg: 1.538 ± 0.053
2.967PheSer: 2.967 ± 0.068
2.691PheThr: 2.691 ± 0.071
3.046PheVal: 3.046 ± 0.095
0.441PheTrp: 0.441 ± 0.029
1.736PheTyr: 1.736 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
3.984GlyAla: 3.984 ± 0.104
0.945GlyCys: 0.945 ± 0.037
3.313GlyAsp: 3.313 ± 0.08
3.684GlyGlu: 3.684 ± 0.083
3.037GlyPhe: 3.037 ± 0.081
4.203GlyGly: 4.203 ± 0.105
1.218GlyHis: 1.218 ± 0.046
6.057GlyIle: 6.057 ± 0.114
5.193GlyLys: 5.193 ± 0.089
5.408GlyLeu: 5.408 ± 0.095
2.023GlyMet: 2.023 ± 0.063
3.018GlyAsn: 3.018 ± 0.077
1.148GlyPro: 1.148 ± 0.048
1.747GlyGln: 1.747 ± 0.054
2.299GlyArg: 2.299 ± 0.065
3.702GlySer: 3.702 ± 0.094
3.838GlyThr: 3.838 ± 0.087
4.332GlyVal: 4.332 ± 0.093
0.673GlyTrp: 0.673 ± 0.048
3.321GlyTyr: 3.321 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.605HisAla: 1.605 ± 0.059
0.291HisCys: 0.291 ± 0.023
1.205HisAsp: 1.205 ± 0.051
1.316HisGlu: 1.316 ± 0.053
0.945HisPhe: 0.945 ± 0.037
1.318HisGly: 1.318 ± 0.047
0.611HisHis: 0.611 ± 0.031
1.736HisIle: 1.736 ± 0.054
1.132HisLys: 1.132 ± 0.044
1.79HisLeu: 1.79 ± 0.047
0.554HisMet: 0.554 ± 0.031
0.903HisAsn: 0.903 ± 0.034
0.921HisPro: 0.921 ± 0.042
0.795HisGln: 0.795 ± 0.037
0.861HisArg: 0.861 ± 0.038
1.195HisSer: 1.195 ± 0.046
1.2HisThr: 1.2 ± 0.047
1.357HisVal: 1.357 ± 0.043
0.176HisTrp: 0.176 ± 0.02
0.941HisTyr: 0.941 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.153IleAla: 6.153 ± 0.113
1.197IleCys: 1.197 ± 0.046
5.044IleAsp: 5.044 ± 0.098
5.211IleGlu: 5.211 ± 0.105
3.387IlePhe: 3.387 ± 0.097
5.343IleGly: 5.343 ± 0.114
1.996IleHis: 1.996 ± 0.053
6.23IleIle: 6.23 ± 0.136
4.847IleLys: 4.847 ± 0.088
8.01IleLeu: 8.01 ± 0.135
2.03IleMet: 2.03 ± 0.052
3.756IleAsn: 3.756 ± 0.09
3.304IlePro: 3.304 ± 0.071
3.315IleGln: 3.315 ± 0.076
3.393IleArg: 3.393 ± 0.067
5.456IleSer: 5.456 ± 0.103
5.02IleThr: 5.02 ± 0.083
5.546IleVal: 5.546 ± 0.113
0.586IleTrp: 0.586 ± 0.034
3.266IleTyr: 3.266 ± 0.086
0.0IleXaa: 0.0 ± 0.0
Lys
4.549LysAla: 4.549 ± 0.092
0.621LysCys: 0.621 ± 0.031
4.726LysAsp: 4.726 ± 0.087
6.537LysGlu: 6.537 ± 0.124
2.296LysPhe: 2.296 ± 0.06
3.962LysGly: 3.962 ± 0.084
1.47LysHis: 1.47 ± 0.049
5.345LysIle: 5.345 ± 0.097
6.556LysLys: 6.556 ± 0.135
6.073LysLeu: 6.073 ± 0.103
2.51LysMet: 2.51 ± 0.06
4.1LysAsn: 4.1 ± 0.091
2.125LysPro: 2.125 ± 0.066
2.925LysGln: 2.925 ± 0.066
2.833LysArg: 2.833 ± 0.077
3.645LysSer: 3.645 ± 0.073
3.993LysThr: 3.993 ± 0.077
4.584LysVal: 4.584 ± 0.083
0.606LysTrp: 0.606 ± 0.032
3.258LysTyr: 3.258 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
6.481LeuAla: 6.481 ± 0.116
1.292LeuCys: 1.292 ± 0.044
5.007LeuAsp: 5.007 ± 0.079
5.882LeuGlu: 5.882 ± 0.101
4.241LeuPhe: 4.241 ± 0.097
5.443LeuGly: 5.443 ± 0.1
1.858LeuHis: 1.858 ± 0.059
6.746LeuIle: 6.746 ± 0.137
6.511LeuLys: 6.511 ± 0.109
8.434LeuLeu: 8.434 ± 0.156
2.711LeuMet: 2.711 ± 0.068
4.458LeuAsn: 4.458 ± 0.1
3.264LeuPro: 3.264 ± 0.078
3.46LeuGln: 3.46 ± 0.079
3.532LeuArg: 3.532 ± 0.082
6.537LeuSer: 6.537 ± 0.12
4.912LeuThr: 4.912 ± 0.092
5.693LeuVal: 5.693 ± 0.11
0.699LeuTrp: 0.699 ± 0.034
3.424LeuTyr: 3.424 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
1.966MetAla: 1.966 ± 0.061
0.296MetCys: 0.296 ± 0.021
1.72MetAsp: 1.72 ± 0.053
1.912MetGlu: 1.912 ± 0.059
1.071MetPhe: 1.071 ± 0.043
1.677MetGly: 1.677 ± 0.054
0.736MetHis: 0.736 ± 0.034
2.673MetIle: 2.673 ± 0.077
2.711MetLys: 2.711 ± 0.058
2.544MetLeu: 2.544 ± 0.059
1.03MetMet: 1.03 ± 0.045
1.901MetAsn: 1.901 ± 0.065
1.063MetPro: 1.063 ± 0.042
1.137MetGln: 1.137 ± 0.047
1.172MetArg: 1.172 ± 0.046
1.755MetSer: 1.755 ± 0.054
1.563MetThr: 1.563 ± 0.051
1.76MetVal: 1.76 ± 0.052
0.216MetTrp: 0.216 ± 0.019
1.032MetTyr: 1.032 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.612AsnAla: 3.612 ± 0.08
0.532AsnCys: 0.532 ± 0.033
2.742AsnAsp: 2.742 ± 0.069
3.353AsnGlu: 3.353 ± 0.072
1.865AsnPhe: 1.865 ± 0.055
3.562AsnGly: 3.562 ± 0.085
1.241AsnHis: 1.241 ± 0.054
4.056AsnIle: 4.056 ± 0.092
3.093AsnLys: 3.093 ± 0.078
4.305AsnLeu: 4.305 ± 0.082
1.403AsnMet: 1.403 ± 0.05
2.28AsnAsn: 2.28 ± 0.068
2.069AsnPro: 2.069 ± 0.061
2.206AsnGln: 2.206 ± 0.069
2.12AsnArg: 2.12 ± 0.064
2.523AsnSer: 2.523 ± 0.068
2.92AsnThr: 2.92 ± 0.071
3.233AsnVal: 3.233 ± 0.066
0.487AsnTrp: 0.487 ± 0.029
2.201AsnTyr: 2.201 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
1.886ProAla: 1.886 ± 0.058
0.363ProCys: 0.363 ± 0.024
1.744ProAsp: 1.744 ± 0.058
2.515ProGlu: 2.515 ± 0.079
1.646ProPhe: 1.646 ± 0.057
1.56ProGly: 1.56 ± 0.055
0.616ProHis: 0.616 ± 0.034
2.536ProIle: 2.536 ± 0.067
2.015ProLys: 2.015 ± 0.067
2.627ProLeu: 2.627 ± 0.062
0.79ProMet: 0.79 ± 0.04
1.651ProAsn: 1.651 ± 0.054
0.485ProPro: 0.485 ± 0.027
1.026ProGln: 1.026 ± 0.041
0.875ProArg: 0.875 ± 0.039
2.053ProSer: 2.053 ± 0.053
2.041ProThr: 2.041 ± 0.068
2.373ProVal: 2.373 ± 0.066
0.302ProTrp: 0.302 ± 0.021
1.398ProTyr: 1.398 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.51GlnAla: 2.51 ± 0.068
0.354GlnCys: 0.354 ± 0.023
1.824GlnAsp: 1.824 ± 0.053
2.587GlnGlu: 2.587 ± 0.075
1.408GlnPhe: 1.408 ± 0.049
1.942GlnGly: 1.942 ± 0.055
0.616GlnHis: 0.616 ± 0.031
2.859GlnIle: 2.859 ± 0.065
3.041GlnLys: 3.041 ± 0.078
3.124GlnLeu: 3.124 ± 0.086
1.164GlnMet: 1.164 ± 0.045
1.909GlnAsn: 1.909 ± 0.061
1.019GlnPro: 1.019 ± 0.048
1.347GlnGln: 1.347 ± 0.056
1.481GlnArg: 1.481 ± 0.053
1.847GlnSer: 1.847 ± 0.059
1.822GlnThr: 1.822 ± 0.052
2.0GlnVal: 2.0 ± 0.056
0.34GlnTrp: 0.34 ± 0.023
1.644GlnTyr: 1.644 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.276ArgAla: 2.276 ± 0.06
0.433ArgCys: 0.433 ± 0.029
1.96ArgAsp: 1.96 ± 0.059
2.765ArgGlu: 2.765 ± 0.083
1.801ArgPhe: 1.801 ± 0.054
1.956ArgGly: 1.956 ± 0.058
0.763ArgHis: 0.763 ± 0.033
3.553ArgIle: 3.553 ± 0.087
3.33ArgLys: 3.33 ± 0.085
3.449ArgLeu: 3.449 ± 0.077
1.333ArgMet: 1.333 ± 0.046
2.232ArgAsn: 2.232 ± 0.06
0.998ArgPro: 0.998 ± 0.045
1.396ArgGln: 1.396 ± 0.055
1.765ArgArg: 1.765 ± 0.064
2.053ArgSer: 2.053 ± 0.068
2.059ArgThr: 2.059 ± 0.065
2.343ArgVal: 2.343 ± 0.067
0.363ArgTrp: 0.363 ± 0.026
1.804ArgTyr: 1.804 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.032SerAla: 4.032 ± 0.081
0.699SerCys: 0.699 ± 0.034
3.315SerAsp: 3.315 ± 0.072
3.694SerGlu: 3.694 ± 0.087
2.949SerPhe: 2.949 ± 0.074
4.172SerGly: 4.172 ± 0.094
1.135SerHis: 1.135 ± 0.045
5.026SerIle: 5.026 ± 0.103
4.014SerLys: 4.014 ± 0.093
5.557SerLeu: 5.557 ± 0.113
1.723SerMet: 1.723 ± 0.051
2.84SerAsn: 2.84 ± 0.072
1.488SerPro: 1.488 ± 0.047
1.773SerGln: 1.773 ± 0.054
2.066SerArg: 2.066 ± 0.059
3.844SerSer: 3.844 ± 0.106
3.467SerThr: 3.467 ± 0.077
4.079SerVal: 4.079 ± 0.078
0.506SerTrp: 0.506 ± 0.028
2.667SerTyr: 2.667 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
4.061ThrAla: 4.061 ± 0.099
0.635ThrCys: 0.635 ± 0.03
3.067ThrAsp: 3.067 ± 0.079
3.369ThrGlu: 3.369 ± 0.068
2.481ThrPhe: 2.481 ± 0.065
3.864ThrGly: 3.864 ± 0.084
1.115ThrHis: 1.115 ± 0.047
4.855ThrIle: 4.855 ± 0.093
3.802ThrLys: 3.802 ± 0.077
5.366ThrLeu: 5.366 ± 0.105
1.589ThrMet: 1.589 ± 0.052
2.734ThrAsn: 2.734 ± 0.075
2.131ThrPro: 2.131 ± 0.082
1.605ThrGln: 1.605 ± 0.052
1.878ThrArg: 1.878 ± 0.05
3.416ThrSer: 3.416 ± 0.076
3.415ThrThr: 3.415 ± 0.086
4.625ThrVal: 4.625 ± 0.102
0.464ThrTrp: 0.464 ± 0.033
2.396ThrTyr: 2.396 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.618ValAla: 4.618 ± 0.113
0.923ValCys: 0.923 ± 0.04
3.971ValAsp: 3.971 ± 0.088
4.473ValGlu: 4.473 ± 0.095
2.951ValPhe: 2.951 ± 0.072
4.166ValGly: 4.166 ± 0.091
1.226ValHis: 1.226 ± 0.05
5.792ValIle: 5.792 ± 0.109
4.522ValLys: 4.522 ± 0.093
6.55ValLeu: 6.55 ± 0.123
1.824ValMet: 1.824 ± 0.053
3.173ValAsn: 3.173 ± 0.079
2.048ValPro: 2.048 ± 0.058
2.058ValGln: 2.058 ± 0.052
2.577ValArg: 2.577 ± 0.073
4.527ValSer: 4.527 ± 0.084
3.857ValThr: 3.857 ± 0.088
4.989ValVal: 4.989 ± 0.103
0.604ValTrp: 0.604 ± 0.034
2.659ValTyr: 2.659 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.457TrpAla: 0.457 ± 0.03
0.131TrpCys: 0.131 ± 0.016
0.467TrpAsp: 0.467 ± 0.026
0.464TrpGlu: 0.464 ± 0.031
0.447TrpPhe: 0.447 ± 0.029
0.547TrpGly: 0.547 ± 0.034
0.191TrpHis: 0.191 ± 0.015
0.825TrpIle: 0.825 ± 0.04
0.612TrpLys: 0.612 ± 0.034
0.977TrpLeu: 0.977 ± 0.043
0.266TrpMet: 0.266 ± 0.02
0.523TrpAsn: 0.523 ± 0.031
0.185TrpPro: 0.185 ± 0.018
0.415TrpGln: 0.415 ± 0.028
0.299TrpArg: 0.299 ± 0.023
0.433TrpSer: 0.433 ± 0.027
0.443TrpThr: 0.443 ± 0.028
0.572TrpVal: 0.572 ± 0.034
0.085TrpTrp: 0.085 ± 0.011
0.421TrpTyr: 0.421 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.951TyrAla: 2.951 ± 0.074
0.596TyrCys: 0.596 ± 0.029
2.663TyrAsp: 2.663 ± 0.068
2.748TyrGlu: 2.748 ± 0.069
2.133TyrPhe: 2.133 ± 0.06
2.758TyrGly: 2.758 ± 0.075
1.141TyrHis: 1.141 ± 0.049
3.354TyrIle: 3.354 ± 0.078
2.513TyrLys: 2.513 ± 0.063
4.107TyrLeu: 4.107 ± 0.094
1.123TyrMet: 1.123 ± 0.043
1.919TyrAsn: 1.919 ± 0.058
1.592TyrPro: 1.592 ± 0.059
1.863TyrGln: 1.863 ± 0.054
2.027TyrArg: 2.027 ± 0.063
2.363TyrSer: 2.363 ± 0.069
2.534TyrThr: 2.534 ± 0.074
2.592TyrVal: 2.592 ± 0.067
0.356TyrTrp: 0.356 ± 0.025
1.968TyrTyr: 1.968 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2034 proteins (612376 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski