Amino acid dipepetide frequency for Rickettsia endosymbiont of Culicoides newsteadi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.278AlaAla: 4.278 ± 0.154
0.784AlaCys: 0.784 ± 0.05
2.828AlaAsp: 2.828 ± 0.111
3.842AlaGlu: 3.842 ± 0.114
2.543AlaPhe: 2.543 ± 0.079
3.593AlaGly: 3.593 ± 0.157
0.861AlaHis: 0.861 ± 0.05
6.151AlaIle: 6.151 ± 0.142
5.71AlaLys: 5.71 ± 0.128
6.17AlaLeu: 6.17 ± 0.158
1.523AlaMet: 1.523 ± 0.059
3.479AlaAsn: 3.479 ± 0.115
1.673AlaPro: 1.673 ± 0.07
1.946AlaGln: 1.946 ± 0.082
2.784AlaArg: 2.784 ± 0.091
4.335AlaSer: 4.335 ± 0.122
3.435AlaThr: 3.435 ± 0.122
3.609AlaVal: 3.609 ± 0.113
0.402AlaTrp: 0.402 ± 0.033
2.039AlaTyr: 2.039 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.532CysAla: 0.532 ± 0.045
0.184CysCys: 0.184 ± 0.027
0.527CysAsp: 0.527 ± 0.035
0.483CysGlu: 0.483 ± 0.036
0.61CysPhe: 0.61 ± 0.043
0.809CysGly: 0.809 ± 0.046
0.317CysHis: 0.317 ± 0.027
0.867CysIle: 0.867 ± 0.05
0.848CysLys: 0.848 ± 0.057
1.139CysLeu: 1.139 ± 0.065
0.202CysMet: 0.202 ± 0.022
0.688CysAsn: 0.688 ± 0.044
0.413CysPro: 0.413 ± 0.034
0.496CysGln: 0.496 ± 0.037
0.454CysArg: 0.454 ± 0.033
1.004CysSer: 1.004 ± 0.048
0.537CysThr: 0.537 ± 0.036
0.534CysVal: 0.534 ± 0.041
0.114CysTrp: 0.114 ± 0.018
0.54CysTyr: 0.54 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.6AspAla: 2.6 ± 0.084
0.664AspCys: 0.664 ± 0.04
2.558AspAsp: 2.558 ± 0.091
3.017AspGlu: 3.017 ± 0.096
2.548AspPhe: 2.548 ± 0.082
2.727AspGly: 2.727 ± 0.093
1.014AspHis: 1.014 ± 0.056
5.461AspIle: 5.461 ± 0.119
4.748AspLys: 4.748 ± 0.119
5.326AspLeu: 5.326 ± 0.124
1.136AspMet: 1.136 ± 0.06
3.497AspAsn: 3.497 ± 0.088
1.515AspPro: 1.515 ± 0.068
1.925AspGln: 1.925 ± 0.073
1.795AspArg: 1.795 ± 0.067
3.487AspSer: 3.487 ± 0.109
2.369AspThr: 2.369 ± 0.081
2.89AspVal: 2.89 ± 0.083
0.506AspTrp: 0.506 ± 0.039
2.278AspTyr: 2.278 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
3.614GluAla: 3.614 ± 0.111
0.462GluCys: 0.462 ± 0.031
2.797GluAsp: 2.797 ± 0.084
4.535GluGlu: 4.535 ± 0.145
2.747GluPhe: 2.747 ± 0.083
2.841GluGly: 2.841 ± 0.106
1.11GluHis: 1.11 ± 0.056
5.819GluIle: 5.819 ± 0.138
5.101GluLys: 5.101 ± 0.138
6.585GluLeu: 6.585 ± 0.14
1.474GluMet: 1.474 ± 0.062
3.425GluAsn: 3.425 ± 0.092
1.289GluPro: 1.289 ± 0.062
3.282GluGln: 3.282 ± 0.141
2.177GluArg: 2.177 ± 0.086
3.248GluSer: 3.248 ± 0.094
2.548GluThr: 2.548 ± 0.088
3.598GluVal: 3.598 ± 0.11
0.441GluTrp: 0.441 ± 0.036
2.454GluTyr: 2.454 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
3.235PheAla: 3.235 ± 0.095
0.794PheCys: 0.794 ± 0.047
2.589PheAsp: 2.589 ± 0.083
2.322PheGlu: 2.322 ± 0.08
2.41PhePhe: 2.41 ± 0.126
2.997PheGly: 2.997 ± 0.1
0.75PheHis: 0.75 ± 0.045
4.361PheIle: 4.361 ± 0.123
2.942PheLys: 2.942 ± 0.088
4.481PheLeu: 4.481 ± 0.126
1.04PheMet: 1.04 ± 0.057
2.641PheAsn: 2.641 ± 0.095
1.328PhePro: 1.328 ± 0.067
1.059PheGln: 1.059 ± 0.06
1.424PheArg: 1.424 ± 0.057
3.777PheSer: 3.777 ± 0.113
2.579PheThr: 2.579 ± 0.084
2.698PheVal: 2.698 ± 0.091
0.457PheTrp: 0.457 ± 0.04
1.832PheTyr: 1.832 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
3.479GlyAla: 3.479 ± 0.167
0.672GlyCys: 0.672 ± 0.044
2.641GlyAsp: 2.641 ± 0.107
3.29GlyGlu: 3.29 ± 0.096
2.652GlyPhe: 2.652 ± 0.091
3.518GlyGly: 3.518 ± 0.144
1.056GlyHis: 1.056 ± 0.051
4.979GlyIle: 4.979 ± 0.114
4.828GlyLys: 4.828 ± 0.134
5.119GlyLeu: 5.119 ± 0.126
1.437GlyMet: 1.437 ± 0.064
2.947GlyAsn: 2.947 ± 0.155
0.867GlyPro: 0.867 ± 0.048
1.795GlyGln: 1.795 ± 0.082
2.265GlyArg: 2.265 ± 0.094
3.829GlySer: 3.829 ± 0.108
2.815GlyThr: 2.815 ± 0.12
3.627GlyVal: 3.627 ± 0.124
0.555GlyTrp: 0.555 ± 0.048
2.252GlyTyr: 2.252 ± 0.068
0.003GlyXaa: 0.003 ± 0.003
His
1.03HisAla: 1.03 ± 0.056
0.288HisCys: 0.288 ± 0.03
1.046HisAsp: 1.046 ± 0.054
0.822HisGlu: 0.822 ± 0.051
0.965HisPhe: 0.965 ± 0.046
1.014HisGly: 1.014 ± 0.049
0.488HisHis: 0.488 ± 0.035
1.728HisIle: 1.728 ± 0.071
1.375HisLys: 1.375 ± 0.063
1.925HisLeu: 1.925 ± 0.07
0.345HisMet: 0.345 ± 0.029
1.318HisAsn: 1.318 ± 0.061
0.794HisPro: 0.794 ± 0.049
0.822HisGln: 0.822 ± 0.045
0.7HisArg: 0.7 ± 0.042
1.315HisSer: 1.315 ± 0.065
0.817HisThr: 0.817 ± 0.048
0.905HisVal: 0.905 ± 0.049
0.14HisTrp: 0.14 ± 0.02
0.864HisTyr: 0.864 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
7.028IleAla: 7.028 ± 0.144
1.248IleCys: 1.248 ± 0.059
5.708IleAsp: 5.708 ± 0.125
5.902IleGlu: 5.902 ± 0.131
4.447IlePhe: 4.447 ± 0.122
5.438IleGly: 5.438 ± 0.139
1.461IleHis: 1.461 ± 0.058
9.963IleIle: 9.963 ± 0.216
7.687IleLys: 7.687 ± 0.171
9.153IleLeu: 9.153 ± 0.197
2.094IleMet: 2.094 ± 0.087
5.819IleAsn: 5.819 ± 0.137
3.023IlePro: 3.023 ± 0.09
2.773IleGln: 2.773 ± 0.087
3.168IleArg: 3.168 ± 0.092
7.428IleSer: 7.428 ± 0.156
5.433IleThr: 5.433 ± 0.128
5.728IleVal: 5.728 ± 0.13
0.737IleTrp: 0.737 ± 0.047
3.461IleTyr: 3.461 ± 0.096
0.0IleXaa: 0.0 ± 0.0
Lys
4.914LysAla: 4.914 ± 0.121
0.719LysCys: 0.719 ± 0.04
4.26LysAsp: 4.26 ± 0.112
5.407LysGlu: 5.407 ± 0.162
3.36LysPhe: 3.36 ± 0.102
3.544LysGly: 3.544 ± 0.096
1.611LysHis: 1.611 ± 0.077
8.427LysIle: 8.427 ± 0.145
6.426LysLys: 6.426 ± 0.164
8.437LysLeu: 8.437 ± 0.149
2.07LysMet: 2.07 ± 0.085
5.313LysAsn: 5.313 ± 0.131
2.343LysPro: 2.343 ± 0.104
3.285LysGln: 3.285 ± 0.093
2.644LysArg: 2.644 ± 0.082
5.082LysSer: 5.082 ± 0.117
3.897LysThr: 3.897 ± 0.12
4.416LysVal: 4.416 ± 0.121
0.527LysTrp: 0.527 ± 0.037
3.355LysTyr: 3.355 ± 0.114
0.0LysXaa: 0.0 ± 0.0
Leu
7.005LeuAla: 7.005 ± 0.168
1.131LeuCys: 1.131 ± 0.059
5.293LeuAsp: 5.293 ± 0.134
6.237LeuGlu: 6.237 ± 0.147
4.551LeuPhe: 4.551 ± 0.162
5.329LeuGly: 5.329 ± 0.122
1.876LeuHis: 1.876 ± 0.071
8.575LeuIle: 8.575 ± 0.185
7.661LeuLys: 7.661 ± 0.147
10.562LeuLeu: 10.562 ± 0.225
2.369LeuMet: 2.369 ± 0.075
5.326LeuAsn: 5.326 ± 0.125
4.115LeuPro: 4.115 ± 0.118
4.047LeuGln: 4.047 ± 0.1
3.51LeuArg: 3.51 ± 0.109
8.1LeuSer: 8.1 ± 0.159
5.503LeuThr: 5.503 ± 0.13
6.177LeuVal: 6.177 ± 0.136
0.828LeuTrp: 0.828 ± 0.051
3.235LeuTyr: 3.235 ± 0.11
0.003LeuXaa: 0.003 ± 0.002
Met
1.603MetAla: 1.603 ± 0.072
0.14MetCys: 0.14 ± 0.017
0.905MetAsp: 0.905 ± 0.051
1.033MetGlu: 1.033 ± 0.056
0.95MetPhe: 0.95 ± 0.046
1.1MetGly: 1.1 ± 0.053
0.537MetHis: 0.537 ± 0.035
2.179MetIle: 2.179 ± 0.073
1.57MetLys: 1.57 ± 0.061
2.685MetLeu: 2.685 ± 0.087
0.664MetMet: 0.664 ± 0.041
1.11MetAsn: 1.11 ± 0.052
0.955MetPro: 0.955 ± 0.049
1.251MetGln: 1.251 ± 0.065
0.916MetArg: 0.916 ± 0.049
1.694MetSer: 1.694 ± 0.07
1.372MetThr: 1.372 ± 0.061
1.531MetVal: 1.531 ± 0.059
0.158MetTrp: 0.158 ± 0.019
0.633MetTyr: 0.633 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
2.815AsnAla: 2.815 ± 0.11
0.695AsnCys: 0.695 ± 0.047
3.152AsnAsp: 3.152 ± 0.103
2.932AsnGlu: 2.932 ± 0.092
3.121AsnPhe: 3.121 ± 0.108
2.68AsnGly: 2.68 ± 0.104
1.222AsnHis: 1.222 ± 0.048
6.873AsnIle: 6.873 ± 0.156
5.132AsnLys: 5.132 ± 0.134
6.374AsnLeu: 6.374 ± 0.154
1.339AsnMet: 1.339 ± 0.065
4.784AsnAsn: 4.784 ± 0.133
2.226AsnPro: 2.226 ± 0.078
2.265AsnGln: 2.265 ± 0.078
1.961AsnArg: 1.961 ± 0.076
4.724AsnSer: 4.724 ± 0.135
2.62AsnThr: 2.62 ± 0.084
2.908AsnVal: 2.908 ± 0.098
0.542AsnTrp: 0.542 ± 0.037
2.644AsnTyr: 2.644 ± 0.088
0.0AsnXaa: 0.0 ± 0.0
Pro
1.733ProAla: 1.733 ± 0.067
0.329ProCys: 0.329 ± 0.031
1.78ProAsp: 1.78 ± 0.077
2.27ProGlu: 2.27 ± 0.081
1.326ProPhe: 1.326 ± 0.066
1.401ProGly: 1.401 ± 0.06
0.615ProHis: 0.615 ± 0.045
3.308ProIle: 3.308 ± 0.101
2.273ProLys: 2.273 ± 0.074
3.064ProLeu: 3.064 ± 0.111
0.623ProMet: 0.623 ± 0.042
2.029ProAsn: 2.029 ± 0.073
1.212ProPro: 1.212 ± 0.136
1.059ProGln: 1.059 ± 0.052
0.968ProArg: 0.968 ± 0.049
2.283ProSer: 2.283 ± 0.084
1.624ProThr: 1.624 ± 0.067
2.044ProVal: 2.044 ± 0.077
0.288ProTrp: 0.288 ± 0.029
1.188ProTyr: 1.188 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
2.387GlnAla: 2.387 ± 0.1
0.309GlnCys: 0.309 ± 0.024
2.133GlnAsp: 2.133 ± 0.09
3.082GlnGlu: 3.082 ± 0.107
1.531GlnPhe: 1.531 ± 0.062
1.881GlnGly: 1.881 ± 0.067
0.706GlnHis: 0.706 ± 0.041
3.658GlnIle: 3.658 ± 0.104
3.144GlnLys: 3.144 ± 0.101
3.803GlnLeu: 3.803 ± 0.119
0.877GlnMet: 0.877 ± 0.042
2.366GlnAsn: 2.366 ± 0.071
1.009GlnPro: 1.009 ± 0.059
2.322GlnGln: 2.322 ± 0.112
1.318GlnArg: 1.318 ± 0.069
2.421GlnSer: 2.421 ± 0.088
1.627GlnThr: 1.627 ± 0.072
2.169GlnVal: 2.169 ± 0.064
0.226GlnTrp: 0.226 ± 0.022
1.367GlnTyr: 1.367 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
2.273ArgAla: 2.273 ± 0.073
0.342ArgCys: 0.342 ± 0.03
1.808ArgAsp: 1.808 ± 0.077
2.216ArgGlu: 2.216 ± 0.077
1.681ArgPhe: 1.681 ± 0.071
2.104ArgGly: 2.104 ± 0.074
0.721ArgHis: 0.721 ± 0.046
3.469ArgIle: 3.469 ± 0.088
2.696ArgLys: 2.696 ± 0.08
3.63ArgLeu: 3.63 ± 0.113
0.856ArgMet: 0.856 ± 0.047
2.083ArgAsn: 2.083 ± 0.08
1.155ArgPro: 1.155 ± 0.055
1.606ArgGln: 1.606 ± 0.075
1.728ArgArg: 1.728 ± 0.074
2.283ArgSer: 2.283 ± 0.085
1.707ArgThr: 1.707 ± 0.064
2.135ArgVal: 2.135 ± 0.079
0.293ArgTrp: 0.293 ± 0.027
1.378ArgTyr: 1.378 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
3.648SerAla: 3.648 ± 0.097
0.918SerCys: 0.918 ± 0.05
3.866SerAsp: 3.866 ± 0.119
3.879SerGlu: 3.879 ± 0.097
3.562SerPhe: 3.562 ± 0.148
4.592SerGly: 4.592 ± 0.114
1.427SerHis: 1.427 ± 0.071
6.857SerIle: 6.857 ± 0.155
5.682SerLys: 5.682 ± 0.133
7.609SerLeu: 7.609 ± 0.154
1.645SerMet: 1.645 ± 0.078
4.569SerAsn: 4.569 ± 0.136
2.12SerPro: 2.12 ± 0.064
2.364SerGln: 2.364 ± 0.076
2.644SerArg: 2.644 ± 0.09
5.848SerSer: 5.848 ± 0.21
3.56SerThr: 3.56 ± 0.114
4.037SerVal: 4.037 ± 0.125
0.667SerTrp: 0.667 ± 0.042
2.771SerTyr: 2.771 ± 0.081
0.003SerXaa: 0.003 ± 0.003
Thr
3.144ThrAla: 3.144 ± 0.086
0.441ThrCys: 0.441 ± 0.032
2.436ThrAsp: 2.436 ± 0.086
2.973ThrGlu: 2.973 ± 0.104
2.031ThrPhe: 2.031 ± 0.081
2.997ThrGly: 2.997 ± 0.101
0.815ThrHis: 0.815 ± 0.047
5.498ThrIle: 5.498 ± 0.148
4.527ThrLys: 4.527 ± 0.111
4.974ThrLeu: 4.974 ± 0.109
1.007ThrMet: 1.007 ± 0.063
3.357ThrAsn: 3.357 ± 0.108
2.029ThrPro: 2.029 ± 0.075
1.523ThrGln: 1.523 ± 0.07
1.751ThrArg: 1.751 ± 0.068
3.749ThrSer: 3.749 ± 0.106
3.121ThrThr: 3.121 ± 0.146
2.859ThrVal: 2.859 ± 0.088
0.298ThrTrp: 0.298 ± 0.029
1.494ThrTyr: 1.494 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.167ValAla: 4.167 ± 0.123
0.615ValCys: 0.615 ± 0.043
3.3ValAsp: 3.3 ± 0.115
3.432ValGlu: 3.432 ± 0.095
2.252ValPhe: 2.252 ± 0.082
3.552ValGly: 3.552 ± 0.115
0.996ValHis: 0.996 ± 0.043
5.718ValIle: 5.718 ± 0.137
4.558ValLys: 4.558 ± 0.113
5.116ValLeu: 5.116 ± 0.108
1.378ValMet: 1.378 ± 0.061
3.355ValAsn: 3.355 ± 0.106
1.93ValPro: 1.93 ± 0.068
2.008ValGln: 2.008 ± 0.077
2.114ValArg: 2.114 ± 0.084
3.969ValSer: 3.969 ± 0.111
3.487ValThr: 3.487 ± 0.103
3.905ValVal: 3.905 ± 0.114
0.454ValTrp: 0.454 ± 0.037
1.795ValTyr: 1.795 ± 0.075
0.003ValXaa: 0.003 ± 0.003
Trp
0.392TrpAla: 0.392 ± 0.033
0.101TrpCys: 0.101 ± 0.016
0.392TrpAsp: 0.392 ± 0.029
0.319TrpGlu: 0.319 ± 0.033
0.488TrpPhe: 0.488 ± 0.034
0.454TrpGly: 0.454 ± 0.034
0.278TrpHis: 0.278 ± 0.027
0.628TrpIle: 0.628 ± 0.042
0.451TrpLys: 0.451 ± 0.035
0.999TrpLeu: 0.999 ± 0.052
0.163TrpMet: 0.163 ± 0.021
0.392TrpAsn: 0.392 ± 0.034
0.182TrpPro: 0.182 ± 0.026
0.713TrpGln: 0.713 ± 0.041
0.381TrpArg: 0.381 ± 0.034
0.669TrpSer: 0.669 ± 0.045
0.283TrpThr: 0.283 ± 0.025
0.428TrpVal: 0.428 ± 0.033
0.099TrpTrp: 0.099 ± 0.014
0.309TrpTyr: 0.309 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.109TyrAla: 2.109 ± 0.084
0.457TyrCys: 0.457 ± 0.037
2.044TyrAsp: 2.044 ± 0.081
1.554TyrGlu: 1.554 ± 0.074
1.943TyrPhe: 1.943 ± 0.071
2.055TyrGly: 2.055 ± 0.07
0.843TyrHis: 0.843 ± 0.044
3.181TyrIle: 3.181 ± 0.106
2.675TyrLys: 2.675 ± 0.087
4.276TyrLeu: 4.276 ± 0.114
0.739TyrMet: 0.739 ± 0.042
2.511TyrAsn: 2.511 ± 0.084
1.243TyrPro: 1.243 ± 0.065
1.795TyrGln: 1.795 ± 0.072
1.461TyrArg: 1.461 ± 0.062
3.017TyrSer: 3.017 ± 0.097
1.692TyrThr: 1.692 ± 0.067
1.904TyrVal: 1.904 ± 0.077
0.389TyrTrp: 0.389 ± 0.035
1.549TyrTyr: 1.549 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.003XaaCys: 0.003 ± 0.003
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.005XaaLeu: 0.005 ± 0.004
0.003XaaMet: 0.003 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.023XaaXaa: 0.023 ± 0.02
Statistics based on 1352 proteins (385443 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski