Amino acid dipepetide frequency for Alcanivorax sp. IO_7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.762AlaAla: 13.762 ± 0.238
1.473AlaCys: 1.473 ± 0.066
6.65AlaAsp: 6.65 ± 0.14
6.61AlaGlu: 6.61 ± 0.137
3.512AlaPhe: 3.512 ± 0.096
11.514AlaGly: 11.514 ± 0.209
2.07AlaHis: 2.07 ± 0.08
3.866AlaIle: 3.866 ± 0.11
2.431AlaLys: 2.431 ± 0.09
13.963AlaLeu: 13.963 ± 0.202
2.963AlaMet: 2.963 ± 0.091
2.541AlaAsn: 2.541 ± 0.101
6.184AlaPro: 6.184 ± 0.145
3.153AlaGln: 3.153 ± 0.096
9.879AlaArg: 9.879 ± 0.198
5.978AlaSer: 5.978 ± 0.143
6.154AlaThr: 6.154 ± 0.135
8.007AlaVal: 8.007 ± 0.147
2.117AlaTrp: 2.117 ± 0.076
2.193AlaTyr: 2.193 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
1.505CysAla: 1.505 ± 0.068
0.414CysCys: 0.414 ± 0.042
0.484CysAsp: 0.484 ± 0.03
0.391CysGlu: 0.391 ± 0.031
0.344CysPhe: 0.344 ± 0.028
1.026CysGly: 1.026 ± 0.048
0.371CysHis: 0.371 ± 0.028
0.314CysIle: 0.314 ± 0.029
0.188CysLys: 0.188 ± 0.024
0.948CysLeu: 0.948 ± 0.048
0.299CysMet: 0.299 ± 0.026
0.236CysAsn: 0.236 ± 0.024
0.913CysPro: 0.913 ± 0.054
0.379CysGln: 0.379 ± 0.031
1.116CysArg: 1.116 ± 0.054
0.838CysSer: 0.838 ± 0.045
0.522CysThr: 0.522 ± 0.037
0.632CysVal: 0.632 ± 0.043
0.447CysTrp: 0.447 ± 0.039
0.243CysTyr: 0.243 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
6.869AspAla: 6.869 ± 0.15
0.464AspCys: 0.464 ± 0.036
4.463AspAsp: 4.463 ± 0.152
3.51AspGlu: 3.51 ± 0.1
1.891AspPhe: 1.891 ± 0.071
6.522AspGly: 6.522 ± 0.158
1.347AspHis: 1.347 ± 0.067
2.393AspIle: 2.393 ± 0.075
1.59AspLys: 1.59 ± 0.074
6.625AspLeu: 6.625 ± 0.153
1.247AspMet: 1.247 ± 0.05
1.947AspAsn: 1.947 ± 0.085
3.276AspPro: 3.276 ± 0.101
2.862AspGln: 2.862 ± 0.099
4.641AspArg: 4.641 ± 0.119
2.697AspSer: 2.697 ± 0.086
3.336AspThr: 3.336 ± 0.093
3.818AspVal: 3.818 ± 0.104
1.021AspTrp: 1.021 ± 0.055
1.954AspTyr: 1.954 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
6.277GluAla: 6.277 ± 0.142
0.414GluCys: 0.414 ± 0.035
3.239GluAsp: 3.239 ± 0.092
3.532GluGlu: 3.532 ± 0.11
1.505GluPhe: 1.505 ± 0.07
4.357GluGly: 4.357 ± 0.119
1.513GluHis: 1.513 ± 0.06
2.313GluIle: 2.313 ± 0.082
1.904GluLys: 1.904 ± 0.084
5.536GluLeu: 5.536 ± 0.14
1.322GluMet: 1.322 ± 0.061
1.766GluAsn: 1.766 ± 0.066
2.797GluPro: 2.797 ± 0.109
3.033GluGln: 3.033 ± 0.087
5.409GluArg: 5.409 ± 0.132
2.561GluSer: 2.561 ± 0.085
2.872GluThr: 2.872 ± 0.095
3.718GluVal: 3.718 ± 0.103
0.642GluTrp: 0.642 ± 0.04
1.34GluTyr: 1.34 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.128PheAla: 3.128 ± 0.105
0.414PheCys: 0.414 ± 0.036
2.238PheAsp: 2.238 ± 0.073
1.909PheGlu: 1.909 ± 0.071
1.194PhePhe: 1.194 ± 0.063
2.94PheGly: 2.94 ± 0.095
0.798PheHis: 0.798 ± 0.045
1.317PheIle: 1.317 ± 0.058
0.818PheLys: 0.818 ± 0.046
2.993PheLeu: 2.993 ± 0.093
0.743PheMet: 0.743 ± 0.046
1.091PheAsn: 1.091 ± 0.052
1.342PhePro: 1.342 ± 0.056
1.299PheGln: 1.299 ± 0.06
2.223PheArg: 2.223 ± 0.078
2.024PheSer: 2.024 ± 0.069
1.806PheThr: 1.806 ± 0.065
2.065PheVal: 2.065 ± 0.074
0.542PheTrp: 0.542 ± 0.042
0.923PheTyr: 0.923 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
9.543GlyAla: 9.543 ± 0.17
1.172GlyCys: 1.172 ± 0.063
6.304GlyAsp: 6.304 ± 0.189
5.243GlyGlu: 5.243 ± 0.132
3.116GlyPhe: 3.116 ± 0.085
8.336GlyGly: 8.336 ± 0.216
2.157GlyHis: 2.157 ± 0.075
3.389GlyIle: 3.389 ± 0.108
2.501GlyLys: 2.501 ± 0.086
9.179GlyLeu: 9.179 ± 0.169
2.205GlyMet: 2.205 ± 0.084
2.453GlyAsn: 2.453 ± 0.09
3.816GlyPro: 3.816 ± 0.12
3.306GlyGln: 3.306 ± 0.095
7.099GlyArg: 7.099 ± 0.13
4.465GlySer: 4.465 ± 0.127
4.435GlyThr: 4.435 ± 0.138
5.725GlyVal: 5.725 ± 0.122
1.656GlyTrp: 1.656 ± 0.071
2.351GlyTyr: 2.351 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.932HisAla: 1.932 ± 0.066
0.276HisCys: 0.276 ± 0.026
1.279HisAsp: 1.279 ± 0.055
1.059HisGlu: 1.059 ± 0.056
0.85HisPhe: 0.85 ± 0.046
2.476HisGly: 2.476 ± 0.085
0.78HisHis: 0.78 ± 0.055
0.838HisIle: 0.838 ± 0.046
0.512HisLys: 0.512 ± 0.033
2.22HisLeu: 2.22 ± 0.086
0.419HisMet: 0.419 ± 0.031
0.462HisAsn: 0.462 ± 0.031
1.483HisPro: 1.483 ± 0.064
0.921HisGln: 0.921 ± 0.05
2.33HisArg: 2.33 ± 0.092
1.071HisSer: 1.071 ± 0.048
0.835HisThr: 0.835 ± 0.047
1.134HisVal: 1.134 ± 0.057
0.522HisTrp: 0.522 ± 0.039
0.75HisTyr: 0.75 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.139IleAla: 4.139 ± 0.109
0.396IleCys: 0.396 ± 0.033
2.815IleAsp: 2.815 ± 0.087
2.388IleGlu: 2.388 ± 0.08
1.064IlePhe: 1.064 ± 0.055
3.301IleGly: 3.301 ± 0.097
0.901IleHis: 0.901 ± 0.044
1.432IleIle: 1.432 ± 0.069
1.365IleLys: 1.365 ± 0.062
3.404IleLeu: 3.404 ± 0.105
0.745IleMet: 0.745 ± 0.04
1.442IleAsn: 1.442 ± 0.067
1.952IlePro: 1.952 ± 0.072
1.372IleGln: 1.372 ± 0.05
2.9IleArg: 2.9 ± 0.08
2.185IleSer: 2.185 ± 0.093
2.461IleThr: 2.461 ± 0.079
2.396IleVal: 2.396 ± 0.084
0.592IleTrp: 0.592 ± 0.038
0.848IleTyr: 0.848 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.211LysAla: 3.211 ± 0.105
0.188LysCys: 0.188 ± 0.023
1.465LysAsp: 1.465 ± 0.063
1.44LysGlu: 1.44 ± 0.068
0.625LysPhe: 0.625 ± 0.043
1.952LysGly: 1.952 ± 0.07
0.562LysHis: 0.562 ± 0.036
0.971LysIle: 0.971 ± 0.052
1.039LysLys: 1.039 ± 0.065
2.546LysLeu: 2.546 ± 0.085
0.562LysMet: 0.562 ± 0.04
0.798LysAsn: 0.798 ± 0.049
1.681LysPro: 1.681 ± 0.079
1.036LysGln: 1.036 ± 0.055
2.17LysArg: 2.17 ± 0.085
1.342LysSer: 1.342 ± 0.067
1.463LysThr: 1.463 ± 0.07
2.243LysVal: 2.243 ± 0.092
0.316LysTrp: 0.316 ± 0.027
0.492LysTyr: 0.492 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
13.847LeuAla: 13.847 ± 0.231
1.044LeuCys: 1.044 ± 0.056
7.531LeuAsp: 7.531 ± 0.156
6.236LeuGlu: 6.236 ± 0.144
3.557LeuPhe: 3.557 ± 0.101
8.331LeuGly: 8.331 ± 0.153
2.243LeuHis: 2.243 ± 0.087
4.38LeuIle: 4.38 ± 0.124
3.04LeuLys: 3.04 ± 0.096
10.87LeuLeu: 10.87 ± 0.207
2.433LeuMet: 2.433 ± 0.086
3.013LeuAsn: 3.013 ± 0.082
5.547LeuPro: 5.547 ± 0.138
2.764LeuGln: 2.764 ± 0.087
7.917LeuArg: 7.917 ± 0.174
6.071LeuSer: 6.071 ± 0.121
6.006LeuThr: 6.006 ± 0.149
7.624LeuVal: 7.624 ± 0.153
1.553LeuTrp: 1.553 ± 0.077
2.386LeuTyr: 2.386 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.918MetAla: 2.918 ± 0.082
0.178MetCys: 0.178 ± 0.02
1.355MetAsp: 1.355 ± 0.058
1.279MetGlu: 1.279 ± 0.047
0.544MetPhe: 0.544 ± 0.042
1.58MetGly: 1.58 ± 0.064
0.424MetHis: 0.424 ± 0.031
1.036MetIle: 1.036 ± 0.051
0.963MetLys: 0.963 ± 0.05
2.456MetLeu: 2.456 ± 0.083
0.579MetMet: 0.579 ± 0.038
0.813MetAsn: 0.813 ± 0.043
1.36MetPro: 1.36 ± 0.065
0.73MetGln: 0.73 ± 0.043
1.558MetArg: 1.558 ± 0.069
1.515MetSer: 1.515 ± 0.065
1.457MetThr: 1.457 ± 0.064
1.731MetVal: 1.731 ± 0.064
0.211MetTrp: 0.211 ± 0.023
0.354MetTyr: 0.354 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.862AsnAla: 2.862 ± 0.093
0.253AsnCys: 0.253 ± 0.024
1.703AsnAsp: 1.703 ± 0.071
1.309AsnGlu: 1.309 ± 0.055
0.778AsnPhe: 0.778 ± 0.045
2.802AsnGly: 2.802 ± 0.089
0.607AsnHis: 0.607 ± 0.039
1.124AsnIle: 1.124 ± 0.054
0.707AsnLys: 0.707 ± 0.047
2.807AsnLeu: 2.807 ± 0.088
0.527AsnMet: 0.527 ± 0.041
0.891AsnAsn: 0.891 ± 0.058
1.909AsnPro: 1.909 ± 0.066
1.179AsnGln: 1.179 ± 0.066
2.13AsnArg: 2.13 ± 0.071
1.257AsnSer: 1.257 ± 0.069
1.402AsnThr: 1.402 ± 0.068
1.718AsnVal: 1.718 ± 0.075
0.487AsnTrp: 0.487 ± 0.037
0.695AsnTyr: 0.695 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
7.548ProAla: 7.548 ± 0.165
0.825ProCys: 0.825 ± 0.052
3.939ProAsp: 3.939 ± 0.108
3.642ProGlu: 3.642 ± 0.106
1.606ProPhe: 1.606 ± 0.067
5.89ProGly: 5.89 ± 0.195
0.978ProHis: 0.978 ± 0.051
1.608ProIle: 1.608 ± 0.069
1.096ProLys: 1.096 ± 0.058
5.002ProLeu: 5.002 ± 0.117
1.385ProMet: 1.385 ± 0.059
1.124ProAsn: 1.124 ± 0.048
3.703ProPro: 3.703 ± 0.143
1.182ProGln: 1.182 ± 0.059
3.763ProArg: 3.763 ± 0.122
2.877ProSer: 2.877 ± 0.102
2.559ProThr: 2.559 ± 0.075
4.453ProVal: 4.453 ± 0.098
1.407ProTrp: 1.407 ± 0.065
1.086ProTyr: 1.086 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
4.694GlnAla: 4.694 ± 0.128
0.314GlnCys: 0.314 ± 0.027
1.884GlnAsp: 1.884 ± 0.075
1.743GlnGlu: 1.743 ± 0.063
0.996GlnPhe: 0.996 ± 0.048
3.409GlnGly: 3.409 ± 0.091
0.7GlnHis: 0.7 ± 0.047
1.299GlnIle: 1.299 ± 0.061
0.813GlnLys: 0.813 ± 0.048
3.239GlnLeu: 3.239 ± 0.101
0.813GlnMet: 0.813 ± 0.054
0.8GlnAsn: 0.8 ± 0.045
1.977GlnPro: 1.977 ± 0.063
1.563GlnGln: 1.563 ± 0.077
3.296GlnArg: 3.296 ± 0.091
1.706GlnSer: 1.706 ± 0.062
1.56GlnThr: 1.56 ± 0.07
2.832GlnVal: 2.832 ± 0.086
0.67GlnTrp: 0.67 ± 0.04
0.785GlnTyr: 0.785 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
8.8ArgAla: 8.8 ± 0.155
1.279ArgCys: 1.279 ± 0.059
4.859ArgAsp: 4.859 ± 0.133
4.616ArgGlu: 4.616 ± 0.125
3.106ArgPhe: 3.106 ± 0.1
5.296ArgGly: 5.296 ± 0.133
2.393ArgHis: 2.393 ± 0.086
3.141ArgIle: 3.141 ± 0.096
2.022ArgLys: 2.022 ± 0.077
9.628ArgLeu: 9.628 ± 0.178
2.017ArgMet: 2.017 ± 0.072
1.849ArgAsn: 1.849 ± 0.078
4.904ArgPro: 4.904 ± 0.159
3.484ArgGln: 3.484 ± 0.099
9.297ArgArg: 9.297 ± 0.253
3.713ArgSer: 3.713 ± 0.114
3.622ArgThr: 3.622 ± 0.096
5.609ArgVal: 5.609 ± 0.119
1.791ArgTrp: 1.791 ± 0.077
2.411ArgTyr: 2.411 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
5.765SerAla: 5.765 ± 0.14
0.647SerCys: 0.647 ± 0.038
2.98SerAsp: 2.98 ± 0.094
2.616SerGlu: 2.616 ± 0.088
1.515SerPhe: 1.515 ± 0.069
5.549SerGly: 5.549 ± 0.156
0.938SerHis: 0.938 ± 0.049
2.024SerIle: 2.024 ± 0.079
1.194SerLys: 1.194 ± 0.061
5.336SerLeu: 5.336 ± 0.121
1.292SerMet: 1.292 ± 0.054
1.43SerAsn: 1.43 ± 0.069
3.173SerPro: 3.173 ± 0.107
1.641SerGln: 1.641 ± 0.066
4.265SerArg: 4.265 ± 0.111
3.018SerSer: 3.018 ± 0.102
2.885SerThr: 2.885 ± 0.09
3.886SerVal: 3.886 ± 0.121
0.973SerTrp: 0.973 ± 0.051
1.244SerTyr: 1.244 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
6.154ThrAla: 6.154 ± 0.146
0.612ThrCys: 0.612 ± 0.042
2.835ThrAsp: 2.835 ± 0.102
2.667ThrGlu: 2.667 ± 0.082
1.706ThrPhe: 1.706 ± 0.075
5.258ThrGly: 5.258 ± 0.131
0.823ThrHis: 0.823 ± 0.043
1.912ThrIle: 1.912 ± 0.074
1.071ThrLys: 1.071 ± 0.056
6.984ThrLeu: 6.984 ± 0.142
0.993ThrMet: 0.993 ± 0.048
1.079ThrAsn: 1.079 ± 0.05
3.55ThrPro: 3.55 ± 0.104
1.247ThrGln: 1.247 ± 0.063
3.936ThrArg: 3.936 ± 0.107
2.647ThrSer: 2.647 ± 0.095
3.068ThrThr: 3.068 ± 0.132
4.493ThrVal: 4.493 ± 0.126
1.018ThrTrp: 1.018 ± 0.054
1.036ThrTyr: 1.036 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
8.404ValAla: 8.404 ± 0.135
0.655ValCys: 0.655 ± 0.042
4.355ValAsp: 4.355 ± 0.11
4.076ValGlu: 4.076 ± 0.12
2.406ValPhe: 2.406 ± 0.082
4.937ValGly: 4.937 ± 0.116
1.505ValHis: 1.505 ± 0.064
3.319ValIle: 3.319 ± 0.103
1.779ValLys: 1.779 ± 0.073
7.639ValLeu: 7.639 ± 0.144
1.58ValMet: 1.58 ± 0.067
2.25ValAsn: 2.25 ± 0.08
3.56ValPro: 3.56 ± 0.108
1.929ValGln: 1.929 ± 0.069
5.065ValArg: 5.065 ± 0.1
4.247ValSer: 4.247 ± 0.095
4.435ValThr: 4.435 ± 0.127
5.474ValVal: 5.474 ± 0.121
0.931ValTrp: 0.931 ± 0.055
1.563ValTyr: 1.563 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.553TrpAla: 1.553 ± 0.064
0.359TrpCys: 0.359 ± 0.031
0.63TrpAsp: 0.63 ± 0.043
0.597TrpGlu: 0.597 ± 0.041
0.532TrpPhe: 0.532 ± 0.04
0.938TrpGly: 0.938 ± 0.045
0.447TrpHis: 0.447 ± 0.034
0.662TrpIle: 0.662 ± 0.045
0.532TrpLys: 0.532 ± 0.039
2.258TrpLeu: 2.258 ± 0.084
0.467TrpMet: 0.467 ± 0.031
0.474TrpAsn: 0.474 ± 0.037
1.352TrpPro: 1.352 ± 0.063
0.665TrpGln: 0.665 ± 0.04
2.383TrpArg: 2.383 ± 0.084
0.923TrpSer: 0.923 ± 0.045
1.079TrpThr: 1.079 ± 0.049
0.996TrpVal: 0.996 ± 0.057
0.492TrpTrp: 0.492 ± 0.035
0.426TrpTyr: 0.426 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.11TyrAla: 2.11 ± 0.07
0.233TyrCys: 0.233 ± 0.024
1.468TyrAsp: 1.468 ± 0.084
1.184TyrGlu: 1.184 ± 0.05
0.961TyrPhe: 0.961 ± 0.047
2.034TyrGly: 2.034 ± 0.073
0.592TyrHis: 0.592 ± 0.033
0.76TyrIle: 0.76 ± 0.042
0.534TyrLys: 0.534 ± 0.039
2.759TyrLeu: 2.759 ± 0.081
0.449TyrMet: 0.449 ± 0.034
0.69TyrAsn: 0.69 ± 0.045
1.197TyrPro: 1.197 ± 0.057
1.347TyrGln: 1.347 ± 0.058
2.463TyrArg: 2.463 ± 0.09
1.237TyrSer: 1.237 ± 0.065
1.129TyrThr: 1.129 ± 0.062
1.555TyrVal: 1.555 ± 0.067
0.376TyrTrp: 0.376 ± 0.034
0.647TyrTyr: 0.647 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2056 proteins (398629 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski