Amino acid dipepetide frequency for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.458AlaAla: 6.458 ± 0.029	1.371AlaCys: 1.371 ± 0.009	2.816AlaAsp: 2.816 ± 0.011	4.569AlaGlu: 4.569 ± 0.018	2.6AlaPhe: 2.6 ± 0.014	4.651AlaGly: 4.651 ± 0.019	1.549AlaHis: 1.549 ± 0.008	2.763AlaIle: 2.763 ± 0.011	3.401AlaLys: 3.401 ± 0.016	6.88AlaLeu: 6.88 ± 0.022	1.466AlaMet: 1.466 ± 0.009	2.038AlaAsn: 2.038 ± 0.01	3.996AlaPro: 3.996 ± 0.02	3.182AlaGln: 3.182 ± 0.014	3.566AlaArg: 3.566 ± 0.015	5.731AlaSer: 5.731 ± 0.02	3.549AlaThr: 3.549 ± 0.016	4.564AlaVal: 4.564 ± 0.013	0.834AlaTrp: 0.834 ± 0.006	1.481AlaTyr: 1.481 ± 0.008	0.0AlaXaa: 0.0 ± 0.0
Cys	1.245CysAla: 1.245 ± 0.009	0.687CysCys: 0.687 ± 0.007	1.017CysAsp: 1.017 ± 0.01	1.307CysGlu: 1.307 ± 0.009	0.849CysPhe: 0.849 ± 0.006	1.8CysGly: 1.8 ± 0.017	0.693CysHis: 0.693 ± 0.006	1.003CysIle: 1.003 ± 0.008	1.21CysLys: 1.21 ± 0.01	2.259CysLeu: 2.259 ± 0.012	0.422CysMet: 0.422 ± 0.004	0.862CysAsn: 0.862 ± 0.009	1.399CysPro: 1.399 ± 0.011	1.072CysGln: 1.072 ± 0.009	1.291CysArg: 1.291 ± 0.008	2.057CysSer: 2.057 ± 0.013	1.095CysThr: 1.095 ± 0.01	1.292CysVal: 1.292 ± 0.009	0.331CysTrp: 0.331 ± 0.004	0.595CysTyr: 0.595 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	2.751AspAla: 2.751 ± 0.011	1.06AspCys: 1.06 ± 0.009	2.612AspAsp: 2.612 ± 0.013	3.418AspGlu: 3.418 ± 0.014	2.109AspPhe: 2.109 ± 0.01	3.2AspGly: 3.2 ± 0.015	1.133AspHis: 1.133 ± 0.007	2.623AspIle: 2.623 ± 0.011	2.576AspLys: 2.576 ± 0.013	4.998AspLeu: 4.998 ± 0.018	1.088AspMet: 1.088 ± 0.006	1.694AspAsn: 1.694 ± 0.01	2.838AspPro: 2.838 ± 0.011	1.831AspGln: 1.831 ± 0.009	2.36AspArg: 2.36 ± 0.013	4.204AspSer: 4.204 ± 0.016	2.467AspThr: 2.467 ± 0.011	3.014AspVal: 3.014 ± 0.013	0.613AspTrp: 0.613 ± 0.005	1.499AspTyr: 1.499 ± 0.008	0.0AspXaa: 0.0 ± 0.0
Glu	5.037GluAla: 5.037 ± 0.02	1.57GluCys: 1.57 ± 0.018	4.429GluAsp: 4.429 ± 0.015	7.913GluGlu: 7.913 ± 0.031	2.061GluPhe: 2.061 ± 0.01	4.08GluGly: 4.08 ± 0.016	1.524GluHis: 1.524 ± 0.008	3.213GluIle: 3.213 ± 0.015	5.68GluLys: 5.68 ± 0.03	6.422GluLeu: 6.422 ± 0.025	1.719GluMet: 1.719 ± 0.01	3.318GluAsn: 3.318 ± 0.014	3.146GluPro: 3.146 ± 0.014	3.164GluGln: 3.164 ± 0.016	3.929GluArg: 3.929 ± 0.017	4.507GluSer: 4.507 ± 0.019	3.508GluThr: 3.508 ± 0.014	4.132GluVal: 4.132 ± 0.013	0.712GluTrp: 0.712 ± 0.005	1.584GluTyr: 1.584 ± 0.009	0.0GluXaa: 0.0 ± 0.0
Phe	1.922PheAla: 1.922 ± 0.01	0.965PheCys: 0.965 ± 0.007	1.649PheAsp: 1.649 ± 0.009	2.033PheGlu: 2.033 ± 0.01	1.707PhePhe: 1.707 ± 0.011	2.158PheGly: 2.158 ± 0.012	1.085PheHis: 1.085 ± 0.006	1.827PheIle: 1.827 ± 0.01	1.856PheLys: 1.856 ± 0.01	4.115PheLeu: 4.115 ± 0.017	0.772PheMet: 0.772 ± 0.005	1.366PheAsn: 1.366 ± 0.007	2.003PhePro: 2.003 ± 0.01	1.804PheGln: 1.804 ± 0.008	1.949PheArg: 1.949 ± 0.01	3.518PheSer: 3.518 ± 0.015	2.062PheThr: 2.062 ± 0.012	2.116PheVal: 2.116 ± 0.01	0.495PheTrp: 0.495 ± 0.005	1.169PheTyr: 1.169 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	4.321GlyAla: 4.321 ± 0.019	1.271GlyCys: 1.271 ± 0.009	3.074GlyAsp: 3.074 ± 0.015	4.151GlyGlu: 4.151 ± 0.021	2.427GlyPhe: 2.427 ± 0.013	4.735GlyGly: 4.735 ± 0.026	1.678GlyHis: 1.678 ± 0.011	2.833GlyIle: 2.833 ± 0.013	3.898GlyLys: 3.898 ± 0.019	5.773GlyLeu: 5.773 ± 0.027	1.323GlyMet: 1.323 ± 0.008	2.371GlyAsn: 2.371 ± 0.011	4.012GlyPro: 4.012 ± 0.036	2.766GlyGln: 2.766 ± 0.015	3.758GlyArg: 3.758 ± 0.016	5.714GlySer: 5.714 ± 0.025	3.542GlyThr: 3.542 ± 0.015	3.531GlyVal: 3.531 ± 0.015	0.83GlyTrp: 0.83 ± 0.006	1.657GlyTyr: 1.657 ± 0.011	0.0GlyXaa: 0.0 ± 0.0
His	1.34HisAla: 1.34 ± 0.007	0.79HisCys: 0.79 ± 0.007	0.896HisAsp: 0.896 ± 0.006	1.357HisGlu: 1.357 ± 0.008	1.084HisPhe: 1.084 ± 0.006	1.541HisGly: 1.541 ± 0.013	0.981HisHis: 0.981 ± 0.008	1.286HisIle: 1.286 ± 0.007	1.33HisLys: 1.33 ± 0.01	2.968HisLeu: 2.968 ± 0.012	0.589HisMet: 0.589 ± 0.005	0.914HisAsn: 0.914 ± 0.007	1.691HisPro: 1.691 ± 0.011	1.399HisGln: 1.399 ± 0.01	1.59HisArg: 1.59 ± 0.009	2.379HisSer: 2.379 ± 0.013	1.668HisThr: 1.668 ± 0.016	1.537HisVal: 1.537 ± 0.007	0.351HisTrp: 0.351 ± 0.004	0.792HisTyr: 0.792 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	2.578IleAla: 2.578 ± 0.011	1.116IleCys: 1.116 ± 0.008	2.021IleAsp: 2.021 ± 0.009	2.636IleGlu: 2.636 ± 0.013	1.941IlePhe: 1.941 ± 0.011	2.213IleGly: 2.213 ± 0.011	1.501IleHis: 1.501 ± 0.012	2.429IleIle: 2.429 ± 0.013	2.71IleLys: 2.71 ± 0.012	4.654IleLeu: 4.654 ± 0.018	1.001IleMet: 1.001 ± 0.007	1.92IleAsn: 1.92 ± 0.009	2.645IlePro: 2.645 ± 0.013	2.36IleGln: 2.36 ± 0.012	2.358IleArg: 2.358 ± 0.01	3.806IleSer: 3.806 ± 0.015	2.625IleThr: 2.625 ± 0.013	2.477IleVal: 2.477 ± 0.011	0.519IleTrp: 0.519 ± 0.004	1.388IleTyr: 1.388 ± 0.008	0.0IleXaa: 0.0 ± 0.0
Lys	4.048LysAla: 4.048 ± 0.017	1.256LysCys: 1.256 ± 0.014	3.208LysAsp: 3.208 ± 0.014	5.318LysGlu: 5.318 ± 0.024	1.76LysPhe: 1.76 ± 0.009	3.226LysGly: 3.226 ± 0.02	1.475LysHis: 1.475 ± 0.009	2.934LysIle: 2.934 ± 0.012	4.814LysLys: 4.814 ± 0.023	5.299LysLeu: 5.299 ± 0.02	1.475LysMet: 1.475 ± 0.009	2.534LysAsn: 2.534 ± 0.013	3.261LysPro: 3.261 ± 0.019	2.727LysGln: 2.727 ± 0.014	3.329LysArg: 3.329 ± 0.016	4.049LysSer: 4.049 ± 0.021	3.232LysThr: 3.232 ± 0.014	3.468LysVal: 3.468 ± 0.013	0.621LysTrp: 0.621 ± 0.006	1.558LysTyr: 1.558 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	6.549LeuAla: 6.549 ± 0.024	2.213LeuCys: 2.213 ± 0.012	4.599LeuAsp: 4.599 ± 0.014	7.198LeuGlu: 7.198 ± 0.026	3.384LeuPhe: 3.384 ± 0.015	5.783LeuGly: 5.783 ± 0.019	2.764LeuHis: 2.764 ± 0.013	3.961LeuIle: 3.961 ± 0.015	5.971LeuLys: 5.971 ± 0.022	10.624LeuLeu: 10.624 ± 0.04	2.011LeuMet: 2.011 ± 0.009	3.564LeuAsn: 3.564 ± 0.013	6.06LeuPro: 6.06 ± 0.022	5.782LeuGln: 5.782 ± 0.022	5.772LeuArg: 5.772 ± 0.019	8.016LeuSer: 8.016 ± 0.023	5.15LeuThr: 5.15 ± 0.016	5.404LeuVal: 5.404 ± 0.017	1.154LeuTrp: 1.154 ± 0.008	2.505LeuTyr: 2.505 ± 0.012	0.0LeuXaa: 0.0 ± 0.0
Met	1.861MetAla: 1.861 ± 0.008	0.413MetCys: 0.413 ± 0.004	1.257MetAsp: 1.257 ± 0.008	1.909MetGlu: 1.909 ± 0.01	0.725MetPhe: 0.725 ± 0.006	1.27MetGly: 1.27 ± 0.007	0.483MetHis: 0.483 ± 0.004	0.861MetIle: 0.861 ± 0.006	1.494MetLys: 1.494 ± 0.008	1.955MetLeu: 1.955 ± 0.01	0.567MetMet: 0.567 ± 0.005	0.917MetAsn: 0.917 ± 0.007	1.086MetPro: 1.086 ± 0.007	0.929MetGln: 0.929 ± 0.007	1.028MetArg: 1.028 ± 0.007	1.562MetSer: 1.562 ± 0.008	1.125MetThr: 1.125 ± 0.006	1.376MetVal: 1.376 ± 0.007	0.249MetTrp: 0.249 ± 0.003	0.554MetTyr: 0.554 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.052AsnAla: 2.052 ± 0.011	0.839AsnCys: 0.839 ± 0.007	1.559AsnAsp: 1.559 ± 0.011	2.344AsnGlu: 2.344 ± 0.013	1.515AsnPhe: 1.515 ± 0.008	2.44AsnGly: 2.44 ± 0.013	0.971AsnHis: 0.971 ± 0.006	2.193AsnIle: 2.193 ± 0.01	2.307AsnLys: 2.307 ± 0.011	3.837AsnLeu: 3.837 ± 0.013	0.923AsnMet: 0.923 ± 0.006	1.587AsnAsn: 1.587 ± 0.009	2.191AsnPro: 2.191 ± 0.01	1.721AsnGln: 1.721 ± 0.009	1.862AsnArg: 1.862 ± 0.009	3.3AsnSer: 3.3 ± 0.015	2.014AsnThr: 2.014 ± 0.009	2.236AsnVal: 2.236 ± 0.011	0.464AsnTrp: 0.464 ± 0.004	1.143AsnTyr: 1.143 ± 0.007	0.0AsnXaa: 0.0 ± 0.0
Pro	4.726ProAla: 4.726 ± 0.023	1.186ProCys: 1.186 ± 0.01	2.717ProAsp: 2.717 ± 0.012	4.326ProGlu: 4.326 ± 0.018	1.93ProPhe: 1.93 ± 0.011	5.131ProGly: 5.131 ± 0.054	1.435ProHis: 1.435 ± 0.008	1.945ProIle: 1.945 ± 0.01	2.807ProLys: 2.807 ± 0.015	5.181ProLeu: 5.181 ± 0.018	1.017ProMet: 1.017 ± 0.007	1.825ProAsn: 1.825 ± 0.011	5.781ProPro: 5.781 ± 0.038	2.833ProGln: 2.833 ± 0.015	3.38ProArg: 3.38 ± 0.015	5.701ProSer: 5.701 ± 0.024	3.093ProThr: 3.093 ± 0.014	3.78ProVal: 3.78 ± 0.016	0.72ProTrp: 0.72 ± 0.006	1.578ProTyr: 1.578 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.487GlnAla: 3.487 ± 0.016	0.97GlnCys: 0.97 ± 0.009	2.328GlnAsp: 2.328 ± 0.009	3.972GlnGlu: 3.972 ± 0.019	1.391GlnPhe: 1.391 ± 0.007	2.833GlnGly: 2.833 ± 0.015	1.327GlnHis: 1.327 ± 0.009	2.031GlnIle: 2.031 ± 0.011	3.089GlnLys: 3.089 ± 0.015	4.732GlnLeu: 4.732 ± 0.018	1.117GlnMet: 1.117 ± 0.008	1.918GlnAsn: 1.918 ± 0.009	2.819GlnPro: 2.819 ± 0.02	3.073GlnGln: 3.073 ± 0.028	2.967GlnArg: 2.967 ± 0.013	3.249GlnSer: 3.249 ± 0.015	2.344GlnThr: 2.344 ± 0.011	2.83GlnVal: 2.83 ± 0.012	0.573GlnTrp: 0.573 ± 0.005	1.13GlnTyr: 1.13 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.747ArgAla: 3.747 ± 0.016	1.216ArgCys: 1.216 ± 0.011	2.693ArgAsp: 2.693 ± 0.012	3.925ArgGlu: 3.925 ± 0.017	1.823ArgPhe: 1.823 ± 0.009	3.607ArgGly: 3.607 ± 0.017	1.58ArgHis: 1.58 ± 0.011	2.475ArgIle: 2.475 ± 0.01	3.699ArgLys: 3.699 ± 0.015	5.311ArgLeu: 5.311 ± 0.017	1.188ArgMet: 1.188 ± 0.007	2.155ArgAsn: 2.155 ± 0.01	3.252ArgPro: 3.252 ± 0.016	2.592ArgGln: 2.592 ± 0.013	4.298ArgArg: 4.298 ± 0.018	4.235ArgSer: 4.235 ± 0.018	2.834ArgThr: 2.834 ± 0.01	3.091ArgVal: 3.091 ± 0.012	0.728ArgTrp: 0.728 ± 0.007	1.388ArgTyr: 1.388 ± 0.007	0.0ArgXaa: 0.0 ± 0.0
Ser	5.342SerAla: 5.342 ± 0.018	1.871SerCys: 1.871 ± 0.011	3.927SerAsp: 3.927 ± 0.015	5.312SerGlu: 5.312 ± 0.02	3.125SerPhe: 3.125 ± 0.013	5.605SerGly: 5.605 ± 0.026	2.231SerHis: 2.231 ± 0.012	3.247SerIle: 3.247 ± 0.012	4.197SerLys: 4.197 ± 0.02	8.312SerLeu: 8.312 ± 0.024	1.606SerMet: 1.606 ± 0.008	2.806SerAsn: 2.806 ± 0.013	5.961SerPro: 5.961 ± 0.029	4.023SerGln: 4.023 ± 0.015	4.587SerArg: 4.587 ± 0.019	9.587SerSer: 9.587 ± 0.043	4.553SerThr: 4.553 ± 0.027	4.888SerVal: 4.888 ± 0.013	1.116SerTrp: 1.116 ± 0.007	2.057SerTyr: 2.057 ± 0.01	0.0SerXaa: 0.0 ± 0.0
Thr	3.727ThrAla: 3.727 ± 0.014	1.298ThrCys: 1.298 ± 0.011	2.466ThrAsp: 2.466 ± 0.012	3.61ThrGlu: 3.61 ± 0.016	2.097ThrPhe: 2.097 ± 0.009	3.712ThrGly: 3.712 ± 0.017	1.381ThrHis: 1.381 ± 0.01	2.409ThrIle: 2.409 ± 0.012	2.729ThrLys: 2.729 ± 0.013	5.276ThrLeu: 5.276 ± 0.015	1.125ThrMet: 1.125 ± 0.007	1.773ThrAsn: 1.773 ± 0.009	3.524ThrPro: 3.524 ± 0.022	2.361ThrGln: 2.361 ± 0.011	2.519ThrArg: 2.519 ± 0.01	4.796ThrSer: 4.796 ± 0.023	3.057ThrThr: 3.057 ± 0.023	3.788ThrVal: 3.788 ± 0.016	0.711ThrTrp: 0.711 ± 0.006	1.392ThrTyr: 1.392 ± 0.009	0.0ThrXaa: 0.0 ± 0.0
Val	4.129ValAla: 4.129 ± 0.015	1.446ValCys: 1.446 ± 0.01	2.89ValAsp: 2.89 ± 0.012	3.812ValGlu: 3.812 ± 0.013	2.397ValPhe: 2.397 ± 0.013	3.33ValGly: 3.33 ± 0.013	1.619ValHis: 1.619 ± 0.009	2.918ValIle: 2.918 ± 0.013	3.421ValLys: 3.421 ± 0.014	6.028ValLeu: 6.028 ± 0.022	1.309ValMet: 1.309 ± 0.008	2.272ValAsn: 2.272 ± 0.011	3.585ValPro: 3.585 ± 0.015	2.763ValGln: 2.763 ± 0.012	2.929ValArg: 2.929 ± 0.01	4.878ValSer: 4.878 ± 0.015	3.718ValThr: 3.718 ± 0.016	3.818ValVal: 3.818 ± 0.016	0.71ValTrp: 0.71 ± 0.006	1.583ValTyr: 1.583 ± 0.009	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.007	0.268TrpCys: 0.268 ± 0.004	0.68TrpAsp: 0.68 ± 0.006	0.826TrpGlu: 0.826 ± 0.006	0.439TrpPhe: 0.439 ± 0.004	0.757TrpGly: 0.757 ± 0.007	0.323TrpHis: 0.323 ± 0.004	0.559TrpIle: 0.559 ± 0.006	0.829TrpLys: 0.829 ± 0.006	1.22TrpLeu: 1.22 ± 0.008	0.32TrpMet: 0.32 ± 0.004	0.56TrpAsn: 0.56 ± 0.005	0.577TrpPro: 0.577 ± 0.005	0.539TrpGln: 0.539 ± 0.005	0.773TrpArg: 0.773 ± 0.005	0.914TrpSer: 0.914 ± 0.007	0.682TrpThr: 0.682 ± 0.006	0.683TrpVal: 0.683 ± 0.006	0.209TrpTrp: 0.209 ± 0.003	0.342TrpTyr: 0.342 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.341TyrAla: 1.341 ± 0.008	0.679TyrCys: 0.679 ± 0.005	1.249TyrAsp: 1.249 ± 0.008	1.712TyrGlu: 1.712 ± 0.01	1.206TyrPhe: 1.206 ± 0.007	1.594TyrGly: 1.594 ± 0.01	0.751TyrHis: 0.751 ± 0.006	1.387TyrIle: 1.387 ± 0.009	1.574TyrLys: 1.574 ± 0.014	2.618TyrLeu: 2.618 ± 0.012	0.585TyrMet: 0.585 ± 0.005	1.102TyrAsn: 1.102 ± 0.007	1.264TyrPro: 1.264 ± 0.008	1.26TyrGln: 1.26 ± 0.007	1.594TyrArg: 1.594 ± 0.01	2.153TyrSer: 2.153 ± 0.01	1.433TyrThr: 1.433 ± 0.01	1.531TyrVal: 1.531 ± 0.01	0.36TyrTrp: 0.36 ± 0.006	0.937TyrTyr: 0.937 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.107XaaXaa: 0.107 ± 0.031

Statistics based on 50125 proteins (27273972 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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