Amino acid dipepetide frequency for Vagococcus fessus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.922AlaAla: 4.922 ± 0.123
0.567AlaCys: 0.567 ± 0.033
3.437AlaAsp: 3.437 ± 0.07
4.562AlaGlu: 4.562 ± 0.114
2.844AlaPhe: 2.844 ± 0.067
4.667AlaGly: 4.667 ± 0.098
1.101AlaHis: 1.101 ± 0.046
5.725AlaIle: 5.725 ± 0.127
5.02AlaLys: 5.02 ± 0.1
6.979AlaLeu: 6.979 ± 0.13
1.956AlaMet: 1.956 ± 0.064
2.807AlaAsn: 2.807 ± 0.061
2.082AlaPro: 2.082 ± 0.073
2.087AlaGln: 2.087 ± 0.062
2.33AlaArg: 2.33 ± 0.064
4.16AlaSer: 4.16 ± 0.088
4.28AlaThr: 4.28 ± 0.089
4.742AlaVal: 4.742 ± 0.095
0.515AlaTrp: 0.515 ± 0.032
2.267AlaTyr: 2.267 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.374CysAla: 0.374 ± 0.023
0.111CysCys: 0.111 ± 0.013
0.45CysAsp: 0.45 ± 0.029
0.486CysGlu: 0.486 ± 0.033
0.317CysPhe: 0.317 ± 0.02
0.609CysGly: 0.609 ± 0.031
0.239CysHis: 0.239 ± 0.02
0.48CysIle: 0.48 ± 0.028
0.294CysLys: 0.294 ± 0.024
0.785CysLeu: 0.785 ± 0.032
0.17CysMet: 0.17 ± 0.017
0.264CysAsn: 0.264 ± 0.019
0.287CysPro: 0.287 ± 0.028
0.311CysGln: 0.311 ± 0.022
0.234CysArg: 0.234 ± 0.018
0.446CysSer: 0.446 ± 0.029
0.329CysThr: 0.329 ± 0.024
0.449CysVal: 0.449 ± 0.024
0.069CysTrp: 0.069 ± 0.011
0.314CysTyr: 0.314 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.184AspAla: 3.184 ± 0.068
0.423AspCys: 0.423 ± 0.027
2.895AspAsp: 2.895 ± 0.076
4.676AspGlu: 4.676 ± 0.097
2.874AspPhe: 2.874 ± 0.069
3.488AspGly: 3.488 ± 0.093
0.867AspHis: 0.867 ± 0.039
4.208AspIle: 4.208 ± 0.083
4.543AspLys: 4.543 ± 0.112
5.252AspLeu: 5.252 ± 0.094
1.626AspMet: 1.626 ± 0.056
2.432AspAsn: 2.432 ± 0.056
1.722AspPro: 1.722 ± 0.055
1.604AspGln: 1.604 ± 0.053
1.952AspArg: 1.952 ± 0.067
3.205AspSer: 3.205 ± 0.068
2.949AspThr: 2.949 ± 0.073
4.072AspVal: 4.072 ± 0.079
0.563AspTrp: 0.563 ± 0.025
2.72AspTyr: 2.72 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.659GluAla: 5.659 ± 0.111
0.428GluCys: 0.428 ± 0.027
4.108GluAsp: 4.108 ± 0.096
7.342GluGlu: 7.342 ± 0.132
2.837GluPhe: 2.837 ± 0.064
4.694GluGly: 4.694 ± 0.107
1.178GluHis: 1.178 ± 0.042
5.452GluIle: 5.452 ± 0.102
6.973GluLys: 6.973 ± 0.135
7.887GluLeu: 7.887 ± 0.117
2.378GluMet: 2.378 ± 0.056
3.8GluAsn: 3.8 ± 0.082
2.222GluPro: 2.222 ± 0.114
2.885GluGln: 2.885 ± 0.084
2.99GluArg: 2.99 ± 0.078
4.045GluSer: 4.045 ± 0.084
4.607GluThr: 4.607 ± 0.086
5.554GluVal: 5.554 ± 0.091
0.665GluTrp: 0.665 ± 0.034
2.217GluTyr: 2.217 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.513PheAla: 2.513 ± 0.066
0.348PheCys: 0.348 ± 0.024
2.775PheAsp: 2.775 ± 0.066
3.025PheGlu: 3.025 ± 0.069
2.153PhePhe: 2.153 ± 0.067
3.106PheGly: 3.106 ± 0.071
0.626PheHis: 0.626 ± 0.032
3.668PheIle: 3.668 ± 0.096
3.028PheLys: 3.028 ± 0.077
4.0PheLeu: 4.0 ± 0.088
1.124PheMet: 1.124 ± 0.043
2.163PheAsn: 2.163 ± 0.056
1.529PhePro: 1.529 ± 0.049
1.226PheGln: 1.226 ± 0.042
1.17PheArg: 1.17 ± 0.045
3.377PheSer: 3.377 ± 0.073
2.393PheThr: 2.393 ± 0.061
2.915PheVal: 2.915 ± 0.066
0.39PheTrp: 0.39 ± 0.027
1.826PheTyr: 1.826 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.463GlyAla: 4.463 ± 0.103
0.563GlyCys: 0.563 ± 0.032
3.425GlyAsp: 3.425 ± 0.08
4.54GlyGlu: 4.54 ± 0.099
3.103GlyPhe: 3.103 ± 0.067
4.576GlyGly: 4.576 ± 0.117
1.194GlyHis: 1.194 ± 0.047
5.641GlyIle: 5.641 ± 0.111
5.167GlyLys: 5.167 ± 0.119
6.643GlyLeu: 6.643 ± 0.115
2.126GlyMet: 2.126 ± 0.058
2.805GlyAsn: 2.805 ± 0.078
1.569GlyPro: 1.569 ± 0.05
2.244GlyGln: 2.244 ± 0.06
2.409GlyArg: 2.409 ± 0.072
4.042GlySer: 4.042 ± 0.081
4.079GlyThr: 4.079 ± 0.092
4.994GlyVal: 4.994 ± 0.102
0.593GlyTrp: 0.593 ± 0.036
2.711GlyTyr: 2.711 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.023HisAla: 1.023 ± 0.038
0.146HisCys: 0.146 ± 0.015
1.025HisAsp: 1.025 ± 0.04
1.094HisGlu: 1.094 ± 0.041
0.888HisPhe: 0.888 ± 0.038
1.134HisGly: 1.134 ± 0.04
0.474HisHis: 0.474 ± 0.028
1.167HisIle: 1.167 ± 0.045
0.891HisLys: 0.891 ± 0.036
1.754HisLeu: 1.754 ± 0.052
0.423HisMet: 0.423 ± 0.028
0.692HisAsn: 0.692 ± 0.037
0.831HisPro: 0.831 ± 0.034
0.671HisGln: 0.671 ± 0.028
0.677HisArg: 0.677 ± 0.037
1.025HisSer: 1.025 ± 0.036
0.918HisThr: 0.918 ± 0.035
1.089HisVal: 1.089 ± 0.039
0.14HisTrp: 0.14 ± 0.016
0.837HisTyr: 0.837 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.489IleAla: 5.489 ± 0.105
0.611IleCys: 0.611 ± 0.028
4.33IleAsp: 4.33 ± 0.081
5.884IleGlu: 5.884 ± 0.09
3.164IlePhe: 3.164 ± 0.086
5.626IleGly: 5.626 ± 0.113
1.2IleHis: 1.2 ± 0.045
5.639IleIle: 5.639 ± 0.116
5.369IleLys: 5.369 ± 0.101
6.76IleLeu: 6.76 ± 0.131
1.967IleMet: 1.967 ± 0.06
3.442IleAsn: 3.442 ± 0.076
3.107IlePro: 3.107 ± 0.075
2.442IleGln: 2.442 ± 0.062
2.594IleArg: 2.594 ± 0.071
5.254IleSer: 5.254 ± 0.103
4.495IleThr: 4.495 ± 0.077
5.398IleVal: 5.398 ± 0.111
0.503IleTrp: 0.503 ± 0.025
2.324IleTyr: 2.324 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
4.777LysAla: 4.777 ± 0.111
0.353LysCys: 0.353 ± 0.024
4.147LysAsp: 4.147 ± 0.118
8.113LysGlu: 8.113 ± 0.149
2.174LysPhe: 2.174 ± 0.059
4.561LysGly: 4.561 ± 0.087
1.067LysHis: 1.067 ± 0.043
5.171LysIle: 5.171 ± 0.099
6.946LysLys: 6.946 ± 0.147
6.478LysLeu: 6.478 ± 0.101
2.469LysMet: 2.469 ± 0.059
4.15LysAsn: 4.15 ± 0.095
2.373LysPro: 2.373 ± 0.102
2.989LysGln: 2.989 ± 0.071
2.978LysArg: 2.978 ± 0.073
3.797LysSer: 3.797 ± 0.079
4.28LysThr: 4.28 ± 0.093
5.332LysVal: 5.332 ± 0.098
0.651LysTrp: 0.651 ± 0.032
2.283LysTyr: 2.283 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
7.648LeuAla: 7.648 ± 0.124
0.641LeuCys: 0.641 ± 0.035
5.45LeuAsp: 5.45 ± 0.098
7.057LeuGlu: 7.057 ± 0.101
4.39LeuPhe: 4.39 ± 0.09
6.621LeuGly: 6.621 ± 0.106
1.385LeuHis: 1.385 ± 0.044
7.3LeuIle: 7.3 ± 0.139
7.041LeuLys: 7.041 ± 0.121
9.708LeuLeu: 9.708 ± 0.161
2.717LeuMet: 2.717 ± 0.083
4.654LeuAsn: 4.654 ± 0.097
3.872LeuPro: 3.872 ± 0.081
2.609LeuGln: 2.609 ± 0.067
2.906LeuArg: 2.906 ± 0.073
7.371LeuSer: 7.371 ± 0.133
6.607LeuThr: 6.607 ± 0.104
7.198LeuVal: 7.198 ± 0.102
0.614LeuTrp: 0.614 ± 0.031
2.826LeuTyr: 2.826 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.13MetAla: 2.13 ± 0.057
0.138MetCys: 0.138 ± 0.014
1.386MetAsp: 1.386 ± 0.041
1.65MetGlu: 1.65 ± 0.054
0.969MetPhe: 0.969 ± 0.041
1.887MetGly: 1.887 ± 0.06
0.327MetHis: 0.327 ± 0.024
2.292MetIle: 2.292 ± 0.071
2.322MetLys: 2.322 ± 0.066
2.571MetLeu: 2.571 ± 0.062
0.999MetMet: 0.999 ± 0.039
1.232MetAsn: 1.232 ± 0.043
1.071MetPro: 1.071 ± 0.043
0.774MetGln: 0.774 ± 0.031
0.984MetArg: 0.984 ± 0.047
1.994MetSer: 1.994 ± 0.062
2.277MetThr: 2.277 ± 0.062
2.03MetVal: 2.03 ± 0.055
0.18MetTrp: 0.18 ± 0.016
0.767MetTyr: 0.767 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.613AsnAla: 2.613 ± 0.063
0.333AsnCys: 0.333 ± 0.022
2.613AsnAsp: 2.613 ± 0.077
3.412AsnGlu: 3.412 ± 0.072
2.003AsnPhe: 2.003 ± 0.054
3.098AsnGly: 3.098 ± 0.081
0.948AsnHis: 0.948 ± 0.042
3.067AsnIle: 3.067 ± 0.075
3.56AsnLys: 3.56 ± 0.087
4.151AsnLeu: 4.151 ± 0.079
1.322AsnMet: 1.322 ± 0.036
2.132AsnAsn: 2.132 ± 0.075
2.04AsnPro: 2.04 ± 0.06
1.971AsnGln: 1.971 ± 0.06
1.788AsnArg: 1.788 ± 0.058
2.721AsnSer: 2.721 ± 0.069
2.498AsnThr: 2.498 ± 0.069
2.945AsnVal: 2.945 ± 0.068
0.471AsnTrp: 0.471 ± 0.026
1.956AsnTyr: 1.956 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.088ProAla: 2.088 ± 0.066
0.176ProCys: 0.176 ± 0.018
2.012ProAsp: 2.012 ± 0.061
3.094ProGlu: 3.094 ± 0.074
1.691ProPhe: 1.691 ± 0.053
2.153ProGly: 2.153 ± 0.062
0.638ProHis: 0.638 ± 0.032
2.6ProIle: 2.6 ± 0.057
2.54ProLys: 2.54 ± 0.071
3.232ProLeu: 3.232 ± 0.071
0.756ProMet: 0.756 ± 0.038
1.836ProAsn: 1.836 ± 0.064
0.687ProPro: 0.687 ± 0.038
1.101ProGln: 1.101 ± 0.04
0.936ProArg: 0.936 ± 0.039
2.073ProSer: 2.073 ± 0.057
2.457ProThr: 2.457 ± 0.142
2.847ProVal: 2.847 ± 0.075
0.296ProTrp: 0.296 ± 0.022
1.284ProTyr: 1.284 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.616GlnAla: 2.616 ± 0.071
0.153GlnCys: 0.153 ± 0.013
1.695GlnAsp: 1.695 ± 0.053
2.825GlnGlu: 2.825 ± 0.071
1.376GlnPhe: 1.376 ± 0.044
2.12GlnGly: 2.12 ± 0.069
0.617GlnHis: 0.617 ± 0.028
2.175GlnIle: 2.175 ± 0.066
2.526GlnLys: 2.526 ± 0.062
4.007GlnLeu: 4.007 ± 0.079
0.84GlnMet: 0.84 ± 0.036
1.439GlnAsn: 1.439 ± 0.052
1.116GlnPro: 1.116 ± 0.046
1.317GlnGln: 1.317 ± 0.055
1.253GlnArg: 1.253 ± 0.045
2.036GlnSer: 2.036 ± 0.055
2.172GlnThr: 2.172 ± 0.075
2.4GlnVal: 2.4 ± 0.061
0.258GlnTrp: 0.258 ± 0.021
1.017GlnTyr: 1.017 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.021ArgAla: 2.021 ± 0.062
0.225ArgCys: 0.225 ± 0.02
1.851ArgAsp: 1.851 ± 0.052
2.78ArgGlu: 2.78 ± 0.073
1.667ArgPhe: 1.667 ± 0.046
2.153ArgGly: 2.153 ± 0.059
0.689ArgHis: 0.689 ± 0.032
2.48ArgIle: 2.48 ± 0.057
2.621ArgLys: 2.621 ± 0.082
3.869ArgLeu: 3.869 ± 0.077
1.005ArgMet: 1.005 ± 0.042
1.493ArgAsn: 1.493 ± 0.05
1.14ArgPro: 1.14 ± 0.043
1.569ArgGln: 1.569 ± 0.057
1.658ArgArg: 1.658 ± 0.054
1.794ArgSer: 1.794 ± 0.06
1.794ArgThr: 1.794 ± 0.05
2.474ArgVal: 2.474 ± 0.061
0.269ArgTrp: 0.269 ± 0.018
1.557ArgTyr: 1.557 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.583SerAla: 3.583 ± 0.068
0.434SerCys: 0.434 ± 0.025
3.557SerAsp: 3.557 ± 0.075
4.906SerGlu: 4.906 ± 0.099
3.14SerPhe: 3.14 ± 0.068
4.378SerGly: 4.378 ± 0.076
1.218SerHis: 1.218 ± 0.041
4.85SerIle: 4.85 ± 0.097
4.535SerLys: 4.535 ± 0.096
6.609SerLeu: 6.609 ± 0.111
1.545SerMet: 1.545 ± 0.052
2.72SerAsn: 2.72 ± 0.071
2.009SerPro: 2.009 ± 0.054
2.355SerGln: 2.355 ± 0.066
2.199SerArg: 2.199 ± 0.056
3.989SerSer: 3.989 ± 0.098
3.355SerThr: 3.355 ± 0.073
4.459SerVal: 4.459 ± 0.092
0.579SerTrp: 0.579 ± 0.028
2.444SerTyr: 2.444 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.033ThrAla: 4.033 ± 0.092
0.41ThrCys: 0.41 ± 0.027
3.449ThrAsp: 3.449 ± 0.087
4.492ThrGlu: 4.492 ± 0.151
2.549ThrPhe: 2.549 ± 0.062
4.234ThrGly: 4.234 ± 0.081
1.191ThrHis: 1.191 ± 0.044
4.913ThrIle: 4.913 ± 0.09
4.075ThrLys: 4.075 ± 0.088
6.009ThrLeu: 6.009 ± 0.111
1.404ThrMet: 1.404 ± 0.051
2.586ThrAsn: 2.586 ± 0.064
2.663ThrPro: 2.663 ± 0.07
1.851ThrGln: 1.851 ± 0.069
1.86ThrArg: 1.86 ± 0.062
3.667ThrSer: 3.667 ± 0.094
3.847ThrThr: 3.847 ± 0.088
4.76ThrVal: 4.76 ± 0.087
0.468ThrTrp: 0.468 ± 0.028
2.177ThrTyr: 2.177 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.471ValAla: 5.471 ± 0.111
0.584ValCys: 0.584 ± 0.03
3.911ValAsp: 3.911 ± 0.088
5.012ValGlu: 5.012 ± 0.093
2.915ValPhe: 2.915 ± 0.075
4.972ValGly: 4.972 ± 0.103
0.965ValHis: 0.965 ± 0.039
5.81ValIle: 5.81 ± 0.097
4.993ValLys: 4.993 ± 0.097
7.027ValLeu: 7.027 ± 0.113
2.121ValMet: 2.121 ± 0.06
2.936ValAsn: 2.936 ± 0.072
2.669ValPro: 2.669 ± 0.067
1.889ValGln: 1.889 ± 0.056
2.297ValArg: 2.297 ± 0.066
5.216ValSer: 5.216 ± 0.092
4.847ValThr: 4.847 ± 0.09
5.557ValVal: 5.557 ± 0.109
0.495ValTrp: 0.495 ± 0.03
2.226ValTyr: 2.226 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.44TrpAla: 0.44 ± 0.028
0.071TrpCys: 0.071 ± 0.01
0.497TrpAsp: 0.497 ± 0.03
0.552TrpGlu: 0.552 ± 0.03
0.407TrpPhe: 0.407 ± 0.028
0.512TrpGly: 0.512 ± 0.034
0.186TrpHis: 0.186 ± 0.015
0.531TrpIle: 0.531 ± 0.03
0.474TrpLys: 0.474 ± 0.024
1.067TrpLeu: 1.067 ± 0.042
0.222TrpMet: 0.222 ± 0.021
0.419TrpAsn: 0.419 ± 0.029
0.177TrpPro: 0.177 ± 0.016
0.387TrpGln: 0.387 ± 0.022
0.338TrpArg: 0.338 ± 0.023
0.501TrpSer: 0.501 ± 0.03
0.459TrpThr: 0.459 ± 0.027
0.5TrpVal: 0.5 ± 0.031
0.072TrpTrp: 0.072 ± 0.01
0.285TrpTyr: 0.285 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.004TyrAla: 2.004 ± 0.056
0.303TyrCys: 0.303 ± 0.022
2.241TyrAsp: 2.241 ± 0.062
2.418TyrGlu: 2.418 ± 0.077
1.893TyrPhe: 1.893 ± 0.066
2.3TyrGly: 2.3 ± 0.052
0.789TyrHis: 0.789 ± 0.034
2.426TyrIle: 2.426 ± 0.071
2.172TyrLys: 2.172 ± 0.075
3.827TyrLeu: 3.827 ± 0.079
0.81TyrMet: 0.81 ± 0.033
1.643TyrAsn: 1.643 ± 0.056
1.329TyrPro: 1.329 ± 0.048
1.677TyrGln: 1.677 ± 0.054
1.556TyrArg: 1.556 ± 0.048
2.151TyrSer: 2.151 ± 0.06
1.992TyrThr: 1.992 ± 0.067
2.199TyrVal: 2.199 ± 0.058
0.306TyrTrp: 0.306 ± 0.022
1.578TyrTyr: 1.578 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2111 proteins (666555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski