Amino acid dipepetide frequency for Acinetobacter phage vB_AbaM_D22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.871AlaAla: 3.871 ± 0.462
0.59AlaCys: 0.59 ± 0.127
2.985AlaAsp: 2.985 ± 0.464
4.133AlaGlu: 4.133 ± 0.307
2.657AlaPhe: 2.657 ± 0.316
3.904AlaGly: 3.904 ± 0.506
0.787AlaHis: 0.787 ± 0.187
5.216AlaIle: 5.216 ± 0.451
5.577AlaLys: 5.577 ± 0.455
5.675AlaLeu: 5.675 ± 0.495
2.034AlaMet: 2.034 ± 0.339
2.919AlaAsn: 2.919 ± 0.582
2.001AlaPro: 2.001 ± 0.295
2.657AlaGln: 2.657 ± 0.363
2.198AlaArg: 2.198 ± 0.266
3.838AlaSer: 3.838 ± 0.375
3.674AlaThr: 3.674 ± 0.443
3.74AlaVal: 3.74 ± 0.359
0.918AlaTrp: 0.918 ± 0.167
2.591AlaTyr: 2.591 ± 0.328
0.0AlaXaa: 0.0 ± 0.0
Cys
0.459CysAla: 0.459 ± 0.136
0.23CysCys: 0.23 ± 0.1
0.689CysAsp: 0.689 ± 0.141
0.886CysGlu: 0.886 ± 0.2
0.525CysPhe: 0.525 ± 0.142
1.279CysGly: 1.279 ± 0.212
0.525CysHis: 0.525 ± 0.138
0.656CysIle: 0.656 ± 0.179
0.918CysLys: 0.918 ± 0.19
0.984CysLeu: 0.984 ± 0.193
0.361CysMet: 0.361 ± 0.121
0.525CysAsn: 0.525 ± 0.133
0.492CysPro: 0.492 ± 0.128
0.426CysGln: 0.426 ± 0.122
0.754CysArg: 0.754 ± 0.158
0.59CysSer: 0.59 ± 0.17
0.59CysThr: 0.59 ± 0.116
0.787CysVal: 0.787 ± 0.174
0.098CysTrp: 0.098 ± 0.051
0.558CysTyr: 0.558 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
4.363AspAla: 4.363 ± 0.371
0.59AspCys: 0.59 ± 0.158
4.691AspAsp: 4.691 ± 0.695
5.216AspGlu: 5.216 ± 0.555
3.576AspPhe: 3.576 ± 0.405
4.92AspGly: 4.92 ± 0.375
1.345AspHis: 1.345 ± 0.247
4.592AspIle: 4.592 ± 0.379
4.363AspLys: 4.363 ± 0.442
5.609AspLeu: 5.609 ± 0.488
1.804AspMet: 1.804 ± 0.284
2.985AspAsn: 2.985 ± 0.302
2.427AspPro: 2.427 ± 0.314
2.165AspGln: 2.165 ± 0.357
2.427AspArg: 2.427 ± 0.27
4.002AspSer: 4.002 ± 0.339
3.313AspThr: 3.313 ± 0.306
4.888AspVal: 4.888 ± 0.397
1.082AspTrp: 1.082 ± 0.192
2.854AspTyr: 2.854 ± 0.337
0.0AspXaa: 0.0 ± 0.0
Glu
4.953GluAla: 4.953 ± 0.394
1.247GluCys: 1.247 ± 0.251
5.052GluAsp: 5.052 ± 0.446
6.265GluGlu: 6.265 ± 0.588
3.543GluPhe: 3.543 ± 0.356
4.396GluGly: 4.396 ± 0.449
1.64GluHis: 1.64 ± 0.248
5.183GluIle: 5.183 ± 0.396
4.953GluLys: 4.953 ± 0.424
5.905GluLeu: 5.905 ± 0.534
2.263GluMet: 2.263 ± 0.263
3.28GluAsn: 3.28 ± 0.277
1.509GluPro: 1.509 ± 0.272
2.296GluGln: 2.296 ± 0.303
3.051GluArg: 3.051 ± 0.289
4.494GluSer: 4.494 ± 0.358
3.215GluThr: 3.215 ± 0.27
6.003GluVal: 6.003 ± 0.537
1.312GluTrp: 1.312 ± 0.192
3.083GluTyr: 3.083 ± 0.231
0.0GluXaa: 0.0 ± 0.0
Phe
2.395PheAla: 2.395 ± 0.328
0.59PheCys: 0.59 ± 0.141
2.985PheAsp: 2.985 ± 0.33
3.543PheGlu: 3.543 ± 0.332
0.984PhePhe: 0.984 ± 0.171
3.576PheGly: 3.576 ± 0.344
0.754PheHis: 0.754 ± 0.162
3.28PheIle: 3.28 ± 0.303
4.1PheLys: 4.1 ± 0.431
3.018PheLeu: 3.018 ± 0.297
1.837PheMet: 1.837 ± 0.243
2.329PheAsn: 2.329 ± 0.28
1.607PhePro: 1.607 ± 0.216
1.575PheGln: 1.575 ± 0.221
1.968PheArg: 1.968 ± 0.224
3.477PheSer: 3.477 ± 0.334
2.395PheThr: 2.395 ± 0.296
2.198PheVal: 2.198 ± 0.239
0.459PheTrp: 0.459 ± 0.13
2.001PheTyr: 2.001 ± 0.259
0.0PheXaa: 0.0 ± 0.0
Gly
3.477GlyAla: 3.477 ± 0.285
1.082GlyCys: 1.082 ± 0.207
5.052GlyAsp: 5.052 ± 0.458
4.855GlyGlu: 4.855 ± 0.368
3.346GlyPhe: 3.346 ± 0.399
4.888GlyGly: 4.888 ± 0.354
1.017GlyHis: 1.017 ± 0.207
4.494GlyIle: 4.494 ± 0.364
4.953GlyLys: 4.953 ± 0.447
5.216GlyLeu: 5.216 ± 0.464
1.476GlyMet: 1.476 ± 0.215
3.608GlyAsn: 3.608 ± 0.365
0.656GlyPro: 0.656 ± 0.149
2.329GlyGln: 2.329 ± 0.367
2.723GlyArg: 2.723 ± 0.278
3.904GlySer: 3.904 ± 0.34
4.592GlyThr: 4.592 ± 0.469
5.281GlyVal: 5.281 ± 0.408
1.214GlyTrp: 1.214 ± 0.172
3.182GlyTyr: 3.182 ± 0.308
0.0GlyXaa: 0.0 ± 0.0
His
0.886HisAla: 0.886 ± 0.175
0.164HisCys: 0.164 ± 0.074
1.214HisAsp: 1.214 ± 0.215
1.148HisGlu: 1.148 ± 0.175
1.115HisPhe: 1.115 ± 0.163
1.443HisGly: 1.443 ± 0.208
0.59HisHis: 0.59 ± 0.147
1.607HisIle: 1.607 ± 0.244
1.411HisLys: 1.411 ± 0.218
1.87HisLeu: 1.87 ± 0.273
0.361HisMet: 0.361 ± 0.102
1.082HisAsn: 1.082 ± 0.23
0.787HisPro: 0.787 ± 0.165
0.492HisGln: 0.492 ± 0.123
0.886HisArg: 0.886 ± 0.187
1.082HisSer: 1.082 ± 0.2
0.918HisThr: 0.918 ± 0.164
1.476HisVal: 1.476 ± 0.224
0.492HisTrp: 0.492 ± 0.131
0.689HisTyr: 0.689 ± 0.183
0.0HisXaa: 0.0 ± 0.0
Ile
4.461IleAla: 4.461 ± 0.333
0.722IleCys: 0.722 ± 0.164
5.675IleAsp: 5.675 ± 0.449
5.281IleGlu: 5.281 ± 0.417
2.329IlePhe: 2.329 ± 0.264
4.199IleGly: 4.199 ± 0.383
1.115IleHis: 1.115 ± 0.19
3.444IleIle: 3.444 ± 0.346
5.577IleLys: 5.577 ± 0.421
4.625IleLeu: 4.625 ± 0.505
1.706IleMet: 1.706 ± 0.238
3.543IleAsn: 3.543 ± 0.305
2.198IlePro: 2.198 ± 0.283
2.362IleGln: 2.362 ± 0.29
3.051IleArg: 3.051 ± 0.307
4.396IleSer: 4.396 ± 0.514
4.297IleThr: 4.297 ± 0.394
4.133IleVal: 4.133 ± 0.379
0.558IleTrp: 0.558 ± 0.12
2.395IleTyr: 2.395 ± 0.253
0.0IleXaa: 0.0 ± 0.0
Lys
6.528LysAla: 6.528 ± 0.654
0.525LysCys: 0.525 ± 0.111
5.248LysAsp: 5.248 ± 0.474
4.888LysGlu: 4.888 ± 0.463
4.232LysPhe: 4.232 ± 0.458
4.527LysGly: 4.527 ± 0.447
1.968LysHis: 1.968 ± 0.276
5.084LysIle: 5.084 ± 0.42
6.036LysLys: 6.036 ± 0.604
6.528LysLeu: 6.528 ± 0.479
2.198LysMet: 2.198 ± 0.261
2.952LysAsn: 2.952 ± 0.305
2.296LysPro: 2.296 ± 0.274
2.624LysGln: 2.624 ± 0.307
3.28LysArg: 3.28 ± 0.355
4.855LysSer: 4.855 ± 0.463
3.936LysThr: 3.936 ± 0.331
6.101LysVal: 6.101 ± 0.591
1.181LysTrp: 1.181 ± 0.196
4.1LysTyr: 4.1 ± 0.438
0.0LysXaa: 0.0 ± 0.0
Leu
4.822LeuAla: 4.822 ± 0.533
1.115LeuCys: 1.115 ± 0.187
5.412LeuAsp: 5.412 ± 0.437
6.036LeuGlu: 6.036 ± 0.394
3.412LeuPhe: 3.412 ± 0.386
5.052LeuGly: 5.052 ± 0.46
1.443LeuHis: 1.443 ± 0.251
5.281LeuIle: 5.281 ± 0.515
6.954LeuLys: 6.954 ± 0.485
5.248LeuLeu: 5.248 ± 0.408
1.968LeuMet: 1.968 ± 0.238
5.445LeuAsn: 5.445 ± 0.475
2.001LeuPro: 2.001 ± 0.239
2.263LeuGln: 2.263 ± 0.253
3.28LeuArg: 3.28 ± 0.378
5.019LeuSer: 5.019 ± 0.421
4.855LeuThr: 4.855 ± 0.455
4.658LeuVal: 4.658 ± 0.409
0.951LeuTrp: 0.951 ± 0.189
2.854LeuTyr: 2.854 ± 0.353
0.0LeuXaa: 0.0 ± 0.0
Met
1.804MetAla: 1.804 ± 0.232
0.295MetCys: 0.295 ± 0.111
1.673MetAsp: 1.673 ± 0.248
2.132MetGlu: 2.132 ± 0.297
0.984MetPhe: 0.984 ± 0.196
1.411MetGly: 1.411 ± 0.243
0.197MetHis: 0.197 ± 0.086
2.165MetIle: 2.165 ± 0.275
2.526MetLys: 2.526 ± 0.316
2.067MetLeu: 2.067 ± 0.254
0.689MetMet: 0.689 ± 0.179
1.476MetAsn: 1.476 ± 0.23
0.853MetPro: 0.853 ± 0.141
0.951MetGln: 0.951 ± 0.167
1.05MetArg: 1.05 ± 0.187
2.755MetSer: 2.755 ± 0.317
1.411MetThr: 1.411 ± 0.2
1.575MetVal: 1.575 ± 0.243
0.23MetTrp: 0.23 ± 0.078
1.017MetTyr: 1.017 ± 0.173
0.0MetXaa: 0.0 ± 0.0
Asn
3.116AsnAla: 3.116 ± 0.7
0.558AsnCys: 0.558 ± 0.168
3.182AsnAsp: 3.182 ± 0.26
2.362AsnGlu: 2.362 ± 0.275
2.099AsnPhe: 2.099 ± 0.248
4.33AsnGly: 4.33 ± 0.375
0.886AsnHis: 0.886 ± 0.148
3.707AsnIle: 3.707 ± 0.39
3.608AsnLys: 3.608 ± 0.376
3.936AsnLeu: 3.936 ± 0.393
1.345AsnMet: 1.345 ± 0.22
2.296AsnAsn: 2.296 ± 0.217
2.034AsnPro: 2.034 ± 0.252
1.64AsnGln: 1.64 ± 0.233
2.362AsnArg: 2.362 ± 0.262
2.821AsnSer: 2.821 ± 0.425
2.919AsnThr: 2.919 ± 0.302
3.379AsnVal: 3.379 ± 0.361
0.656AsnTrp: 0.656 ± 0.152
2.067AsnTyr: 2.067 ± 0.297
0.0AsnXaa: 0.0 ± 0.0
Pro
1.411ProAla: 1.411 ± 0.224
0.361ProCys: 0.361 ± 0.102
2.165ProAsp: 2.165 ± 0.277
3.247ProGlu: 3.247 ± 0.453
1.05ProPhe: 1.05 ± 0.181
0.0ProGly: 0.0 ± 0.0
0.459ProHis: 0.459 ± 0.13
1.837ProIle: 1.837 ± 0.224
2.624ProLys: 2.624 ± 0.254
1.87ProLeu: 1.87 ± 0.248
0.918ProMet: 0.918 ± 0.183
1.771ProAsn: 1.771 ± 0.299
0.984ProPro: 0.984 ± 0.153
0.951ProGln: 0.951 ± 0.16
1.017ProArg: 1.017 ± 0.231
2.526ProSer: 2.526 ± 0.299
1.575ProThr: 1.575 ± 0.203
2.493ProVal: 2.493 ± 0.357
0.197ProTrp: 0.197 ± 0.084
1.673ProTyr: 1.673 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
2.985GlnAla: 2.985 ± 0.532
0.328GlnCys: 0.328 ± 0.103
1.903GlnAsp: 1.903 ± 0.219
2.46GlnGlu: 2.46 ± 0.251
1.476GlnPhe: 1.476 ± 0.227
2.854GlnGly: 2.854 ± 0.388
0.59GlnHis: 0.59 ± 0.117
2.001GlnIle: 2.001 ± 0.247
2.001GlnLys: 2.001 ± 0.223
2.657GlnLeu: 2.657 ± 0.284
1.443GlnMet: 1.443 ± 0.266
1.476GlnAsn: 1.476 ± 0.284
0.886GlnPro: 0.886 ± 0.171
1.05GlnGln: 1.05 ± 0.187
1.935GlnArg: 1.935 ± 0.216
2.132GlnSer: 2.132 ± 0.376
1.607GlnThr: 1.607 ± 0.234
2.132GlnVal: 2.132 ± 0.249
0.394GlnTrp: 0.394 ± 0.11
1.64GlnTyr: 1.64 ± 0.228
0.0GlnXaa: 0.0 ± 0.0
Arg
2.067ArgAla: 2.067 ± 0.299
0.525ArgCys: 0.525 ± 0.123
2.526ArgAsp: 2.526 ± 0.285
3.805ArgGlu: 3.805 ± 0.383
2.559ArgPhe: 2.559 ± 0.326
2.887ArgGly: 2.887 ± 0.339
1.05ArgHis: 1.05 ± 0.182
3.444ArgIle: 3.444 ± 0.263
3.674ArgLys: 3.674 ± 0.367
3.412ArgLeu: 3.412 ± 0.354
0.886ArgMet: 0.886 ± 0.175
2.034ArgAsn: 2.034 ± 0.238
1.05ArgPro: 1.05 ± 0.198
1.247ArgGln: 1.247 ± 0.19
2.034ArgArg: 2.034 ± 0.288
1.968ArgSer: 1.968 ± 0.322
2.296ArgThr: 2.296 ± 0.288
3.576ArgVal: 3.576 ± 0.346
0.59ArgTrp: 0.59 ± 0.143
1.935ArgTyr: 1.935 ± 0.274
0.0ArgXaa: 0.0 ± 0.0
Ser
3.608SerAla: 3.608 ± 0.555
0.918SerCys: 0.918 ± 0.208
4.068SerAsp: 4.068 ± 0.431
4.461SerGlu: 4.461 ± 0.445
2.723SerPhe: 2.723 ± 0.305
5.412SerGly: 5.412 ± 0.481
1.017SerHis: 1.017 ± 0.187
3.379SerIle: 3.379 ± 0.381
5.281SerLys: 5.281 ± 0.406
4.724SerLeu: 4.724 ± 0.382
1.607SerMet: 1.607 ± 0.188
3.182SerAsn: 3.182 ± 0.256
1.607SerPro: 1.607 ± 0.257
2.624SerGln: 2.624 ± 0.295
2.69SerArg: 2.69 ± 0.262
4.002SerSer: 4.002 ± 0.522
4.068SerThr: 4.068 ± 0.366
4.396SerVal: 4.396 ± 0.394
0.722SerTrp: 0.722 ± 0.153
3.116SerTyr: 3.116 ± 0.327
0.0SerXaa: 0.0 ± 0.0
Thr
3.871ThrAla: 3.871 ± 0.534
0.722ThrCys: 0.722 ± 0.137
3.182ThrAsp: 3.182 ± 0.355
3.576ThrGlu: 3.576 ± 0.312
2.952ThrPhe: 2.952 ± 0.324
4.166ThrGly: 4.166 ± 0.381
1.443ThrHis: 1.443 ± 0.206
3.379ThrIle: 3.379 ± 0.339
4.494ThrLys: 4.494 ± 0.319
5.183ThrLeu: 5.183 ± 0.352
1.148ThrMet: 1.148 ± 0.246
2.263ThrAsn: 2.263 ± 0.272
1.903ThrPro: 1.903 ± 0.23
1.903ThrGln: 1.903 ± 0.294
2.755ThrArg: 2.755 ± 0.313
3.28ThrSer: 3.28 ± 0.433
3.51ThrThr: 3.51 ± 0.406
3.707ThrVal: 3.707 ± 0.436
0.853ThrTrp: 0.853 ± 0.141
1.804ThrTyr: 1.804 ± 0.258
0.0ThrXaa: 0.0 ± 0.0
Val
3.904ValAla: 3.904 ± 0.38
0.853ValCys: 0.853 ± 0.18
5.183ValAsp: 5.183 ± 0.501
5.577ValGlu: 5.577 ± 0.405
2.985ValPhe: 2.985 ± 0.305
4.428ValGly: 4.428 ± 0.402
1.312ValHis: 1.312 ± 0.215
4.232ValIle: 4.232 ± 0.382
5.281ValLys: 5.281 ± 0.437
5.117ValLeu: 5.117 ± 0.475
1.739ValMet: 1.739 ± 0.227
3.674ValAsn: 3.674 ± 0.336
2.067ValPro: 2.067 ± 0.235
2.198ValGln: 2.198 ± 0.293
3.149ValArg: 3.149 ± 0.436
4.855ValSer: 4.855 ± 0.356
3.805ValThr: 3.805 ± 0.397
5.412ValVal: 5.412 ± 0.483
0.984ValTrp: 0.984 ± 0.192
3.083ValTyr: 3.083 ± 0.331
0.0ValXaa: 0.0 ± 0.0
Trp
0.722TrpAla: 0.722 ± 0.147
0.23TrpCys: 0.23 ± 0.07
1.148TrpAsp: 1.148 ± 0.178
1.082TrpGlu: 1.082 ± 0.211
0.886TrpPhe: 0.886 ± 0.175
0.689TrpGly: 0.689 ± 0.174
0.328TrpHis: 0.328 ± 0.096
0.918TrpIle: 0.918 ± 0.178
0.918TrpLys: 0.918 ± 0.176
0.886TrpLeu: 0.886 ± 0.164
0.525TrpMet: 0.525 ± 0.134
0.558TrpAsn: 0.558 ± 0.114
0.098TrpPro: 0.098 ± 0.046
0.492TrpGln: 0.492 ± 0.095
0.787TrpArg: 0.787 ± 0.163
0.853TrpSer: 0.853 ± 0.152
0.918TrpThr: 0.918 ± 0.152
1.05TrpVal: 1.05 ± 0.165
0.164TrpTrp: 0.164 ± 0.066
0.623TrpTyr: 0.623 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.263TyrAla: 2.263 ± 0.281
0.689TyrCys: 0.689 ± 0.163
3.182TyrAsp: 3.182 ± 0.313
2.69TyrGlu: 2.69 ± 0.265
1.64TyrPhe: 1.64 ± 0.251
2.985TyrGly: 2.985 ± 0.288
1.247TyrHis: 1.247 ± 0.224
2.165TyrIle: 2.165 ± 0.211
3.838TyrLys: 3.838 ± 0.378
3.543TyrLeu: 3.543 ± 0.301
0.918TyrMet: 0.918 ± 0.155
1.903TyrAsn: 1.903 ± 0.291
1.673TyrPro: 1.673 ± 0.238
1.706TyrGln: 1.706 ± 0.268
2.165TyrArg: 2.165 ± 0.295
2.788TyrSer: 2.788 ± 0.292
2.198TyrThr: 2.198 ± 0.304
2.854TyrVal: 2.854 ± 0.294
0.82TyrTrp: 0.82 ± 0.161
1.607TyrTyr: 1.607 ± 0.235
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 159 proteins (30486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski