Amino acid dipepetide frequency for Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.061AlaAla: 12.061 ± 0.178	0.94AlaCys: 0.94 ± 0.039	5.947AlaAsp: 5.947 ± 0.108	6.465AlaGlu: 6.465 ± 0.113	3.765AlaPhe: 3.765 ± 0.069	8.023AlaGly: 8.023 ± 0.114	2.574AlaHis: 2.574 ± 0.063	5.924AlaIle: 5.924 ± 0.083	3.975AlaLys: 3.975 ± 0.081	12.419AlaLeu: 12.419 ± 0.163	2.963AlaMet: 2.963 ± 0.074	3.176AlaAsn: 3.176 ± 0.085	4.715AlaPro: 4.715 ± 0.102	5.347AlaGln: 5.347 ± 0.104	6.836AlaArg: 6.836 ± 0.113	5.579AlaSer: 5.579 ± 0.098	5.056AlaThr: 5.056 ± 0.085	7.376AlaVal: 7.376 ± 0.109	1.392AlaTrp: 1.392 ± 0.048	2.351AlaTyr: 2.351 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.962CysAla: 0.962 ± 0.034	0.1CysCys: 0.1 ± 0.013	0.541CysAsp: 0.541 ± 0.03	0.41CysGlu: 0.41 ± 0.026	0.261CysPhe: 0.261 ± 0.019	0.832CysGly: 0.832 ± 0.035	0.275CysHis: 0.275 ± 0.02	0.361CysIle: 0.361 ± 0.024	0.202CysLys: 0.202 ± 0.016	0.774CysLeu: 0.774 ± 0.039	0.145CysMet: 0.145 ± 0.014	0.246CysAsn: 0.246 ± 0.017	0.552CysPro: 0.552 ± 0.032	0.301CysGln: 0.301 ± 0.02	0.514CysArg: 0.514 ± 0.03	0.465CysSer: 0.465 ± 0.026	0.427CysThr: 0.427 ± 0.025	0.585CysVal: 0.585 ± 0.025	0.096CysTrp: 0.096 ± 0.011	0.183CysTyr: 0.183 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.139AspAla: 6.139 ± 0.104	0.498AspCys: 0.498 ± 0.022	3.06AspAsp: 3.06 ± 0.074	3.642AspGlu: 3.642 ± 0.078	2.336AspPhe: 2.336 ± 0.056	4.154AspGly: 4.154 ± 0.086	1.382AspHis: 1.382 ± 0.042	3.133AspIle: 3.133 ± 0.07	1.993AspLys: 1.993 ± 0.055	5.757AspLeu: 5.757 ± 0.096	1.36AspMet: 1.36 ± 0.042	1.51AspAsn: 1.51 ± 0.046	2.909AspPro: 2.909 ± 0.075	2.649AspGln: 2.649 ± 0.06	3.656AspArg: 3.656 ± 0.074	2.876AspSer: 2.876 ± 0.063	2.749AspThr: 2.749 ± 0.06	3.85AspVal: 3.85 ± 0.071	1.081AspTrp: 1.081 ± 0.037	1.627AspTyr: 1.627 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.818GluAla: 5.818 ± 0.102	0.44GluCys: 0.44 ± 0.021	2.286GluAsp: 2.286 ± 0.051	2.604GluGlu: 2.604 ± 0.077	1.828GluPhe: 1.828 ± 0.051	3.533GluGly: 3.533 ± 0.075	1.489GluHis: 1.489 ± 0.048	3.315GluIle: 3.315 ± 0.075	2.352GluLys: 2.352 ± 0.061	5.514GluLeu: 5.514 ± 0.093	1.443GluMet: 1.443 ± 0.048	1.805GluAsn: 1.805 ± 0.042	2.766GluPro: 2.766 ± 0.068	3.275GluGln: 3.275 ± 0.064	4.317GluArg: 4.317 ± 0.087	3.28GluSer: 3.28 ± 0.071	2.92GluThr: 2.92 ± 0.068	3.462GluVal: 3.462 ± 0.083	0.687GluTrp: 0.687 ± 0.031	1.172GluTyr: 1.172 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.846PheAla: 3.846 ± 0.08	0.381PheCys: 0.381 ± 0.026	2.758PheAsp: 2.758 ± 0.06	2.125PheGlu: 2.125 ± 0.055	1.593PhePhe: 1.593 ± 0.054	3.497PheGly: 3.497 ± 0.082	0.769PheHis: 0.769 ± 0.031	2.109PheIle: 2.109 ± 0.055	1.294PheLys: 1.294 ± 0.041	3.398PheLeu: 3.398 ± 0.079	0.984PheMet: 0.984 ± 0.038	1.473PheAsn: 1.473 ± 0.05	1.457PhePro: 1.457 ± 0.045	1.062PheGln: 1.062 ± 0.035	1.899PheArg: 1.899 ± 0.052	2.603PheSer: 2.603 ± 0.062	2.112PheThr: 2.112 ± 0.049	2.795PheVal: 2.795 ± 0.063	0.652PheTrp: 0.652 ± 0.032	1.072PheTyr: 1.072 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	6.857GlyAla: 6.857 ± 0.112	0.787GlyCys: 0.787 ± 0.039	3.97GlyAsp: 3.97 ± 0.074	4.03GlyGlu: 4.03 ± 0.084	3.528GlyPhe: 3.528 ± 0.077	5.855GlyGly: 5.855 ± 0.145	1.938GlyHis: 1.938 ± 0.047	4.569GlyIle: 4.569 ± 0.08	3.533GlyLys: 3.533 ± 0.085	8.266GlyLeu: 8.266 ± 0.114	2.317GlyMet: 2.317 ± 0.064	2.327GlyAsn: 2.327 ± 0.074	2.137GlyPro: 2.137 ± 0.051	3.399GlyGln: 3.399 ± 0.069	4.363GlyArg: 4.363 ± 0.074	4.376GlySer: 4.376 ± 0.091	3.97GlyThr: 3.97 ± 0.094	5.846GlyVal: 5.846 ± 0.094	1.202GlyTrp: 1.202 ± 0.045	2.265GlyTyr: 2.265 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.424HisAla: 2.424 ± 0.062	0.255HisCys: 0.255 ± 0.019	1.355HisAsp: 1.355 ± 0.051	1.248HisGlu: 1.248 ± 0.046	0.966HisPhe: 0.966 ± 0.039	1.875HisGly: 1.875 ± 0.047	0.716HisHis: 0.716 ± 0.036	1.288HisIle: 1.288 ± 0.046	0.694HisLys: 0.694 ± 0.03	2.619HisLeu: 2.619 ± 0.06	0.581HisMet: 0.581 ± 0.025	0.685HisAsn: 0.685 ± 0.029	1.678HisPro: 1.678 ± 0.048	1.034HisGln: 1.034 ± 0.038	1.581HisArg: 1.581 ± 0.043	1.24HisSer: 1.24 ± 0.041	1.201HisThr: 1.201 ± 0.041	1.468HisVal: 1.468 ± 0.041	0.526HisTrp: 0.526 ± 0.029	0.721HisTyr: 0.721 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.238IleAla: 6.238 ± 0.102	0.439IleCys: 0.439 ± 0.024	4.226IleAsp: 4.226 ± 0.079	4.26IleGlu: 4.26 ± 0.075	1.79IlePhe: 1.79 ± 0.051	4.783IleGly: 4.783 ± 0.082	1.353IleHis: 1.353 ± 0.05	2.755IleIle: 2.755 ± 0.081	2.277IleLys: 2.277 ± 0.061	4.945IleLeu: 4.945 ± 0.093	1.19IleMet: 1.19 ± 0.039	2.364IleAsn: 2.364 ± 0.055	2.729IlePro: 2.729 ± 0.057	2.05IleGln: 2.05 ± 0.064	3.419IleArg: 3.419 ± 0.07	3.42IleSer: 3.42 ± 0.069	3.464IleThr: 3.464 ± 0.077	3.897IleVal: 3.897 ± 0.078	0.612IleTrp: 0.612 ± 0.028	1.255IleTyr: 1.255 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.971LysAla: 3.971 ± 0.08	0.163LysCys: 0.163 ± 0.017	1.871LysAsp: 1.871 ± 0.057	1.783LysGlu: 1.783 ± 0.046	1.118LysPhe: 1.118 ± 0.038	2.359LysGly: 2.359 ± 0.06	0.859LysHis: 0.859 ± 0.031	2.279LysIle: 2.279 ± 0.066	1.878LysLys: 1.878 ± 0.054	3.541LysLeu: 3.541 ± 0.073	0.997LysMet: 0.997 ± 0.036	1.511LysAsn: 1.511 ± 0.047	2.474LysPro: 2.474 ± 0.063	1.849LysGln: 1.849 ± 0.053	2.281LysArg: 2.281 ± 0.057	2.372LysSer: 2.372 ± 0.06	2.551LysThr: 2.551 ± 0.065	2.343LysVal: 2.343 ± 0.065	0.365LysTrp: 0.365 ± 0.023	0.834LysTyr: 0.834 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.245LeuAla: 12.245 ± 0.161	0.821LeuCys: 0.821 ± 0.035	6.355LeuAsp: 6.355 ± 0.098	4.971LeuGlu: 4.971 ± 0.1	4.022LeuPhe: 4.022 ± 0.096	7.842LeuGly: 7.842 ± 0.119	2.273LeuHis: 2.273 ± 0.06	6.641LeuIle: 6.641 ± 0.1	4.225LeuLys: 4.225 ± 0.067	10.586LeuLeu: 10.586 ± 0.159	2.662LeuMet: 2.662 ± 0.066	3.905LeuAsn: 3.905 ± 0.07	5.772LeuPro: 5.772 ± 0.091	3.376LeuGln: 3.376 ± 0.075	6.175LeuArg: 6.175 ± 0.113	7.075LeuSer: 7.075 ± 0.102	6.084LeuThr: 6.084 ± 0.097	7.159LeuVal: 7.159 ± 0.106	1.297LeuTrp: 1.297 ± 0.054	2.045LeuTyr: 2.045 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.903MetAla: 2.903 ± 0.065	0.12MetCys: 0.12 ± 0.014	1.292MetAsp: 1.292 ± 0.046	0.946MetGlu: 0.946 ± 0.039	0.738MetPhe: 0.738 ± 0.029	1.816MetGly: 1.816 ± 0.052	0.531MetHis: 0.531 ± 0.025	1.543MetIle: 1.543 ± 0.049	1.079MetLys: 1.079 ± 0.04	2.48MetLeu: 2.48 ± 0.065	0.737MetMet: 0.737 ± 0.031	1.215MetAsn: 1.215 ± 0.041	1.403MetPro: 1.403 ± 0.039	1.135MetGln: 1.135 ± 0.035	1.581MetArg: 1.581 ± 0.039	1.854MetSer: 1.854 ± 0.052	1.741MetThr: 1.741 ± 0.045	1.737MetVal: 1.737 ± 0.047	0.185MetTrp: 0.185 ± 0.017	0.414MetTyr: 0.414 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.461AsnAla: 3.461 ± 0.071	0.261AsnCys: 0.261 ± 0.02	1.762AsnAsp: 1.762 ± 0.051	1.753AsnGlu: 1.753 ± 0.048	1.041AsnPhe: 1.041 ± 0.039	2.564AsnGly: 2.564 ± 0.067	0.817AsnHis: 0.817 ± 0.032	1.883AsnIle: 1.883 ± 0.052	1.189AsnLys: 1.189 ± 0.032	3.431AsnLeu: 3.431 ± 0.071	0.766AsnMet: 0.766 ± 0.032	1.18AsnAsn: 1.18 ± 0.043	2.374AsnPro: 2.374 ± 0.054	1.731AsnGln: 1.731 ± 0.053	2.268AsnArg: 2.268 ± 0.061	1.669AsnSer: 1.669 ± 0.055	1.92AsnThr: 1.92 ± 0.052	1.983AsnVal: 1.983 ± 0.055	0.541AsnTrp: 0.541 ± 0.028	0.844AsnTyr: 0.844 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.18ProAla: 5.18 ± 0.095	0.335ProCys: 0.335 ± 0.022	3.498ProAsp: 3.498 ± 0.075	3.569ProGlu: 3.569 ± 0.064	1.941ProPhe: 1.941 ± 0.053	3.502ProGly: 3.502 ± 0.074	1.058ProHis: 1.058 ± 0.041	2.745ProIle: 2.745 ± 0.055	1.934ProLys: 1.934 ± 0.056	4.822ProLeu: 4.822 ± 0.09	1.331ProMet: 1.331 ± 0.043	1.834ProAsn: 1.834 ± 0.047	2.267ProPro: 2.267 ± 0.066	2.068ProGln: 2.068 ± 0.056	2.298ProArg: 2.298 ± 0.065	2.879ProSer: 2.879 ± 0.058	2.813ProThr: 2.813 ± 0.071	4.108ProVal: 4.108 ± 0.084	0.683ProTrp: 0.683 ± 0.027	1.156ProTyr: 1.156 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	5.026GlnAla: 5.026 ± 0.097	0.317GlnCys: 0.317 ± 0.021	1.735GlnAsp: 1.735 ± 0.041	1.794GlnGlu: 1.794 ± 0.051	1.597GlnPhe: 1.597 ± 0.045	3.027GlnGly: 3.027 ± 0.064	1.066GlnHis: 1.066 ± 0.041	2.863GlnIle: 2.863 ± 0.071	1.708GlnLys: 1.708 ± 0.05	4.387GlnLeu: 4.387 ± 0.089	1.196GlnMet: 1.196 ± 0.045	1.461GlnAsn: 1.461 ± 0.052	2.414GlnPro: 2.414 ± 0.06	2.248GlnGln: 2.248 ± 0.075	2.763GlnArg: 2.763 ± 0.064	2.928GlnSer: 2.928 ± 0.075	2.799GlnThr: 2.799 ± 0.082	2.851GlnVal: 2.851 ± 0.067	0.695GlnTrp: 0.695 ± 0.029	0.975GlnTyr: 0.975 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	6.305ArgAla: 6.305 ± 0.101	0.472ArgCys: 0.472 ± 0.029	3.39ArgAsp: 3.39 ± 0.071	3.481ArgGlu: 3.481 ± 0.078	2.733ArgPhe: 2.733 ± 0.065	3.866ArgGly: 3.866 ± 0.08	1.788ArgHis: 1.788 ± 0.05	3.796ArgIle: 3.796 ± 0.071	1.958ArgLys: 1.958 ± 0.06	7.452ArgLeu: 7.452 ± 0.112	1.551ArgMet: 1.551 ± 0.046	1.809ArgAsn: 1.809 ± 0.046	2.675ArgPro: 2.675 ± 0.057	3.022ArgGln: 3.022 ± 0.063	4.097ArgArg: 4.097 ± 0.081	3.292ArgSer: 3.292 ± 0.064	2.627ArgThr: 2.627 ± 0.059	4.543ArgVal: 4.543 ± 0.08	1.004ArgTrp: 1.004 ± 0.035	1.869ArgTyr: 1.869 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	6.431SerAla: 6.431 ± 0.1	0.461SerCys: 0.461 ± 0.027	3.2SerAsp: 3.2 ± 0.07	2.974SerGlu: 2.974 ± 0.067	2.16SerPhe: 2.16 ± 0.051	5.377SerGly: 5.377 ± 0.114	1.277SerHis: 1.277 ± 0.04	3.165SerIle: 3.165 ± 0.068	2.064SerLys: 2.064 ± 0.056	6.209SerLeu: 6.209 ± 0.095	1.572SerMet: 1.572 ± 0.05	1.909SerAsn: 1.909 ± 0.054	2.968SerPro: 2.968 ± 0.066	2.279SerGln: 2.279 ± 0.062	3.302SerArg: 3.302 ± 0.073	3.72SerSer: 3.72 ± 0.086	3.321SerThr: 3.321 ± 0.062	4.315SerVal: 4.315 ± 0.091	0.74SerTrp: 0.74 ± 0.031	1.367SerTyr: 1.367 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	5.917ThrAla: 5.917 ± 0.105	0.411ThrCys: 0.411 ± 0.029	3.083ThrAsp: 3.083 ± 0.065	2.908ThrGlu: 2.908 ± 0.065	1.795ThrPhe: 1.795 ± 0.056	4.711ThrGly: 4.711 ± 0.096	1.426ThrHis: 1.426 ± 0.046	2.868ThrIle: 2.868 ± 0.062	1.618ThrLys: 1.618 ± 0.058	6.322ThrLeu: 6.322 ± 0.112	1.07ThrMet: 1.07 ± 0.033	1.645ThrAsn: 1.645 ± 0.044	3.469ThrPro: 3.469 ± 0.071	2.451ThrGln: 2.451 ± 0.061	3.155ThrArg: 3.155 ± 0.062	2.837ThrSer: 2.837 ± 0.062	3.123ThrThr: 3.123 ± 0.079	4.081ThrVal: 4.081 ± 0.072	0.622ThrTrp: 0.622 ± 0.029	1.197ThrTyr: 1.197 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	7.514ValAla: 7.514 ± 0.105	0.66ValCys: 0.66 ± 0.035	4.142ValAsp: 4.142 ± 0.066	3.752ValGlu: 3.752 ± 0.088	2.901ValPhe: 2.901 ± 0.061	5.125ValGly: 5.125 ± 0.097	1.549ValHis: 1.549 ± 0.041	4.397ValIle: 4.397 ± 0.086	2.326ValLys: 2.326 ± 0.066	7.694ValLeu: 7.694 ± 0.113	1.799ValMet: 1.799 ± 0.052	2.28ValAsn: 2.28 ± 0.059	3.345ValPro: 3.345 ± 0.067	2.511ValGln: 2.511 ± 0.059	4.272ValArg: 4.272 ± 0.073	4.276ValSer: 4.276 ± 0.077	3.996ValThr: 3.996 ± 0.078	5.386ValVal: 5.386 ± 0.085	0.874ValTrp: 0.874 ± 0.041	1.587ValTyr: 1.587 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.185TrpAla: 1.185 ± 0.044	0.133TrpCys: 0.133 ± 0.013	0.56TrpAsp: 0.56 ± 0.026	0.413TrpGlu: 0.413 ± 0.023	0.633TrpPhe: 0.633 ± 0.029	0.84TrpGly: 0.84 ± 0.035	0.445TrpHis: 0.445 ± 0.025	0.757TrpIle: 0.757 ± 0.032	0.381TrpLys: 0.381 ± 0.021	2.181TrpLeu: 2.181 ± 0.063	0.369TrpMet: 0.369 ± 0.025	0.353TrpAsn: 0.353 ± 0.022	0.687TrpPro: 0.687 ± 0.032	0.887TrpGln: 0.887 ± 0.035	1.117TrpArg: 1.117 ± 0.039	0.75TrpSer: 0.75 ± 0.033	0.577TrpThr: 0.577 ± 0.03	1.062TrpVal: 1.062 ± 0.039	0.223TrpTrp: 0.223 ± 0.018	0.344TrpTyr: 0.344 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.399TyrAla: 2.399 ± 0.059	0.238TyrCys: 0.238 ± 0.018	1.332TyrAsp: 1.332 ± 0.064	1.18TyrGlu: 1.18 ± 0.045	1.131TyrPhe: 1.131 ± 0.039	1.955TyrGly: 1.955 ± 0.057	0.568TyrHis: 0.568 ± 0.029	1.076TyrIle: 1.076 ± 0.033	0.719TyrLys: 0.719 ± 0.03	2.734TyrLeu: 2.734 ± 0.055	0.417TyrMet: 0.417 ± 0.023	0.748TyrAsn: 0.748 ± 0.031	1.229TyrPro: 1.229 ± 0.041	1.177TyrGln: 1.177 ± 0.038	1.838TyrArg: 1.838 ± 0.047	1.319TyrSer: 1.319 ± 0.044	1.259TyrThr: 1.259 ± 0.048	1.537TyrVal: 1.537 ± 0.051	0.42TyrTrp: 0.42 ± 0.024	0.689TyrTyr: 0.689 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2354 proteins (761027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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