Amino acid dipepetide frequency for Phlox virus B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.486AlaAla: 4.486 ± 1.815
1.38AlaCys: 1.38 ± 1.193
4.141AlaAsp: 4.141 ± 1.626
4.141AlaGlu: 4.141 ± 0.742
2.761AlaPhe: 2.761 ± 0.953
3.796AlaGly: 3.796 ± 0.997
1.725AlaHis: 1.725 ± 0.846
4.141AlaIle: 4.141 ± 1.862
6.556AlaLys: 6.556 ± 1.386
6.211AlaLeu: 6.211 ± 1.094
1.725AlaMet: 1.725 ± 0.575
2.415AlaAsn: 2.415 ± 2.143
1.38AlaPro: 1.38 ± 1.277
2.07AlaGln: 2.07 ± 1.427
2.07AlaArg: 2.07 ± 1.166
5.866AlaSer: 5.866 ± 1.208
3.796AlaThr: 3.796 ± 0.966
3.451AlaVal: 3.451 ± 0.463
0.69AlaTrp: 0.69 ± 0.518
3.106AlaTyr: 3.106 ± 1.135
0.0AlaXaa: 0.0 ± 0.0
Cys
1.725CysAla: 1.725 ± 0.517
0.345CysCys: 0.345 ± 0.169
0.69CysAsp: 0.69 ± 0.597
0.69CysGlu: 0.69 ± 0.339
2.07CysPhe: 2.07 ± 1.016
2.415CysGly: 2.415 ± 1.393
0.0CysHis: 0.0 ± 0.0
1.38CysIle: 1.38 ± 0.677
1.38CysLys: 1.38 ± 1.04
2.415CysLeu: 2.415 ± 1.022
0.345CysMet: 0.345 ± 0.657
0.69CysAsn: 0.69 ± 0.597
1.035CysPro: 1.035 ± 0.573
0.69CysGln: 0.69 ± 0.619
2.415CysArg: 2.415 ± 0.812
0.69CysSer: 0.69 ± 0.597
2.415CysThr: 2.415 ± 0.369
2.415CysVal: 2.415 ± 1.269
0.345CysTrp: 0.345 ± 0.169
0.69CysTyr: 0.69 ± 0.339
0.0CysXaa: 0.0 ± 0.0
Asp
2.761AspAla: 2.761 ± 0.74
1.035AspCys: 1.035 ± 0.536
3.451AspAsp: 3.451 ± 1.373
5.866AspGlu: 5.866 ± 1.275
3.451AspPhe: 3.451 ± 0.699
3.451AspGly: 3.451 ± 1.315
0.69AspHis: 0.69 ± 0.635
1.725AspIle: 1.725 ± 0.536
2.07AspLys: 2.07 ± 1.016
3.451AspLeu: 3.451 ± 0.871
1.38AspMet: 1.38 ± 0.503
2.415AspAsn: 2.415 ± 0.812
3.451AspPro: 3.451 ± 1.402
2.07AspGln: 2.07 ± 1.181
2.761AspArg: 2.761 ± 0.924
1.725AspSer: 1.725 ± 0.536
2.415AspThr: 2.415 ± 0.811
4.486AspVal: 4.486 ± 0.772
1.38AspTrp: 1.38 ± 0.503
2.415AspTyr: 2.415 ± 0.369
0.0AspXaa: 0.0 ± 0.0
Glu
5.521GluAla: 5.521 ± 1.605
1.725GluCys: 1.725 ± 0.846
2.415GluAsp: 2.415 ± 0.97
7.937GluGlu: 7.937 ± 1.617
6.211GluPhe: 6.211 ± 1.274
6.556GluGly: 6.556 ± 1.824
2.07GluHis: 2.07 ± 1.016
4.141GluIle: 4.141 ± 1.575
5.866GluLys: 5.866 ± 1.929
4.141GluLeu: 4.141 ± 1.575
2.761GluMet: 2.761 ± 0.936
3.451GluAsn: 3.451 ± 1.319
3.451GluPro: 3.451 ± 1.257
1.725GluGln: 1.725 ± 0.846
2.761GluArg: 2.761 ± 1.071
4.141GluSer: 4.141 ± 2.152
1.38GluThr: 1.38 ± 0.677
4.831GluVal: 4.831 ± 1.514
1.035GluTrp: 1.035 ± 0.482
2.761GluTyr: 2.761 ± 1.551
0.0GluXaa: 0.0 ± 0.0
Phe
3.106PheAla: 3.106 ± 1.202
0.345PheCys: 0.345 ± 0.169
3.451PheAsp: 3.451 ± 0.699
5.521PheGlu: 5.521 ± 0.773
3.451PhePhe: 3.451 ± 0.583
2.761PheGly: 2.761 ± 0.997
1.725PheHis: 1.725 ± 0.993
1.725PheIle: 1.725 ± 0.517
2.761PheLys: 2.761 ± 1.354
5.521PheLeu: 5.521 ± 1.713
1.035PheMet: 1.035 ± 0.508
2.761PheAsn: 2.761 ± 0.816
0.69PhePro: 0.69 ± 0.339
3.106PheGln: 3.106 ± 1.202
3.796PheArg: 3.796 ± 0.966
3.451PheSer: 3.451 ± 1.02
3.451PheThr: 3.451 ± 1.02
3.106PheVal: 3.106 ± 1.982
0.345PheTrp: 0.345 ± 0.169
1.725PheTyr: 1.725 ± 0.846
0.345PheXaa: 0.345 ± 0.169
Gly
4.831GlyAla: 4.831 ± 1.271
0.69GlyCys: 0.69 ± 0.619
2.761GlyAsp: 2.761 ± 0.614
4.141GlyGlu: 4.141 ± 1.39
2.415GlyPhe: 2.415 ± 2.32
4.831GlyGly: 4.831 ± 1.331
1.035GlyHis: 1.035 ± 0.508
2.761GlyIle: 2.761 ± 0.749
5.176GlyLys: 5.176 ± 1.326
6.556GlyLeu: 6.556 ± 1.606
0.69GlyMet: 0.69 ± 0.339
2.761GlyAsn: 2.761 ± 1.025
2.761GlyPro: 2.761 ± 0.614
1.38GlyGln: 1.38 ± 1.148
3.796GlyArg: 3.796 ± 1.251
6.901GlySer: 6.901 ± 0.967
4.141GlyThr: 4.141 ± 0.733
7.246GlyVal: 7.246 ± 0.926
2.07GlyTrp: 2.07 ± 0.586
1.38GlyTyr: 1.38 ± 0.677
0.0GlyXaa: 0.0 ± 0.0
His
0.69HisAla: 0.69 ± 0.339
0.69HisCys: 0.69 ± 0.619
1.38HisAsp: 1.38 ± 0.67
0.69HisGlu: 0.69 ± 0.597
0.69HisPhe: 0.69 ± 0.339
1.035HisGly: 1.035 ± 1.559
0.345HisHis: 0.345 ± 0.169
2.07HisIle: 2.07 ± 0.683
1.38HisLys: 1.38 ± 0.677
5.521HisLeu: 5.521 ± 1.633
0.345HisMet: 0.345 ± 0.56
0.345HisAsn: 0.345 ± 0.664
1.035HisPro: 1.035 ± 0.482
0.345HisGln: 0.345 ± 0.169
1.035HisArg: 1.035 ± 0.536
2.07HisSer: 2.07 ± 0.595
2.415HisThr: 2.415 ± 0.607
1.725HisVal: 1.725 ± 0.846
0.0HisTrp: 0.0 ± 0.0
0.69HisTyr: 0.69 ± 0.518
0.0HisXaa: 0.0 ± 0.0
Ile
2.761IleAla: 2.761 ± 1.508
1.725IleCys: 1.725 ± 0.517
2.415IleAsp: 2.415 ± 0.811
4.831IleGlu: 4.831 ± 1.189
1.725IlePhe: 1.725 ± 0.667
4.831IleGly: 4.831 ± 2.017
2.07IleHis: 2.07 ± 0.595
3.451IleIle: 3.451 ± 1.016
4.486IleLys: 4.486 ± 1.029
3.796IleLeu: 3.796 ± 1.315
1.035IleMet: 1.035 ± 0.508
2.07IleAsn: 2.07 ± 0.788
2.07IlePro: 2.07 ± 0.586
2.415IleGln: 2.415 ± 1.243
2.07IleArg: 2.07 ± 1.181
3.106IleSer: 3.106 ± 0.721
1.38IleThr: 1.38 ± 0.635
3.796IleVal: 3.796 ± 1.91
0.0IleTrp: 0.0 ± 0.0
1.725IleTyr: 1.725 ± 0.517
0.0IleXaa: 0.0 ± 0.0
Lys
4.831LysAla: 4.831 ± 1.779
1.035LysCys: 1.035 ± 0.573
5.176LysAsp: 5.176 ± 1.213
3.796LysGlu: 3.796 ± 1.429
3.451LysPhe: 3.451 ± 0.913
5.176LysGly: 5.176 ± 1.162
1.38LysHis: 1.38 ± 0.677
3.796LysIle: 3.796 ± 1.018
5.521LysLys: 5.521 ± 1.167
7.937LysLeu: 7.937 ± 0.872
0.69LysMet: 0.69 ± 0.339
2.761LysAsn: 2.761 ± 1.354
2.415LysPro: 2.415 ± 0.989
2.761LysGln: 2.761 ± 0.924
4.141LysArg: 4.141 ± 1.004
4.486LysSer: 4.486 ± 1.495
2.07LysThr: 2.07 ± 0.755
4.831LysVal: 4.831 ± 1.639
0.69LysTrp: 0.69 ± 0.339
2.415LysTyr: 2.415 ± 0.89
0.0LysXaa: 0.0 ± 0.0
Leu
4.831LeuAla: 4.831 ± 1.339
3.106LeuCys: 3.106 ± 1.256
3.451LeuAsp: 3.451 ± 0.699
8.282LeuGlu: 8.282 ± 2.602
3.451LeuPhe: 3.451 ± 1.261
5.521LeuGly: 5.521 ± 1.839
1.38LeuHis: 1.38 ± 0.677
8.282LeuIle: 8.282 ± 3.49
8.282LeuLys: 8.282 ± 2.12
8.627LeuLeu: 8.627 ± 3.97
1.035LeuMet: 1.035 ± 0.482
2.07LeuAsn: 2.07 ± 0.786
4.486LeuPro: 4.486 ± 1.67
1.725LeuGln: 1.725 ± 0.986
3.796LeuArg: 3.796 ± 1.682
8.282LeuSer: 8.282 ± 1.094
3.106LeuThr: 3.106 ± 1.298
6.211LeuVal: 6.211 ± 1.084
0.69LeuTrp: 0.69 ± 0.339
3.106LeuTyr: 3.106 ± 0.952
0.0LeuXaa: 0.0 ± 0.0
Met
2.761MetAla: 2.761 ± 0.953
0.69MetCys: 0.69 ± 0.339
1.725MetAsp: 1.725 ± 0.517
2.415MetGlu: 2.415 ± 1.185
0.345MetPhe: 0.345 ± 0.763
1.725MetGly: 1.725 ± 1.626
1.38MetHis: 1.38 ± 0.503
0.345MetIle: 0.345 ± 0.169
0.69MetLys: 0.69 ± 0.339
1.035MetLeu: 1.035 ± 0.508
1.035MetMet: 1.035 ± 0.508
1.035MetAsn: 1.035 ± 0.482
2.415MetPro: 2.415 ± 0.981
1.035MetGln: 1.035 ± 0.508
2.07MetArg: 2.07 ± 0.683
0.345MetSer: 0.345 ± 0.664
0.345MetThr: 0.345 ± 0.169
1.725MetVal: 1.725 ± 0.604
0.0MetTrp: 0.0 ± 0.0
0.69MetTyr: 0.69 ± 0.339
0.0MetXaa: 0.0 ± 0.0
Asn
1.38AsnAla: 1.38 ± 0.503
1.725AsnCys: 1.725 ± 1.308
2.07AsnAsp: 2.07 ± 0.683
2.415AsnGlu: 2.415 ± 0.811
2.761AsnPhe: 2.761 ± 0.953
2.415AsnGly: 2.415 ± 0.593
1.035AsnHis: 1.035 ± 0.536
2.07AsnIle: 2.07 ± 0.877
2.415AsnLys: 2.415 ± 0.97
3.106AsnLeu: 3.106 ± 0.892
1.035AsnMet: 1.035 ± 1.111
3.106AsnAsn: 3.106 ± 2.451
1.035AsnPro: 1.035 ± 0.508
0.69AsnGln: 0.69 ± 0.597
2.07AsnArg: 2.07 ± 0.574
4.486AsnSer: 4.486 ± 1.756
2.415AsnThr: 2.415 ± 0.811
1.725AsnVal: 1.725 ± 0.604
1.035AsnTrp: 1.035 ± 0.508
2.07AsnTyr: 2.07 ± 0.683
0.0AsnXaa: 0.0 ± 0.0
Pro
2.415ProAla: 2.415 ± 0.989
1.38ProCys: 1.38 ± 0.677
3.796ProAsp: 3.796 ± 0.983
3.106ProGlu: 3.106 ± 1.445
1.725ProPhe: 1.725 ± 1.57
3.451ProGly: 3.451 ± 0.43
1.38ProHis: 1.38 ± 0.943
1.38ProIle: 1.38 ± 0.67
2.07ProLys: 2.07 ± 0.964
3.106ProLeu: 3.106 ± 0.754
2.07ProMet: 2.07 ± 0.683
2.07ProAsn: 2.07 ± 0.768
3.106ProPro: 3.106 ± 1.825
1.38ProGln: 1.38 ± 0.625
1.725ProArg: 1.725 ± 0.894
1.725ProSer: 1.725 ± 0.575
3.106ProThr: 3.106 ± 1.445
1.035ProVal: 1.035 ± 0.482
0.69ProTrp: 0.69 ± 0.635
2.07ProTyr: 2.07 ± 0.586
0.0ProXaa: 0.0 ± 0.0
Gln
2.07GlnAla: 2.07 ± 1.072
0.345GlnCys: 0.345 ± 0.733
1.38GlnAsp: 1.38 ± 0.67
2.07GlnGlu: 2.07 ± 0.683
0.69GlnPhe: 0.69 ± 0.339
2.415GlnGly: 2.415 ± 1.185
1.38GlnHis: 1.38 ± 0.67
3.106GlnIle: 3.106 ± 1.655
1.38GlnLys: 1.38 ± 1.277
4.486GlnLeu: 4.486 ± 1.319
0.345GlnMet: 0.345 ± 0.169
0.69GlnAsn: 0.69 ± 1.205
2.07GlnPro: 2.07 ± 0.595
0.0GlnGln: 0.0 ± 0.0
1.38GlnArg: 1.38 ± 0.503
3.106GlnSer: 3.106 ± 0.956
1.035GlnThr: 1.035 ± 0.573
1.38GlnVal: 1.38 ± 0.705
0.345GlnTrp: 0.345 ± 0.664
1.035GlnTyr: 1.035 ± 0.809
0.0GlnXaa: 0.0 ± 0.0
Arg
5.521ArgAla: 5.521 ± 1.328
1.38ArgCys: 1.38 ± 1.655
1.38ArgAsp: 1.38 ± 0.677
3.106ArgGlu: 3.106 ± 0.842
6.556ArgPhe: 6.556 ± 0.829
3.796ArgGly: 3.796 ± 1.271
1.38ArgHis: 1.38 ± 1.692
1.725ArgIle: 1.725 ± 0.947
3.106ArgLys: 3.106 ± 0.517
3.796ArgLeu: 3.796 ± 0.701
2.07ArgMet: 2.07 ± 0.683
2.07ArgAsn: 2.07 ± 0.683
2.415ArgPro: 2.415 ± 0.593
2.415ArgGln: 2.415 ± 1.501
2.761ArgArg: 2.761 ± 1.803
3.106ArgSer: 3.106 ± 1.392
1.725ArgThr: 1.725 ± 0.536
2.415ArgVal: 2.415 ± 0.896
0.345ArgTrp: 0.345 ± 0.169
2.415ArgTyr: 2.415 ± 1.16
0.0ArgXaa: 0.0 ± 0.0
Ser
5.176SerAla: 5.176 ± 1.42
2.415SerCys: 2.415 ± 0.836
5.521SerAsp: 5.521 ± 0.944
4.486SerGlu: 4.486 ± 0.944
2.415SerPhe: 2.415 ± 1.42
4.486SerGly: 4.486 ± 1.029
1.725SerHis: 1.725 ± 0.517
1.725SerIle: 1.725 ± 0.894
6.211SerLys: 6.211 ± 1.581
5.176SerLeu: 5.176 ± 1.853
1.035SerMet: 1.035 ± 0.508
1.725SerAsn: 1.725 ± 1.239
3.451SerPro: 3.451 ± 1.104
3.106SerGln: 3.106 ± 1.118
5.521SerArg: 5.521 ± 1.706
5.866SerSer: 5.866 ± 3.472
5.521SerThr: 5.521 ± 1.228
3.796SerVal: 3.796 ± 0.982
1.035SerTrp: 1.035 ± 0.573
1.38SerTyr: 1.38 ± 0.499
0.0SerXaa: 0.0 ± 0.0
Thr
2.761ThrAla: 2.761 ± 1.34
1.035ThrCys: 1.035 ± 0.508
1.725ThrAsp: 1.725 ± 0.986
4.141ThrGlu: 4.141 ± 1.171
4.141ThrPhe: 4.141 ± 0.873
4.486ThrGly: 4.486 ± 1.526
1.38ThrHis: 1.38 ± 0.677
2.415ThrIle: 2.415 ± 1.185
2.761ThrLys: 2.761 ± 0.932
4.831ThrLeu: 4.831 ± 1.512
1.38ThrMet: 1.38 ± 0.466
2.07ThrAsn: 2.07 ± 0.964
0.69ThrPro: 0.69 ± 0.635
0.69ThrGln: 0.69 ± 0.635
2.761ThrArg: 2.761 ± 1.094
3.796ThrSer: 3.796 ± 1.523
2.761ThrThr: 2.761 ± 1.34
3.106ThrVal: 3.106 ± 0.956
0.0ThrTrp: 0.0 ± 0.0
1.38ThrTyr: 1.38 ± 1.259
0.0ThrXaa: 0.0 ± 0.0
Val
3.796ValAla: 3.796 ± 1.333
2.415ValCys: 2.415 ± 0.812
3.796ValAsp: 3.796 ± 0.983
4.486ValGlu: 4.486 ± 1.226
2.761ValPhe: 2.761 ± 1.679
2.761ValGly: 2.761 ± 0.383
1.38ValHis: 1.38 ± 0.503
4.141ValIle: 4.141 ± 1.558
3.796ValLys: 3.796 ± 1.744
4.831ValLeu: 4.831 ± 1.861
1.38ValMet: 1.38 ± 0.648
3.796ValAsn: 3.796 ± 0.975
2.415ValPro: 2.415 ± 1.22
2.761ValGln: 2.761 ± 0.614
5.521ValArg: 5.521 ± 1.315
5.176ValSer: 5.176 ± 1.609
3.106ValThr: 3.106 ± 1.202
4.141ValVal: 4.141 ± 0.73
0.0ValTrp: 0.0 ± 0.0
2.761ValTyr: 2.761 ± 1.026
0.0ValXaa: 0.0 ± 0.0
Trp
0.69TrpAla: 0.69 ± 0.932
0.69TrpCys: 0.69 ± 0.597
0.0TrpAsp: 0.0 ± 0.0
0.345TrpGlu: 0.345 ± 0.664
1.38TrpPhe: 1.38 ± 0.677
0.0TrpGly: 0.0 ± 0.0
0.345TrpHis: 0.345 ± 0.169
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.07TrpLeu: 2.07 ± 1.016
0.345TrpMet: 0.345 ± 0.169
0.69TrpAsn: 0.69 ± 0.518
0.69TrpPro: 0.69 ± 0.518
0.0TrpGln: 0.0 ± 0.0
0.345TrpArg: 0.345 ± 0.169
1.035TrpSer: 1.035 ± 0.508
0.0TrpThr: 0.0 ± 0.0
2.07TrpVal: 2.07 ± 0.586
0.0TrpTrp: 0.0 ± 0.0
0.69TrpTyr: 0.69 ± 0.339
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.796TyrAla: 3.796 ± 0.956
0.69TyrCys: 0.69 ± 0.619
1.725TyrAsp: 1.725 ± 1.146
2.415TyrGlu: 2.415 ± 0.69
1.725TyrPhe: 1.725 ± 0.517
2.415TyrGly: 2.415 ± 1.176
0.69TyrHis: 0.69 ± 0.339
1.38TyrIle: 1.38 ± 0.677
3.451TyrLys: 3.451 ± 0.869
3.106TyrLeu: 3.106 ± 1.169
1.725TyrMet: 1.725 ± 1.094
2.07TyrAsn: 2.07 ± 0.964
1.725TyrPro: 1.725 ± 0.846
0.345TyrGln: 0.345 ± 0.169
0.69TyrArg: 0.69 ± 0.339
2.415TyrSer: 2.415 ± 0.896
1.725TyrThr: 1.725 ± 1.761
2.07TyrVal: 2.07 ± 1.062
0.69TyrTrp: 0.69 ± 0.339
0.345TyrTyr: 0.345 ± 0.169
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.345XaaTyr: 0.345 ± 0.169
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski