Amino acid dipepetide frequency for Paramesorhizobium deserti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.42AlaAla: 15.42 ± 0.159	0.936AlaCys: 0.936 ± 0.027	6.423AlaAsp: 6.423 ± 0.069	7.58AlaGlu: 7.58 ± 0.088	4.69AlaPhe: 4.69 ± 0.059	10.273AlaGly: 10.273 ± 0.102	2.209AlaHis: 2.209 ± 0.039	6.991AlaIle: 6.991 ± 0.079	4.179AlaLys: 4.179 ± 0.057	12.568AlaLeu: 12.568 ± 0.104	3.375AlaMet: 3.375 ± 0.044	3.032AlaAsn: 3.032 ± 0.045	4.823AlaPro: 4.823 ± 0.067	3.463AlaGln: 3.463 ± 0.052	7.917AlaArg: 7.917 ± 0.094	6.227AlaSer: 6.227 ± 0.073	5.493AlaThr: 5.493 ± 0.074	8.6AlaVal: 8.6 ± 0.079	1.416AlaTrp: 1.416 ± 0.031	2.638AlaTyr: 2.638 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.82CysAla: 0.82 ± 0.026	0.103CysCys: 0.103 ± 0.009	0.478CysAsp: 0.478 ± 0.016	0.411CysGlu: 0.411 ± 0.018	0.341CysPhe: 0.341 ± 0.015	0.892CysGly: 0.892 ± 0.023	0.227CysHis: 0.227 ± 0.014	0.427CysIle: 0.427 ± 0.016	0.174CysLys: 0.174 ± 0.012	0.751CysLeu: 0.751 ± 0.025	0.151CysMet: 0.151 ± 0.01	0.19CysAsn: 0.19 ± 0.011	0.388CysPro: 0.388 ± 0.016	0.211CysGln: 0.211 ± 0.012	0.564CysArg: 0.564 ± 0.021	0.416CysSer: 0.416 ± 0.017	0.383CysThr: 0.383 ± 0.016	0.559CysVal: 0.559 ± 0.02	0.119CysTrp: 0.119 ± 0.008	0.185CysTyr: 0.185 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.277AspAla: 6.277 ± 0.064	0.455AspCys: 0.455 ± 0.018	3.008AspAsp: 3.008 ± 0.05	3.603AspGlu: 3.603 ± 0.05	2.276AspPhe: 2.276 ± 0.035	5.074AspGly: 5.074 ± 0.066	1.262AspHis: 1.262 ± 0.031	3.623AspIle: 3.623 ± 0.052	1.804AspLys: 1.804 ± 0.039	5.678AspLeu: 5.678 ± 0.063	1.402AspMet: 1.402 ± 0.031	1.426AspAsn: 1.426 ± 0.03	3.358AspPro: 3.358 ± 0.055	1.653AspGln: 1.653 ± 0.035	4.17AspArg: 4.17 ± 0.061	1.939AspSer: 1.939 ± 0.037	2.492AspThr: 2.492 ± 0.041	3.883AspVal: 3.883 ± 0.056	0.936AspTrp: 0.936 ± 0.026	1.525AspTyr: 1.525 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.605GluAla: 7.605 ± 0.085	0.352GluCys: 0.352 ± 0.016	2.887GluAsp: 2.887 ± 0.054	3.746GluGlu: 3.746 ± 0.059	1.819GluPhe: 1.819 ± 0.037	4.37GluGly: 4.37 ± 0.061	1.23GluHis: 1.23 ± 0.033	3.946GluIle: 3.946 ± 0.053	3.057GluLys: 3.057 ± 0.047	5.309GluLeu: 5.309 ± 0.062	1.701GluMet: 1.701 ± 0.03	2.064GluAsn: 2.064 ± 0.038	2.774GluPro: 2.774 ± 0.046	2.051GluGln: 2.051 ± 0.043	4.905GluArg: 4.905 ± 0.063	2.339GluSer: 2.339 ± 0.04	3.766GluThr: 3.766 ± 0.048	3.694GluVal: 3.694 ± 0.05	0.733GluTrp: 0.733 ± 0.023	1.102GluTyr: 1.102 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.562PheAla: 4.562 ± 0.058	0.384PheCys: 0.384 ± 0.017	2.632PheAsp: 2.632 ± 0.043	2.222PheGlu: 2.222 ± 0.038	1.609PhePhe: 1.609 ± 0.039	3.813PheGly: 3.813 ± 0.052	0.838PheHis: 0.838 ± 0.027	2.122PheIle: 2.122 ± 0.04	1.017PheLys: 1.017 ± 0.032	3.756PheLeu: 3.756 ± 0.054	0.884PheMet: 0.884 ± 0.022	1.128PheAsn: 1.128 ± 0.029	1.724PhePro: 1.724 ± 0.035	1.097PheGln: 1.097 ± 0.026	2.397PheArg: 2.397 ± 0.043	2.488PheSer: 2.488 ± 0.04	2.065PheThr: 2.065 ± 0.04	2.905PheVal: 2.905 ± 0.055	0.575PheTrp: 0.575 ± 0.021	0.977PheTyr: 0.977 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.663GlyAla: 8.663 ± 0.101	0.797GlyCys: 0.797 ± 0.023	4.285GlyAsp: 4.285 ± 0.064	5.035GlyGlu: 5.035 ± 0.065	3.688GlyPhe: 3.688 ± 0.053	7.236GlyGly: 7.236 ± 0.147	1.785GlyHis: 1.785 ± 0.037	5.348GlyIle: 5.348 ± 0.061	3.632GlyLys: 3.632 ± 0.061	8.642GlyLeu: 8.642 ± 0.086	2.383GlyMet: 2.383 ± 0.041	2.476GlyAsn: 2.476 ± 0.054	3.292GlyPro: 3.292 ± 0.05	2.721GlyGln: 2.721 ± 0.043	5.851GlyArg: 5.851 ± 0.071	4.73GlySer: 4.73 ± 0.07	4.718GlyThr: 4.718 ± 0.104	6.003GlyVal: 6.003 ± 0.065	1.298GlyTrp: 1.298 ± 0.035	2.383GlyTyr: 2.383 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.16HisAla: 2.16 ± 0.038	0.217HisCys: 0.217 ± 0.011	1.266HisAsp: 1.266 ± 0.031	1.145HisGlu: 1.145 ± 0.029	0.897HisPhe: 0.897 ± 0.026	1.941HisGly: 1.941 ± 0.039	0.59HisHis: 0.59 ± 0.024	1.106HisIle: 1.106 ± 0.026	0.513HisLys: 0.513 ± 0.02	2.127HisLeu: 2.127 ± 0.042	0.518HisMet: 0.518 ± 0.019	0.45HisAsn: 0.45 ± 0.015	1.338HisPro: 1.338 ± 0.033	0.57HisGln: 0.57 ± 0.02	1.404HisArg: 1.404 ± 0.034	0.981HisSer: 0.981 ± 0.027	0.777HisThr: 0.777 ± 0.023	1.473HisVal: 1.473 ± 0.033	0.336HisTrp: 0.336 ± 0.015	0.566HisTyr: 0.566 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.111IleAla: 8.111 ± 0.079	0.556IleCys: 0.556 ± 0.021	3.866IleAsp: 3.866 ± 0.055	3.934IleGlu: 3.934 ± 0.057	2.173IlePhe: 2.173 ± 0.034	5.556IleGly: 5.556 ± 0.064	1.024IleHis: 1.024 ± 0.031	3.125IleIle: 3.125 ± 0.049	1.553IleLys: 1.553 ± 0.035	5.224IleLeu: 5.224 ± 0.072	1.199IleMet: 1.199 ± 0.031	1.69IleAsn: 1.69 ± 0.035	2.663IlePro: 2.663 ± 0.043	1.263IleGln: 1.263 ± 0.031	3.798IleArg: 3.798 ± 0.052	3.412IleSer: 3.412 ± 0.049	2.888IleThr: 2.888 ± 0.043	4.72IleVal: 4.72 ± 0.066	0.677IleTrp: 0.677 ± 0.025	1.277IleTyr: 1.277 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.547LysAla: 4.547 ± 0.065	0.168LysCys: 0.168 ± 0.01	1.832LysAsp: 1.832 ± 0.038	1.983LysGlu: 1.983 ± 0.045	0.961LysPhe: 0.961 ± 0.027	2.904LysGly: 2.904 ± 0.048	0.663LysHis: 0.663 ± 0.02	1.991LysIle: 1.991 ± 0.041	1.559LysLys: 1.559 ± 0.035	3.551LysLeu: 3.551 ± 0.051	0.847LysMet: 0.847 ± 0.023	1.095LysAsn: 1.095 ± 0.028	2.314LysPro: 2.314 ± 0.047	1.112LysGln: 1.112 ± 0.026	2.534LysArg: 2.534 ± 0.042	2.05LysSer: 2.05 ± 0.04	2.212LysThr: 2.212 ± 0.044	2.486LysVal: 2.486 ± 0.048	0.41LysTrp: 0.41 ± 0.02	0.693LysTyr: 0.693 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.882LeuAla: 12.882 ± 0.121	0.831LeuCys: 0.831 ± 0.025	5.908LeuAsp: 5.908 ± 0.063	5.277LeuGlu: 5.277 ± 0.065	3.876LeuPhe: 3.876 ± 0.063	8.054LeuGly: 8.054 ± 0.08	1.792LeuHis: 1.792 ± 0.033	5.651LeuIle: 5.651 ± 0.067	3.962LeuLys: 3.962 ± 0.055	9.433LeuLeu: 9.433 ± 0.131	2.443LeuMet: 2.443 ± 0.039	2.678LeuAsn: 2.678 ± 0.045	5.422LeuPro: 5.422 ± 0.062	2.703LeuGln: 2.703 ± 0.039	6.303LeuArg: 6.303 ± 0.078	6.612LeuSer: 6.612 ± 0.065	5.652LeuThr: 5.652 ± 0.072	7.351LeuVal: 7.351 ± 0.076	1.11LeuTrp: 1.11 ± 0.026	2.248LeuTyr: 2.248 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.07MetAla: 3.07 ± 0.043	0.144MetCys: 0.144 ± 0.009	1.122MetAsp: 1.122 ± 0.027	1.27MetGlu: 1.27 ± 0.029	0.743MetPhe: 0.743 ± 0.022	1.82MetGly: 1.82 ± 0.036	0.468MetHis: 0.468 ± 0.017	1.5MetIle: 1.5 ± 0.034	1.168MetLys: 1.168 ± 0.029	2.6MetLeu: 2.6 ± 0.044	0.739MetMet: 0.739 ± 0.022	0.828MetAsn: 0.828 ± 0.026	1.544MetPro: 1.544 ± 0.028	0.877MetGln: 0.877 ± 0.024	1.903MetArg: 1.903 ± 0.04	1.631MetSer: 1.631 ± 0.033	1.87MetThr: 1.87 ± 0.034	1.732MetVal: 1.732 ± 0.035	0.221MetTrp: 0.221 ± 0.013	0.305MetTyr: 0.305 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.316AsnAla: 3.316 ± 0.046	0.235AsnCys: 0.235 ± 0.014	1.504AsnAsp: 1.504 ± 0.031	1.466AsnGlu: 1.466 ± 0.03	1.049AsnPhe: 1.049 ± 0.027	2.725AsnGly: 2.725 ± 0.06	0.555AsnHis: 0.555 ± 0.019	1.652AsnIle: 1.652 ± 0.035	0.776AsnLys: 0.776 ± 0.023	2.694AsnLeu: 2.694 ± 0.044	0.698AsnMet: 0.698 ± 0.02	0.806AsnAsn: 0.806 ± 0.028	1.977AsnPro: 1.977 ± 0.039	0.807AsnGln: 0.807 ± 0.023	1.92AsnArg: 1.92 ± 0.036	1.363AsnSer: 1.363 ± 0.032	1.336AsnThr: 1.336 ± 0.038	2.095AsnVal: 2.095 ± 0.038	0.491AsnTrp: 0.491 ± 0.02	0.745AsnTyr: 0.745 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.796ProAla: 5.796 ± 0.074	0.276ProCys: 0.276 ± 0.014	3.63ProAsp: 3.63 ± 0.057	3.776ProGlu: 3.776 ± 0.057	2.076ProPhe: 2.076 ± 0.036	4.279ProGly: 4.279 ± 0.062	1.074ProHis: 1.074 ± 0.025	2.421ProIle: 2.421 ± 0.05	1.742ProLys: 1.742 ± 0.036	4.761ProLeu: 4.761 ± 0.06	1.118ProMet: 1.118 ± 0.027	1.285ProAsn: 1.285 ± 0.027	2.235ProPro: 2.235 ± 0.052	1.697ProGln: 1.697 ± 0.037	2.763ProArg: 2.763 ± 0.039	2.729ProSer: 2.729 ± 0.044	2.307ProThr: 2.307 ± 0.041	4.326ProVal: 4.326 ± 0.052	0.648ProTrp: 0.648 ± 0.021	1.259ProTyr: 1.259 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.73GlnAla: 3.73 ± 0.049	0.184GlnCys: 0.184 ± 0.012	1.361GlnAsp: 1.361 ± 0.033	1.666GlnGlu: 1.666 ± 0.037	1.104GlnPhe: 1.104 ± 0.024	2.185GlnGly: 2.185 ± 0.042	0.603GlnHis: 0.603 ± 0.017	1.877GlnIle: 1.877 ± 0.039	1.235GlnLys: 1.235 ± 0.026	2.751GlnLeu: 2.751 ± 0.041	0.926GlnMet: 0.926 ± 0.027	0.919GlnAsn: 0.919 ± 0.025	1.761GlnPro: 1.761 ± 0.037	1.124GlnGln: 1.124 ± 0.027	2.237GlnArg: 2.237 ± 0.039	1.773GlnSer: 1.773 ± 0.033	1.67GlnThr: 1.67 ± 0.034	2.027GlnVal: 2.027 ± 0.039	0.409GlnTrp: 0.409 ± 0.017	0.641GlnTyr: 0.641 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.078ArgAla: 7.078 ± 0.088	0.417ArgCys: 0.417 ± 0.017	3.941ArgAsp: 3.941 ± 0.06	4.317ArgGlu: 4.317 ± 0.063	2.964ArgPhe: 2.964 ± 0.05	4.462ArgGly: 4.462 ± 0.062	1.682ArgHis: 1.682 ± 0.033	4.423ArgIle: 4.423 ± 0.065	2.509ArgLys: 2.509 ± 0.042	7.407ArgLeu: 7.407 ± 0.075	1.916ArgMet: 1.916 ± 0.033	2.112ArgAsn: 2.112 ± 0.04	3.235ArgPro: 3.235 ± 0.045	2.642ArgGln: 2.642 ± 0.043	5.311ArgArg: 5.311 ± 0.075	3.661ArgSer: 3.661 ± 0.053	3.285ArgThr: 3.285 ± 0.051	4.405ArgVal: 4.405 ± 0.055	0.912ArgTrp: 0.912 ± 0.026	1.739ArgTyr: 1.739 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.032SerAla: 6.032 ± 0.071	0.404SerCys: 0.404 ± 0.017	3.003SerAsp: 3.003 ± 0.047	2.896SerGlu: 2.896 ± 0.044	2.415SerPhe: 2.415 ± 0.04	5.766SerGly: 5.766 ± 0.088	1.102SerHis: 1.102 ± 0.026	3.098SerIle: 3.098 ± 0.041	1.691SerLys: 1.691 ± 0.037	5.534SerLeu: 5.534 ± 0.057	1.325SerMet: 1.325 ± 0.032	1.46SerAsn: 1.46 ± 0.035	2.765SerPro: 2.765 ± 0.042	1.643SerGln: 1.643 ± 0.032	3.662SerArg: 3.662 ± 0.054	3.114SerSer: 3.114 ± 0.054	2.707SerThr: 2.707 ± 0.048	4.111SerVal: 4.111 ± 0.059	0.767SerTrp: 0.767 ± 0.025	1.374SerTyr: 1.374 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.043ThrAla: 6.043 ± 0.078	0.398ThrCys: 0.398 ± 0.017	2.678ThrAsp: 2.678 ± 0.04	2.712ThrGlu: 2.712 ± 0.041	2.06ThrPhe: 2.06 ± 0.036	5.209ThrGly: 5.209 ± 0.078	1.026ThrHis: 1.026 ± 0.024	3.303ThrIle: 3.303 ± 0.049	1.553ThrLys: 1.553 ± 0.034	5.791ThrLeu: 5.791 ± 0.098	1.194ThrMet: 1.194 ± 0.027	1.329ThrAsn: 1.329 ± 0.037	3.03ThrPro: 3.03 ± 0.044	1.359ThrGln: 1.359 ± 0.035	3.231ThrArg: 3.231 ± 0.047	2.864ThrSer: 2.864 ± 0.049	2.724ThrThr: 2.724 ± 0.055	4.292ThrVal: 4.292 ± 0.064	0.639ThrTrp: 0.639 ± 0.02	1.256ThrTyr: 1.256 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.467ValAla: 8.467 ± 0.086	0.566ValCys: 0.566 ± 0.02	3.932ValAsp: 3.932 ± 0.056	4.545ValGlu: 4.545 ± 0.066	2.922ValPhe: 2.922 ± 0.044	5.319ValGly: 5.319 ± 0.06	1.42ValHis: 1.42 ± 0.031	4.312ValIle: 4.312 ± 0.063	2.585ValLys: 2.585 ± 0.046	7.541ValLeu: 7.541 ± 0.083	1.89ValMet: 1.89 ± 0.032	2.092ValAsn: 2.092 ± 0.043	3.647ValPro: 3.647 ± 0.044	1.873ValGln: 1.873 ± 0.039	4.562ValArg: 4.562 ± 0.055	4.445ValSer: 4.445 ± 0.057	4.47ValThr: 4.47 ± 0.072	5.467ValVal: 5.467 ± 0.072	0.907ValTrp: 0.907 ± 0.026	1.576ValTyr: 1.576 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.17TrpAla: 1.17 ± 0.031	0.123TrpCys: 0.123 ± 0.009	0.629TrpAsp: 0.629 ± 0.021	0.559TrpGlu: 0.559 ± 0.016	0.535TrpPhe: 0.535 ± 0.02	0.878TrpGly: 0.878 ± 0.026	0.32TrpHis: 0.32 ± 0.015	0.681TrpIle: 0.681 ± 0.02	0.538TrpLys: 0.538 ± 0.019	1.655TrpLeu: 1.655 ± 0.035	0.362TrpMet: 0.362 ± 0.018	0.499TrpAsn: 0.499 ± 0.021	0.692TrpPro: 0.692 ± 0.024	0.565TrpGln: 0.565 ± 0.022	1.104TrpArg: 1.104 ± 0.029	0.84TrpSer: 0.84 ± 0.026	0.741TrpThr: 0.741 ± 0.024	0.758TrpVal: 0.758 ± 0.023	0.24TrpTrp: 0.24 ± 0.011	0.322TrpTyr: 0.322 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.504TyrAla: 2.504 ± 0.041	0.242TyrCys: 0.242 ± 0.011	1.46TyrAsp: 1.46 ± 0.039	1.307TyrGlu: 1.307 ± 0.031	0.998TyrPhe: 0.998 ± 0.025	2.207TyrGly: 2.207 ± 0.047	0.505TyrHis: 0.505 ± 0.02	1.112TyrIle: 1.112 ± 0.027	0.667TyrLys: 0.667 ± 0.021	2.415TyrLeu: 2.415 ± 0.044	0.482TyrMet: 0.482 ± 0.017	0.655TyrAsn: 0.655 ± 0.021	1.217TyrPro: 1.217 ± 0.03	0.753TyrGln: 0.753 ± 0.022	1.883TyrArg: 1.883 ± 0.04	1.257TyrSer: 1.257 ± 0.027	1.132TyrThr: 1.132 ± 0.029	1.651TyrVal: 1.651 ± 0.035	0.364TyrTrp: 0.364 ± 0.018	0.639TyrTyr: 0.639 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4946 proteins (1548363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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