Amino acid dipepetide frequency for Beijerinckiaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.791AlaAla: 18.791 ± 0.221	1.273AlaCys: 1.273 ± 0.046	6.033AlaAsp: 6.033 ± 0.087	7.349AlaGlu: 7.349 ± 0.093	4.727AlaPhe: 4.727 ± 0.085	11.043AlaGly: 11.043 ± 0.121	2.469AlaHis: 2.469 ± 0.048	7.153AlaIle: 7.153 ± 0.106	5.255AlaLys: 5.255 ± 0.087	12.939AlaLeu: 12.939 ± 0.134	3.058AlaMet: 3.058 ± 0.062	3.357AlaAsn: 3.357 ± 0.07	6.176AlaPro: 6.176 ± 0.091	3.865AlaGln: 3.865 ± 0.065	9.901AlaArg: 9.901 ± 0.132	6.891AlaSer: 6.891 ± 0.093	5.997AlaThr: 5.997 ± 0.072	7.948AlaVal: 7.948 ± 0.102	1.545AlaTrp: 1.545 ± 0.039	2.6AlaTyr: 2.6 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.334CysAla: 1.334 ± 0.043	0.151CysCys: 0.151 ± 0.016	0.609CysAsp: 0.609 ± 0.029	0.59CysGlu: 0.59 ± 0.022	0.392CysPhe: 0.392 ± 0.025	1.014CysGly: 1.014 ± 0.033	0.267CysHis: 0.267 ± 0.017	0.468CysIle: 0.468 ± 0.021	0.29CysLys: 0.29 ± 0.019	1.06CysLeu: 1.06 ± 0.035	0.176CysMet: 0.176 ± 0.013	0.29CysAsn: 0.29 ± 0.018	0.595CysPro: 0.595 ± 0.029	0.279CysGln: 0.279 ± 0.017	0.791CysArg: 0.791 ± 0.027	0.488CysSer: 0.488 ± 0.027	0.469CysThr: 0.469 ± 0.023	0.778CysVal: 0.778 ± 0.029	0.122CysTrp: 0.122 ± 0.012	0.21CysTyr: 0.21 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.485AspAla: 6.485 ± 0.092	0.549AspCys: 0.549 ± 0.024	2.598AspAsp: 2.598 ± 0.059	3.142AspGlu: 3.142 ± 0.064	2.309AspPhe: 2.309 ± 0.049	4.649AspGly: 4.649 ± 0.077	1.212AspHis: 1.212 ± 0.038	2.798AspIle: 2.798 ± 0.061	1.762AspLys: 1.762 ± 0.049	5.483AspLeu: 5.483 ± 0.084	1.12AspMet: 1.12 ± 0.035	1.198AspAsn: 1.198 ± 0.035	3.371AspPro: 3.371 ± 0.071	1.509AspGln: 1.509 ± 0.046	3.886AspArg: 3.886 ± 0.058	2.38AspSer: 2.38 ± 0.058	2.22AspThr: 2.22 ± 0.048	3.673AspVal: 3.673 ± 0.069	0.855AspTrp: 0.855 ± 0.026	1.4AspTyr: 1.4 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.794GluAla: 7.794 ± 0.107	0.462GluCys: 0.462 ± 0.022	2.524GluAsp: 2.524 ± 0.059	2.788GluGlu: 2.788 ± 0.059	1.885GluPhe: 1.885 ± 0.046	3.812GluGly: 3.812 ± 0.07	1.19GluHis: 1.19 ± 0.04	3.711GluIle: 3.711 ± 0.063	2.491GluLys: 2.491 ± 0.057	5.011GluLeu: 5.011 ± 0.071	1.329GluMet: 1.329 ± 0.039	1.7GluAsn: 1.7 ± 0.043	2.755GluPro: 2.755 ± 0.064	1.805GluGln: 1.805 ± 0.048	4.944GluArg: 4.944 ± 0.078	2.697GluSer: 2.697 ± 0.054	3.463GluThr: 3.463 ± 0.07	3.466GluVal: 3.466 ± 0.064	0.741GluTrp: 0.741 ± 0.032	0.93GluTyr: 0.93 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	5.204PheAla: 5.204 ± 0.082	0.538PheCys: 0.538 ± 0.025	2.77PheAsp: 2.77 ± 0.07	2.301PheGlu: 2.301 ± 0.052	1.671PhePhe: 1.671 ± 0.044	3.808PheGly: 3.808 ± 0.072	0.841PheHis: 0.841 ± 0.031	1.707PheIle: 1.707 ± 0.047	1.219PheLys: 1.219 ± 0.032	3.681PheLeu: 3.681 ± 0.071	0.717PheMet: 0.717 ± 0.026	1.168PheAsn: 1.168 ± 0.038	1.818PhePro: 1.818 ± 0.046	0.955PheGln: 0.955 ± 0.035	2.501PheArg: 2.501 ± 0.055	2.405PheSer: 2.405 ± 0.056	1.983PheThr: 1.983 ± 0.056	3.018PheVal: 3.018 ± 0.056	0.585PheTrp: 0.585 ± 0.027	0.916PheTyr: 0.916 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	9.518GlyAla: 9.518 ± 0.114	0.916GlyCys: 0.916 ± 0.035	4.059GlyAsp: 4.059 ± 0.076	4.711GlyGlu: 4.711 ± 0.071	3.798GlyPhe: 3.798 ± 0.063	7.221GlyGly: 7.221 ± 0.124	1.995GlyHis: 1.995 ± 0.046	4.361GlyIle: 4.361 ± 0.076	3.608GlyLys: 3.608 ± 0.07	8.746GlyLeu: 8.746 ± 0.099	1.939GlyMet: 1.939 ± 0.051	2.324GlyAsn: 2.324 ± 0.059	3.775GlyPro: 3.775 ± 0.067	2.69GlyGln: 2.69 ± 0.06	6.215GlyArg: 6.215 ± 0.091	4.543GlySer: 4.543 ± 0.076	4.449GlyThr: 4.449 ± 0.076	5.765GlyVal: 5.765 ± 0.075	1.247GlyTrp: 1.247 ± 0.039	2.05GlyTyr: 2.05 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.585HisAla: 2.585 ± 0.057	0.304HisCys: 0.304 ± 0.019	1.187HisAsp: 1.187 ± 0.037	1.146HisGlu: 1.146 ± 0.033	1.019HisPhe: 1.019 ± 0.04	2.159HisGly: 2.159 ± 0.044	0.615HisHis: 0.615 ± 0.047	1.009HisIle: 1.009 ± 0.034	0.632HisLys: 0.632 ± 0.026	2.143HisLeu: 2.143 ± 0.047	0.457HisMet: 0.457 ± 0.021	0.502HisAsn: 0.502 ± 0.024	1.368HisPro: 1.368 ± 0.043	0.581HisGln: 0.581 ± 0.026	1.569HisArg: 1.569 ± 0.044	0.999HisSer: 0.999 ± 0.031	0.817HisThr: 0.817 ± 0.03	1.58HisVal: 1.58 ± 0.043	0.343HisTrp: 0.343 ± 0.023	0.615HisTyr: 0.615 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.807IleAla: 7.807 ± 0.106	0.618IleCys: 0.618 ± 0.025	3.554IleAsp: 3.554 ± 0.061	4.008IleGlu: 4.008 ± 0.066	1.98IlePhe: 1.98 ± 0.048	4.801IleGly: 4.801 ± 0.071	1.005IleHis: 1.005 ± 0.031	2.279IleIle: 2.279 ± 0.05	1.787IleLys: 1.787 ± 0.052	4.736IleLeu: 4.736 ± 0.069	0.953IleMet: 0.953 ± 0.032	1.38IleAsn: 1.38 ± 0.043	2.459IlePro: 2.459 ± 0.055	1.117IleGln: 1.117 ± 0.036	2.979IleArg: 2.979 ± 0.062	2.836IleSer: 2.836 ± 0.056	2.372IleThr: 2.372 ± 0.053	4.604IleVal: 4.604 ± 0.082	0.643IleTrp: 0.643 ± 0.026	1.177IleTyr: 1.177 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.494LysAla: 4.494 ± 0.073	0.291LysCys: 0.291 ± 0.017	1.818LysAsp: 1.818 ± 0.049	1.837LysGlu: 1.837 ± 0.047	1.151LysPhe: 1.151 ± 0.033	2.74LysGly: 2.74 ± 0.056	0.779LysHis: 0.779 ± 0.028	2.399LysIle: 2.399 ± 0.053	1.561LysLys: 1.561 ± 0.042	3.907LysLeu: 3.907 ± 0.068	0.894LysMet: 0.894 ± 0.027	1.144LysAsn: 1.144 ± 0.035	2.364LysPro: 2.364 ± 0.056	1.193LysGln: 1.193 ± 0.035	2.81LysArg: 2.81 ± 0.052	2.212LysSer: 2.212 ± 0.052	2.288LysThr: 2.288 ± 0.055	2.32LysVal: 2.32 ± 0.049	0.391LysTrp: 0.391 ± 0.021	0.688LysTyr: 0.688 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.504LeuAla: 14.504 ± 0.148	1.053LeuCys: 1.053 ± 0.037	6.013LeuAsp: 6.013 ± 0.093	5.109LeuGlu: 5.109 ± 0.092	3.663LeuPhe: 3.663 ± 0.061	8.118LeuGly: 8.118 ± 0.093	2.053LeuHis: 2.053 ± 0.049	5.103LeuIle: 5.103 ± 0.076	3.669LeuLys: 3.669 ± 0.071	9.279LeuLeu: 9.279 ± 0.124	1.989LeuMet: 1.989 ± 0.051	2.56LeuAsn: 2.56 ± 0.057	5.65LeuPro: 5.65 ± 0.089	2.634LeuGln: 2.634 ± 0.054	7.499LeuArg: 7.499 ± 0.1	5.969LeuSer: 5.969 ± 0.09	5.195LeuThr: 5.195 ± 0.081	6.994LeuVal: 6.994 ± 0.096	1.159LeuTrp: 1.159 ± 0.041	2.033LeuTyr: 2.033 ± 0.052	0.001LeuXaa: 0.001 ± 0.001
Met	2.631MetAla: 2.631 ± 0.054	0.167MetCys: 0.167 ± 0.014	0.978MetAsp: 0.978 ± 0.034	1.042MetGlu: 1.042 ± 0.037	0.686MetPhe: 0.686 ± 0.027	1.522MetGly: 1.522 ± 0.037	0.44MetHis: 0.44 ± 0.022	1.293MetIle: 1.293 ± 0.039	0.949MetLys: 0.949 ± 0.034	2.134MetLeu: 2.134 ± 0.042	0.461MetMet: 0.461 ± 0.025	0.711MetAsn: 0.711 ± 0.029	1.437MetPro: 1.437 ± 0.034	0.71MetGln: 0.71 ± 0.026	1.901MetArg: 1.901 ± 0.046	1.345MetSer: 1.345 ± 0.041	1.535MetThr: 1.535 ± 0.043	1.352MetVal: 1.352 ± 0.037	0.212MetTrp: 0.212 ± 0.014	0.263MetTyr: 0.263 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.295AsnAla: 3.295 ± 0.06	0.32AsnCys: 0.32 ± 0.019	1.385AsnAsp: 1.385 ± 0.037	1.381AsnGlu: 1.381 ± 0.037	1.157AsnPhe: 1.157 ± 0.037	2.513AsnGly: 2.513 ± 0.058	0.587AsnHis: 0.587 ± 0.026	1.479AsnIle: 1.479 ± 0.045	0.84AsnLys: 0.84 ± 0.033	2.838AsnLeu: 2.838 ± 0.055	0.573AsnMet: 0.573 ± 0.027	0.802AsnAsn: 0.802 ± 0.034	1.96AsnPro: 1.96 ± 0.048	0.9AsnGln: 0.9 ± 0.03	1.869AsnArg: 1.869 ± 0.047	1.424AsnSer: 1.424 ± 0.042	1.263AsnThr: 1.263 ± 0.045	1.89AsnVal: 1.89 ± 0.049	0.447AsnTrp: 0.447 ± 0.025	0.741AsnTyr: 0.741 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.742ProAla: 6.742 ± 0.097	0.526ProCys: 0.526 ± 0.026	3.325ProAsp: 3.325 ± 0.068	3.368ProGlu: 3.368 ± 0.068	2.182ProPhe: 2.182 ± 0.052	5.09ProGly: 5.09 ± 0.08	1.217ProHis: 1.217 ± 0.037	2.385ProIle: 2.385 ± 0.043	1.997ProLys: 1.997 ± 0.043	4.982ProLeu: 4.982 ± 0.081	1.17ProMet: 1.17 ± 0.034	1.59ProAsn: 1.59 ± 0.04	3.693ProPro: 3.693 ± 0.094	1.716ProGln: 1.716 ± 0.047	3.743ProArg: 3.743 ± 0.065	3.207ProSer: 3.207 ± 0.066	2.294ProThr: 2.294 ± 0.056	4.006ProVal: 4.006 ± 0.07	0.716ProTrp: 0.716 ± 0.027	1.203ProTyr: 1.203 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.778GlnAla: 3.778 ± 0.068	0.25GlnCys: 0.25 ± 0.016	1.424GlnAsp: 1.424 ± 0.046	1.456GlnGlu: 1.456 ± 0.044	1.072GlnPhe: 1.072 ± 0.034	2.314GlnGly: 2.314 ± 0.054	0.66GlnHis: 0.66 ± 0.028	1.863GlnIle: 1.863 ± 0.052	1.222GlnLys: 1.222 ± 0.037	2.681GlnLeu: 2.681 ± 0.058	0.738GlnMet: 0.738 ± 0.026	0.945GlnAsn: 0.945 ± 0.032	1.622GlnPro: 1.622 ± 0.045	0.932GlnGln: 0.932 ± 0.035	2.321GlnArg: 2.321 ± 0.056	1.725GlnSer: 1.725 ± 0.049	1.724GlnThr: 1.724 ± 0.043	1.775GlnVal: 1.775 ± 0.044	0.41GlnTrp: 0.41 ± 0.022	0.585GlnTyr: 0.585 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.986ArgAla: 8.986 ± 0.11	0.693ArgCys: 0.693 ± 0.031	4.004ArgAsp: 4.004 ± 0.068	4.363ArgGlu: 4.363 ± 0.079	3.16ArgPhe: 3.16 ± 0.068	5.378ArgGly: 5.378 ± 0.079	1.812ArgHis: 1.812 ± 0.051	4.049ArgIle: 4.049 ± 0.062	2.735ArgLys: 2.735 ± 0.058	8.486ArgLeu: 8.486 ± 0.108	1.645ArgMet: 1.645 ± 0.039	1.969ArgAsn: 1.969 ± 0.048	3.974ArgPro: 3.974 ± 0.075	2.519ArgGln: 2.519 ± 0.053	6.638ArgArg: 6.638 ± 0.11	3.759ArgSer: 3.759 ± 0.067	3.367ArgThr: 3.367 ± 0.061	4.506ArgVal: 4.506 ± 0.071	1.016ArgTrp: 1.016 ± 0.036	1.663ArgTyr: 1.663 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.264SerAla: 6.264 ± 0.083	0.62SerCys: 0.62 ± 0.026	2.653SerAsp: 2.653 ± 0.054	2.745SerGlu: 2.745 ± 0.056	2.534SerPhe: 2.534 ± 0.054	5.528SerGly: 5.528 ± 0.082	1.226SerHis: 1.226 ± 0.04	2.823SerIle: 2.823 ± 0.056	1.825SerLys: 1.825 ± 0.047	5.646SerLeu: 5.646 ± 0.068	1.21SerMet: 1.21 ± 0.033	1.555SerAsn: 1.555 ± 0.044	3.212SerPro: 3.212 ± 0.06	1.622SerGln: 1.622 ± 0.046	4.005SerArg: 4.005 ± 0.071	3.228SerSer: 3.228 ± 0.062	2.396SerThr: 2.396 ± 0.056	3.718SerVal: 3.718 ± 0.063	0.697SerTrp: 0.697 ± 0.028	1.281SerTyr: 1.281 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.821ThrAla: 5.821 ± 0.083	0.501ThrCys: 0.501 ± 0.025	2.231ThrAsp: 2.231 ± 0.055	2.273ThrGlu: 2.273 ± 0.051	1.959ThrPhe: 1.959 ± 0.048	4.889ThrGly: 4.889 ± 0.079	1.0ThrHis: 1.0 ± 0.032	3.04ThrIle: 3.04 ± 0.055	1.75ThrLys: 1.75 ± 0.043	5.44ThrLeu: 5.44 ± 0.071	1.11ThrMet: 1.11 ± 0.033	1.459ThrAsn: 1.459 ± 0.05	3.314ThrPro: 3.314 ± 0.068	1.353ThrGln: 1.353 ± 0.038	3.271ThrArg: 3.271 ± 0.067	2.714ThrSer: 2.714 ± 0.061	2.51ThrThr: 2.51 ± 0.054	3.653ThrVal: 3.653 ± 0.061	0.585ThrTrp: 0.585 ± 0.026	1.129ThrTyr: 1.129 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.761ValAla: 8.761 ± 0.126	0.705ValCys: 0.705 ± 0.029	3.615ValAsp: 3.615 ± 0.064	4.253ValGlu: 4.253 ± 0.078	2.802ValPhe: 2.802 ± 0.053	4.591ValGly: 4.591 ± 0.074	1.434ValHis: 1.434 ± 0.043	3.589ValIle: 3.589 ± 0.066	2.506ValLys: 2.506 ± 0.051	7.144ValLeu: 7.144 ± 0.097	1.49ValMet: 1.49 ± 0.037	1.922ValAsn: 1.922 ± 0.045	3.632ValPro: 3.632 ± 0.075	1.816ValGln: 1.816 ± 0.049	4.716ValArg: 4.716 ± 0.076	4.08ValSer: 4.08 ± 0.071	4.014ValThr: 4.014 ± 0.07	5.194ValVal: 5.194 ± 0.073	0.867ValTrp: 0.867 ± 0.031	1.447ValTyr: 1.447 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.078TrpAla: 1.078 ± 0.037	0.152TrpCys: 0.152 ± 0.014	0.508TrpAsp: 0.508 ± 0.025	0.494TrpGlu: 0.494 ± 0.024	0.591TrpPhe: 0.591 ± 0.024	0.839TrpGly: 0.839 ± 0.032	0.343TrpHis: 0.343 ± 0.017	0.674TrpIle: 0.674 ± 0.025	0.482TrpLys: 0.482 ± 0.024	1.679TrpLeu: 1.679 ± 0.041	0.329TrpMet: 0.329 ± 0.016	0.46TrpAsn: 0.46 ± 0.024	0.847TrpPro: 0.847 ± 0.032	0.553TrpGln: 0.553 ± 0.025	1.41TrpArg: 1.41 ± 0.039	0.791TrpSer: 0.791 ± 0.031	0.756TrpThr: 0.756 ± 0.029	0.696TrpVal: 0.696 ± 0.029	0.243TrpTrp: 0.243 ± 0.017	0.271TrpTyr: 0.271 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.051	0.285TyrCys: 0.285 ± 0.02	1.309TyrAsp: 1.309 ± 0.04	1.144TyrGlu: 1.144 ± 0.039	1.07TyrPhe: 1.07 ± 0.037	1.904TyrGly: 1.904 ± 0.058	0.484TyrHis: 0.484 ± 0.025	0.911TyrIle: 0.911 ± 0.034	0.702TyrLys: 0.702 ± 0.027	2.232TyrLeu: 2.232 ± 0.047	0.412TyrMet: 0.412 ± 0.022	0.626TyrAsn: 0.626 ± 0.029	1.13TyrPro: 1.13 ± 0.034	0.746TyrGln: 0.746 ± 0.029	1.752TyrArg: 1.752 ± 0.049	1.096TyrSer: 1.096 ± 0.033	0.889TyrThr: 0.889 ± 0.035	1.642TyrVal: 1.642 ± 0.045	0.37TyrTrp: 0.37 ± 0.021	0.596TyrTyr: 0.596 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3557 proteins (927747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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