Amino acid dipepetide frequency for Cutthroat trout virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.509AlaAla: 3.509 ± 0.702
3.509AlaCys: 3.509 ± 0.837
2.339AlaAsp: 2.339 ± 0.468
3.119AlaGlu: 3.119 ± 1.091
2.729AlaPhe: 2.729 ± 0.878
1.949AlaGly: 1.949 ± 0.47
2.339AlaHis: 2.339 ± 1.323
4.678AlaIle: 4.678 ± 0.042
4.288AlaLys: 4.288 ± 1.232
6.628AlaLeu: 6.628 ± 0.576
1.17AlaMet: 1.17 ± 1.391
2.729AlaAsn: 2.729 ± 0.491
7.407AlaPro: 7.407 ± 1.072
1.17AlaGln: 1.17 ± 0.728
2.729AlaArg: 2.729 ± 1.372
5.458AlaSer: 5.458 ± 2.503
7.407AlaThr: 7.407 ± 1.552
6.628AlaVal: 6.628 ± 1.347
0.39AlaTrp: 0.39 ± 0.219
0.78AlaTyr: 0.78 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
0.39CysAla: 0.39 ± 0.219
0.78CysCys: 0.78 ± 0.438
1.559CysAsp: 1.559 ± 0.3
0.39CysGlu: 0.39 ± 0.219
0.78CysPhe: 0.78 ± 0.438
1.949CysGly: 1.949 ± 1.192
0.78CysHis: 0.78 ± 0.341
1.559CysIle: 1.559 ± 0.3
0.78CysLys: 0.78 ± 0.341
2.729CysLeu: 2.729 ± 1.171
1.17CysMet: 1.17 ± 0.411
0.39CysAsn: 0.39 ± 0.523
0.39CysPro: 0.39 ± 0.523
0.78CysGln: 0.78 ± 0.667
1.17CysArg: 1.17 ± 0.658
1.559CysSer: 1.559 ± 0.3
1.17CysThr: 1.17 ± 0.658
0.78CysVal: 0.78 ± 0.438
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.509AspAla: 3.509 ± 1.211
1.949AspCys: 1.949 ± 0.542
3.509AspAsp: 3.509 ± 1.211
1.559AspGlu: 1.559 ± 0.877
2.339AspPhe: 2.339 ± 1.315
2.729AspGly: 2.729 ± 0.874
1.17AspHis: 1.17 ± 0.658
1.949AspIle: 1.949 ± 1.096
1.949AspLys: 1.949 ± 0.47
4.678AspLeu: 4.678 ± 0.899
1.559AspMet: 1.559 ± 0.435
1.17AspAsn: 1.17 ± 0.234
4.288AspPro: 4.288 ± 0.219
1.17AspGln: 1.17 ± 0.658
1.17AspArg: 1.17 ± 0.658
6.238AspSer: 6.238 ± 2.085
7.797AspThr: 7.797 ± 1.417
1.559AspVal: 1.559 ± 0.3
0.78AspTrp: 0.78 ± 0.438
1.17AspTyr: 1.17 ± 0.658
0.0AspXaa: 0.0 ± 0.0
Glu
1.559GluAla: 1.559 ± 0.3
0.78GluCys: 0.78 ± 0.438
1.559GluAsp: 1.559 ± 0.877
0.78GluGlu: 0.78 ± 0.438
2.339GluPhe: 2.339 ± 0.468
1.559GluGly: 1.559 ± 0.3
1.17GluHis: 1.17 ± 0.658
3.119GluIle: 3.119 ± 0.599
3.119GluLys: 3.119 ± 0.762
4.288GluLeu: 4.288 ± 0.51
0.78GluMet: 0.78 ± 0.667
1.17GluAsn: 1.17 ± 0.658
2.339GluPro: 2.339 ± 0.428
1.949GluGln: 1.949 ± 1.096
1.559GluArg: 1.559 ± 0.877
2.339GluSer: 2.339 ± 0.652
1.17GluThr: 1.17 ± 0.658
2.339GluVal: 2.339 ± 0.669
0.39GluTrp: 0.39 ± 0.219
0.39GluTyr: 0.39 ± 0.219
0.0GluXaa: 0.0 ± 0.0
Phe
3.119PheAla: 3.119 ± 0.265
1.17PheCys: 1.17 ± 0.234
3.119PheAsp: 3.119 ± 0.762
2.339PheGlu: 2.339 ± 0.468
1.17PhePhe: 1.17 ± 0.234
1.949PheGly: 1.949 ± 1.192
1.559PheHis: 1.559 ± 0.3
2.339PheIle: 2.339 ± 0.669
3.119PheLys: 3.119 ± 2.046
3.509PheLeu: 3.509 ± 1.368
1.559PheMet: 1.559 ± 0.681
1.559PheAsn: 1.559 ± 0.3
2.339PhePro: 2.339 ± 1.022
0.78PheGln: 0.78 ± 0.438
2.729PheArg: 2.729 ± 1.113
4.288PheSer: 4.288 ± 0.943
3.899PheThr: 3.899 ± 0.94
0.78PheVal: 0.78 ± 0.438
0.78PheTrp: 0.78 ± 0.438
0.78PheTyr: 0.78 ± 0.438
0.0PheXaa: 0.0 ± 0.0
Gly
3.899GlyAla: 3.899 ± 0.708
0.39GlyCys: 0.39 ± 0.219
4.288GlyAsp: 4.288 ± 0.779
3.119GlyGlu: 3.119 ± 1.091
2.729GlyPhe: 2.729 ± 0.491
1.17GlyGly: 1.17 ± 0.658
0.39GlyHis: 0.39 ± 0.219
2.339GlyIle: 2.339 ± 0.669
2.339GlyLys: 2.339 ± 0.428
6.628GlyLeu: 6.628 ± 2.952
1.949GlyMet: 1.949 ± 0.844
2.339GlyAsn: 2.339 ± 1.709
4.288GlyPro: 4.288 ± 2.394
2.729GlyGln: 2.729 ± 0.491
1.949GlyArg: 1.949 ± 1.096
3.899GlySer: 3.899 ± 0.436
3.899GlyThr: 3.899 ± 2.383
2.339GlyVal: 2.339 ± 0.669
1.559GlyTrp: 1.559 ± 0.877
1.949GlyTyr: 1.949 ± 0.47
0.0GlyXaa: 0.0 ± 0.0
His
2.339HisAla: 2.339 ± 0.428
1.17HisCys: 1.17 ± 0.234
1.559HisAsp: 1.559 ± 0.877
0.39HisGlu: 0.39 ± 0.219
0.78HisPhe: 0.78 ± 0.341
0.78HisGly: 0.78 ± 1.045
1.559HisHis: 1.559 ± 0.877
0.39HisIle: 0.39 ± 0.219
0.39HisLys: 0.39 ± 0.219
3.119HisLeu: 3.119 ± 1.358
0.78HisMet: 0.78 ± 0.438
1.17HisAsn: 1.17 ± 0.658
1.17HisPro: 1.17 ± 1.391
1.559HisGln: 1.559 ± 0.564
2.339HisArg: 2.339 ± 0.997
3.119HisSer: 3.119 ± 0.873
3.899HisThr: 3.899 ± 1.032
2.729HisVal: 2.729 ± 1.534
0.0HisTrp: 0.0 ± 0.0
1.949HisTyr: 1.949 ± 0.864
0.0HisXaa: 0.0 ± 0.0
Ile
3.509IleAla: 3.509 ± 1.368
0.39IleCys: 0.39 ± 0.219
0.78IleAsp: 0.78 ± 0.341
2.729IleGlu: 2.729 ± 1.534
1.949IlePhe: 1.949 ± 1.096
4.288IleGly: 4.288 ± 0.219
1.559IleHis: 1.559 ± 0.726
3.509IleIle: 3.509 ± 0.837
1.949IleLys: 1.949 ± 0.47
5.068IleLeu: 5.068 ± 1.302
0.78IleMet: 0.78 ± 0.341
4.288IleAsn: 4.288 ± 1.96
2.729IlePro: 2.729 ± 0.874
3.119IleGln: 3.119 ± 0.762
2.729IleArg: 2.729 ± 0.491
5.068IleSer: 5.068 ± 0.934
3.899IleThr: 3.899 ± 0.708
1.17IleVal: 1.17 ± 0.234
0.78IleTrp: 0.78 ± 0.438
1.949IleTyr: 1.949 ± 1.096
0.0IleXaa: 0.0 ± 0.0
Lys
3.119LysAla: 3.119 ± 1.362
1.559LysCys: 1.559 ± 0.3
1.949LysAsp: 1.949 ± 1.096
3.509LysGlu: 3.509 ± 1.973
1.17LysPhe: 1.17 ± 0.658
2.729LysGly: 2.729 ± 1.534
1.17LysHis: 1.17 ± 0.658
3.119LysIle: 3.119 ± 0.762
1.949LysLys: 1.949 ± 1.096
3.119LysLeu: 3.119 ± 1.079
1.17LysMet: 1.17 ± 0.234
1.17LysAsn: 1.17 ± 0.234
2.339LysPro: 2.339 ± 0.669
1.17LysGln: 1.17 ± 0.658
1.559LysArg: 1.559 ± 0.877
3.899LysSer: 3.899 ± 1.142
3.509LysThr: 3.509 ± 0.757
3.509LysVal: 3.509 ± 0.654
0.78LysTrp: 0.78 ± 0.341
2.339LysTyr: 2.339 ± 0.652
0.0LysXaa: 0.0 ± 0.0
Leu
7.018LeuAla: 7.018 ± 1.673
1.949LeuCys: 1.949 ± 0.45
5.848LeuAsp: 5.848 ± 1.409
3.119LeuGlu: 3.119 ± 0.657
2.729LeuPhe: 2.729 ± 0.874
3.899LeuGly: 3.899 ± 1.084
2.729LeuHis: 2.729 ± 0.447
4.678LeuIle: 4.678 ± 0.937
4.288LeuLys: 4.288 ± 1.96
6.628LeuLeu: 6.628 ± 2.447
0.78LeuMet: 0.78 ± 0.667
3.899LeuAsn: 3.899 ± 1.084
7.018LeuPro: 7.018 ± 2.275
6.238LeuGln: 6.238 ± 1.564
3.119LeuArg: 3.119 ± 0.657
8.967LeuSer: 8.967 ± 7.374
10.916LeuThr: 10.916 ± 2.224
7.018LeuVal: 7.018 ± 1.283
0.78LeuTrp: 0.78 ± 0.667
1.559LeuTyr: 1.559 ± 0.3
0.0LeuXaa: 0.0 ± 0.0
Met
1.17MetAla: 1.17 ± 0.855
0.0MetCys: 0.0 ± 0.0
2.339MetAsp: 2.339 ± 0.468
2.729MetGlu: 2.729 ± 1.113
0.39MetPhe: 0.39 ± 0.74
1.17MetGly: 1.17 ± 1.391
1.17MetHis: 1.17 ± 0.662
0.78MetIle: 0.78 ± 0.438
1.17MetLys: 1.17 ± 0.658
1.17MetLeu: 1.17 ± 0.728
0.0MetMet: 0.0 ± 0.0
0.78MetAsn: 0.78 ± 0.438
1.17MetPro: 1.17 ± 0.658
0.78MetGln: 0.78 ± 0.667
0.39MetArg: 0.39 ± 0.523
0.39MetSer: 0.39 ± 0.74
1.949MetThr: 1.949 ± 0.844
2.729MetVal: 2.729 ± 1.8
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.729AsnAla: 2.729 ± 0.491
1.17AsnCys: 1.17 ± 0.234
1.949AsnAsp: 1.949 ± 0.47
1.17AsnGlu: 1.17 ± 0.658
1.17AsnPhe: 1.17 ± 0.658
3.119AsnGly: 3.119 ± 0.599
1.949AsnHis: 1.949 ± 0.47
3.509AsnIle: 3.509 ± 1.211
1.559AsnLys: 1.559 ± 0.877
4.288AsnLeu: 4.288 ± 0.989
1.17AsnMet: 1.17 ± 0.234
2.339AsnAsn: 2.339 ± 0.468
3.119AsnPro: 3.119 ± 0.657
1.949AsnGln: 1.949 ± 1.096
0.78AsnArg: 0.78 ± 0.341
2.339AsnSer: 2.339 ± 1.311
3.509AsnThr: 3.509 ± 0.757
1.17AsnVal: 1.17 ± 0.234
0.78AsnTrp: 0.78 ± 0.916
1.17AsnTyr: 1.17 ± 0.234
0.0AsnXaa: 0.0 ± 0.0
Pro
5.068ProAla: 5.068 ± 0.227
1.17ProCys: 1.17 ± 0.728
4.678ProAsp: 4.678 ± 1.338
1.17ProGlu: 1.17 ± 0.234
1.949ProPhe: 1.949 ± 1.53
5.848ProGly: 5.848 ± 1.583
3.119ProHis: 3.119 ± 1.079
2.729ProIle: 2.729 ± 0.447
2.729ProLys: 2.729 ± 0.491
5.458ProLeu: 5.458 ± 2.569
1.17ProMet: 1.17 ± 1.581
1.949ProAsn: 1.949 ± 1.192
7.407ProPro: 7.407 ± 0.894
4.288ProGln: 4.288 ± 1.637
2.339ProArg: 2.339 ± 0.669
10.136ProSer: 10.136 ± 3.796
7.797ProThr: 7.797 ± 1.758
3.119ProVal: 3.119 ± 0.265
0.39ProTrp: 0.39 ± 0.219
1.949ProTyr: 1.949 ± 1.096
0.0ProXaa: 0.0 ± 0.0
Gln
4.678GlnAla: 4.678 ± 0.83
0.39GlnCys: 0.39 ± 0.219
1.559GlnAsp: 1.559 ± 0.877
0.39GlnGlu: 0.39 ± 0.523
2.729GlnPhe: 2.729 ± 1.765
3.899GlnGly: 3.899 ± 0.708
0.78GlnHis: 0.78 ± 0.341
2.729GlnIle: 2.729 ± 0.447
1.559GlnLys: 1.559 ± 0.726
4.678GlnLeu: 4.678 ± 1.751
0.39GlnMet: 0.39 ± 0.219
2.729GlnAsn: 2.729 ± 1.534
4.288GlnPro: 4.288 ± 0.51
0.0GlnGln: 0.0 ± 0.0
1.949GlnArg: 1.949 ± 1.096
2.339GlnSer: 2.339 ± 1.022
3.509GlnThr: 3.509 ± 0.654
1.559GlnVal: 1.559 ± 0.3
0.39GlnTrp: 0.39 ± 0.74
0.39GlnTyr: 0.39 ± 0.523
0.0GlnXaa: 0.0 ± 0.0
Arg
3.509ArgAla: 3.509 ± 1.973
0.0ArgCys: 0.0 ± 0.0
1.949ArgAsp: 1.949 ± 0.47
1.17ArgGlu: 1.17 ± 0.662
1.17ArgPhe: 1.17 ± 0.658
2.729ArgGly: 2.729 ± 0.878
1.17ArgHis: 1.17 ± 0.658
1.949ArgIle: 1.949 ± 0.47
1.949ArgLys: 1.949 ± 0.47
5.848ArgLeu: 5.848 ± 1.517
0.39ArgMet: 0.39 ± 0.219
1.949ArgAsn: 1.949 ± 0.45
4.288ArgPro: 4.288 ± 1.514
2.339ArgGln: 2.339 ± 0.468
2.339ArgArg: 2.339 ± 1.022
5.068ArgSer: 5.068 ± 0.914
2.339ArgThr: 2.339 ± 0.428
2.339ArgVal: 2.339 ± 0.428
0.0ArgTrp: 0.0 ± 0.0
2.729ArgTyr: 2.729 ± 0.878
0.0ArgXaa: 0.0 ± 0.0
Ser
7.407SerAla: 7.407 ± 3.354
0.78SerCys: 0.78 ± 0.341
3.509SerAsp: 3.509 ± 1.211
2.339SerGlu: 2.339 ± 1.709
5.458SerPhe: 5.458 ± 2.384
5.458SerGly: 5.458 ± 0.893
3.119SerHis: 3.119 ± 1.079
5.848SerIle: 5.848 ± 1.626
3.509SerLys: 3.509 ± 1.306
9.747SerLeu: 9.747 ± 5.65
1.949SerMet: 1.949 ± 0.864
2.729SerAsn: 2.729 ± 0.878
5.068SerPro: 5.068 ± 2.416
3.509SerGln: 3.509 ± 2.814
5.848SerArg: 5.848 ± 3.27
9.357SerSer: 9.357 ± 2.335
8.967SerThr: 8.967 ± 1.597
3.899SerVal: 3.899 ± 0.436
0.78SerTrp: 0.78 ± 0.667
3.509SerTyr: 3.509 ± 0.702
0.0SerXaa: 0.0 ± 0.0
Thr
8.187ThrAla: 8.187 ± 1.541
1.17ThrCys: 1.17 ± 0.658
4.288ThrAsp: 4.288 ± 0.989
2.339ThrGlu: 2.339 ± 0.468
5.458ThrPhe: 5.458 ± 2.503
4.288ThrGly: 4.288 ± 1.135
1.949ThrHis: 1.949 ± 0.47
2.339ThrIle: 2.339 ± 1.315
2.339ThrLys: 2.339 ± 0.997
6.238ThrLeu: 6.238 ± 2.829
1.949ThrMet: 1.949 ± 0.45
3.899ThrAsn: 3.899 ± 1.154
8.577ThrPro: 8.577 ± 0.86
3.119ThrGln: 3.119 ± 0.265
5.458ThrArg: 5.458 ± 0.982
12.086ThrSer: 12.086 ± 2.079
9.357ThrThr: 9.357 ± 0.712
7.797ThrVal: 7.797 ± 2.066
0.39ThrTrp: 0.39 ± 0.219
2.339ThrTyr: 2.339 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
3.899ValAla: 3.899 ± 1.032
1.17ValCys: 1.17 ± 0.234
3.899ValAsp: 3.899 ± 1.878
0.78ValGlu: 0.78 ± 0.438
4.288ValPhe: 4.288 ± 0.989
1.949ValGly: 1.949 ± 0.542
2.339ValHis: 2.339 ± 0.468
3.509ValIle: 3.509 ± 0.837
2.729ValLys: 2.729 ± 0.491
5.068ValLeu: 5.068 ± 1.258
0.39ValMet: 0.39 ± 0.219
2.729ValAsn: 2.729 ± 0.878
4.288ValPro: 4.288 ± 1.235
1.949ValGln: 1.949 ± 0.542
3.119ValArg: 3.119 ± 0.599
4.288ValSer: 4.288 ± 0.85
4.678ValThr: 4.678 ± 0.718
5.848ValVal: 5.848 ± 1.171
0.39ValTrp: 0.39 ± 0.523
1.949ValTyr: 1.949 ± 0.45
0.0ValXaa: 0.0 ± 0.0
Trp
0.39TrpAla: 0.39 ± 0.74
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.78TrpPhe: 0.78 ± 0.341
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.17TrpLys: 1.17 ± 0.658
1.17TrpLeu: 1.17 ± 0.662
0.39TrpMet: 0.39 ± 0.74
1.17TrpAsn: 1.17 ± 0.234
0.39TrpPro: 0.39 ± 0.219
0.39TrpGln: 0.39 ± 0.219
0.0TrpArg: 0.0 ± 0.0
1.17TrpSer: 1.17 ± 0.662
1.559TrpThr: 1.559 ± 0.3
0.39TrpVal: 0.39 ± 0.219
0.0TrpTrp: 0.0 ± 0.0
0.39TrpTyr: 0.39 ± 0.219
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.949TyrAla: 1.949 ± 1.096
0.0TyrCys: 0.0 ± 0.0
1.559TyrAsp: 1.559 ± 0.877
1.559TyrGlu: 1.559 ± 0.3
0.78TyrPhe: 0.78 ± 0.341
2.729TyrGly: 2.729 ± 0.491
1.17TyrHis: 1.17 ± 0.234
1.17TyrIle: 1.17 ± 0.658
1.949TyrLys: 1.949 ± 0.542
3.119TyrLeu: 3.119 ± 0.657
0.39TyrMet: 0.39 ± 0.204
0.78TyrAsn: 0.78 ± 0.341
1.559TyrPro: 1.559 ± 0.726
1.949TyrGln: 1.949 ± 0.47
1.949TyrArg: 1.949 ± 0.47
0.78TyrSer: 0.78 ± 0.916
2.339TyrThr: 2.339 ± 0.468
1.559TyrVal: 1.559 ± 0.3
0.0TyrTrp: 0.0 ± 0.0
0.39TyrTyr: 0.39 ± 0.219
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski