Amino acid dipepetide frequency for Aeromicrobium marinum DSM 15272

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.636AlaAla: 19.636 ± 0.226	0.965AlaCys: 0.965 ± 0.031	9.123AlaAsp: 9.123 ± 0.121	8.249AlaGlu: 8.249 ± 0.121	3.569AlaPhe: 3.569 ± 0.064	12.719AlaGly: 12.719 ± 0.144	2.46AlaHis: 2.46 ± 0.054	4.393AlaIle: 4.393 ± 0.078	2.208AlaLys: 2.208 ± 0.062	12.443AlaLeu: 12.443 ± 0.15	2.817AlaMet: 2.817 ± 0.061	1.86AlaAsn: 1.86 ± 0.044	6.014AlaPro: 6.014 ± 0.114	3.363AlaGln: 3.363 ± 0.073	9.255AlaArg: 9.255 ± 0.107	6.199AlaSer: 6.199 ± 0.078	7.602AlaThr: 7.602 ± 0.087	12.331AlaVal: 12.331 ± 0.157	1.905AlaTrp: 1.905 ± 0.05	2.231AlaTyr: 2.231 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.767CysAla: 0.767 ± 0.029	0.074CysCys: 0.074 ± 0.009	0.457CysAsp: 0.457 ± 0.023	0.363CysGlu: 0.363 ± 0.023	0.212CysPhe: 0.212 ± 0.014	0.872CysGly: 0.872 ± 0.03	0.175CysHis: 0.175 ± 0.014	0.185CysIle: 0.185 ± 0.014	0.095CysLys: 0.095 ± 0.011	0.608CysLeu: 0.608 ± 0.028	0.105CysMet: 0.105 ± 0.01	0.124CysAsn: 0.124 ± 0.012	0.449CysPro: 0.449 ± 0.023	0.179CysGln: 0.179 ± 0.015	0.598CysArg: 0.598 ± 0.028	0.423CysSer: 0.423 ± 0.022	0.459CysThr: 0.459 ± 0.023	0.588CysVal: 0.588 ± 0.024	0.087CysTrp: 0.087 ± 0.011	0.107CysTyr: 0.107 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.162AspAla: 8.162 ± 0.107	0.399AspCys: 0.399 ± 0.025	5.277AspAsp: 5.277 ± 0.1	4.598AspGlu: 4.598 ± 0.084	1.771AspPhe: 1.771 ± 0.045	6.642AspGly: 6.642 ± 0.107	1.757AspHis: 1.757 ± 0.044	2.159AspIle: 2.159 ± 0.047	0.941AspLys: 0.941 ± 0.034	8.055AspLeu: 8.055 ± 0.088	0.843AspMet: 0.843 ± 0.029	0.926AspAsn: 0.926 ± 0.031	4.895AspPro: 4.895 ± 0.079	1.842AspGln: 1.842 ± 0.043	5.531AspArg: 5.531 ± 0.088	2.449AspSer: 2.449 ± 0.056	3.255AspThr: 3.255 ± 0.055	6.311AspVal: 6.311 ± 0.096	0.874AspTrp: 0.874 ± 0.028	1.099AspTyr: 1.099 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.333GluAla: 7.333 ± 0.103	0.325GluCys: 0.325 ± 0.02	2.909GluAsp: 2.909 ± 0.063	2.82GluGlu: 2.82 ± 0.063	1.786GluPhe: 1.786 ± 0.05	4.029GluGly: 4.029 ± 0.064	1.601GluHis: 1.601 ± 0.044	2.83GluIle: 2.83 ± 0.048	1.144GluLys: 1.144 ± 0.048	6.26GluLeu: 6.26 ± 0.088	1.002GluMet: 1.002 ± 0.033	0.994GluAsn: 0.994 ± 0.031	3.322GluPro: 3.322 ± 0.084	2.392GluGln: 2.392 ± 0.056	5.135GluArg: 5.135 ± 0.083	2.844GluSer: 2.844 ± 0.047	2.905GluThr: 2.905 ± 0.057	5.627GluVal: 5.627 ± 0.085	0.777GluTrp: 0.777 ± 0.033	1.014GluTyr: 1.014 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.87PheAla: 3.87 ± 0.073	0.266PheCys: 0.266 ± 0.018	2.366PheAsp: 2.366 ± 0.047	1.74PheGlu: 1.74 ± 0.038	0.927PhePhe: 0.927 ± 0.04	3.321PheGly: 3.321 ± 0.063	0.57PheHis: 0.57 ± 0.025	0.901PheIle: 0.901 ± 0.036	0.428PheLys: 0.428 ± 0.025	2.592PheLeu: 2.592 ± 0.057	0.445PheMet: 0.445 ± 0.021	0.556PheAsn: 0.556 ± 0.027	1.247PhePro: 1.247 ± 0.04	0.604PheGln: 0.604 ± 0.027	1.837PheArg: 1.837 ± 0.044	1.648PheSer: 1.648 ± 0.044	2.104PheThr: 2.104 ± 0.051	2.85PheVal: 2.85 ± 0.057	0.402PheTrp: 0.402 ± 0.022	0.647PheTyr: 0.647 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.151GlyAla: 10.151 ± 0.11	0.738GlyCys: 0.738 ± 0.028	5.774GlyAsp: 5.774 ± 0.086	4.905GlyGlu: 4.905 ± 0.073	3.183GlyPhe: 3.183 ± 0.057	8.179GlyGly: 8.179 ± 0.116	2.16GlyHis: 2.16 ± 0.052	3.939GlyIle: 3.939 ± 0.068	1.766GlyLys: 1.766 ± 0.048	9.483GlyLeu: 9.483 ± 0.109	1.841GlyMet: 1.841 ± 0.052	1.503GlyAsn: 1.503 ± 0.048	4.765GlyPro: 4.765 ± 0.078	2.641GlyGln: 2.641 ± 0.053	7.515GlyArg: 7.515 ± 0.118	5.544GlySer: 5.544 ± 0.084	5.809GlyThr: 5.809 ± 0.089	8.228GlyVal: 8.228 ± 0.107	1.675GlyTrp: 1.675 ± 0.043	2.0GlyTyr: 2.0 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.462HisAla: 2.462 ± 0.058	0.156HisCys: 0.156 ± 0.015	1.569HisAsp: 1.569 ± 0.048	1.296HisGlu: 1.296 ± 0.035	0.564HisPhe: 0.564 ± 0.024	2.303HisGly: 2.303 ± 0.047	0.785HisHis: 0.785 ± 0.029	0.509HisIle: 0.509 ± 0.023	0.249HisLys: 0.249 ± 0.015	2.629HisLeu: 2.629 ± 0.058	0.272HisMet: 0.272 ± 0.016	0.306HisAsn: 0.306 ± 0.019	1.645HisPro: 1.645 ± 0.042	0.57HisGln: 0.57 ± 0.023	2.035HisArg: 2.035 ± 0.048	0.837HisSer: 0.837 ± 0.034	1.117HisThr: 1.117 ± 0.033	2.146HisVal: 2.146 ± 0.049	0.293HisTrp: 0.293 ± 0.018	0.394HisTyr: 0.394 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.318IleAla: 5.318 ± 0.088	0.285IleCys: 0.285 ± 0.017	3.24IleAsp: 3.24 ± 0.072	2.499IleGlu: 2.499 ± 0.052	0.923IlePhe: 0.923 ± 0.033	4.215IleGly: 4.215 ± 0.069	0.673IleHis: 0.673 ± 0.027	1.293IleIle: 1.293 ± 0.04	0.681IleLys: 0.681 ± 0.025	2.739IleLeu: 2.739 ± 0.061	0.556IleMet: 0.556 ± 0.03	0.779IleAsn: 0.779 ± 0.029	1.735IlePro: 1.735 ± 0.042	0.751IleGln: 0.751 ± 0.029	2.398IleArg: 2.398 ± 0.056	2.021IleSer: 2.021 ± 0.048	2.547IleThr: 2.547 ± 0.053	3.573IleVal: 3.573 ± 0.074	0.383IleTrp: 0.383 ± 0.019	0.558IleTyr: 0.558 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.169LysAla: 2.169 ± 0.058	0.074LysCys: 0.074 ± 0.009	0.976LysAsp: 0.976 ± 0.035	0.912LysGlu: 0.912 ± 0.034	0.472LysPhe: 0.472 ± 0.022	1.326LysGly: 1.326 ± 0.042	0.347LysHis: 0.347 ± 0.018	0.814LysIle: 0.814 ± 0.035	0.656LysLys: 0.656 ± 0.038	1.521LysLeu: 1.521 ± 0.043	0.33LysMet: 0.33 ± 0.022	0.459LysAsn: 0.459 ± 0.023	0.989LysPro: 0.989 ± 0.036	0.571LysGln: 0.571 ± 0.026	1.324LysArg: 1.324 ± 0.045	0.972LysSer: 0.972 ± 0.034	1.039LysThr: 1.039 ± 0.035	1.648LysVal: 1.648 ± 0.046	0.186LysTrp: 0.186 ± 0.016	0.349LysTyr: 0.349 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.318LeuAla: 14.318 ± 0.167	0.631LeuCys: 0.631 ± 0.025	7.324LeuAsp: 7.324 ± 0.1	5.254LeuGlu: 5.254 ± 0.082	2.488LeuPhe: 2.488 ± 0.065	9.218LeuGly: 9.218 ± 0.112	2.026LeuHis: 2.026 ± 0.051	3.092LeuIle: 3.092 ± 0.064	1.621LeuLys: 1.621 ± 0.046	9.96LeuLeu: 9.96 ± 0.134	1.633LeuMet: 1.633 ± 0.045	1.556LeuAsn: 1.556 ± 0.056	5.445LeuPro: 5.445 ± 0.078	2.626LeuGln: 2.626 ± 0.057	7.658LeuArg: 7.658 ± 0.107	4.99LeuSer: 4.99 ± 0.077	6.637LeuThr: 6.637 ± 0.093	10.648LeuVal: 10.648 ± 0.15	1.131LeuTrp: 1.131 ± 0.037	1.439LeuTyr: 1.439 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.41MetAla: 2.41 ± 0.054	0.126MetCys: 0.126 ± 0.012	0.937MetAsp: 0.937 ± 0.032	0.742MetGlu: 0.742 ± 0.026	0.57MetPhe: 0.57 ± 0.023	1.339MetGly: 1.339 ± 0.037	0.349MetHis: 0.349 ± 0.018	0.769MetIle: 0.769 ± 0.031	0.442MetLys: 0.442 ± 0.024	1.766MetLeu: 1.766 ± 0.051	0.324MetMet: 0.324 ± 0.02	0.467MetAsn: 0.467 ± 0.023	1.069MetPro: 1.069 ± 0.037	0.511MetGln: 0.511 ± 0.021	1.446MetArg: 1.446 ± 0.037	1.496MetSer: 1.496 ± 0.039	1.805MetThr: 1.805 ± 0.042	1.531MetVal: 1.531 ± 0.043	0.202MetTrp: 0.202 ± 0.016	0.266MetTyr: 0.266 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.075AsnAla: 2.075 ± 0.049	0.148AsnCys: 0.148 ± 0.013	0.991AsnAsp: 0.991 ± 0.031	0.797AsnGlu: 0.797 ± 0.031	0.481AsnPhe: 0.481 ± 0.023	1.606AsnGly: 1.606 ± 0.043	0.372AsnHis: 0.372 ± 0.02	0.713AsnIle: 0.713 ± 0.033	0.308AsnLys: 0.308 ± 0.019	1.808AsnLeu: 1.808 ± 0.044	0.268AsnMet: 0.268 ± 0.019	0.383AsnAsn: 0.383 ± 0.024	1.31AsnPro: 1.31 ± 0.042	0.522AsnGln: 0.522 ± 0.022	1.282AsnArg: 1.282 ± 0.04	0.819AsnSer: 0.819 ± 0.034	1.005AsnThr: 1.005 ± 0.037	1.438AsnVal: 1.438 ± 0.039	0.229AsnTrp: 0.229 ± 0.017	0.359AsnTyr: 0.359 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.284ProAla: 7.284 ± 0.11	0.283ProCys: 0.283 ± 0.018	4.483ProAsp: 4.483 ± 0.066	3.838ProGlu: 3.838 ± 0.094	1.594ProPhe: 1.594 ± 0.042	5.594ProGly: 5.594 ± 0.078	1.248ProHis: 1.248 ± 0.034	1.696ProIle: 1.696 ± 0.042	0.868ProLys: 0.868 ± 0.033	4.535ProLeu: 4.535 ± 0.07	1.063ProMet: 1.063 ± 0.029	0.876ProAsn: 0.876 ± 0.033	2.877ProPro: 2.877 ± 0.088	1.415ProGln: 1.415 ± 0.046	3.88ProArg: 3.88 ± 0.066	3.003ProSer: 3.003 ± 0.06	3.583ProThr: 3.583 ± 0.07	5.521ProVal: 5.521 ± 0.08	0.924ProTrp: 0.924 ± 0.032	1.035ProTyr: 1.035 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.406GlnAla: 3.406 ± 0.064	0.156GlnCys: 0.156 ± 0.012	1.22GlnAsp: 1.22 ± 0.037	1.157GlnGlu: 1.157 ± 0.034	0.828GlnPhe: 0.828 ± 0.029	2.043GlnGly: 2.043 ± 0.046	0.705GlnHis: 0.705 ± 0.025	1.384GlnIle: 1.384 ± 0.04	0.513GlnLys: 0.513 ± 0.026	3.069GlnLeu: 3.069 ± 0.062	0.7GlnMet: 0.7 ± 0.03	0.496GlnAsn: 0.496 ± 0.026	1.458GlnPro: 1.458 ± 0.045	1.139GlnGln: 1.139 ± 0.04	2.482GlnArg: 2.482 ± 0.056	1.246GlnSer: 1.246 ± 0.039	1.419GlnThr: 1.419 ± 0.042	3.041GlnVal: 3.041 ± 0.054	0.505GlnTrp: 0.505 ± 0.023	0.513GlnTyr: 0.513 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.782ArgAla: 8.782 ± 0.121	0.514ArgCys: 0.514 ± 0.027	4.613ArgAsp: 4.613 ± 0.076	4.405ArgGlu: 4.405 ± 0.087	2.417ArgPhe: 2.417 ± 0.055	5.676ArgGly: 5.676 ± 0.085	2.016ArgHis: 2.016 ± 0.045	3.403ArgIle: 3.403 ± 0.066	1.278ArgLys: 1.278 ± 0.044	8.236ArgLeu: 8.236 ± 0.105	1.732ArgMet: 1.732 ± 0.037	1.242ArgAsn: 1.242 ± 0.04	4.547ArgPro: 4.547 ± 0.081	2.257ArgGln: 2.257 ± 0.046	7.701ArgArg: 7.701 ± 0.133	4.58ArgSer: 4.58 ± 0.074	5.011ArgThr: 5.011 ± 0.082	6.339ArgVal: 6.339 ± 0.093	1.435ArgTrp: 1.435 ± 0.041	1.55ArgTyr: 1.55 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.499SerAla: 6.499 ± 0.079	0.35SerCys: 0.35 ± 0.021	3.1SerAsp: 3.1 ± 0.062	2.543SerGlu: 2.543 ± 0.06	1.746SerPhe: 1.746 ± 0.045	5.617SerGly: 5.617 ± 0.084	1.0SerHis: 1.0 ± 0.034	2.132SerIle: 2.132 ± 0.054	0.926SerLys: 0.926 ± 0.032	4.992SerLeu: 4.992 ± 0.081	1.287SerMet: 1.287 ± 0.035	0.938SerAsn: 0.938 ± 0.036	3.024SerPro: 3.024 ± 0.055	1.263SerGln: 1.263 ± 0.034	3.834SerArg: 3.834 ± 0.075	3.239SerSer: 3.239 ± 0.073	3.719SerThr: 3.719 ± 0.067	4.651SerVal: 4.651 ± 0.075	0.823SerTrp: 0.823 ± 0.03	1.087SerTyr: 1.087 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.857ThrAla: 7.857 ± 0.099	0.471ThrCys: 0.471 ± 0.021	4.22ThrAsp: 4.22 ± 0.073	3.357ThrGlu: 3.357 ± 0.062	2.123ThrPhe: 2.123 ± 0.048	6.252ThrGly: 6.252 ± 0.092	1.212ThrHis: 1.212 ± 0.039	2.476ThrIle: 2.476 ± 0.051	0.996ThrLys: 0.996 ± 0.033	5.605ThrLeu: 5.605 ± 0.08	1.167ThrMet: 1.167 ± 0.038	1.05ThrAsn: 1.05 ± 0.035	3.813ThrPro: 3.813 ± 0.073	1.425ThrGln: 1.425 ± 0.045	4.096ThrArg: 4.096 ± 0.069	3.629ThrSer: 3.629 ± 0.066	4.462ThrThr: 4.462 ± 0.092	6.315ThrVal: 6.315 ± 0.091	0.98ThrTrp: 0.98 ± 0.035	1.351ThrTyr: 1.351 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	13.015ValAla: 13.015 ± 0.145	0.653ValCys: 0.653 ± 0.027	6.954ValAsp: 6.954 ± 0.099	5.935ValGlu: 5.935 ± 0.079	2.483ValPhe: 2.483 ± 0.066	8.033ValGly: 8.033 ± 0.108	2.03ValHis: 2.03 ± 0.052	3.357ValIle: 3.357 ± 0.067	1.471ValLys: 1.471 ± 0.045	9.824ValLeu: 9.824 ± 0.123	1.645ValMet: 1.645 ± 0.046	1.767ValAsn: 1.767 ± 0.046	5.317ValPro: 5.317 ± 0.072	2.392ValGln: 2.392 ± 0.049	6.931ValArg: 6.931 ± 0.1	4.911ValSer: 4.911 ± 0.082	6.334ValThr: 6.334 ± 0.094	11.23ValVal: 11.23 ± 0.141	1.228ValTrp: 1.228 ± 0.039	1.448ValTyr: 1.448 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.574TrpAla: 1.574 ± 0.038	0.175TrpCys: 0.175 ± 0.018	0.881TrpAsp: 0.881 ± 0.031	0.635TrpGlu: 0.635 ± 0.028	0.536TrpPhe: 0.536 ± 0.021	1.036TrpGly: 1.036 ± 0.038	0.321TrpHis: 0.321 ± 0.018	0.639TrpIle: 0.639 ± 0.028	0.259TrpLys: 0.259 ± 0.016	1.59TrpLeu: 1.59 ± 0.04	0.314TrpMet: 0.314 ± 0.018	0.322TrpAsn: 0.322 ± 0.021	0.771TrpPro: 0.771 ± 0.031	0.544TrpGln: 0.544 ± 0.026	1.193TrpArg: 1.193 ± 0.037	1.05TrpSer: 1.05 ± 0.036	1.025TrpThr: 1.025 ± 0.033	1.189TrpVal: 1.189 ± 0.039	0.381TrpTrp: 0.381 ± 0.023	0.256TrpTyr: 0.256 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.253TyrAla: 2.253 ± 0.053	0.138TyrCys: 0.138 ± 0.014	1.372TyrAsp: 1.372 ± 0.042	1.002TyrGlu: 1.002 ± 0.04	0.646TyrPhe: 0.646 ± 0.027	1.78TyrGly: 1.78 ± 0.046	0.33TyrHis: 0.33 ± 0.019	0.484TyrIle: 0.484 ± 0.022	0.284TyrLys: 0.284 ± 0.02	1.983TyrLeu: 1.983 ± 0.047	0.224TyrMet: 0.224 ± 0.016	0.311TyrAsn: 0.311 ± 0.02	0.905TyrPro: 0.905 ± 0.033	0.473TyrGln: 0.473 ± 0.025	1.604TyrArg: 1.604 ± 0.048	0.872TyrSer: 0.872 ± 0.033	1.018TyrThr: 1.018 ± 0.036	1.754TyrVal: 1.754 ± 0.046	0.272TyrTrp: 0.272 ± 0.016	0.375TyrTyr: 0.375 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3077 proteins (937159 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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