Amino acid dipepetide frequency for Halomonas huangheensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.697AlaAla: 11.697 ± 0.137
1.162AlaCys: 1.162 ± 0.03
6.051AlaAsp: 6.051 ± 0.083
7.208AlaGlu: 7.208 ± 0.098
3.67AlaPhe: 3.67 ± 0.054
8.845AlaGly: 8.845 ± 0.096
2.12AlaHis: 2.12 ± 0.043
5.716AlaIle: 5.716 ± 0.07
1.87AlaLys: 1.87 ± 0.043
12.882AlaLeu: 12.882 ± 0.127
3.38AlaMet: 3.38 ± 0.06
2.833AlaAsn: 2.833 ± 0.05
4.441AlaPro: 4.441 ± 0.083
4.088AlaGln: 4.088 ± 0.055
7.479AlaArg: 7.479 ± 0.096
6.649AlaSer: 6.649 ± 0.079
5.509AlaThr: 5.509 ± 0.087
7.418AlaVal: 7.418 ± 0.085
1.768AlaTrp: 1.768 ± 0.044
2.126AlaTyr: 2.126 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.916CysAla: 0.916 ± 0.03
0.149CysCys: 0.149 ± 0.011
0.569CysAsp: 0.569 ± 0.021
0.531CysGlu: 0.531 ± 0.02
0.357CysPhe: 0.357 ± 0.018
0.958CysGly: 0.958 ± 0.029
0.322CysHis: 0.322 ± 0.016
0.407CysIle: 0.407 ± 0.018
0.191CysLys: 0.191 ± 0.013
1.081CysLeu: 1.081 ± 0.03
0.217CysMet: 0.217 ± 0.012
0.243CysAsn: 0.243 ± 0.015
0.493CysPro: 0.493 ± 0.021
0.418CysGln: 0.418 ± 0.018
0.738CysArg: 0.738 ± 0.025
0.562CysSer: 0.562 ± 0.023
0.403CysThr: 0.403 ± 0.017
0.7CysVal: 0.7 ± 0.023
0.17CysTrp: 0.17 ± 0.011
0.261CysTyr: 0.261 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.501AspAla: 6.501 ± 0.114
0.504AspCys: 0.504 ± 0.021
3.995AspAsp: 3.995 ± 0.091
4.041AspGlu: 4.041 ± 0.054
2.061AspPhe: 2.061 ± 0.038
5.243AspGly: 5.243 ± 0.148
1.477AspHis: 1.477 ± 0.033
3.309AspIle: 3.309 ± 0.049
1.467AspLys: 1.467 ± 0.037
5.424AspLeu: 5.424 ± 0.07
1.374AspMet: 1.374 ± 0.03
1.961AspAsn: 1.961 ± 0.057
3.035AspPro: 3.035 ± 0.083
2.365AspGln: 2.365 ± 0.052
3.403AspArg: 3.403 ± 0.063
3.54AspSer: 3.54 ± 0.062
3.101AspThr: 3.101 ± 0.087
4.233AspVal: 4.233 ± 0.067
1.017AspTrp: 1.017 ± 0.026
1.723AspTyr: 1.723 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
7.174GluAla: 7.174 ± 0.086
0.485GluCys: 0.485 ± 0.019
3.358GluAsp: 3.358 ± 0.055
3.773GluGlu: 3.773 ± 0.074
1.713GluPhe: 1.713 ± 0.035
4.681GluGly: 4.681 ± 0.066
1.802GluHis: 1.802 ± 0.041
2.911GluIle: 2.911 ± 0.051
1.675GluLys: 1.675 ± 0.045
7.014GluLeu: 7.014 ± 0.095
1.486GluMet: 1.486 ± 0.033
1.602GluAsn: 1.602 ± 0.04
2.569GluPro: 2.569 ± 0.045
3.658GluGln: 3.658 ± 0.06
5.375GluArg: 5.375 ± 0.076
3.493GluSer: 3.493 ± 0.057
2.909GluThr: 2.909 ± 0.042
4.766GluVal: 4.766 ± 0.064
0.85GluTrp: 0.85 ± 0.022
1.3GluTyr: 1.3 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.51PheAla: 3.51 ± 0.063
0.376PheCys: 0.376 ± 0.016
2.454PheAsp: 2.454 ± 0.048
2.02PheGlu: 2.02 ± 0.039
1.304PhePhe: 1.304 ± 0.037
3.174PheGly: 3.174 ± 0.056
0.897PheHis: 0.897 ± 0.032
1.829PheIle: 1.829 ± 0.045
0.839PheLys: 0.839 ± 0.025
3.099PheLeu: 3.099 ± 0.05
0.845PheMet: 0.845 ± 0.03
1.122PheAsn: 1.122 ± 0.03
1.387PhePro: 1.387 ± 0.032
1.122PheGln: 1.122 ± 0.029
1.887PheArg: 1.887 ± 0.038
2.463PheSer: 2.463 ± 0.048
1.968PheThr: 1.968 ± 0.039
2.442PheVal: 2.442 ± 0.043
0.473PheTrp: 0.473 ± 0.025
0.902PheTyr: 0.902 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
7.436GlyAla: 7.436 ± 0.097
0.929GlyCys: 0.929 ± 0.027
4.759GlyAsp: 4.759 ± 0.106
5.304GlyGlu: 5.304 ± 0.08
3.209GlyPhe: 3.209 ± 0.057
6.538GlyGly: 6.538 ± 0.114
1.998GlyHis: 1.998 ± 0.041
4.684GlyIle: 4.684 ± 0.068
2.591GlyLys: 2.591 ± 0.047
9.018GlyLeu: 9.018 ± 0.104
2.608GlyMet: 2.608 ± 0.049
2.592GlyAsn: 2.592 ± 0.074
2.754GlyPro: 2.754 ± 0.042
3.319GlyGln: 3.319 ± 0.057
5.124GlyArg: 5.124 ± 0.065
5.051GlySer: 5.051 ± 0.088
4.093GlyThr: 4.093 ± 0.101
6.403GlyVal: 6.403 ± 0.085
1.412GlyTrp: 1.412 ± 0.035
2.418GlyTyr: 2.418 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.309HisAla: 2.309 ± 0.042
0.323HisCys: 0.323 ± 0.016
1.505HisAsp: 1.505 ± 0.038
1.304HisGlu: 1.304 ± 0.037
0.987HisPhe: 0.987 ± 0.027
2.165HisGly: 2.165 ± 0.039
0.826HisHis: 0.826 ± 0.025
1.055HisIle: 1.055 ± 0.035
0.495HisLys: 0.495 ± 0.016
2.659HisLeu: 2.659 ± 0.049
0.532HisMet: 0.532 ± 0.023
0.611HisAsn: 0.611 ± 0.02
1.451HisPro: 1.451 ± 0.038
1.196HisGln: 1.196 ± 0.035
1.642HisArg: 1.642 ± 0.043
1.325HisSer: 1.325 ± 0.033
1.016HisThr: 1.016 ± 0.03
1.507HisVal: 1.507 ± 0.038
0.429HisTrp: 0.429 ± 0.019
0.722HisTyr: 0.722 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.009IleAla: 6.009 ± 0.083
0.492IleCys: 0.492 ± 0.019
3.709IleAsp: 3.709 ± 0.059
3.613IleGlu: 3.613 ± 0.054
1.545IlePhe: 1.545 ± 0.04
4.739IleGly: 4.739 ± 0.076
1.088IleHis: 1.088 ± 0.032
2.352IleIle: 2.352 ± 0.054
1.398IleLys: 1.398 ± 0.036
4.277IleLeu: 4.277 ± 0.063
1.058IleMet: 1.058 ± 0.029
1.787IleAsn: 1.787 ± 0.039
2.328IlePro: 2.328 ± 0.044
1.514IleGln: 1.514 ± 0.033
2.839IleArg: 2.839 ± 0.049
3.158IleSer: 3.158 ± 0.052
2.837IleThr: 2.837 ± 0.06
3.445IleVal: 3.445 ± 0.06
0.521IleTrp: 0.521 ± 0.021
1.113IleTyr: 1.113 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.823LysAla: 2.823 ± 0.052
0.16LysCys: 0.16 ± 0.012
1.266LysAsp: 1.266 ± 0.038
1.332LysGlu: 1.332 ± 0.04
0.575LysPhe: 0.575 ± 0.022
2.037LysGly: 2.037 ± 0.045
0.53LysHis: 0.53 ± 0.025
0.997LysIle: 0.997 ± 0.031
0.746LysLys: 0.746 ± 0.034
2.559LysLeu: 2.559 ± 0.042
0.531LysMet: 0.531 ± 0.02
0.541LysAsn: 0.541 ± 0.022
1.33LysPro: 1.33 ± 0.032
1.034LysGln: 1.034 ± 0.028
2.033LysArg: 2.033 ± 0.046
1.413LysSer: 1.413 ± 0.036
1.238LysThr: 1.238 ± 0.032
2.063LysVal: 2.063 ± 0.049
0.291LysTrp: 0.291 ± 0.016
0.503LysTyr: 0.503 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
13.61LeuAla: 13.61 ± 0.132
1.135LeuCys: 1.135 ± 0.032
7.009LeuAsp: 7.009 ± 0.084
7.178LeuGlu: 7.178 ± 0.081
3.593LeuPhe: 3.593 ± 0.062
9.076LeuGly: 9.076 ± 0.119
2.281LeuHis: 2.281 ± 0.047
5.511LeuIle: 5.511 ± 0.081
3.309LeuLys: 3.309 ± 0.062
11.601LeuLeu: 11.601 ± 0.144
3.037LeuMet: 3.037 ± 0.055
3.039LeuAsn: 3.039 ± 0.056
5.911LeuPro: 5.911 ± 0.084
3.382LeuGln: 3.382 ± 0.054
6.498LeuArg: 6.498 ± 0.086
7.427LeuSer: 7.427 ± 0.083
5.805LeuThr: 5.805 ± 0.069
8.539LeuVal: 8.539 ± 0.106
1.441LeuTrp: 1.441 ± 0.036
2.344LeuTyr: 2.344 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.328MetAla: 3.328 ± 0.061
0.185MetCys: 0.185 ± 0.013
1.253MetAsp: 1.253 ± 0.03
1.263MetGlu: 1.263 ± 0.032
0.808MetPhe: 0.808 ± 0.025
1.939MetGly: 1.939 ± 0.037
0.527MetHis: 0.527 ± 0.019
1.384MetIle: 1.384 ± 0.035
0.803MetLys: 0.803 ± 0.028
2.99MetLeu: 2.99 ± 0.052
0.715MetMet: 0.715 ± 0.027
0.785MetAsn: 0.785 ± 0.025
1.483MetPro: 1.483 ± 0.032
1.099MetGln: 1.099 ± 0.029
1.596MetArg: 1.596 ± 0.033
1.936MetSer: 1.936 ± 0.037
1.808MetThr: 1.808 ± 0.037
1.905MetVal: 1.905 ± 0.044
0.225MetTrp: 0.225 ± 0.015
0.364MetTyr: 0.364 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.093AsnAla: 3.093 ± 0.055
0.237AsnCys: 0.237 ± 0.012
1.769AsnAsp: 1.769 ± 0.066
1.55AsnGlu: 1.55 ± 0.038
0.906AsnPhe: 0.906 ± 0.029
2.515AsnGly: 2.515 ± 0.065
0.654AsnHis: 0.654 ± 0.023
1.505AsnIle: 1.505 ± 0.034
0.615AsnLys: 0.615 ± 0.025
2.907AsnLeu: 2.907 ± 0.047
0.675AsnMet: 0.675 ± 0.024
0.859AsnAsn: 0.859 ± 0.028
1.747AsnPro: 1.747 ± 0.036
1.075AsnGln: 1.075 ± 0.03
1.755AsnArg: 1.755 ± 0.034
1.588AsnSer: 1.588 ± 0.034
1.472AsnThr: 1.472 ± 0.04
2.019AsnVal: 2.019 ± 0.056
0.411AsnTrp: 0.411 ± 0.018
0.707AsnTyr: 0.707 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
4.539ProAla: 4.539 ± 0.062
0.387ProCys: 0.387 ± 0.016
3.215ProAsp: 3.215 ± 0.082
3.786ProGlu: 3.786 ± 0.052
1.698ProPhe: 1.698 ± 0.036
4.181ProGly: 4.181 ± 0.058
1.116ProHis: 1.116 ± 0.033
2.019ProIle: 2.019 ± 0.038
0.891ProLys: 0.891 ± 0.031
5.39ProLeu: 5.39 ± 0.072
1.259ProMet: 1.259 ± 0.033
1.242ProAsn: 1.242 ± 0.034
2.07ProPro: 2.07 ± 0.048
2.003ProGln: 2.003 ± 0.037
2.871ProArg: 2.871 ± 0.055
2.925ProSer: 2.925 ± 0.053
2.337ProThr: 2.337 ± 0.05
3.82ProVal: 3.82 ± 0.053
0.76ProTrp: 0.76 ± 0.027
1.031ProTyr: 1.031 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.012GlnAla: 5.012 ± 0.076
0.352GlnCys: 0.352 ± 0.016
1.824GlnAsp: 1.824 ± 0.041
1.905GlnGlu: 1.905 ± 0.042
1.13GlnPhe: 1.13 ± 0.028
3.2GlnGly: 3.2 ± 0.054
1.162GlnHis: 1.162 ± 0.03
1.67GlnIle: 1.67 ± 0.036
0.837GlnLys: 0.837 ± 0.025
5.107GlnLeu: 5.107 ± 0.072
0.96GlnMet: 0.96 ± 0.026
0.854GlnAsn: 0.854 ± 0.027
2.098GlnPro: 2.098 ± 0.044
2.967GlnGln: 2.967 ± 0.067
3.905GlnArg: 3.905 ± 0.066
2.236GlnSer: 2.236 ± 0.045
1.77GlnThr: 1.77 ± 0.043
2.922GlnVal: 2.922 ± 0.049
0.71GlnTrp: 0.71 ± 0.023
0.837GlnTyr: 0.837 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
5.773ArgAla: 5.773 ± 0.076
0.637ArgCys: 0.637 ± 0.024
4.046ArgAsp: 4.046 ± 0.061
4.9ArgGlu: 4.9 ± 0.09
2.625ArgPhe: 2.625 ± 0.044
4.339ArgGly: 4.339 ± 0.059
2.217ArgHis: 2.217 ± 0.049
3.431ArgIle: 3.431 ± 0.055
1.732ArgLys: 1.732 ± 0.043
8.786ArgLeu: 8.786 ± 0.121
1.787ArgMet: 1.787 ± 0.037
1.767ArgAsn: 1.767 ± 0.041
2.781ArgPro: 2.781 ± 0.045
3.515ArgGln: 3.515 ± 0.07
5.14ArgArg: 5.14 ± 0.094
3.504ArgSer: 3.504 ± 0.055
2.699ArgThr: 2.699 ± 0.047
4.674ArgVal: 4.674 ± 0.065
1.079ArgTrp: 1.079 ± 0.032
2.087ArgTyr: 2.087 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.202SerAla: 6.202 ± 0.074
0.551SerCys: 0.551 ± 0.022
3.618SerAsp: 3.618 ± 0.066
3.641SerGlu: 3.641 ± 0.046
2.139SerPhe: 2.139 ± 0.042
5.699SerGly: 5.699 ± 0.068
1.433SerHis: 1.433 ± 0.032
2.943SerIle: 2.943 ± 0.055
1.177SerLys: 1.177 ± 0.033
7.211SerLeu: 7.211 ± 0.084
1.755SerMet: 1.755 ± 0.043
1.69SerAsn: 1.69 ± 0.036
2.902SerPro: 2.902 ± 0.045
2.359SerGln: 2.359 ± 0.047
4.343SerArg: 4.343 ± 0.065
4.087SerSer: 4.087 ± 0.071
3.12SerThr: 3.12 ± 0.044
4.352SerVal: 4.352 ± 0.067
0.988SerTrp: 0.988 ± 0.026
1.316SerTyr: 1.316 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.264ThrAla: 5.264 ± 0.088
0.446ThrCys: 0.446 ± 0.019
2.861ThrAsp: 2.861 ± 0.086
2.651ThrGlu: 2.651 ± 0.044
1.862ThrPhe: 1.862 ± 0.044
4.365ThrGly: 4.365 ± 0.073
1.104ThrHis: 1.104 ± 0.03
2.354ThrIle: 2.354 ± 0.056
0.686ThrLys: 0.686 ± 0.023
6.771ThrLeu: 6.771 ± 0.078
1.089ThrMet: 1.089 ± 0.026
1.377ThrAsn: 1.377 ± 0.055
3.418ThrPro: 3.418 ± 0.056
1.878ThrGln: 1.878 ± 0.041
3.477ThrArg: 3.477 ± 0.054
3.23ThrSer: 3.23 ± 0.054
2.959ThrThr: 2.959 ± 0.088
3.616ThrVal: 3.616 ± 0.132
0.642ThrTrp: 0.642 ± 0.024
1.047ThrTyr: 1.047 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.349ValAla: 8.349 ± 0.088
0.704ValCys: 0.704 ± 0.024
4.521ValAsp: 4.521 ± 0.099
4.814ValGlu: 4.814 ± 0.072
2.543ValPhe: 2.543 ± 0.048
5.612ValGly: 5.612 ± 0.075
1.415ValHis: 1.415 ± 0.036
4.14ValIle: 4.14 ± 0.055
1.806ValLys: 1.806 ± 0.043
7.767ValLeu: 7.767 ± 0.091
2.188ValMet: 2.188 ± 0.04
2.137ValAsn: 2.137 ± 0.049
3.397ValPro: 3.397 ± 0.056
2.281ValGln: 2.281 ± 0.044
4.203ValArg: 4.203 ± 0.064
4.676ValSer: 4.676 ± 0.055
4.312ValThr: 4.312 ± 0.108
6.093ValVal: 6.093 ± 0.082
0.895ValTrp: 0.895 ± 0.029
1.523ValTyr: 1.523 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.028
0.196TrpCys: 0.196 ± 0.012
0.614TrpAsp: 0.614 ± 0.021
0.635TrpGlu: 0.635 ± 0.023
0.497TrpPhe: 0.497 ± 0.021
0.945TrpGly: 0.945 ± 0.026
0.433TrpHis: 0.433 ± 0.017
0.675TrpIle: 0.675 ± 0.026
0.409TrpLys: 0.409 ± 0.016
2.431TrpLeu: 2.431 ± 0.055
0.411TrpMet: 0.411 ± 0.014
0.407TrpAsn: 0.407 ± 0.017
0.702TrpPro: 0.702 ± 0.027
1.091TrpGln: 1.091 ± 0.03
1.183TrpArg: 1.183 ± 0.032
0.825TrpSer: 0.825 ± 0.026
0.575TrpThr: 0.575 ± 0.023
0.971TrpVal: 0.971 ± 0.027
0.322TrpTrp: 0.322 ± 0.018
0.333TrpTyr: 0.333 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.269TyrAla: 2.269 ± 0.036
0.275TyrCys: 0.275 ± 0.015
1.38TyrAsp: 1.38 ± 0.038
1.143TyrGlu: 1.143 ± 0.036
0.894TyrPhe: 0.894 ± 0.024
1.988TyrGly: 1.988 ± 0.042
0.656TyrHis: 0.656 ± 0.021
0.932TyrIle: 0.932 ± 0.028
0.462TyrLys: 0.462 ± 0.019
2.754TyrLeu: 2.754 ± 0.046
0.489TyrMet: 0.489 ± 0.019
0.609TyrAsn: 0.609 ± 0.023
1.244TyrPro: 1.244 ± 0.032
1.091TyrGln: 1.091 ± 0.031
2.029TyrArg: 2.029 ± 0.041
1.437TyrSer: 1.437 ± 0.033
1.169TyrThr: 1.169 ± 0.027
1.488TyrVal: 1.488 ± 0.033
0.349TyrTrp: 0.349 ± 0.017
0.695TyrTyr: 0.695 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4209 proteins (1385470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski