Amino acid dipepetide frequency for Filimonas sp. YR581

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.75AlaAla: 9.75 ± 0.095
0.836AlaCys: 0.836 ± 0.024
4.879AlaAsp: 4.879 ± 0.059
4.399AlaGlu: 4.399 ± 0.056
3.782AlaPhe: 3.782 ± 0.042
7.65AlaGly: 7.65 ± 0.073
1.453AlaHis: 1.453 ± 0.028
5.399AlaIle: 5.399 ± 0.054
3.783AlaLys: 3.783 ± 0.046
7.909AlaLeu: 7.909 ± 0.076
1.872AlaMet: 1.872 ± 0.032
3.865AlaAsn: 3.865 ± 0.062
3.076AlaPro: 3.076 ± 0.056
3.427AlaGln: 3.427 ± 0.042
3.4AlaArg: 3.4 ± 0.037
5.212AlaSer: 5.212 ± 0.065
5.888AlaThr: 5.888 ± 0.102
6.35AlaVal: 6.35 ± 0.071
1.044AlaTrp: 1.044 ± 0.023
3.465AlaTyr: 3.465 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.639CysAla: 0.639 ± 0.023
0.176CysCys: 0.176 ± 0.009
0.402CysAsp: 0.402 ± 0.036
0.401CysGlu: 0.401 ± 0.015
0.479CysPhe: 0.479 ± 0.014
0.661CysGly: 0.661 ± 0.018
0.187CysHis: 0.187 ± 0.01
0.671CysIle: 0.671 ± 0.017
0.512CysLys: 0.512 ± 0.017
0.879CysLeu: 0.879 ± 0.02
0.248CysMet: 0.248 ± 0.01
0.456CysAsn: 0.456 ± 0.015
0.309CysPro: 0.309 ± 0.012
0.248CysGln: 0.248 ± 0.011
0.432CysArg: 0.432 ± 0.015
0.607CysSer: 0.607 ± 0.022
0.594CysThr: 0.594 ± 0.02
0.547CysVal: 0.547 ± 0.016
0.124CysTrp: 0.124 ± 0.007
0.415CysTyr: 0.415 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.36AspAla: 4.36 ± 0.066
0.373AspCys: 0.373 ± 0.014
2.143AspAsp: 2.143 ± 0.036
2.66AspGlu: 2.66 ± 0.042
2.427AspPhe: 2.427 ± 0.038
3.638AspGly: 3.638 ± 0.064
0.792AspHis: 0.792 ± 0.017
3.518AspIle: 3.518 ± 0.047
3.418AspLys: 3.418 ± 0.041
3.869AspLeu: 3.869 ± 0.044
1.201AspMet: 1.201 ± 0.022
2.732AspAsn: 2.732 ± 0.049
1.587AspPro: 1.587 ± 0.033
1.355AspGln: 1.355 ± 0.022
1.835AspArg: 1.835 ± 0.03
3.465AspSer: 3.465 ± 0.06
3.132AspThr: 3.132 ± 0.055
3.263AspVal: 3.263 ± 0.046
0.738AspTrp: 0.738 ± 0.017
2.458AspTyr: 2.458 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
4.789GluAla: 4.789 ± 0.061
0.356GluCys: 0.356 ± 0.013
2.293GluAsp: 2.293 ± 0.035
3.587GluGlu: 3.587 ± 0.077
1.831GluPhe: 1.831 ± 0.03
3.439GluGly: 3.439 ± 0.044
0.977GluHis: 0.977 ± 0.022
3.186GluIle: 3.186 ± 0.046
4.201GluLys: 4.201 ± 0.054
4.957GluLeu: 4.957 ± 0.069
1.377GluMet: 1.377 ± 0.027
2.667GluAsn: 2.667 ± 0.033
1.478GluPro: 1.478 ± 0.029
2.631GluGln: 2.631 ± 0.041
2.269GluArg: 2.269 ± 0.043
2.346GluSer: 2.346 ± 0.034
2.79GluThr: 2.79 ± 0.034
3.76GluVal: 3.76 ± 0.049
0.76GluTrp: 0.76 ± 0.019
1.949GluTyr: 1.949 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.281PheAla: 3.281 ± 0.04
0.457PheCys: 0.457 ± 0.016
2.444PheAsp: 2.444 ± 0.037
2.299PheGlu: 2.299 ± 0.036
2.141PhePhe: 2.141 ± 0.035
2.783PheGly: 2.783 ± 0.04
0.821PheHis: 0.821 ± 0.018
2.898PheIle: 2.898 ± 0.048
2.349PheLys: 2.349 ± 0.033
3.712PheLeu: 3.712 ± 0.049
1.053PheMet: 1.053 ± 0.021
2.711PheAsn: 2.711 ± 0.039
1.568PhePro: 1.568 ± 0.026
1.382PheGln: 1.382 ± 0.026
1.98PheArg: 1.98 ± 0.03
3.523PheSer: 3.523 ± 0.043
3.759PheThr: 3.759 ± 0.059
2.627PheVal: 2.627 ± 0.034
0.567PheTrp: 0.567 ± 0.017
1.998PheTyr: 1.998 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
5.387GlyAla: 5.387 ± 0.068
0.751GlyCys: 0.751 ± 0.027
3.328GlyAsp: 3.328 ± 0.044
3.232GlyGlu: 3.232 ± 0.042
3.357GlyPhe: 3.357 ± 0.038
5.328GlyGly: 5.328 ± 0.086
1.216GlyHis: 1.216 ± 0.027
5.119GlyIle: 5.119 ± 0.059
4.944GlyLys: 4.944 ± 0.059
5.832GlyLeu: 5.832 ± 0.061
1.783GlyMet: 1.783 ± 0.031
4.289GlyAsn: 4.289 ± 0.062
1.642GlyPro: 1.642 ± 0.056
2.303GlyGln: 2.303 ± 0.038
2.916GlyArg: 2.916 ± 0.039
4.792GlySer: 4.792 ± 0.068
4.942GlyThr: 4.942 ± 0.114
4.988GlyVal: 4.988 ± 0.07
1.091GlyTrp: 1.091 ± 0.022
3.38GlyTyr: 3.38 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.397HisAla: 1.397 ± 0.028
0.216HisCys: 0.216 ± 0.009
0.784HisAsp: 0.784 ± 0.021
0.937HisGlu: 0.937 ± 0.024
1.188HisPhe: 1.188 ± 0.026
1.105HisGly: 1.105 ± 0.029
0.525HisHis: 0.525 ± 0.018
1.424HisIle: 1.424 ± 0.027
0.941HisLys: 0.941 ± 0.026
1.985HisLeu: 1.985 ± 0.034
0.415HisMet: 0.415 ± 0.013
0.934HisAsn: 0.934 ± 0.024
0.983HisPro: 0.983 ± 0.023
0.764HisGln: 0.764 ± 0.016
0.808HisArg: 0.808 ± 0.024
1.088HisSer: 1.088 ± 0.023
1.278HisThr: 1.278 ± 0.028
1.001HisVal: 1.001 ± 0.023
0.284HisTrp: 0.284 ± 0.013
0.967HisTyr: 0.967 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.729IleAla: 5.729 ± 0.055
0.652IleCys: 0.652 ± 0.02
3.459IleAsp: 3.459 ± 0.038
3.364IleGlu: 3.364 ± 0.052
2.143IlePhe: 2.143 ± 0.035
3.921IleGly: 3.921 ± 0.049
1.293IleHis: 1.293 ± 0.026
3.913IleIle: 3.913 ± 0.048
3.627IleLys: 3.627 ± 0.046
4.796IleLeu: 4.796 ± 0.059
1.147IleMet: 1.147 ± 0.024
3.46IleAsn: 3.46 ± 0.045
2.781IlePro: 2.781 ± 0.036
2.484IleGln: 2.484 ± 0.034
2.784IleArg: 2.784 ± 0.034
4.344IleSer: 4.344 ± 0.047
4.996IleThr: 4.996 ± 0.059
3.798IleVal: 3.798 ± 0.047
0.65IleTrp: 0.65 ± 0.02
2.398IleTyr: 2.398 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
5.383LysAla: 5.383 ± 0.058
0.321LysCys: 0.321 ± 0.012
3.313LysAsp: 3.313 ± 0.035
4.181LysGlu: 4.181 ± 0.056
1.611LysPhe: 1.611 ± 0.026
4.391LysGly: 4.391 ± 0.047
1.085LysHis: 1.085 ± 0.024
3.319LysIle: 3.319 ± 0.045
4.395LysLys: 4.395 ± 0.057
4.967LysLeu: 4.967 ± 0.05
1.562LysMet: 1.562 ± 0.022
3.118LysAsn: 3.118 ± 0.038
2.487LysPro: 2.487 ± 0.037
2.864LysGln: 2.864 ± 0.039
2.528LysArg: 2.528 ± 0.034
2.95LysSer: 2.95 ± 0.044
3.542LysThr: 3.542 ± 0.041
3.939LysVal: 3.939 ± 0.049
0.783LysTrp: 0.783 ± 0.017
2.265LysTyr: 2.265 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
7.482LeuAla: 7.482 ± 0.071
0.935LeuCys: 0.935 ± 0.026
4.036LeuAsp: 4.036 ± 0.047
4.496LeuGlu: 4.496 ± 0.055
4.498LeuPhe: 4.498 ± 0.063
5.317LeuGly: 5.317 ± 0.054
2.058LeuHis: 2.058 ± 0.034
4.905LeuIle: 4.905 ± 0.059
5.605LeuLys: 5.605 ± 0.067
10.871LeuLeu: 10.871 ± 0.12
2.049LeuMet: 2.049 ± 0.032
4.775LeuAsn: 4.775 ± 0.052
4.767LeuPro: 4.767 ± 0.055
5.133LeuGln: 5.133 ± 0.065
3.913LeuArg: 3.913 ± 0.045
6.487LeuSer: 6.487 ± 0.061
5.87LeuThr: 5.87 ± 0.065
5.969LeuVal: 5.969 ± 0.055
1.048LeuTrp: 1.048 ± 0.027
3.799LeuTyr: 3.799 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
1.961MetAla: 1.961 ± 0.031
0.154MetCys: 0.154 ± 0.008
1.058MetAsp: 1.058 ± 0.022
1.31MetGlu: 1.31 ± 0.025
0.707MetPhe: 0.707 ± 0.017
1.534MetGly: 1.534 ± 0.03
0.485MetHis: 0.485 ± 0.014
1.208MetIle: 1.208 ± 0.025
1.8MetLys: 1.8 ± 0.029
2.214MetLeu: 2.214 ± 0.035
0.552MetMet: 0.552 ± 0.018
1.243MetAsn: 1.243 ± 0.022
1.23MetPro: 1.23 ± 0.025
1.257MetGln: 1.257 ± 0.022
1.129MetArg: 1.129 ± 0.019
1.244MetSer: 1.244 ± 0.023
1.033MetThr: 1.033 ± 0.02
1.452MetVal: 1.452 ± 0.028
0.195MetTrp: 0.195 ± 0.01
0.789MetTyr: 0.789 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
4.484AsnAla: 4.484 ± 0.057
0.448AsnCys: 0.448 ± 0.017
2.581AsnAsp: 2.581 ± 0.059
2.577AsnGlu: 2.577 ± 0.042
2.058AsnPhe: 2.058 ± 0.033
4.425AsnGly: 4.425 ± 0.071
0.84AsnHis: 0.84 ± 0.021
3.517AsnIle: 3.517 ± 0.044
3.132AsnLys: 3.132 ± 0.04
4.243AsnLeu: 4.243 ± 0.055
1.155AsnMet: 1.155 ± 0.022
3.443AsnAsn: 3.443 ± 0.055
2.405AsnPro: 2.405 ± 0.034
1.859AsnGln: 1.859 ± 0.031
2.498AsnArg: 2.498 ± 0.034
3.277AsnSer: 3.277 ± 0.05
3.912AsnThr: 3.912 ± 0.065
3.131AsnVal: 3.131 ± 0.047
0.777AsnTrp: 0.777 ± 0.019
2.531AsnTyr: 2.531 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
4.681ProAla: 4.681 ± 0.065
0.27ProCys: 0.27 ± 0.012
2.646ProAsp: 2.646 ± 0.036
2.583ProGlu: 2.583 ± 0.042
1.936ProPhe: 1.936 ± 0.028
3.273ProGly: 3.273 ± 0.041
0.723ProHis: 0.723 ± 0.019
1.635ProIle: 1.635 ± 0.029
1.521ProLys: 1.521 ± 0.03
3.709ProLeu: 3.709 ± 0.041
0.776ProMet: 0.776 ± 0.017
1.531ProAsn: 1.531 ± 0.031
1.283ProPro: 1.283 ± 0.032
1.554ProGln: 1.554 ± 0.031
1.22ProArg: 1.22 ± 0.021
2.122ProSer: 2.122 ± 0.036
1.811ProThr: 1.811 ± 0.044
4.291ProVal: 4.291 ± 0.062
0.467ProTrp: 0.467 ± 0.014
1.616ProTyr: 1.616 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.495GlnAla: 3.495 ± 0.045
0.258GlnCys: 0.258 ± 0.011
1.483GlnAsp: 1.483 ± 0.025
2.172GlnGlu: 2.172 ± 0.037
1.725GlnPhe: 1.725 ± 0.027
2.218GlnGly: 2.218 ± 0.04
1.052GlnHis: 1.052 ± 0.024
1.903GlnIle: 1.903 ± 0.031
2.417GlnLys: 2.417 ± 0.041
5.204GlnLeu: 5.204 ± 0.06
0.973GlnMet: 0.973 ± 0.022
1.796GlnAsn: 1.796 ± 0.03
2.101GlnPro: 2.101 ± 0.035
3.548GlnGln: 3.548 ± 0.071
1.795GlnArg: 1.795 ± 0.031
2.229GlnSer: 2.229 ± 0.031
2.253GlnThr: 2.253 ± 0.037
3.154GlnVal: 3.154 ± 0.039
0.665GlnTrp: 0.665 ± 0.016
1.94GlnTyr: 1.94 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.672ArgAla: 2.672 ± 0.037
0.325ArgCys: 0.325 ± 0.012
1.859ArgAsp: 1.859 ± 0.032
2.281ArgGlu: 2.281 ± 0.044
2.412ArgPhe: 2.412 ± 0.037
2.234ArgGly: 2.234 ± 0.029
0.815ArgHis: 0.815 ± 0.017
2.979ArgIle: 2.979 ± 0.039
2.888ArgLys: 2.888 ± 0.045
4.432ArgLeu: 4.432 ± 0.053
1.178ArgMet: 1.178 ± 0.024
2.477ArgAsn: 2.477 ± 0.037
1.491ArgPro: 1.491 ± 0.031
1.912ArgGln: 1.912 ± 0.032
1.851ArgArg: 1.851 ± 0.032
2.346ArgSer: 2.346 ± 0.03
2.31ArgThr: 2.31 ± 0.033
2.721ArgVal: 2.721 ± 0.038
0.718ArgTrp: 0.718 ± 0.019
2.177ArgTyr: 2.177 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
5.232SerAla: 5.232 ± 0.06
0.678SerCys: 0.678 ± 0.02
2.912SerAsp: 2.912 ± 0.037
2.555SerGlu: 2.555 ± 0.037
3.608SerPhe: 3.608 ± 0.048
5.169SerGly: 5.169 ± 0.078
1.091SerHis: 1.091 ± 0.021
4.009SerIle: 4.009 ± 0.038
3.041SerLys: 3.041 ± 0.04
6.283SerLeu: 6.283 ± 0.054
1.306SerMet: 1.306 ± 0.023
3.251SerAsn: 3.251 ± 0.05
2.279SerPro: 2.279 ± 0.036
2.009SerGln: 2.009 ± 0.033
2.717SerArg: 2.717 ± 0.037
4.179SerSer: 4.179 ± 0.072
3.704SerThr: 3.704 ± 0.058
4.526SerVal: 4.526 ± 0.062
0.91SerTrp: 0.91 ± 0.022
3.056SerTyr: 3.056 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
6.565ThrAla: 6.565 ± 0.112
0.505ThrCys: 0.505 ± 0.019
3.54ThrAsp: 3.54 ± 0.06
2.98ThrGlu: 2.98 ± 0.038
2.625ThrPhe: 2.625 ± 0.041
6.262ThrGly: 6.262 ± 0.114
1.136ThrHis: 1.136 ± 0.024
4.399ThrIle: 4.399 ± 0.065
2.508ThrLys: 2.508 ± 0.033
6.094ThrLeu: 6.094 ± 0.066
1.045ThrMet: 1.045 ± 0.02
2.959ThrAsn: 2.959 ± 0.051
3.18ThrPro: 3.18 ± 0.062
2.182ThrGln: 2.182 ± 0.032
2.539ThrArg: 2.539 ± 0.039
4.004ThrSer: 4.004 ± 0.066
4.634ThrThr: 4.634 ± 0.09
5.043ThrVal: 5.043 ± 0.105
0.82ThrTrp: 0.82 ± 0.021
2.873ThrTyr: 2.873 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
5.925ValAla: 5.925 ± 0.063
0.709ValCys: 0.709 ± 0.023
2.987ValAsp: 2.987 ± 0.036
3.002ValGlu: 3.002 ± 0.044
3.19ValPhe: 3.19 ± 0.038
3.4ValGly: 3.4 ± 0.042
1.258ValHis: 1.258 ± 0.025
4.595ValIle: 4.595 ± 0.049
4.541ValLys: 4.541 ± 0.049
6.677ValLeu: 6.677 ± 0.066
1.571ValMet: 1.571 ± 0.027
4.059ValAsn: 4.059 ± 0.061
2.845ValPro: 2.845 ± 0.039
2.735ValGln: 2.735 ± 0.034
2.615ValArg: 2.615 ± 0.031
4.628ValSer: 4.628 ± 0.061
5.385ValThr: 5.385 ± 0.124
4.931ValVal: 4.931 ± 0.059
0.805ValTrp: 0.805 ± 0.021
2.885ValTyr: 2.885 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.857TrpAla: 0.857 ± 0.02
0.164TrpCys: 0.164 ± 0.008
0.619TrpAsp: 0.619 ± 0.016
0.682TrpGlu: 0.682 ± 0.017
0.58TrpPhe: 0.58 ± 0.019
0.883TrpGly: 0.883 ± 0.021
0.305TrpHis: 0.305 ± 0.013
0.703TrpIle: 0.703 ± 0.018
0.881TrpLys: 0.881 ± 0.02
1.445TrpLeu: 1.445 ± 0.027
0.378TrpMet: 0.378 ± 0.013
0.779TrpAsn: 0.779 ± 0.019
0.405TrpPro: 0.405 ± 0.015
0.867TrpGln: 0.867 ± 0.018
0.583TrpArg: 0.583 ± 0.017
0.752TrpSer: 0.752 ± 0.023
0.703TrpThr: 0.703 ± 0.021
0.818TrpVal: 0.818 ± 0.02
0.245TrpTrp: 0.245 ± 0.011
0.622TrpTyr: 0.622 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.372TyrAla: 3.372 ± 0.038
0.405TyrCys: 0.405 ± 0.013
2.199TyrAsp: 2.199 ± 0.036
1.945TyrGlu: 1.945 ± 0.032
2.055TyrPhe: 2.055 ± 0.028
2.989TyrGly: 2.989 ± 0.045
0.912TyrHis: 0.912 ± 0.021
2.441TyrIle: 2.441 ± 0.032
2.5TyrLys: 2.5 ± 0.034
3.935TyrLeu: 3.935 ± 0.045
0.91TyrMet: 0.91 ± 0.019
2.747TyrAsn: 2.747 ± 0.046
1.752TyrPro: 1.752 ± 0.029
1.87TyrGln: 1.87 ± 0.029
2.264TyrArg: 2.264 ± 0.034
2.917TyrSer: 2.917 ± 0.042
3.356TyrThr: 3.356 ± 0.069
2.435TyrVal: 2.435 ± 0.031
0.579TyrTrp: 0.579 ± 0.016
2.258TyrTyr: 2.258 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6102 proteins (2383604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski