Amino acid dipepetide frequency for Staphylococcus phage vB_SauS_JS02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.856AlaAla: 2.856 ± 0.707
0.214AlaCys: 0.214 ± 0.119
2.713AlaAsp: 2.713 ± 0.525
3.998AlaGlu: 3.998 ± 0.545
1.571AlaPhe: 1.571 ± 0.294
3.712AlaGly: 3.712 ± 0.741
1.071AlaHis: 1.071 ± 0.285
4.497AlaIle: 4.497 ± 0.775
6.425AlaLys: 6.425 ± 1.044
5.069AlaLeu: 5.069 ± 0.736
1.499AlaMet: 1.499 ± 0.246
4.14AlaAsn: 4.14 ± 0.873
1.499AlaPro: 1.499 ± 0.408
1.856AlaGln: 1.856 ± 0.373
2.57AlaArg: 2.57 ± 0.373
4.497AlaSer: 4.497 ± 0.802
3.712AlaThr: 3.712 ± 0.456
2.784AlaVal: 2.784 ± 0.525
1.142AlaTrp: 1.142 ± 0.391
2.57AlaTyr: 2.57 ± 0.519
0.0AlaXaa: 0.0 ± 0.0
Cys
0.143CysAla: 0.143 ± 0.089
0.0CysCys: 0.0 ± 0.0
0.143CysAsp: 0.143 ± 0.091
0.357CysGlu: 0.357 ± 0.21
0.357CysPhe: 0.357 ± 0.181
0.286CysGly: 0.286 ± 0.157
0.143CysHis: 0.143 ± 0.103
0.428CysIle: 0.428 ± 0.171
0.5CysLys: 0.5 ± 0.19
0.5CysLeu: 0.5 ± 0.197
0.286CysMet: 0.286 ± 0.195
0.214CysAsn: 0.214 ± 0.15
0.143CysPro: 0.143 ± 0.099
0.143CysGln: 0.143 ± 0.097
0.428CysArg: 0.428 ± 0.193
0.214CysSer: 0.214 ± 0.112
0.214CysThr: 0.214 ± 0.12
0.143CysVal: 0.143 ± 0.109
0.0CysTrp: 0.0 ± 0.0
0.357CysTyr: 0.357 ± 0.193
0.0CysXaa: 0.0 ± 0.0
Asp
2.57AspAla: 2.57 ± 0.593
0.214AspCys: 0.214 ± 0.133
3.926AspAsp: 3.926 ± 0.614
5.14AspGlu: 5.14 ± 0.774
3.427AspPhe: 3.427 ± 0.513
3.07AspGly: 3.07 ± 0.496
0.857AspHis: 0.857 ± 0.205
4.926AspIle: 4.926 ± 0.557
7.067AspLys: 7.067 ± 0.699
5.425AspLeu: 5.425 ± 0.65
2.142AspMet: 2.142 ± 0.348
2.784AspAsn: 2.784 ± 0.4
1.214AspPro: 1.214 ± 0.326
1.285AspGln: 1.285 ± 0.213
2.07AspArg: 2.07 ± 0.415
3.284AspSer: 3.284 ± 0.626
3.498AspThr: 3.498 ± 0.517
3.926AspVal: 3.926 ± 0.457
0.928AspTrp: 0.928 ± 0.244
3.355AspTyr: 3.355 ± 0.614
0.0AspXaa: 0.0 ± 0.0
Glu
4.854GluAla: 4.854 ± 0.643
0.5GluCys: 0.5 ± 0.205
5.069GluAsp: 5.069 ± 0.746
7.067GluGlu: 7.067 ± 1.16
2.927GluPhe: 2.927 ± 0.511
3.355GluGly: 3.355 ± 0.517
0.857GluHis: 0.857 ± 0.247
5.354GluIle: 5.354 ± 0.846
8.424GluLys: 8.424 ± 0.867
7.21GluLeu: 7.21 ± 0.765
2.284GluMet: 2.284 ± 0.431
5.925GluAsn: 5.925 ± 0.689
1.428GluPro: 1.428 ± 0.402
3.355GluGln: 3.355 ± 0.553
3.07GluArg: 3.07 ± 0.528
3.569GluSer: 3.569 ± 0.504
4.14GluThr: 4.14 ± 0.635
3.998GluVal: 3.998 ± 0.473
0.857GluTrp: 0.857 ± 0.198
3.141GluTyr: 3.141 ± 0.73
0.0GluXaa: 0.0 ± 0.0
Phe
1.642PheAla: 1.642 ± 0.354
0.428PheCys: 0.428 ± 0.177
3.141PheAsp: 3.141 ± 0.416
3.07PheGlu: 3.07 ± 0.476
0.857PhePhe: 0.857 ± 0.23
2.784PheGly: 2.784 ± 0.573
0.5PheHis: 0.5 ± 0.174
3.569PheIle: 3.569 ± 0.631
3.784PheLys: 3.784 ± 0.587
1.927PheLeu: 1.927 ± 0.321
1.071PheMet: 1.071 ± 0.246
3.498PheAsn: 3.498 ± 0.52
0.785PhePro: 0.785 ± 0.255
1.142PheGln: 1.142 ± 0.276
1.071PheArg: 1.071 ± 0.25
1.856PheSer: 1.856 ± 0.384
1.499PheThr: 1.499 ± 0.358
1.927PheVal: 1.927 ± 0.384
0.357PheTrp: 0.357 ± 0.145
1.713PheTyr: 1.713 ± 0.373
0.0PheXaa: 0.0 ± 0.0
Gly
3.998GlyAla: 3.998 ± 0.966
0.214GlyCys: 0.214 ± 0.116
3.641GlyAsp: 3.641 ± 0.542
3.784GlyGlu: 3.784 ± 0.427
2.07GlyPhe: 2.07 ± 0.344
5.211GlyGly: 5.211 ± 1.162
1.499GlyHis: 1.499 ± 0.298
3.498GlyIle: 3.498 ± 0.428
5.711GlyLys: 5.711 ± 0.675
5.782GlyLeu: 5.782 ± 0.912
1.285GlyMet: 1.285 ± 0.429
3.427GlyAsn: 3.427 ± 0.558
0.928GlyPro: 0.928 ± 0.229
1.571GlyGln: 1.571 ± 0.357
1.999GlyArg: 1.999 ± 0.406
3.926GlySer: 3.926 ± 0.54
3.784GlyThr: 3.784 ± 0.564
4.355GlyVal: 4.355 ± 0.707
1.071GlyTrp: 1.071 ± 0.315
2.427GlyTyr: 2.427 ± 0.543
0.0GlyXaa: 0.0 ± 0.0
His
1.071HisAla: 1.071 ± 0.239
0.071HisCys: 0.071 ± 0.07
0.999HisAsp: 0.999 ± 0.31
1.142HisGlu: 1.142 ± 0.274
0.714HisPhe: 0.714 ± 0.188
1.214HisGly: 1.214 ± 0.319
0.357HisHis: 0.357 ± 0.171
1.642HisIle: 1.642 ± 0.43
1.571HisLys: 1.571 ± 0.334
1.713HisLeu: 1.713 ± 0.319
0.428HisMet: 0.428 ± 0.178
0.928HisAsn: 0.928 ± 0.269
0.785HisPro: 0.785 ± 0.215
0.714HisGln: 0.714 ± 0.214
0.857HisArg: 0.857 ± 0.272
1.214HisSer: 1.214 ± 0.24
1.071HisThr: 1.071 ± 0.333
0.642HisVal: 0.642 ± 0.27
0.214HisTrp: 0.214 ± 0.108
1.071HisTyr: 1.071 ± 0.271
0.0HisXaa: 0.0 ± 0.0
Ile
4.426IleAla: 4.426 ± 0.558
0.357IleCys: 0.357 ± 0.217
4.64IleAsp: 4.64 ± 0.645
5.64IleGlu: 5.64 ± 0.597
2.499IlePhe: 2.499 ± 0.533
3.355IleGly: 3.355 ± 0.492
1.785IleHis: 1.785 ± 0.323
4.069IleIle: 4.069 ± 0.735
7.781IleLys: 7.781 ± 0.801
5.14IleLeu: 5.14 ± 0.747
1.642IleMet: 1.642 ± 0.355
4.997IleAsn: 4.997 ± 0.535
2.427IlePro: 2.427 ± 0.416
1.571IleGln: 1.571 ± 0.301
3.284IleArg: 3.284 ± 0.427
4.997IleSer: 4.997 ± 0.652
4.283IleThr: 4.283 ± 0.676
3.855IleVal: 3.855 ± 0.682
0.571IleTrp: 0.571 ± 0.254
2.784IleTyr: 2.784 ± 0.502
0.0IleXaa: 0.0 ± 0.0
Lys
8.067LysAla: 8.067 ± 1.143
0.214LysCys: 0.214 ± 0.13
4.997LysAsp: 4.997 ± 0.558
8.281LysGlu: 8.281 ± 0.916
2.07LysPhe: 2.07 ± 0.366
5.497LysGly: 5.497 ± 0.899
2.07LysHis: 2.07 ± 0.41
6.282LysIle: 6.282 ± 0.721
8.21LysLys: 8.21 ± 0.947
8.852LysLeu: 8.852 ± 0.97
3.141LysMet: 3.141 ± 0.411
6.068LysAsn: 6.068 ± 0.784
2.427LysPro: 2.427 ± 0.404
5.568LysGln: 5.568 ± 0.58
3.926LysArg: 3.926 ± 0.658
6.139LysSer: 6.139 ± 1.224
5.497LysThr: 5.497 ± 0.613
5.354LysVal: 5.354 ± 0.778
1.927LysTrp: 1.927 ± 0.501
4.569LysTyr: 4.569 ± 0.603
0.0LysXaa: 0.0 ± 0.0
Leu
4.212LeuAla: 4.212 ± 0.785
0.357LeuCys: 0.357 ± 0.165
5.211LeuAsp: 5.211 ± 0.948
7.21LeuGlu: 7.21 ± 0.717
2.57LeuPhe: 2.57 ± 0.321
4.64LeuGly: 4.64 ± 0.955
1.071LeuHis: 1.071 ± 0.292
5.283LeuIle: 5.283 ± 0.62
9.138LeuLys: 9.138 ± 1.067
6.568LeuLeu: 6.568 ± 0.785
1.785LeuMet: 1.785 ± 0.286
5.425LeuAsn: 5.425 ± 0.644
2.998LeuPro: 2.998 ± 0.491
3.141LeuGln: 3.141 ± 0.536
3.569LeuArg: 3.569 ± 0.517
5.568LeuSer: 5.568 ± 0.683
5.497LeuThr: 5.497 ± 0.661
3.855LeuVal: 3.855 ± 0.454
0.428LeuTrp: 0.428 ± 0.168
3.07LeuTyr: 3.07 ± 0.685
0.0LeuXaa: 0.0 ± 0.0
Met
1.428MetAla: 1.428 ± 0.275
0.143MetCys: 0.143 ± 0.097
1.285MetAsp: 1.285 ± 0.262
1.499MetGlu: 1.499 ± 0.359
0.928MetPhe: 0.928 ± 0.3
1.571MetGly: 1.571 ± 0.513
0.357MetHis: 0.357 ± 0.148
1.356MetIle: 1.356 ± 0.27
2.713MetLys: 2.713 ± 0.467
1.713MetLeu: 1.713 ± 0.415
0.428MetMet: 0.428 ± 0.201
1.999MetAsn: 1.999 ± 0.455
0.857MetPro: 0.857 ± 0.197
1.642MetGln: 1.642 ± 0.44
0.999MetArg: 0.999 ± 0.244
2.356MetSer: 2.356 ± 0.407
2.284MetThr: 2.284 ± 0.307
0.999MetVal: 0.999 ± 0.203
0.286MetTrp: 0.286 ± 0.148
0.999MetTyr: 0.999 ± 0.221
0.0MetXaa: 0.0 ± 0.0
Asn
4.069AsnAla: 4.069 ± 0.498
0.214AsnCys: 0.214 ± 0.161
4.069AsnAsp: 4.069 ± 0.522
4.497AsnGlu: 4.497 ± 0.598
2.142AsnPhe: 2.142 ± 0.434
4.283AsnGly: 4.283 ± 0.612
0.999AsnHis: 0.999 ± 0.282
4.783AsnIle: 4.783 ± 0.492
6.925AsnLys: 6.925 ± 0.644
4.926AsnLeu: 4.926 ± 0.464
1.071AsnMet: 1.071 ± 0.261
4.783AsnAsn: 4.783 ± 0.909
2.427AsnPro: 2.427 ± 0.326
2.784AsnGln: 2.784 ± 0.512
2.927AsnArg: 2.927 ± 0.553
4.64AsnSer: 4.64 ± 0.701
3.712AsnThr: 3.712 ± 0.395
3.569AsnVal: 3.569 ± 0.659
0.999AsnTrp: 0.999 ± 0.285
3.141AsnTyr: 3.141 ± 0.581
0.0AsnXaa: 0.0 ± 0.0
Pro
1.214ProAla: 1.214 ± 0.228
0.214ProCys: 0.214 ± 0.14
1.356ProAsp: 1.356 ± 0.318
2.427ProGlu: 2.427 ± 0.528
1.142ProPhe: 1.142 ± 0.339
1.642ProGly: 1.642 ± 0.307
0.357ProHis: 0.357 ± 0.156
1.856ProIle: 1.856 ± 0.35
2.213ProLys: 2.213 ± 0.471
2.356ProLeu: 2.356 ± 0.411
0.714ProMet: 0.714 ± 0.255
1.999ProAsn: 1.999 ± 0.344
0.642ProPro: 0.642 ± 0.195
1.142ProGln: 1.142 ± 0.26
1.214ProArg: 1.214 ± 0.19
2.284ProSer: 2.284 ± 0.329
1.642ProThr: 1.642 ± 0.334
1.428ProVal: 1.428 ± 0.412
0.286ProTrp: 0.286 ± 0.111
1.071ProTyr: 1.071 ± 0.287
0.0ProXaa: 0.0 ± 0.0
Gln
2.57GlnAla: 2.57 ± 0.42
0.286GlnCys: 0.286 ± 0.129
2.213GlnAsp: 2.213 ± 0.486
2.713GlnGlu: 2.713 ± 0.433
1.571GlnPhe: 1.571 ± 0.328
2.142GlnGly: 2.142 ± 0.402
0.857GlnHis: 0.857 ± 0.214
3.07GlnIle: 3.07 ± 0.529
3.141GlnLys: 3.141 ± 0.46
3.355GlnLeu: 3.355 ± 0.413
0.785GlnMet: 0.785 ± 0.291
2.57GlnAsn: 2.57 ± 0.534
1.142GlnPro: 1.142 ± 0.247
1.285GlnGln: 1.285 ± 0.368
2.07GlnArg: 2.07 ± 0.367
2.499GlnSer: 2.499 ± 0.363
1.142GlnThr: 1.142 ± 0.389
2.427GlnVal: 2.427 ± 0.466
0.5GlnTrp: 0.5 ± 0.19
1.642GlnTyr: 1.642 ± 0.312
0.0GlnXaa: 0.0 ± 0.0
Arg
2.499ArgAla: 2.499 ± 0.436
0.143ArgCys: 0.143 ± 0.145
2.927ArgAsp: 2.927 ± 0.395
2.641ArgGlu: 2.641 ± 0.54
1.856ArgPhe: 1.856 ± 0.316
2.213ArgGly: 2.213 ± 0.389
0.714ArgHis: 0.714 ± 0.196
3.355ArgIle: 3.355 ± 0.502
4.569ArgLys: 4.569 ± 0.514
3.569ArgLeu: 3.569 ± 0.637
0.928ArgMet: 0.928 ± 0.252
2.356ArgAsn: 2.356 ± 0.323
0.642ArgPro: 0.642 ± 0.268
1.499ArgGln: 1.499 ± 0.276
1.856ArgArg: 1.856 ± 0.394
1.856ArgSer: 1.856 ± 0.419
2.499ArgThr: 2.499 ± 0.405
2.07ArgVal: 2.07 ± 0.325
0.428ArgTrp: 0.428 ± 0.153
2.499ArgTyr: 2.499 ± 0.518
0.0ArgXaa: 0.0 ± 0.0
Ser
3.712SerAla: 3.712 ± 0.782
0.357SerCys: 0.357 ± 0.178
4.783SerAsp: 4.783 ± 0.512
4.64SerGlu: 4.64 ± 0.686
2.427SerPhe: 2.427 ± 0.439
4.569SerGly: 4.569 ± 0.858
1.142SerHis: 1.142 ± 0.253
3.855SerIle: 3.855 ± 0.489
6.71SerLys: 6.71 ± 1.226
4.283SerLeu: 4.283 ± 0.487
2.284SerMet: 2.284 ± 0.483
4.854SerAsn: 4.854 ± 0.54
1.642SerPro: 1.642 ± 0.358
2.713SerGln: 2.713 ± 0.481
2.427SerArg: 2.427 ± 0.389
3.926SerSer: 3.926 ± 0.764
3.212SerThr: 3.212 ± 0.457
3.855SerVal: 3.855 ± 0.594
0.928SerTrp: 0.928 ± 0.251
2.142SerTyr: 2.142 ± 0.346
0.0SerXaa: 0.0 ± 0.0
Thr
3.284ThrAla: 3.284 ± 0.551
0.286ThrCys: 0.286 ± 0.144
3.284ThrAsp: 3.284 ± 0.513
3.926ThrGlu: 3.926 ± 0.58
2.57ThrPhe: 2.57 ± 0.361
3.855ThrGly: 3.855 ± 0.513
1.713ThrHis: 1.713 ± 0.403
4.426ThrIle: 4.426 ± 0.579
5.425ThrLys: 5.425 ± 0.678
4.14ThrLeu: 4.14 ± 0.494
0.714ThrMet: 0.714 ± 0.234
3.355ThrAsn: 3.355 ± 0.503
2.356ThrPro: 2.356 ± 0.342
1.785ThrGln: 1.785 ± 0.282
1.856ThrArg: 1.856 ± 0.337
3.427ThrSer: 3.427 ± 0.518
3.07ThrThr: 3.07 ± 0.562
4.14ThrVal: 4.14 ± 0.513
0.428ThrTrp: 0.428 ± 0.198
2.57ThrTyr: 2.57 ± 0.46
0.0ThrXaa: 0.0 ± 0.0
Val
2.856ValAla: 2.856 ± 0.464
0.286ValCys: 0.286 ± 0.146
3.926ValAsp: 3.926 ± 0.682
5.497ValGlu: 5.497 ± 0.639
2.356ValPhe: 2.356 ± 0.461
3.141ValGly: 3.141 ± 0.557
0.857ValHis: 0.857 ± 0.228
4.069ValIle: 4.069 ± 0.627
4.497ValLys: 4.497 ± 0.615
4.426ValLeu: 4.426 ± 0.563
1.571ValMet: 1.571 ± 0.306
3.855ValAsn: 3.855 ± 0.59
1.428ValPro: 1.428 ± 0.329
2.213ValGln: 2.213 ± 0.393
2.57ValArg: 2.57 ± 0.455
4.069ValSer: 4.069 ± 0.53
2.927ValThr: 2.927 ± 0.486
3.141ValVal: 3.141 ± 0.496
0.5ValTrp: 0.5 ± 0.183
1.927ValTyr: 1.927 ± 0.503
0.0ValXaa: 0.0 ± 0.0
Trp
0.714TrpAla: 0.714 ± 0.2
0.0TrpCys: 0.0 ± 0.0
0.428TrpAsp: 0.428 ± 0.204
0.857TrpGlu: 0.857 ± 0.253
1.071TrpPhe: 1.071 ± 0.362
0.642TrpGly: 0.642 ± 0.257
0.0TrpHis: 0.0 ± 0.0
0.928TrpIle: 0.928 ± 0.293
0.714TrpLys: 0.714 ± 0.21
1.142TrpLeu: 1.142 ± 0.223
0.286TrpMet: 0.286 ± 0.174
1.071TrpAsn: 1.071 ± 0.316
0.357TrpPro: 0.357 ± 0.193
0.642TrpGln: 0.642 ± 0.195
0.5TrpArg: 0.5 ± 0.191
1.071TrpSer: 1.071 ± 0.396
0.571TrpThr: 0.571 ± 0.174
0.857TrpVal: 0.857 ± 0.237
0.143TrpTrp: 0.143 ± 0.122
0.642TrpTyr: 0.642 ± 0.254
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.213TyrAla: 2.213 ± 0.341
0.5TyrCys: 0.5 ± 0.18
2.356TyrAsp: 2.356 ± 0.416
2.998TyrGlu: 2.998 ± 0.53
1.499TyrPhe: 1.499 ± 0.362
3.07TyrGly: 3.07 ± 0.545
1.214TyrHis: 1.214 ± 0.337
2.856TyrIle: 2.856 ± 0.587
3.641TyrLys: 3.641 ± 0.518
3.498TyrLeu: 3.498 ± 0.482
1.428TyrMet: 1.428 ± 0.301
2.713TyrAsn: 2.713 ± 0.59
1.071TyrPro: 1.071 ± 0.284
1.927TyrGln: 1.927 ± 0.321
1.856TyrArg: 1.856 ± 0.477
3.07TyrSer: 3.07 ± 0.426
2.356TyrThr: 2.356 ± 0.412
2.784TyrVal: 2.784 ± 0.582
0.642TyrTrp: 0.642 ± 0.172
1.428TyrTyr: 1.428 ± 0.389
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski