Amino acid dipepetide frequency for Salmonella phage vB_SenM_PA13076

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.42AlaAla: 8.42 ± 0.981
0.771AlaCys: 0.771 ± 0.215
5.463AlaAsp: 5.463 ± 0.604
6.62AlaGlu: 6.62 ± 0.96
1.671AlaPhe: 1.671 ± 0.291
5.013AlaGly: 5.013 ± 0.789
1.928AlaHis: 1.928 ± 0.361
5.977AlaIle: 5.977 ± 0.587
6.17AlaLys: 6.17 ± 0.75
6.427AlaLeu: 6.427 ± 0.805
2.057AlaMet: 2.057 ± 0.317
4.306AlaAsn: 4.306 ± 0.533
2.828AlaPro: 2.828 ± 0.38
2.956AlaGln: 2.956 ± 0.474
3.663AlaArg: 3.663 ± 0.582
4.949AlaSer: 4.949 ± 0.516
5.849AlaThr: 5.849 ± 1.089
4.885AlaVal: 4.885 ± 0.608
1.478AlaTrp: 1.478 ± 0.355
2.507AlaTyr: 2.507 ± 0.429
0.0AlaXaa: 0.0 ± 0.0
Cys
0.578CysAla: 0.578 ± 0.248
0.129CysCys: 0.129 ± 0.091
1.028CysAsp: 1.028 ± 0.277
0.514CysGlu: 0.514 ± 0.211
0.514CysPhe: 0.514 ± 0.23
0.9CysGly: 0.9 ± 0.221
0.257CysHis: 0.257 ± 0.142
0.578CysIle: 0.578 ± 0.206
1.35CysLys: 1.35 ± 0.287
0.964CysLeu: 0.964 ± 0.286
0.386CysMet: 0.386 ± 0.156
1.093CysAsn: 1.093 ± 0.205
0.386CysPro: 0.386 ± 0.145
0.193CysGln: 0.193 ± 0.115
0.514CysArg: 0.514 ± 0.149
0.193CysSer: 0.193 ± 0.111
0.45CysThr: 0.45 ± 0.171
0.578CysVal: 0.578 ± 0.167
0.064CysTrp: 0.064 ± 0.06
0.643CysTyr: 0.643 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
4.37AspAla: 4.37 ± 0.605
0.9AspCys: 0.9 ± 0.236
3.406AspAsp: 3.406 ± 0.389
5.335AspGlu: 5.335 ± 0.571
2.442AspPhe: 2.442 ± 0.38
5.463AspGly: 5.463 ± 0.64
0.771AspHis: 0.771 ± 0.219
4.628AspIle: 4.628 ± 0.566
3.406AspLys: 3.406 ± 0.437
4.756AspLeu: 4.756 ± 0.528
1.928AspMet: 1.928 ± 0.356
3.728AspAsn: 3.728 ± 0.599
2.828AspPro: 2.828 ± 0.359
2.057AspGln: 2.057 ± 0.39
2.507AspArg: 2.507 ± 0.369
3.792AspSer: 3.792 ± 0.557
2.956AspThr: 2.956 ± 0.436
5.206AspVal: 5.206 ± 0.45
1.543AspTrp: 1.543 ± 0.411
2.121AspTyr: 2.121 ± 0.438
0.0AspXaa: 0.0 ± 0.0
Glu
5.463GluAla: 5.463 ± 0.77
0.45GluCys: 0.45 ± 0.15
3.021GluAsp: 3.021 ± 0.45
5.142GluGlu: 5.142 ± 0.814
2.828GluPhe: 2.828 ± 0.461
4.949GluGly: 4.949 ± 0.468
1.157GluHis: 1.157 ± 0.293
2.635GluIle: 2.635 ± 0.41
3.471GluLys: 3.471 ± 0.587
6.684GluLeu: 6.684 ± 0.635
2.378GluMet: 2.378 ± 0.403
2.378GluAsn: 2.378 ± 0.394
1.671GluPro: 1.671 ± 0.28
2.828GluGln: 2.828 ± 0.428
3.214GluArg: 3.214 ± 0.431
3.921GluSer: 3.921 ± 0.551
2.378GluThr: 2.378 ± 0.4
4.563GluVal: 4.563 ± 0.55
1.028GluTrp: 1.028 ± 0.25
2.828GluTyr: 2.828 ± 0.404
0.0GluXaa: 0.0 ± 0.0
Phe
2.25PheAla: 2.25 ± 0.483
0.386PheCys: 0.386 ± 0.139
2.378PheAsp: 2.378 ± 0.397
1.864PheGlu: 1.864 ± 0.38
1.157PhePhe: 1.157 ± 0.306
2.314PheGly: 2.314 ± 0.506
0.578PheHis: 0.578 ± 0.185
2.185PheIle: 2.185 ± 0.354
1.928PheLys: 1.928 ± 0.375
2.571PheLeu: 2.571 ± 0.479
1.028PheMet: 1.028 ± 0.247
3.021PheAsn: 3.021 ± 0.404
1.093PhePro: 1.093 ± 0.205
1.028PheGln: 1.028 ± 0.281
1.992PheArg: 1.992 ± 0.365
2.314PheSer: 2.314 ± 0.348
2.764PheThr: 2.764 ± 0.463
2.314PheVal: 2.314 ± 0.408
0.386PheTrp: 0.386 ± 0.162
0.9PheTyr: 0.9 ± 0.216
0.0PheXaa: 0.0 ± 0.0
Gly
5.656GlyAla: 5.656 ± 0.753
0.836GlyCys: 0.836 ± 0.22
3.663GlyAsp: 3.663 ± 0.576
3.342GlyGlu: 3.342 ± 0.45
2.764GlyPhe: 2.764 ± 0.569
5.784GlyGly: 5.784 ± 0.969
1.671GlyHis: 1.671 ± 0.294
4.499GlyIle: 4.499 ± 0.51
5.656GlyLys: 5.656 ± 0.579
5.399GlyLeu: 5.399 ± 0.603
1.221GlyMet: 1.221 ± 0.27
3.728GlyAsn: 3.728 ± 0.48
1.8GlyPro: 1.8 ± 0.344
2.057GlyGln: 2.057 ± 0.324
2.892GlyArg: 2.892 ± 0.531
4.049GlySer: 4.049 ± 0.327
4.563GlyThr: 4.563 ± 0.661
6.17GlyVal: 6.17 ± 0.759
1.35GlyTrp: 1.35 ± 0.37
2.699GlyTyr: 2.699 ± 0.425
0.0GlyXaa: 0.0 ± 0.0
His
0.9HisAla: 0.9 ± 0.239
0.193HisCys: 0.193 ± 0.112
1.028HisAsp: 1.028 ± 0.268
0.964HisGlu: 0.964 ± 0.269
0.45HisPhe: 0.45 ± 0.15
1.093HisGly: 1.093 ± 0.268
0.321HisHis: 0.321 ± 0.135
1.285HisIle: 1.285 ± 0.368
1.093HisLys: 1.093 ± 0.241
1.35HisLeu: 1.35 ± 0.289
0.578HisMet: 0.578 ± 0.175
1.028HisAsn: 1.028 ± 0.222
0.964HisPro: 0.964 ± 0.336
0.964HisGln: 0.964 ± 0.258
0.514HisArg: 0.514 ± 0.168
0.964HisSer: 0.964 ± 0.229
0.771HisThr: 0.771 ± 0.238
1.028HisVal: 1.028 ± 0.197
0.257HisTrp: 0.257 ± 0.126
1.157HisTyr: 1.157 ± 0.196
0.0HisXaa: 0.0 ± 0.0
Ile
5.206IleAla: 5.206 ± 0.515
0.578IleCys: 0.578 ± 0.206
3.921IleAsp: 3.921 ± 0.494
3.342IleGlu: 3.342 ± 0.478
1.864IlePhe: 1.864 ± 0.292
3.342IleGly: 3.342 ± 0.472
0.964IleHis: 0.964 ± 0.224
2.892IleIle: 2.892 ± 0.376
4.435IleLys: 4.435 ± 0.581
4.113IleLeu: 4.113 ± 0.686
0.836IleMet: 0.836 ± 0.229
4.049IleAsn: 4.049 ± 0.62
3.021IlePro: 3.021 ± 0.487
2.25IleGln: 2.25 ± 0.333
2.828IleArg: 2.828 ± 0.382
2.507IleSer: 2.507 ± 0.392
4.435IleThr: 4.435 ± 0.657
4.628IleVal: 4.628 ± 0.539
0.9IleTrp: 0.9 ± 0.246
2.892IleTyr: 2.892 ± 0.444
0.0IleXaa: 0.0 ± 0.0
Lys
5.977LysAla: 5.977 ± 0.943
0.578LysCys: 0.578 ± 0.201
3.342LysAsp: 3.342 ± 0.49
4.435LysGlu: 4.435 ± 0.643
2.571LysPhe: 2.571 ± 0.474
3.342LysGly: 3.342 ± 0.527
1.157LysHis: 1.157 ± 0.229
3.021LysIle: 3.021 ± 0.469
3.085LysLys: 3.085 ± 0.429
5.399LysLeu: 5.399 ± 0.672
2.25LysMet: 2.25 ± 0.428
2.25LysAsn: 2.25 ± 0.386
3.535LysPro: 3.535 ± 0.521
3.085LysGln: 3.085 ± 0.421
2.571LysArg: 2.571 ± 0.472
3.342LysSer: 3.342 ± 0.57
3.085LysThr: 3.085 ± 0.461
5.142LysVal: 5.142 ± 0.626
1.093LysTrp: 1.093 ± 0.234
2.121LysTyr: 2.121 ± 0.39
0.0LysXaa: 0.0 ± 0.0
Leu
6.941LeuAla: 6.941 ± 0.66
1.221LeuCys: 1.221 ± 0.303
5.142LeuAsp: 5.142 ± 0.537
5.206LeuGlu: 5.206 ± 0.579
2.507LeuPhe: 2.507 ± 0.371
4.628LeuGly: 4.628 ± 0.504
0.964LeuHis: 0.964 ± 0.28
4.049LeuIle: 4.049 ± 0.493
5.142LeuLys: 5.142 ± 0.69
4.885LeuLeu: 4.885 ± 0.609
2.635LeuMet: 2.635 ± 0.456
3.406LeuAsn: 3.406 ± 0.399
4.306LeuPro: 4.306 ± 0.53
3.149LeuGln: 3.149 ± 0.497
4.499LeuArg: 4.499 ± 0.427
4.049LeuSer: 4.049 ± 0.575
6.106LeuThr: 6.106 ± 0.59
5.463LeuVal: 5.463 ± 0.644
1.157LeuTrp: 1.157 ± 0.289
2.635LeuTyr: 2.635 ± 0.369
0.0LeuXaa: 0.0 ± 0.0
Met
2.314MetAla: 2.314 ± 0.362
0.514MetCys: 0.514 ± 0.18
2.314MetAsp: 2.314 ± 0.32
1.478MetGlu: 1.478 ± 0.35
1.093MetPhe: 1.093 ± 0.243
1.221MetGly: 1.221 ± 0.229
0.386MetHis: 0.386 ± 0.14
1.285MetIle: 1.285 ± 0.296
1.414MetLys: 1.414 ± 0.268
2.121MetLeu: 2.121 ± 0.282
0.964MetMet: 0.964 ± 0.208
1.157MetAsn: 1.157 ± 0.248
1.414MetPro: 1.414 ± 0.313
1.221MetGln: 1.221 ± 0.28
1.928MetArg: 1.928 ± 0.377
2.25MetSer: 2.25 ± 0.365
2.378MetThr: 2.378 ± 0.409
1.607MetVal: 1.607 ± 0.34
0.129MetTrp: 0.129 ± 0.094
0.9MetTyr: 0.9 ± 0.257
0.0MetXaa: 0.0 ± 0.0
Asn
4.756AsnAla: 4.756 ± 0.614
0.643AsnCys: 0.643 ± 0.19
3.406AsnAsp: 3.406 ± 0.456
2.314AsnGlu: 2.314 ± 0.333
1.992AsnPhe: 1.992 ± 0.261
5.077AsnGly: 5.077 ± 0.5
0.386AsnHis: 0.386 ± 0.137
3.921AsnIle: 3.921 ± 0.591
3.599AsnLys: 3.599 ± 0.504
3.471AsnLeu: 3.471 ± 0.443
1.285AsnMet: 1.285 ± 0.266
2.185AsnAsn: 2.185 ± 0.357
3.085AsnPro: 3.085 ± 0.338
1.8AsnGln: 1.8 ± 0.275
2.507AsnArg: 2.507 ± 0.403
2.442AsnSer: 2.442 ± 0.424
3.535AsnThr: 3.535 ± 0.443
3.728AsnVal: 3.728 ± 0.492
1.543AsnTrp: 1.543 ± 0.229
1.221AsnTyr: 1.221 ± 0.334
0.0AsnXaa: 0.0 ± 0.0
Pro
3.406ProAla: 3.406 ± 0.471
0.45ProCys: 0.45 ± 0.157
3.663ProAsp: 3.663 ± 0.467
2.635ProGlu: 2.635 ± 0.411
1.607ProPhe: 1.607 ± 0.363
2.828ProGly: 2.828 ± 0.435
0.45ProHis: 0.45 ± 0.149
1.8ProIle: 1.8 ± 0.322
2.057ProLys: 2.057 ± 0.402
3.085ProLeu: 3.085 ± 0.364
1.157ProMet: 1.157 ± 0.298
2.185ProAsn: 2.185 ± 0.39
1.992ProPro: 1.992 ± 0.281
1.478ProGln: 1.478 ± 0.254
2.057ProArg: 2.057 ± 0.37
2.185ProSer: 2.185 ± 0.474
3.085ProThr: 3.085 ± 0.398
3.599ProVal: 3.599 ± 0.504
0.643ProTrp: 0.643 ± 0.194
1.285ProTyr: 1.285 ± 0.248
0.0ProXaa: 0.0 ± 0.0
Gln
3.921GlnAla: 3.921 ± 0.584
0.193GlnCys: 0.193 ± 0.119
1.8GlnAsp: 1.8 ± 0.346
2.314GlnGlu: 2.314 ± 0.386
1.735GlnPhe: 1.735 ± 0.264
1.992GlnGly: 1.992 ± 0.435
0.707GlnHis: 0.707 ± 0.206
2.892GlnIle: 2.892 ± 0.318
1.864GlnLys: 1.864 ± 0.375
4.37GlnLeu: 4.37 ± 0.438
1.671GlnMet: 1.671 ± 0.325
1.735GlnAsn: 1.735 ± 0.329
1.285GlnPro: 1.285 ± 0.304
1.928GlnGln: 1.928 ± 0.397
1.607GlnArg: 1.607 ± 0.307
1.607GlnSer: 1.607 ± 0.224
1.478GlnThr: 1.478 ± 0.303
2.378GlnVal: 2.378 ± 0.433
0.771GlnTrp: 0.771 ± 0.217
1.414GlnTyr: 1.414 ± 0.308
0.0GlnXaa: 0.0 ± 0.0
Arg
3.728ArgAla: 3.728 ± 0.476
0.643ArgCys: 0.643 ± 0.187
2.378ArgAsp: 2.378 ± 0.407
2.699ArgGlu: 2.699 ± 0.484
1.414ArgPhe: 1.414 ± 0.313
3.278ArgGly: 3.278 ± 0.515
1.028ArgHis: 1.028 ± 0.256
3.406ArgIle: 3.406 ± 0.514
3.406ArgLys: 3.406 ± 0.565
3.792ArgLeu: 3.792 ± 0.437
1.285ArgMet: 1.285 ± 0.278
2.442ArgAsn: 2.442 ± 0.29
1.8ArgPro: 1.8 ± 0.316
2.507ArgGln: 2.507 ± 0.336
2.571ArgArg: 2.571 ± 0.382
2.314ArgSer: 2.314 ± 0.342
2.956ArgThr: 2.956 ± 0.358
2.892ArgVal: 2.892 ± 0.431
0.836ArgTrp: 0.836 ± 0.218
1.414ArgTyr: 1.414 ± 0.291
0.0ArgXaa: 0.0 ± 0.0
Ser
5.077SerAla: 5.077 ± 0.692
0.514SerCys: 0.514 ± 0.193
4.113SerAsp: 4.113 ± 0.528
3.278SerGlu: 3.278 ± 0.331
2.057SerPhe: 2.057 ± 0.336
4.563SerGly: 4.563 ± 0.497
0.643SerHis: 0.643 ± 0.2
3.085SerIle: 3.085 ± 0.456
3.278SerLys: 3.278 ± 0.473
4.178SerLeu: 4.178 ± 0.429
1.221SerMet: 1.221 ± 0.387
3.214SerAsn: 3.214 ± 0.489
2.314SerPro: 2.314 ± 0.488
1.478SerGln: 1.478 ± 0.295
2.185SerArg: 2.185 ± 0.394
3.342SerSer: 3.342 ± 0.509
4.435SerThr: 4.435 ± 0.569
4.499SerVal: 4.499 ± 0.702
0.578SerTrp: 0.578 ± 0.196
2.378SerTyr: 2.378 ± 0.388
0.0SerXaa: 0.0 ± 0.0
Thr
5.592ThrAla: 5.592 ± 0.822
0.514ThrCys: 0.514 ± 0.18
4.049ThrAsp: 4.049 ± 0.748
3.471ThrGlu: 3.471 ± 0.504
2.121ThrPhe: 2.121 ± 0.346
5.335ThrGly: 5.335 ± 0.583
0.9ThrHis: 0.9 ± 0.226
3.342ThrIle: 3.342 ± 0.436
3.406ThrLys: 3.406 ± 0.521
5.206ThrLeu: 5.206 ± 0.786
1.607ThrMet: 1.607 ± 0.326
3.149ThrAsn: 3.149 ± 0.43
2.507ThrPro: 2.507 ± 0.412
1.8ThrGln: 1.8 ± 0.33
2.378ThrArg: 2.378 ± 0.475
4.242ThrSer: 4.242 ± 0.552
3.471ThrThr: 3.471 ± 0.64
7.584ThrVal: 7.584 ± 1.433
1.157ThrTrp: 1.157 ± 0.281
2.507ThrTyr: 2.507 ± 0.455
0.0ThrXaa: 0.0 ± 0.0
Val
5.849ValAla: 5.849 ± 0.737
0.836ValCys: 0.836 ± 0.246
5.72ValAsp: 5.72 ± 0.623
5.077ValGlu: 5.077 ± 0.555
1.864ValPhe: 1.864 ± 0.308
5.077ValGly: 5.077 ± 0.658
1.028ValHis: 1.028 ± 0.295
3.921ValIle: 3.921 ± 0.605
4.435ValLys: 4.435 ± 0.534
5.913ValLeu: 5.913 ± 0.661
2.314ValMet: 2.314 ± 0.39
4.756ValAsn: 4.756 ± 0.508
2.699ValPro: 2.699 ± 0.361
3.021ValGln: 3.021 ± 0.415
3.085ValArg: 3.085 ± 0.346
4.37ValSer: 4.37 ± 0.614
7.006ValThr: 7.006 ± 1.506
5.849ValVal: 5.849 ± 0.732
1.093ValTrp: 1.093 ± 0.238
2.442ValTyr: 2.442 ± 0.447
0.0ValXaa: 0.0 ± 0.0
Trp
1.157TrpAla: 1.157 ± 0.228
0.257TrpCys: 0.257 ± 0.137
1.35TrpAsp: 1.35 ± 0.25
0.707TrpGlu: 0.707 ± 0.268
0.771TrpPhe: 0.771 ± 0.203
1.221TrpGly: 1.221 ± 0.329
0.45TrpHis: 0.45 ± 0.172
1.093TrpIle: 1.093 ± 0.208
0.386TrpLys: 0.386 ± 0.143
1.285TrpLeu: 1.285 ± 0.285
0.386TrpMet: 0.386 ± 0.138
0.514TrpAsn: 0.514 ± 0.159
0.578TrpPro: 0.578 ± 0.195
0.321TrpGln: 0.321 ± 0.119
0.964TrpArg: 0.964 ± 0.246
1.607TrpSer: 1.607 ± 0.374
0.707TrpThr: 0.707 ± 0.197
1.478TrpVal: 1.478 ± 0.298
0.386TrpTrp: 0.386 ± 0.142
1.221TrpTyr: 1.221 ± 0.272
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.378TyrAla: 2.378 ± 0.387
0.707TyrCys: 0.707 ± 0.178
2.956TyrAsp: 2.956 ± 0.387
2.25TyrGlu: 2.25 ± 0.447
1.028TyrPhe: 1.028 ± 0.271
2.378TyrGly: 2.378 ± 0.354
1.157TyrHis: 1.157 ± 0.299
2.507TyrIle: 2.507 ± 0.372
1.8TyrLys: 1.8 ± 0.358
2.121TyrLeu: 2.121 ± 0.473
0.836TyrMet: 0.836 ± 0.214
2.571TyrAsn: 2.571 ± 0.446
1.543TyrPro: 1.543 ± 0.313
1.543TyrGln: 1.543 ± 0.297
2.314TyrArg: 2.314 ± 0.354
2.057TyrSer: 2.057 ± 0.341
1.928TyrThr: 1.928 ± 0.361
2.764TyrVal: 2.764 ± 0.449
0.45TyrTrp: 0.45 ± 0.159
1.671TyrTyr: 1.671 ± 0.359
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (15560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski