Amino acid dipepetide frequency for Lactobacillus virus LP65

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.167AlaAla: 3.167 ± 0.419
0.376AlaCys: 0.376 ± 0.113
3.731AlaAsp: 3.731 ± 0.328
2.845AlaGlu: 2.845 ± 0.271
2.523AlaPhe: 2.523 ± 0.229
4.187AlaGly: 4.187 ± 0.518
0.778AlaHis: 0.778 ± 0.126
4.428AlaIle: 4.428 ± 0.349
5.18AlaLys: 5.18 ± 0.489
4.402AlaLeu: 4.402 ± 0.345
1.53AlaMet: 1.53 ± 0.211
4.724AlaAsn: 4.724 ± 0.599
1.315AlaPro: 1.315 ± 0.201
2.254AlaGln: 2.254 ± 0.462
2.308AlaArg: 2.308 ± 0.244
5.69AlaSer: 5.69 ± 0.831
4.294AlaThr: 4.294 ± 0.487
4.536AlaVal: 4.536 ± 0.521
0.456AlaTrp: 0.456 ± 0.098
2.791AlaTyr: 2.791 ± 0.288
0.0AlaXaa: 0.0 ± 0.0
Cys
0.242CysAla: 0.242 ± 0.091
0.081CysCys: 0.081 ± 0.039
0.617CysAsp: 0.617 ± 0.134
0.295CysGlu: 0.295 ± 0.096
0.242CysPhe: 0.242 ± 0.088
0.832CysGly: 0.832 ± 0.147
0.188CysHis: 0.188 ± 0.076
0.376CysIle: 0.376 ± 0.096
0.483CysLys: 0.483 ± 0.137
0.429CysLeu: 0.429 ± 0.122
0.107CysMet: 0.107 ± 0.051
0.403CysAsn: 0.403 ± 0.117
0.295CysPro: 0.295 ± 0.095
0.134CysGln: 0.134 ± 0.06
0.134CysArg: 0.134 ± 0.055
0.349CysSer: 0.349 ± 0.111
0.215CysThr: 0.215 ± 0.067
0.429CysVal: 0.429 ± 0.106
0.081CysTrp: 0.081 ± 0.043
0.429CysTyr: 0.429 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
4.428AspAla: 4.428 ± 0.353
0.403AspCys: 0.403 ± 0.11
5.314AspAsp: 5.314 ± 0.42
4.885AspGlu: 4.885 ± 0.422
2.684AspPhe: 2.684 ± 0.288
5.475AspGly: 5.475 ± 0.428
0.751AspHis: 0.751 ± 0.158
5.395AspIle: 5.395 ± 0.41
6.227AspLys: 6.227 ± 0.468
5.475AspLeu: 5.475 ± 0.364
1.664AspMet: 1.664 ± 0.229
5.207AspAsn: 5.207 ± 0.368
1.637AspPro: 1.637 ± 0.241
1.1AspGln: 1.1 ± 0.172
2.442AspArg: 2.442 ± 0.294
6.307AspSer: 6.307 ± 0.384
4.992AspThr: 4.992 ± 0.408
3.757AspVal: 3.757 ± 0.332
0.993AspTrp: 0.993 ± 0.167
4.053AspTyr: 4.053 ± 0.396
0.0AspXaa: 0.0 ± 0.0
Glu
3.57GluAla: 3.57 ± 0.416
0.322GluCys: 0.322 ± 0.087
4.267GluAsp: 4.267 ± 0.364
3.892GluGlu: 3.892 ± 0.392
2.228GluPhe: 2.228 ± 0.258
2.093GluGly: 2.093 ± 0.215
1.235GluHis: 1.235 ± 0.179
4.08GluIle: 4.08 ± 0.383
4.616GluLys: 4.616 ± 0.485
5.985GluLeu: 5.985 ± 0.513
1.584GluMet: 1.584 ± 0.221
3.221GluAsn: 3.221 ± 0.38
1.235GluPro: 1.235 ± 0.178
2.738GluGln: 2.738 ± 0.258
2.254GluArg: 2.254 ± 0.252
4.267GluSer: 4.267 ± 0.398
3.301GluThr: 3.301 ± 0.363
2.603GluVal: 2.603 ± 0.31
0.671GluTrp: 0.671 ± 0.133
3.382GluTyr: 3.382 ± 0.371
0.0GluXaa: 0.0 ± 0.0
Phe
1.342PheAla: 1.342 ± 0.211
0.268PheCys: 0.268 ± 0.078
2.899PheAsp: 2.899 ± 0.27
1.369PheGlu: 1.369 ± 0.252
0.778PhePhe: 0.778 ± 0.195
2.228PheGly: 2.228 ± 0.264
0.376PheHis: 0.376 ± 0.107
2.523PheIle: 2.523 ± 0.36
3.167PheLys: 3.167 ± 0.374
1.852PheLeu: 1.852 ± 0.23
0.805PheMet: 0.805 ± 0.147
3.489PheAsn: 3.489 ± 0.355
1.288PhePro: 1.288 ± 0.218
0.832PheGln: 0.832 ± 0.132
1.315PheArg: 1.315 ± 0.203
3.865PheSer: 3.865 ± 0.411
2.791PheThr: 2.791 ± 0.283
2.925PheVal: 2.925 ± 0.309
0.376PheTrp: 0.376 ± 0.109
1.825PheTyr: 1.825 ± 0.241
0.0PheXaa: 0.0 ± 0.0
Gly
2.952GlyAla: 2.952 ± 0.649
0.295GlyCys: 0.295 ± 0.09
5.099GlyAsp: 5.099 ± 0.413
2.899GlyGlu: 2.899 ± 0.283
2.496GlyPhe: 2.496 ± 0.285
3.65GlyGly: 3.65 ± 0.485
0.913GlyHis: 0.913 ± 0.143
4.616GlyIle: 4.616 ± 0.371
5.099GlyLys: 5.099 ± 0.354
5.099GlyLeu: 5.099 ± 0.438
1.1GlyMet: 1.1 ± 0.178
4.428GlyAsn: 4.428 ± 0.468
0.349GlyPro: 0.349 ± 0.093
2.228GlyGln: 2.228 ± 0.212
2.093GlyArg: 2.093 ± 0.237
6.012GlySer: 6.012 ± 0.643
4.428GlyThr: 4.428 ± 0.584
4.965GlyVal: 4.965 ± 0.414
0.778GlyTrp: 0.778 ± 0.166
4.053GlyTyr: 4.053 ± 0.386
0.0GlyXaa: 0.0 ± 0.0
His
0.698HisAla: 0.698 ± 0.159
0.161HisCys: 0.161 ± 0.076
1.181HisAsp: 1.181 ± 0.192
0.644HisGlu: 0.644 ± 0.124
0.59HisPhe: 0.59 ± 0.144
1.315HisGly: 1.315 ± 0.181
0.215HisHis: 0.215 ± 0.079
0.913HisIle: 0.913 ± 0.141
1.02HisLys: 1.02 ± 0.189
0.59HisLeu: 0.59 ± 0.113
0.483HisMet: 0.483 ± 0.122
1.154HisAsn: 1.154 ± 0.219
0.429HisPro: 0.429 ± 0.107
0.456HisGln: 0.456 ± 0.106
0.564HisArg: 0.564 ± 0.117
0.993HisSer: 0.993 ± 0.145
0.725HisThr: 0.725 ± 0.12
1.637HisVal: 1.637 ± 0.229
0.188HisTrp: 0.188 ± 0.07
0.913HisTyr: 0.913 ± 0.151
0.0HisXaa: 0.0 ± 0.0
Ile
4.912IleAla: 4.912 ± 0.511
0.429IleCys: 0.429 ± 0.126
5.368IleAsp: 5.368 ± 0.391
3.811IleGlu: 3.811 ± 0.346
1.664IlePhe: 1.664 ± 0.197
3.838IleGly: 3.838 ± 0.404
0.805IleHis: 0.805 ± 0.129
3.757IleIle: 3.757 ± 0.34
6.307IleLys: 6.307 ± 0.43
4.214IleLeu: 4.214 ± 0.332
1.798IleMet: 1.798 ± 0.247
5.636IleAsn: 5.636 ± 0.543
2.067IlePro: 2.067 ± 0.247
1.745IleGln: 1.745 ± 0.235
2.469IleArg: 2.469 ± 0.237
5.878IleSer: 5.878 ± 0.363
4.402IleThr: 4.402 ± 0.418
4.321IleVal: 4.321 ± 0.42
0.322IleTrp: 0.322 ± 0.095
2.925IleTyr: 2.925 ± 0.268
0.0IleXaa: 0.0 ± 0.0
Lys
4.831LysAla: 4.831 ± 0.318
0.564LysCys: 0.564 ± 0.161
6.549LysAsp: 6.549 ± 0.446
5.422LysGlu: 5.422 ± 0.556
3.167LysPhe: 3.167 ± 0.351
4.455LysGly: 4.455 ± 0.522
1.584LysHis: 1.584 ± 0.194
4.589LysIle: 4.589 ± 0.321
5.314LysLys: 5.314 ± 0.519
7.273LysLeu: 7.273 ± 0.483
1.637LysMet: 1.637 ± 0.232
4.133LysAsn: 4.133 ± 0.386
1.906LysPro: 1.906 ± 0.222
3.194LysGln: 3.194 ± 0.313
3.248LysArg: 3.248 ± 0.299
7.032LysSer: 7.032 ± 0.729
4.294LysThr: 4.294 ± 0.317
4.938LysVal: 4.938 ± 0.37
0.456LysTrp: 0.456 ± 0.125
4.294LysTyr: 4.294 ± 0.333
0.0LysXaa: 0.0 ± 0.0
Leu
4.804LeuAla: 4.804 ± 0.314
0.376LeuCys: 0.376 ± 0.101
7.032LeuAsp: 7.032 ± 0.52
5.475LeuGlu: 5.475 ± 0.399
2.442LeuPhe: 2.442 ± 0.257
5.395LeuGly: 5.395 ± 0.385
0.886LeuHis: 0.886 ± 0.132
4.912LeuIle: 4.912 ± 0.332
6.227LeuLys: 6.227 ± 0.448
5.314LeuLeu: 5.314 ± 0.454
1.557LeuMet: 1.557 ± 0.205
4.912LeuAsn: 4.912 ± 0.346
2.013LeuPro: 2.013 ± 0.259
2.12LeuGln: 2.12 ± 0.252
2.228LeuArg: 2.228 ± 0.215
7.381LeuSer: 7.381 ± 0.409
4.858LeuThr: 4.858 ± 0.364
4.965LeuVal: 4.965 ± 0.341
0.725LeuTrp: 0.725 ± 0.113
3.516LeuTyr: 3.516 ± 0.345
0.0LeuXaa: 0.0 ± 0.0
Met
1.369MetAla: 1.369 ± 0.222
0.215MetCys: 0.215 ± 0.074
1.127MetAsp: 1.127 ± 0.155
1.235MetGlu: 1.235 ± 0.176
0.859MetPhe: 0.859 ± 0.129
0.832MetGly: 0.832 ± 0.167
0.268MetHis: 0.268 ± 0.095
1.422MetIle: 1.422 ± 0.162
1.879MetLys: 1.879 ± 0.233
2.281MetLeu: 2.281 ± 0.244
0.349MetMet: 0.349 ± 0.086
1.369MetAsn: 1.369 ± 0.206
0.483MetPro: 0.483 ± 0.118
0.913MetGln: 0.913 ± 0.146
0.886MetArg: 0.886 ± 0.165
2.04MetSer: 2.04 ± 0.214
1.852MetThr: 1.852 ± 0.207
1.235MetVal: 1.235 ± 0.21
0.107MetTrp: 0.107 ± 0.059
0.859MetTyr: 0.859 ± 0.145
0.0MetXaa: 0.0 ± 0.0
Asn
4.589AsnAla: 4.589 ± 0.662
0.429AsnCys: 0.429 ± 0.109
4.563AsnAsp: 4.563 ± 0.363
3.355AsnGlu: 3.355 ± 0.346
2.228AsnPhe: 2.228 ± 0.228
5.663AsnGly: 5.663 ± 0.616
1.127AsnHis: 1.127 ± 0.16
4.455AsnIle: 4.455 ± 0.38
5.663AsnLys: 5.663 ± 0.408
5.234AsnLeu: 5.234 ± 0.32
1.959AsnMet: 1.959 ± 0.198
5.073AsnAsn: 5.073 ± 0.496
2.201AsnPro: 2.201 ± 0.232
2.201AsnGln: 2.201 ± 0.236
2.442AsnArg: 2.442 ± 0.282
6.468AsnSer: 6.468 ± 0.502
4.241AsnThr: 4.241 ± 0.334
3.892AsnVal: 3.892 ± 0.262
0.483AsnTrp: 0.483 ± 0.124
3.248AsnTyr: 3.248 ± 0.25
0.0AsnXaa: 0.0 ± 0.0
Pro
1.691ProAla: 1.691 ± 0.195
0.134ProCys: 0.134 ± 0.068
1.879ProAsp: 1.879 ± 0.23
1.906ProGlu: 1.906 ± 0.286
1.1ProPhe: 1.1 ± 0.177
0.805ProGly: 0.805 ± 0.146
0.376ProHis: 0.376 ± 0.101
1.798ProIle: 1.798 ± 0.215
1.959ProLys: 1.959 ± 0.221
2.228ProLeu: 2.228 ± 0.232
0.322ProMet: 0.322 ± 0.086
2.228ProAsn: 2.228 ± 0.254
0.376ProPro: 0.376 ± 0.107
0.859ProGln: 0.859 ± 0.148
0.913ProArg: 0.913 ± 0.152
2.147ProSer: 2.147 ± 0.221
1.288ProThr: 1.288 ± 0.187
2.228ProVal: 2.228 ± 0.178
0.268ProTrp: 0.268 ± 0.089
1.422ProTyr: 1.422 ± 0.229
0.0ProXaa: 0.0 ± 0.0
Gln
2.899GlnAla: 2.899 ± 0.453
0.054GlnCys: 0.054 ± 0.041
2.04GlnAsp: 2.04 ± 0.27
1.825GlnGlu: 1.825 ± 0.243
1.53GlnPhe: 1.53 ± 0.173
1.906GlnGly: 1.906 ± 0.321
0.671GlnHis: 0.671 ± 0.128
2.362GlnIle: 2.362 ± 0.396
1.315GlnLys: 1.315 ± 0.171
2.818GlnLeu: 2.818 ± 0.265
0.939GlnMet: 0.939 ± 0.147
1.691GlnAsn: 1.691 ± 0.2
1.127GlnPro: 1.127 ± 0.193
1.154GlnGln: 1.154 ± 0.177
1.422GlnArg: 1.422 ± 0.185
2.389GlnSer: 2.389 ± 0.319
2.12GlnThr: 2.12 ± 0.394
2.093GlnVal: 2.093 ± 0.246
0.242GlnTrp: 0.242 ± 0.079
1.852GlnTyr: 1.852 ± 0.243
0.0GlnXaa: 0.0 ± 0.0
Arg
2.389ArgAla: 2.389 ± 0.264
0.295ArgCys: 0.295 ± 0.089
1.959ArgAsp: 1.959 ± 0.208
2.04ArgGlu: 2.04 ± 0.256
1.503ArgPhe: 1.503 ± 0.216
1.61ArgGly: 1.61 ± 0.208
0.644ArgHis: 0.644 ± 0.133
2.469ArgIle: 2.469 ± 0.232
2.684ArgLys: 2.684 ± 0.29
3.462ArgLeu: 3.462 ± 0.291
0.886ArgMet: 0.886 ± 0.143
1.959ArgAsn: 1.959 ± 0.23
0.913ArgPro: 0.913 ± 0.174
1.181ArgGln: 1.181 ± 0.197
1.208ArgArg: 1.208 ± 0.204
2.254ArgSer: 2.254 ± 0.237
2.442ArgThr: 2.442 ± 0.253
3.033ArgVal: 3.033 ± 0.344
0.376ArgTrp: 0.376 ± 0.098
1.932ArgTyr: 1.932 ± 0.201
0.081ArgXaa: 0.081 ± 0.048
Ser
5.368SerAla: 5.368 ± 0.73
0.242SerCys: 0.242 ± 0.078
6.576SerAsp: 6.576 ± 0.44
4.885SerGlu: 4.885 ± 0.345
3.14SerPhe: 3.14 ± 0.307
6.522SerGly: 6.522 ± 0.594
1.422SerHis: 1.422 ± 0.174
5.609SerIle: 5.609 ± 0.467
7.488SerLys: 7.488 ± 0.64
6.79SerLeu: 6.79 ± 0.484
1.637SerMet: 1.637 ± 0.191
6.28SerAsn: 6.28 ± 0.538
2.174SerPro: 2.174 ± 0.309
3.006SerGln: 3.006 ± 0.383
2.55SerArg: 2.55 ± 0.281
7.918SerSer: 7.918 ± 0.728
4.697SerThr: 4.697 ± 0.533
5.931SerVal: 5.931 ± 0.39
0.913SerTrp: 0.913 ± 0.148
4.241SerTyr: 4.241 ± 0.363
0.0SerXaa: 0.0 ± 0.0
Thr
4.267ThrAla: 4.267 ± 0.886
0.403ThrCys: 0.403 ± 0.108
4.133ThrAsp: 4.133 ± 0.328
3.328ThrGlu: 3.328 ± 0.41
2.416ThrPhe: 2.416 ± 0.265
4.643ThrGly: 4.643 ± 0.487
0.805ThrHis: 0.805 ± 0.135
4.348ThrIle: 4.348 ± 0.352
4.375ThrLys: 4.375 ± 0.292
4.589ThrLeu: 4.589 ± 0.339
1.02ThrMet: 1.02 ± 0.161
4.455ThrAsn: 4.455 ± 0.409
2.308ThrPro: 2.308 ± 0.241
2.55ThrGln: 2.55 ± 0.375
2.201ThrArg: 2.201 ± 0.262
5.502ThrSer: 5.502 ± 0.53
4.697ThrThr: 4.697 ± 0.508
4.965ThrVal: 4.965 ± 0.377
0.617ThrTrp: 0.617 ± 0.138
2.845ThrTyr: 2.845 ± 0.301
0.0ThrXaa: 0.0 ± 0.0
Val
4.482ValAla: 4.482 ± 0.446
0.644ValCys: 0.644 ± 0.139
4.589ValAsp: 4.589 ± 0.368
4.241ValGlu: 4.241 ± 0.381
2.496ValPhe: 2.496 ± 0.3
4.67ValGly: 4.67 ± 0.505
0.751ValHis: 0.751 ± 0.129
4.643ValIle: 4.643 ± 0.382
4.938ValLys: 4.938 ± 0.362
4.589ValLeu: 4.589 ± 0.36
1.181ValMet: 1.181 ± 0.148
4.912ValAsn: 4.912 ± 0.329
2.013ValPro: 2.013 ± 0.24
1.745ValGln: 1.745 ± 0.212
1.959ValArg: 1.959 ± 0.218
6.254ValSer: 6.254 ± 0.332
5.099ValThr: 5.099 ± 0.396
4.267ValVal: 4.267 ± 0.389
0.51ValTrp: 0.51 ± 0.13
3.006ValTyr: 3.006 ± 0.287
0.027ValXaa: 0.027 ± 0.024
Trp
0.322TrpAla: 0.322 ± 0.079
0.161TrpCys: 0.161 ± 0.066
0.59TrpAsp: 0.59 ± 0.132
0.617TrpGlu: 0.617 ± 0.141
0.483TrpPhe: 0.483 ± 0.114
0.537TrpGly: 0.537 ± 0.108
0.134TrpHis: 0.134 ± 0.064
0.778TrpIle: 0.778 ± 0.172
0.671TrpLys: 0.671 ± 0.141
0.778TrpLeu: 0.778 ± 0.149
0.215TrpMet: 0.215 ± 0.086
0.644TrpAsn: 0.644 ± 0.156
0.215TrpPro: 0.215 ± 0.07
0.215TrpGln: 0.215 ± 0.105
0.483TrpArg: 0.483 ± 0.101
0.617TrpSer: 0.617 ± 0.111
0.564TrpThr: 0.564 ± 0.117
0.564TrpVal: 0.564 ± 0.104
0.161TrpTrp: 0.161 ± 0.065
0.537TrpTyr: 0.537 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.167TyrAla: 3.167 ± 0.254
0.51TyrCys: 0.51 ± 0.106
3.677TyrAsp: 3.677 ± 0.331
2.577TyrGlu: 2.577 ± 0.284
1.745TyrPhe: 1.745 ± 0.217
2.899TyrGly: 2.899 ± 0.261
0.913TyrHis: 0.913 ± 0.171
3.194TyrIle: 3.194 ± 0.301
4.267TyrLys: 4.267 ± 0.358
3.731TyrLeu: 3.731 ± 0.416
0.778TyrMet: 0.778 ± 0.145
3.596TyrAsn: 3.596 ± 0.277
1.584TyrPro: 1.584 ± 0.209
1.825TyrGln: 1.825 ± 0.224
2.201TyrArg: 2.201 ± 0.245
4.026TyrSer: 4.026 ± 0.394
3.167TyrThr: 3.167 ± 0.337
3.704TyrVal: 3.704 ± 0.289
0.564TyrTrp: 0.564 ± 0.118
2.791TyrTyr: 2.791 ± 0.348
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.027XaaAla: 0.027 ± 0.024
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.027XaaHis: 0.027 ± 0.025
0.027XaaIle: 0.027 ± 0.027
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.027XaaVal: 0.027 ± 0.029
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 165 proteins (37260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski