Amino acid dipepetide frequency for Human circovirus VS6600022

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.203AlaAla: 3.203 ± 1.38
1.601AlaCys: 1.601 ± 0.69
3.203AlaAsp: 3.203 ± 1.03
1.601AlaGlu: 1.601 ± 0.69
0.0AlaPhe: 0.0 ± 0.0
2.402AlaGly: 2.402 ± 1.263
0.801AlaHis: 0.801 ± 0.71
0.0AlaIle: 0.0 ± 0.0
0.801AlaLys: 0.801 ± 0.676
3.203AlaLeu: 3.203 ± 1.676
1.601AlaMet: 1.601 ± 1.043
4.003AlaAsn: 4.003 ± 1.979
1.601AlaPro: 1.601 ± 0.763
1.601AlaGln: 1.601 ± 0.763
3.203AlaArg: 3.203 ± 1.72
4.804AlaSer: 4.804 ± 2.479
2.402AlaThr: 2.402 ± 1.144
2.402AlaVal: 2.402 ± 1.144
1.601AlaTrp: 1.601 ± 0.942
1.601AlaTyr: 1.601 ± 1.351
0.0AlaXaa: 0.0 ± 0.0
Cys
0.801CysAla: 0.801 ± 0.676
0.801CysCys: 0.801 ± 0.676
0.801CysAsp: 0.801 ± 0.569
1.601CysGlu: 1.601 ± 0.69
0.0CysPhe: 0.0 ± 0.0
0.801CysGly: 0.801 ± 0.901
0.0CysHis: 0.0 ± 0.0
2.402CysIle: 2.402 ± 1.069
0.0CysLys: 0.0 ± 0.0
0.801CysLeu: 0.801 ± 0.71
0.801CysMet: 0.801 ± 0.569
1.601CysAsn: 1.601 ± 0.942
0.801CysPro: 0.801 ± 0.676
0.0CysGln: 0.0 ± 0.0
0.801CysArg: 0.801 ± 0.901
1.601CysSer: 1.601 ± 0.69
0.801CysThr: 0.801 ± 0.676
0.801CysVal: 0.801 ± 0.901
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.601AspAla: 1.601 ± 0.69
3.203AspCys: 3.203 ± 1.155
3.203AspAsp: 3.203 ± 1.72
2.402AspGlu: 2.402 ± 1.069
0.801AspPhe: 0.801 ± 0.901
4.003AspGly: 4.003 ± 2.102
1.601AspHis: 1.601 ± 1.351
1.601AspIle: 1.601 ± 0.69
0.801AspLys: 0.801 ± 0.569
1.601AspLeu: 1.601 ± 1.138
3.203AspMet: 3.203 ± 1.943
0.801AspAsn: 0.801 ± 0.569
7.206AspPro: 7.206 ± 2.133
4.003AspGln: 4.003 ± 1.658
0.0AspArg: 0.0 ± 0.0
4.804AspSer: 4.804 ± 1.276
0.801AspThr: 0.801 ± 0.569
4.003AspVal: 4.003 ± 1.892
0.0AspTrp: 0.0 ± 0.0
1.601AspTyr: 1.601 ± 1.138
0.0AspXaa: 0.0 ± 0.0
Glu
4.804GluAla: 4.804 ± 2.651
0.0GluCys: 0.0 ± 0.0
3.203GluAsp: 3.203 ± 1.155
0.0GluGlu: 0.0 ± 0.0
2.402GluPhe: 2.402 ± 1.069
2.402GluGly: 2.402 ± 0.507
1.601GluHis: 1.601 ± 1.138
0.0GluIle: 0.0 ± 0.0
0.801GluLys: 0.801 ± 0.901
0.801GluLeu: 0.801 ± 0.569
0.0GluMet: 0.0 ± 0.0
1.601GluAsn: 1.601 ± 0.938
0.0GluPro: 0.0 ± 0.0
0.0GluGln: 0.0 ± 0.0
4.003GluArg: 4.003 ± 1.456
5.604GluSer: 5.604 ± 2.514
4.003GluThr: 4.003 ± 1.707
0.801GluVal: 0.801 ± 0.901
0.801GluTrp: 0.801 ± 0.676
0.801GluTyr: 0.801 ± 0.676
0.0GluXaa: 0.0 ± 0.0
Phe
0.801PheAla: 0.801 ± 0.569
0.0PheCys: 0.0 ± 0.0
4.804PheAsp: 4.804 ± 1.482
0.0PheGlu: 0.0 ± 0.0
0.0PhePhe: 0.0 ± 0.0
2.402PheGly: 2.402 ± 1.242
0.801PheHis: 0.801 ± 0.569
0.801PheIle: 0.801 ± 0.676
0.801PheLys: 0.801 ± 0.676
1.601PheLeu: 1.601 ± 0.938
0.0PheMet: 0.0 ± 0.0
3.203PheAsn: 3.203 ± 1.03
2.402PhePro: 2.402 ± 1.231
1.601PheGln: 1.601 ± 0.763
0.0PheArg: 0.0 ± 0.0
0.801PheSer: 0.801 ± 0.71
2.402PheThr: 2.402 ± 1.172
3.203PheVal: 3.203 ± 1.155
0.801PheTrp: 0.801 ± 0.676
1.601PheTyr: 1.601 ± 0.69
0.0PheXaa: 0.0 ± 0.0
Gly
3.203GlyAla: 3.203 ± 1.03
0.0GlyCys: 0.0 ± 0.0
3.203GlyAsp: 3.203 ± 1.565
2.402GlyGlu: 2.402 ± 1.707
2.402GlyPhe: 2.402 ± 1.242
4.804GlyGly: 4.804 ± 1.653
1.601GlyHis: 1.601 ± 1.138
1.601GlyIle: 1.601 ± 0.69
4.804GlyLys: 4.804 ± 1.482
3.203GlyLeu: 3.203 ± 1.527
2.402GlyMet: 2.402 ± 1.369
0.0GlyAsn: 0.0 ± 0.0
4.804GlyPro: 4.804 ± 1.314
1.601GlyGln: 1.601 ± 0.69
4.003GlyArg: 4.003 ± 2.532
5.604GlySer: 5.604 ± 0.226
8.006GlyThr: 8.006 ± 3.282
3.203GlyVal: 3.203 ± 1.079
1.601GlyTrp: 1.601 ± 0.694
2.402GlyTyr: 2.402 ± 1.069
0.0GlyXaa: 0.0 ± 0.0
His
2.402HisAla: 2.402 ± 1.263
0.801HisCys: 0.801 ± 0.71
0.0HisAsp: 0.0 ± 0.0
0.801HisGlu: 0.801 ± 0.569
0.801HisPhe: 0.801 ± 0.676
0.801HisGly: 0.801 ± 0.71
0.0HisHis: 0.0 ± 0.0
3.203HisIle: 3.203 ± 2.141
2.402HisLys: 2.402 ± 0.81
1.601HisLeu: 1.601 ± 0.69
0.0HisMet: 0.0 ± 0.0
3.203HisAsn: 3.203 ± 1.198
3.203HisPro: 3.203 ± 1.164
1.601HisGln: 1.601 ± 0.694
3.203HisArg: 3.203 ± 1.023
2.402HisSer: 2.402 ± 1.36
5.604HisThr: 5.604 ± 3.134
0.801HisVal: 0.801 ± 0.569
0.0HisTrp: 0.0 ± 0.0
0.801HisTyr: 0.801 ± 0.569
0.0HisXaa: 0.0 ± 0.0
Ile
0.801IleAla: 0.801 ± 0.676
0.0IleCys: 0.0 ± 0.0
0.801IleAsp: 0.801 ± 0.569
1.601IleGlu: 1.601 ± 1.138
1.601IlePhe: 1.601 ± 0.942
3.203IleGly: 3.203 ± 0.918
5.604IleHis: 5.604 ± 3.314
3.203IleIle: 3.203 ± 2.032
5.604IleLys: 5.604 ± 2.836
9.608IleLeu: 9.608 ± 2.288
0.801IleMet: 0.801 ± 0.58
1.601IleAsn: 1.601 ± 1.351
5.604IlePro: 5.604 ± 1.157
7.206IleGln: 7.206 ± 3.257
9.608IleArg: 9.608 ± 4.0
5.604IleSer: 5.604 ± 1.736
4.003IleThr: 4.003 ± 1.686
3.203IleVal: 3.203 ± 1.079
0.801IleTrp: 0.801 ± 0.569
1.601IleTyr: 1.601 ± 1.03
0.0IleXaa: 0.0 ± 0.0
Lys
0.801LysAla: 0.801 ± 0.901
0.0LysCys: 0.0 ± 0.0
2.402LysAsp: 2.402 ± 1.069
1.601LysGlu: 1.601 ± 0.938
2.402LysPhe: 2.402 ± 1.242
3.203LysGly: 3.203 ± 1.638
0.801LysHis: 0.801 ± 0.901
3.203LysIle: 3.203 ± 1.03
3.203LysLys: 3.203 ± 1.164
4.003LysLeu: 4.003 ± 1.074
0.801LysMet: 0.801 ± 0.676
3.203LysAsn: 3.203 ± 1.943
2.402LysPro: 2.402 ± 1.715
0.801LysGln: 0.801 ± 0.901
4.003LysArg: 4.003 ± 1.804
5.604LysSer: 5.604 ± 1.449
3.203LysThr: 3.203 ± 1.377
4.003LysVal: 4.003 ± 1.2
0.0LysTrp: 0.0 ± 0.0
4.003LysTyr: 4.003 ± 1.86
0.0LysXaa: 0.0 ± 0.0
Leu
4.003LeuAla: 4.003 ± 0.98
0.0LeuCys: 0.0 ± 0.0
4.003LeuAsp: 4.003 ± 1.707
2.402LeuGlu: 2.402 ± 1.242
1.601LeuPhe: 1.601 ± 1.351
1.601LeuGly: 1.601 ± 0.942
1.601LeuHis: 1.601 ± 0.694
4.003LeuIle: 4.003 ± 1.106
1.601LeuLys: 1.601 ± 0.763
0.0LeuLeu: 0.0 ± 0.0
0.801LeuMet: 0.801 ± 0.71
1.601LeuAsn: 1.601 ± 0.69
9.608LeuPro: 9.608 ± 3.532
1.601LeuGln: 1.601 ± 1.138
8.807LeuArg: 8.807 ± 5.411
2.402LeuSer: 2.402 ± 1.715
7.206LeuThr: 7.206 ± 4.486
7.206LeuVal: 7.206 ± 1.68
1.601LeuTrp: 1.601 ± 1.138
4.003LeuTyr: 4.003 ± 1.712
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
3.203MetGlu: 3.203 ± 1.877
0.0MetPhe: 0.0 ± 0.0
0.801MetGly: 0.801 ± 0.676
0.0MetHis: 0.0 ± 0.0
2.402MetIle: 2.402 ± 1.231
0.801MetLys: 0.801 ± 0.901
0.801MetLeu: 0.801 ± 0.676
0.0MetMet: 0.0 ± 0.0
3.203MetAsn: 3.203 ± 1.155
3.203MetPro: 3.203 ± 0.918
0.801MetGln: 0.801 ± 0.71
1.601MetArg: 1.601 ± 0.694
4.804MetSer: 4.804 ± 2.514
1.601MetThr: 1.601 ± 0.942
3.203MetVal: 3.203 ± 1.155
0.801MetTrp: 0.801 ± 0.676
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
0.801AsnGlu: 0.801 ± 0.569
1.601AsnPhe: 1.601 ± 0.763
2.402AsnGly: 2.402 ± 2.027
3.203AsnHis: 3.203 ± 1.198
10.408AsnIle: 10.408 ± 2.138
4.003AsnLys: 4.003 ± 1.21
3.203AsnLeu: 3.203 ± 1.198
0.0AsnMet: 0.0 ± 0.0
3.203AsnAsn: 3.203 ± 1.388
2.402AsnPro: 2.402 ± 1.172
2.402AsnGln: 2.402 ± 0.94
2.402AsnArg: 2.402 ± 1.172
1.601AsnSer: 1.601 ± 0.69
5.604AsnThr: 5.604 ± 2.31
0.801AsnVal: 0.801 ± 0.676
2.402AsnTrp: 2.402 ± 1.715
0.801AsnTyr: 0.801 ± 0.676
0.0AsnXaa: 0.0 ± 0.0
Pro
2.402ProAla: 2.402 ± 0.94
0.0ProCys: 0.0 ± 0.0
4.804ProAsp: 4.804 ± 2.407
3.203ProGlu: 3.203 ± 1.155
1.601ProPhe: 1.601 ± 0.763
3.203ProGly: 3.203 ± 1.38
2.402ProHis: 2.402 ± 1.523
4.003ProIle: 4.003 ± 1.795
4.804ProLys: 4.804 ± 2.407
6.405ProLeu: 6.405 ± 1.939
0.0ProMet: 0.0 ± 0.593
1.601ProAsn: 1.601 ± 0.694
3.203ProPro: 3.203 ± 0.918
0.801ProGln: 0.801 ± 0.569
8.006ProArg: 8.006 ± 2.605
4.003ProSer: 4.003 ± 1.572
7.206ProThr: 7.206 ± 1.124
7.206ProVal: 7.206 ± 2.424
0.801ProTrp: 0.801 ± 0.901
2.402ProTyr: 2.402 ± 1.75
0.0ProXaa: 0.0 ± 0.0
Gln
2.402GlnAla: 2.402 ± 1.801
0.0GlnCys: 0.0 ± 0.0
2.402GlnAsp: 2.402 ± 1.263
2.402GlnGlu: 2.402 ± 1.263
0.801GlnPhe: 0.801 ± 0.676
4.003GlnGly: 4.003 ± 1.2
2.402GlnHis: 2.402 ± 1.36
3.203GlnIle: 3.203 ± 1.887
1.601GlnLys: 1.601 ± 1.138
8.807GlnLeu: 8.807 ± 2.327
1.601GlnMet: 1.601 ± 0.763
2.402GlnAsn: 2.402 ± 1.172
1.601GlnPro: 1.601 ± 1.138
0.0GlnGln: 0.0 ± 0.0
5.604GlnArg: 5.604 ± 2.124
0.801GlnSer: 0.801 ± 0.71
0.0GlnThr: 0.0 ± 0.0
0.801GlnVal: 0.801 ± 0.569
0.0GlnTrp: 0.0 ± 0.0
0.801GlnTyr: 0.801 ± 0.71
0.0GlnXaa: 0.0 ± 0.0
Arg
4.003ArgAla: 4.003 ± 3.551
1.601ArgCys: 1.601 ± 1.351
1.601ArgAsp: 1.601 ± 0.763
1.601ArgGlu: 1.601 ± 0.69
1.601ArgPhe: 1.601 ± 1.03
8.006ArgGly: 8.006 ± 3.282
4.804ArgHis: 4.804 ± 2.123
6.405ArgIle: 6.405 ± 2.891
5.604ArgLys: 5.604 ± 1.32
6.405ArgLeu: 6.405 ± 1.4
0.801ArgMet: 0.801 ± 0.676
3.203ArgAsn: 3.203 ± 1.388
4.003ArgPro: 4.003 ± 1.074
8.807ArgGln: 8.807 ± 1.242
14.412ArgArg: 14.412 ± 6.365
5.604ArgSer: 5.604 ± 2.564
4.003ArgThr: 4.003 ± 2.723
4.003ArgVal: 4.003 ± 1.892
0.0ArgTrp: 0.0 ± 0.0
4.804ArgTyr: 4.804 ± 1.013
0.0ArgXaa: 0.0 ± 0.0
Ser
4.003SerAla: 4.003 ± 0.842
2.402SerCys: 2.402 ± 1.715
4.003SerAsp: 4.003 ± 1.707
3.203SerGlu: 3.203 ± 1.676
4.003SerPhe: 4.003 ± 0.616
6.405SerGly: 6.405 ± 1.184
1.601SerHis: 1.601 ± 0.763
3.203SerIle: 3.203 ± 1.198
3.203SerLys: 3.203 ± 0.418
3.203SerLeu: 3.203 ± 1.155
4.804SerMet: 4.804 ± 2.211
4.003SerAsn: 4.003 ± 1.686
7.206SerPro: 7.206 ± 6.184
4.003SerGln: 4.003 ± 0.584
4.003SerArg: 4.003 ± 2.723
8.006SerSer: 8.006 ± 2.742
9.608SerThr: 9.608 ± 3.159
4.804SerVal: 4.804 ± 1.314
1.601SerTrp: 1.601 ± 0.69
0.801SerTyr: 0.801 ± 0.901
0.0SerXaa: 0.0 ± 0.0
Thr
2.402ThrAla: 2.402 ± 1.263
0.801ThrCys: 0.801 ± 0.569
3.203ThrAsp: 3.203 ± 2.702
1.601ThrGlu: 1.601 ± 1.351
2.402ThrPhe: 2.402 ± 1.172
3.203ThrGly: 3.203 ± 1.638
2.402ThrHis: 2.402 ± 1.231
11.209ThrIle: 11.209 ± 6.384
3.203ThrLys: 3.203 ± 0.418
2.402ThrLeu: 2.402 ± 1.231
4.804ThrMet: 4.804 ± 1.013
4.804ThrAsn: 4.804 ± 3.267
6.405ThrPro: 6.405 ± 1.644
0.801ThrGln: 0.801 ± 0.901
6.405ThrArg: 6.405 ± 1.541
10.408ThrSer: 10.408 ± 3.504
14.412ThrThr: 14.412 ± 5.494
2.402ThrVal: 2.402 ± 1.242
1.601ThrTrp: 1.601 ± 0.69
1.601ThrTyr: 1.601 ± 1.03
0.0ThrXaa: 0.0 ± 0.0
Val
3.203ValAla: 3.203 ± 1.877
3.203ValCys: 3.203 ± 1.03
5.604ValAsp: 5.604 ± 2.375
0.801ValGlu: 0.801 ± 0.569
2.402ValPhe: 2.402 ± 1.707
4.003ValGly: 4.003 ± 2.532
0.801ValHis: 0.801 ± 0.569
2.402ValIle: 2.402 ± 1.231
3.203ValLys: 3.203 ± 1.876
5.604ValLeu: 5.604 ± 0.867
1.601ValMet: 1.601 ± 1.577
1.601ValAsn: 1.601 ± 1.351
1.601ValPro: 1.601 ± 1.351
2.402ValGln: 2.402 ± 1.36
4.003ValArg: 4.003 ± 2.532
4.003ValSer: 4.003 ± 2.566
3.203ValThr: 3.203 ± 0.418
1.601ValVal: 1.601 ± 1.351
0.0ValTrp: 0.0 ± 0.0
4.804ValTyr: 4.804 ± 2.138
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.801TrpCys: 0.801 ± 0.569
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.801TrpPhe: 0.801 ± 0.569
0.801TrpGly: 0.801 ± 0.569
0.801TrpHis: 0.801 ± 0.676
1.601TrpIle: 1.601 ± 0.942
1.601TrpLys: 1.601 ± 0.69
0.0TrpLeu: 0.0 ± 0.0
1.601TrpMet: 1.601 ± 0.942
0.801TrpAsn: 0.801 ± 0.676
0.801TrpPro: 0.801 ± 0.71
0.0TrpGln: 0.0 ± 0.0
1.601TrpArg: 1.601 ± 0.69
2.402TrpSer: 2.402 ± 1.715
0.801TrpThr: 0.801 ± 0.676
0.0TrpVal: 0.0 ± 0.0
0.801TrpTrp: 0.801 ± 0.569
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.801TyrAla: 0.801 ± 0.71
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
2.402TyrGlu: 2.402 ± 0.807
0.801TyrPhe: 0.801 ± 0.569
2.402TyrGly: 2.402 ± 0.81
0.801TyrHis: 0.801 ± 0.569
7.206TyrIle: 7.206 ± 2.779
0.801TyrLys: 0.801 ± 0.569
2.402TyrLeu: 2.402 ± 2.027
0.801TyrMet: 0.801 ± 0.901
1.601TyrAsn: 1.601 ± 0.69
0.801TyrPro: 0.801 ± 0.569
1.601TyrGln: 1.601 ± 1.138
5.604TyrArg: 5.604 ± 2.843
3.203TyrSer: 3.203 ± 1.676
1.601TyrThr: 1.601 ± 0.69
1.601TyrVal: 1.601 ± 0.69
0.0TyrTrp: 0.0 ± 0.0
0.801TyrTyr: 0.801 ± 0.569
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1250 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski