Amino acid dipepetide frequency for Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.558AlaAla: 6.558 ± 0.031	1.291AlaCys: 1.291 ± 0.01	3.246AlaAsp: 3.246 ± 0.014	4.268AlaGlu: 4.268 ± 0.02	2.802AlaPhe: 2.802 ± 0.014	4.181AlaGly: 4.181 ± 0.021	1.306AlaHis: 1.306 ± 0.01	3.818AlaIle: 3.818 ± 0.016	3.94AlaLys: 3.94 ± 0.017	6.724AlaLeu: 6.724 ± 0.024	1.73AlaMet: 1.73 ± 0.011	2.664AlaAsn: 2.664 ± 0.013	2.725AlaPro: 2.725 ± 0.017	2.124AlaGln: 2.124 ± 0.013	3.331AlaArg: 3.331 ± 0.015	6.13AlaSer: 6.13 ± 0.022	3.531AlaThr: 3.531 ± 0.016	4.924AlaVal: 4.924 ± 0.021	0.761AlaTrp: 0.761 ± 0.006	1.839AlaTyr: 1.839 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.007	0.568CysCys: 0.568 ± 0.007	0.9CysAsp: 0.9 ± 0.009	0.94CysGlu: 0.94 ± 0.008	0.932CysPhe: 0.932 ± 0.008	1.389CysGly: 1.389 ± 0.009	0.473CysHis: 0.473 ± 0.007	1.036CysIle: 1.036 ± 0.009	1.179CysLys: 1.179 ± 0.01	1.969CysLeu: 1.969 ± 0.012	0.46CysMet: 0.46 ± 0.006	0.864CysAsn: 0.864 ± 0.007	0.929CysPro: 0.929 ± 0.008	0.633CysGln: 0.633 ± 0.006	1.056CysArg: 1.056 ± 0.009	1.854CysSer: 1.854 ± 0.011	0.856CysThr: 0.856 ± 0.007	1.072CysVal: 1.072 ± 0.008	0.262CysTrp: 0.262 ± 0.004	0.574CysTyr: 0.574 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.531AspAla: 3.531 ± 0.016	0.976AspCys: 0.976 ± 0.008	3.646AspAsp: 3.646 ± 0.019	3.945AspGlu: 3.945 ± 0.017	2.341AspPhe: 2.341 ± 0.012	3.806AspGly: 3.806 ± 0.017	1.222AspHis: 1.222 ± 0.008	3.093AspIle: 3.093 ± 0.012	2.777AspLys: 2.777 ± 0.013	5.142AspLeu: 5.142 ± 0.02	1.305AspMet: 1.305 ± 0.009	2.148AspAsn: 2.148 ± 0.013	2.529AspPro: 2.529 ± 0.012	1.773AspGln: 1.773 ± 0.012	2.423AspArg: 2.423 ± 0.014	4.209AspSer: 4.209 ± 0.02	2.174AspThr: 2.174 ± 0.013	3.67AspVal: 3.67 ± 0.015	0.71AspTrp: 0.71 ± 0.007	1.576AspTyr: 1.576 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	4.775GluAla: 4.775 ± 0.022	0.945GluCys: 0.945 ± 0.009	3.888GluAsp: 3.888 ± 0.018	5.889GluGlu: 5.889 ± 0.031	2.429GluPhe: 2.429 ± 0.012	3.662GluGly: 3.662 ± 0.017	1.231GluHis: 1.231 ± 0.009	3.872GluIle: 3.872 ± 0.016	4.746GluLys: 4.746 ± 0.025	6.157GluLeu: 6.157 ± 0.026	1.715GluMet: 1.715 ± 0.011	3.165GluAsn: 3.165 ± 0.015	2.118GluPro: 2.118 ± 0.014	2.182GluGln: 2.182 ± 0.014	3.424GluArg: 3.424 ± 0.016	4.634GluSer: 4.634 ± 0.019	3.034GluThr: 3.034 ± 0.015	4.174GluVal: 4.174 ± 0.018	0.727GluTrp: 0.727 ± 0.006	1.671GluTyr: 1.671 ± 0.01	0.0GluXaa: 0.0 ± 0.0
Phe	2.597PheAla: 2.597 ± 0.013	0.966PheCys: 0.966 ± 0.01	2.405PheAsp: 2.405 ± 0.013	2.338PheGlu: 2.338 ± 0.012	2.046PhePhe: 2.046 ± 0.013	3.08PheGly: 3.08 ± 0.016	1.12PheHis: 1.12 ± 0.009	2.198PheIle: 2.198 ± 0.011	2.166PheLys: 2.166 ± 0.012	4.373PheLeu: 4.373 ± 0.022	0.968PheMet: 0.968 ± 0.008	1.835PheAsn: 1.835 ± 0.012	2.122PhePro: 2.122 ± 0.011	1.605PheGln: 1.605 ± 0.011	2.059PheArg: 2.059 ± 0.011	4.172PheSer: 4.172 ± 0.017	2.003PheThr: 2.003 ± 0.011	2.826PheVal: 2.826 ± 0.014	0.591PheTrp: 0.591 ± 0.007	1.303PheTyr: 1.303 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	3.831GlyAla: 3.831 ± 0.018	1.279GlyCys: 1.279 ± 0.01	3.337GlyAsp: 3.337 ± 0.015	3.568GlyGlu: 3.568 ± 0.014	3.143GlyPhe: 3.143 ± 0.016	4.966GlyGly: 4.966 ± 0.032	1.526GlyHis: 1.526 ± 0.01	3.667GlyIle: 3.667 ± 0.018	4.106GlyLys: 4.106 ± 0.016	5.988GlyLeu: 5.988 ± 0.022	1.53GlyMet: 1.53 ± 0.01	3.281GlyAsn: 3.281 ± 0.017	2.481GlyPro: 2.481 ± 0.015	2.146GlyGln: 2.146 ± 0.012	3.448GlyArg: 3.448 ± 0.02	6.013GlySer: 6.013 ± 0.024	3.247GlyThr: 3.247 ± 0.015	4.155GlyVal: 4.155 ± 0.018	0.868GlyTrp: 0.868 ± 0.008	2.036GlyTyr: 2.036 ± 0.011	0.0GlyXaa: 0.0 ± 0.0
His	1.395HisAla: 1.395 ± 0.009	0.531HisCys: 0.531 ± 0.006	1.133HisAsp: 1.133 ± 0.007	1.259HisGlu: 1.259 ± 0.009	1.085HisPhe: 1.085 ± 0.008	1.638HisGly: 1.638 ± 0.011	0.908HisHis: 0.908 ± 0.011	1.222HisIle: 1.222 ± 0.009	1.163HisLys: 1.163 ± 0.008	2.49HisLeu: 2.49 ± 0.015	0.543HisMet: 0.543 ± 0.006	0.992HisAsn: 0.992 ± 0.008	1.292HisPro: 1.292 ± 0.01	1.05HisGln: 1.05 ± 0.009	1.329HisArg: 1.329 ± 0.009	1.958HisSer: 1.958 ± 0.012	0.908HisThr: 0.908 ± 0.007	1.541HisVal: 1.541 ± 0.009	0.3HisTrp: 0.3 ± 0.004	0.71HisTyr: 0.71 ± 0.005	0.0HisXaa: 0.0 ± 0.0
Ile	3.645IleAla: 3.645 ± 0.013	1.177IleCys: 1.177 ± 0.01	2.96IleAsp: 2.96 ± 0.014	3.263IleGlu: 3.263 ± 0.016	2.434IlePhe: 2.434 ± 0.012	3.471IleGly: 3.471 ± 0.018	1.289IleHis: 1.289 ± 0.01	2.959IleIle: 2.959 ± 0.014	2.964IleLys: 2.964 ± 0.014	5.456IleLeu: 5.456 ± 0.02	1.146IleMet: 1.146 ± 0.009	2.309IleAsn: 2.309 ± 0.012	3.038IlePro: 3.038 ± 0.019	1.963IleGln: 1.963 ± 0.012	2.672IleArg: 2.672 ± 0.014	4.975IleSer: 4.975 ± 0.016	2.566IleThr: 2.566 ± 0.014	3.515IleVal: 3.515 ± 0.015	0.729IleTrp: 0.729 ± 0.007	1.55IleTyr: 1.55 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	4.049LysAla: 4.049 ± 0.017	0.985LysCys: 0.985 ± 0.009	3.277LysAsp: 3.277 ± 0.016	4.6LysGlu: 4.6 ± 0.022	2.319LysPhe: 2.319 ± 0.013	3.5LysGly: 3.5 ± 0.017	1.324LysHis: 1.324 ± 0.009	3.392LysIle: 3.392 ± 0.015	4.553LysLys: 4.553 ± 0.023	6.258LysLeu: 6.258 ± 0.025	1.497LysMet: 1.497 ± 0.01	2.767LysAsn: 2.767 ± 0.013	2.693LysPro: 2.693 ± 0.015	2.34LysGln: 2.34 ± 0.013	3.514LysArg: 3.514 ± 0.018	4.703LysSer: 4.703 ± 0.021	2.776LysThr: 2.776 ± 0.013	3.844LysVal: 3.844 ± 0.017	0.799LysTrp: 0.799 ± 0.008	1.657LysTyr: 1.657 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	6.681LeuAla: 6.681 ± 0.023	1.907LeuCys: 1.907 ± 0.013	5.246LeuAsp: 5.246 ± 0.021	6.57LeuGlu: 6.57 ± 0.03	3.968LeuPhe: 3.968 ± 0.018	5.833LeuGly: 5.833 ± 0.023	2.588LeuHis: 2.588 ± 0.015	4.801LeuIle: 4.801 ± 0.02	6.484LeuLys: 6.484 ± 0.023	10.156LeuLeu: 10.156 ± 0.035	2.199LeuMet: 2.199 ± 0.013	4.192LeuAsn: 4.192 ± 0.017	5.262LeuPro: 5.262 ± 0.02	4.509LeuGln: 4.509 ± 0.018	5.507LeuArg: 5.507 ± 0.022	8.925LeuSer: 8.925 ± 0.031	4.585LeuThr: 4.585 ± 0.021	6.38LeuVal: 6.38 ± 0.02	1.18LeuTrp: 1.18 ± 0.009	2.615LeuTyr: 2.615 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	2.041MetAla: 2.041 ± 0.011	0.334MetCys: 0.334 ± 0.005	1.378MetAsp: 1.378 ± 0.01	1.878MetGlu: 1.878 ± 0.011	0.819MetPhe: 0.819 ± 0.006	1.627MetGly: 1.627 ± 0.011	0.566MetHis: 0.566 ± 0.006	1.209MetIle: 1.209 ± 0.01	1.606MetLys: 1.606 ± 0.01	2.222MetLeu: 2.222 ± 0.012	0.676MetMet: 0.676 ± 0.007	1.037MetAsn: 1.037 ± 0.008	1.089MetPro: 1.089 ± 0.009	0.998MetGln: 0.998 ± 0.008	1.181MetArg: 1.181 ± 0.008	1.756MetSer: 1.756 ± 0.01	1.039MetThr: 1.039 ± 0.007	1.55MetVal: 1.55 ± 0.01	0.271MetTrp: 0.271 ± 0.004	0.578MetTyr: 0.578 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.71AsnAla: 2.71 ± 0.012	0.91AsnCys: 0.91 ± 0.009	2.186AsnAsp: 2.186 ± 0.013	2.655AsnGlu: 2.655 ± 0.013	2.098AsnPhe: 2.098 ± 0.011	3.297AsnGly: 3.297 ± 0.016	1.079AsnHis: 1.079 ± 0.008	2.544AsnIle: 2.544 ± 0.012	2.495AsnLys: 2.495 ± 0.013	5.018AsnLeu: 5.018 ± 0.025	1.108AsnMet: 1.108 ± 0.008	2.604AsnAsn: 2.604 ± 0.021	2.278AsnPro: 2.278 ± 0.011	1.77AsnGln: 1.77 ± 0.012	2.019AsnArg: 2.019 ± 0.011	4.071AsnSer: 4.071 ± 0.019	1.9AsnThr: 1.9 ± 0.012	2.852AsnVal: 2.852 ± 0.012	0.585AsnTrp: 0.585 ± 0.006	1.346AsnTyr: 1.346 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	3.083ProAla: 3.083 ± 0.016	0.757ProCys: 0.757 ± 0.008	2.429ProAsp: 2.429 ± 0.014	3.153ProGlu: 3.153 ± 0.015	1.975ProPhe: 1.975 ± 0.011	2.709ProGly: 2.709 ± 0.014	1.077ProHis: 1.077 ± 0.009	2.303ProIle: 2.303 ± 0.013	2.657ProLys: 2.657 ± 0.014	4.326ProLeu: 4.326 ± 0.018	0.938ProMet: 0.938 ± 0.008	2.258ProAsn: 2.258 ± 0.014	3.514ProPro: 3.514 ± 0.037	1.806ProGln: 1.806 ± 0.014	2.3ProArg: 2.3 ± 0.014	4.994ProSer: 4.994 ± 0.022	2.443ProThr: 2.443 ± 0.013	3.162ProVal: 3.162 ± 0.015	0.592ProTrp: 0.592 ± 0.006	1.298ProTyr: 1.298 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	2.397GlnAla: 2.397 ± 0.014	0.595GlnCys: 0.595 ± 0.007	1.678GlnAsp: 1.678 ± 0.011	2.416GlnGlu: 2.416 ± 0.013	1.47GlnPhe: 1.47 ± 0.01	2.113GlnGly: 2.113 ± 0.013	0.967GlnHis: 0.967 ± 0.01	2.039GlnIle: 2.039 ± 0.011	2.366GlnLys: 2.366 ± 0.014	3.887GlnLeu: 3.887 ± 0.019	1.022GlnMet: 1.022 ± 0.009	1.906GlnAsn: 1.906 ± 0.012	1.736GlnPro: 1.736 ± 0.014	2.251GlnGln: 2.251 ± 0.029	2.122GlnArg: 2.122 ± 0.012	2.97GlnSer: 2.97 ± 0.016	1.674GlnThr: 1.674 ± 0.011	2.42GlnVal: 2.42 ± 0.012	0.457GlnTrp: 0.457 ± 0.005	0.96GlnTyr: 0.96 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.279ArgAla: 3.279 ± 0.014	0.949ArgCys: 0.949 ± 0.008	2.652ArgAsp: 2.652 ± 0.017	3.388ArgGlu: 3.388 ± 0.019	2.193ArgPhe: 2.193 ± 0.012	3.131ArgGly: 3.131 ± 0.017	1.261ArgHis: 1.261 ± 0.009	2.914ArgIle: 2.914 ± 0.015	3.664ArgLys: 3.664 ± 0.016	5.129ArgLeu: 5.129 ± 0.022	1.288ArgMet: 1.288 ± 0.01	2.493ArgAsn: 2.493 ± 0.012	2.228ArgPro: 2.228 ± 0.012	1.89ArgGln: 1.89 ± 0.011	3.726ArgArg: 3.726 ± 0.02	4.212ArgSer: 4.212 ± 0.022	2.387ArgThr: 2.387 ± 0.013	3.251ArgVal: 3.251 ± 0.014	0.704ArgTrp: 0.704 ± 0.007	1.479ArgTyr: 1.479 ± 0.009	0.0ArgXaa: 0.0 ± 0.0
Ser	5.487SerAla: 5.487 ± 0.021	1.774SerCys: 1.774 ± 0.012	4.359SerAsp: 4.359 ± 0.018	4.87SerGlu: 4.87 ± 0.021	4.103SerPhe: 4.103 ± 0.018	5.995SerGly: 5.995 ± 0.024	1.985SerHis: 1.985 ± 0.012	4.624SerIle: 4.624 ± 0.018	5.035SerLys: 5.035 ± 0.019	9.077SerLeu: 9.077 ± 0.032	2.037SerMet: 2.037 ± 0.013	4.211SerAsn: 4.211 ± 0.019	4.33SerPro: 4.33 ± 0.025	3.123SerGln: 3.123 ± 0.017	4.455SerArg: 4.455 ± 0.019	10.999SerSer: 10.999 ± 0.045	4.535SerThr: 4.535 ± 0.019	5.413SerVal: 5.413 ± 0.023	1.143SerTrp: 1.143 ± 0.01	2.321SerTyr: 2.321 ± 0.012	0.0SerXaa: 0.0 ± 0.0
Thr	3.415ThrAla: 3.415 ± 0.018	0.928ThrCys: 0.928 ± 0.007	2.284ThrAsp: 2.284 ± 0.012	2.798ThrGlu: 2.798 ± 0.014	2.019ThrPhe: 2.019 ± 0.013	3.243ThrGly: 3.243 ± 0.015	1.005ThrHis: 1.005 ± 0.008	2.666ThrIle: 2.666 ± 0.013	2.597ThrLys: 2.597 ± 0.014	4.618ThrLeu: 4.618 ± 0.016	1.084ThrMet: 1.084 ± 0.008	2.063ThrAsn: 2.063 ± 0.013	2.421ThrPro: 2.421 ± 0.012	1.504ThrGln: 1.504 ± 0.009	2.274ThrArg: 2.274 ± 0.012	4.534ThrSer: 4.534 ± 0.021	2.756ThrThr: 2.756 ± 0.016	3.34ThrVal: 3.34 ± 0.015	0.609ThrTrp: 0.609 ± 0.006	1.349ThrTyr: 1.349 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.841ValAla: 4.841 ± 0.02	1.173ValCys: 1.173 ± 0.008	3.755ValAsp: 3.755 ± 0.018	4.258ValGlu: 4.258 ± 0.018	2.715ValPhe: 2.715 ± 0.015	4.148ValGly: 4.148 ± 0.017	1.508ValHis: 1.508 ± 0.009	3.531ValIle: 3.531 ± 0.016	3.902ValLys: 3.902 ± 0.017	6.434ValLeu: 6.434 ± 0.022	1.509ValMet: 1.509 ± 0.01	2.72ValAsn: 2.72 ± 0.016	3.228ValPro: 3.228 ± 0.016	2.352ValGln: 2.352 ± 0.015	3.104ValArg: 3.104 ± 0.015	5.573ValSer: 5.573 ± 0.02	3.213ValThr: 3.213 ± 0.017	4.785ValVal: 4.785 ± 0.02	0.75ValTrp: 0.75 ± 0.007	1.919ValTyr: 1.919 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.782TrpAla: 0.782 ± 0.008	0.24TrpCys: 0.24 ± 0.004	0.68TrpAsp: 0.68 ± 0.007	0.779TrpGlu: 0.779 ± 0.008	0.537TrpPhe: 0.537 ± 0.006	0.724TrpGly: 0.724 ± 0.009	0.298TrpHis: 0.298 ± 0.004	0.72TrpIle: 0.72 ± 0.007	0.922TrpLys: 0.922 ± 0.008	1.275TrpLeu: 1.275 ± 0.01	0.351TrpMet: 0.351 ± 0.004	0.68TrpAsn: 0.68 ± 0.007	0.513TrpPro: 0.513 ± 0.006	0.467TrpGln: 0.467 ± 0.006	0.806TrpArg: 0.806 ± 0.008	0.933TrpSer: 0.933 ± 0.008	0.624TrpThr: 0.624 ± 0.007	0.769TrpVal: 0.769 ± 0.006	0.239TrpTrp: 0.239 ± 0.004	0.336TrpTyr: 0.336 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.795TyrAla: 1.795 ± 0.012	0.659TyrCys: 0.659 ± 0.008	1.56TyrAsp: 1.56 ± 0.011	1.606TyrGlu: 1.606 ± 0.011	1.342TyrPhe: 1.342 ± 0.009	2.102TyrGly: 2.102 ± 0.014	0.715TyrHis: 0.715 ± 0.006	1.473TyrIle: 1.473 ± 0.009	1.525TyrLys: 1.525 ± 0.011	2.891TyrLeu: 2.891 ± 0.014	0.745TyrMet: 0.745 ± 0.006	1.338TyrAsn: 1.338 ± 0.009	1.25TyrPro: 1.25 ± 0.008	0.96TyrGln: 0.96 ± 0.008	1.469TyrArg: 1.469 ± 0.009	2.261TyrSer: 2.261 ± 0.012	1.256TyrThr: 1.256 ± 0.009	1.774TyrVal: 1.774 ± 0.012	0.396TyrTrp: 0.396 ± 0.006	0.963TyrTyr: 0.963 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 44004 proteins (16339298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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