Amino acid dipepetide frequency for Leucobacter komagatae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.628AlaAla: 20.628 ± 0.246
0.697AlaCys: 0.697 ± 0.031
7.426AlaAsp: 7.426 ± 0.091
9.207AlaGlu: 9.207 ± 0.112
3.983AlaPhe: 3.983 ± 0.075
12.609AlaGly: 12.609 ± 0.151
2.354AlaHis: 2.354 ± 0.06
6.287AlaIle: 6.287 ± 0.088
3.358AlaLys: 3.358 ± 0.068
14.07AlaLeu: 14.07 ± 0.162
2.735AlaMet: 2.735 ± 0.053
2.777AlaAsn: 2.777 ± 0.065
6.095AlaPro: 6.095 ± 0.102
4.06AlaGln: 4.06 ± 0.077
8.446AlaArg: 8.446 ± 0.122
7.207AlaSer: 7.207 ± 0.09
7.631AlaThr: 7.631 ± 0.124
10.717AlaVal: 10.717 ± 0.13
1.671AlaTrp: 1.671 ± 0.048
2.243AlaTyr: 2.243 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.66CysAla: 0.66 ± 0.03
0.044CysCys: 0.044 ± 0.007
0.324CysAsp: 0.324 ± 0.017
0.294CysGlu: 0.294 ± 0.019
0.169CysPhe: 0.169 ± 0.013
0.55CysGly: 0.55 ± 0.025
0.09CysHis: 0.09 ± 0.012
0.182CysIle: 0.182 ± 0.013
0.064CysLys: 0.064 ± 0.009
0.434CysLeu: 0.434 ± 0.023
0.081CysMet: 0.081 ± 0.01
0.118CysAsn: 0.118 ± 0.01
0.244CysPro: 0.244 ± 0.017
0.133CysGln: 0.133 ± 0.013
0.259CysArg: 0.259 ± 0.019
0.368CysSer: 0.368 ± 0.022
0.324CysThr: 0.324 ± 0.023
0.447CysVal: 0.447 ± 0.024
0.064CysTrp: 0.064 ± 0.009
0.107CysTyr: 0.107 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.841AspAla: 7.841 ± 0.115
0.228AspCys: 0.228 ± 0.016
3.195AspAsp: 3.195 ± 0.072
4.085AspGlu: 4.085 ± 0.071
1.82AspPhe: 1.82 ± 0.047
5.387AspGly: 5.387 ± 0.086
1.06AspHis: 1.06 ± 0.036
2.432AspIle: 2.432 ± 0.054
1.049AspLys: 1.049 ± 0.037
5.423AspLeu: 5.423 ± 0.085
0.887AspMet: 0.887 ± 0.031
1.002AspAsn: 1.002 ± 0.035
3.911AspPro: 3.911 ± 0.08
1.373AspGln: 1.373 ± 0.043
3.904AspArg: 3.904 ± 0.07
2.879AspSer: 2.879 ± 0.061
3.168AspThr: 3.168 ± 0.063
4.55AspVal: 4.55 ± 0.097
0.821AspTrp: 0.821 ± 0.032
1.225AspTyr: 1.225 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
7.841GluAla: 7.841 ± 0.11
0.294GluCys: 0.294 ± 0.02
2.695GluAsp: 2.695 ± 0.062
3.393GluGlu: 3.393 ± 0.069
2.054GluPhe: 2.054 ± 0.05
4.394GluGly: 4.394 ± 0.082
1.676GluHis: 1.676 ± 0.048
3.317GluIle: 3.317 ± 0.072
1.408GluLys: 1.408 ± 0.049
7.83GluLeu: 7.83 ± 0.104
1.157GluMet: 1.157 ± 0.038
1.409GluAsn: 1.409 ± 0.044
3.002GluPro: 3.002 ± 0.069
2.659GluGln: 2.659 ± 0.063
5.544GluArg: 5.544 ± 0.092
3.241GluSer: 3.241 ± 0.062
3.474GluThr: 3.474 ± 0.061
4.876GluVal: 4.876 ± 0.071
0.923GluTrp: 0.923 ± 0.034
1.288GluTyr: 1.288 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.551PheAla: 4.551 ± 0.068
0.17PheCys: 0.17 ± 0.014
2.372PheAsp: 2.372 ± 0.051
2.029PheGlu: 2.029 ± 0.054
1.137PhePhe: 1.137 ± 0.035
3.542PheGly: 3.542 ± 0.072
0.522PheHis: 0.522 ± 0.026
1.289PheIle: 1.289 ± 0.042
0.557PheLys: 0.557 ± 0.025
2.821PheLeu: 2.821 ± 0.07
0.51PheMet: 0.51 ± 0.026
0.766PheAsn: 0.766 ± 0.03
1.5PhePro: 1.5 ± 0.045
0.778PheGln: 0.778 ± 0.031
1.639PheArg: 1.639 ± 0.041
2.057PheSer: 2.057 ± 0.057
2.461PheThr: 2.461 ± 0.057
2.868PheVal: 2.868 ± 0.075
0.462PheTrp: 0.462 ± 0.022
0.597PheTyr: 0.597 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
11.435GlyAla: 11.435 ± 0.127
0.526GlyCys: 0.526 ± 0.025
4.929GlyAsp: 4.929 ± 0.085
5.897GlyGlu: 5.897 ± 0.086
3.337GlyPhe: 3.337 ± 0.068
8.052GlyGly: 8.052 ± 0.111
1.646GlyHis: 1.646 ± 0.045
4.773GlyIle: 4.773 ± 0.086
2.748GlyLys: 2.748 ± 0.063
8.839GlyLeu: 8.839 ± 0.12
1.983GlyMet: 1.983 ± 0.05
2.084GlyAsn: 2.084 ± 0.066
3.496GlyPro: 3.496 ± 0.066
2.577GlyGln: 2.577 ± 0.053
5.317GlyArg: 5.317 ± 0.09
5.818GlySer: 5.818 ± 0.088
5.634GlyThr: 5.634 ± 0.088
8.193GlyVal: 8.193 ± 0.111
1.519GlyTrp: 1.519 ± 0.05
2.222GlyTyr: 2.222 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.366HisAla: 2.366 ± 0.061
0.115HisCys: 0.115 ± 0.012
1.117HisAsp: 1.117 ± 0.036
1.244HisGlu: 1.244 ± 0.041
0.643HisPhe: 0.643 ± 0.029
1.902HisGly: 1.902 ± 0.052
0.448HisHis: 0.448 ± 0.024
0.72HisIle: 0.72 ± 0.034
0.307HisLys: 0.307 ± 0.018
1.873HisLeu: 1.873 ± 0.051
0.328HisMet: 0.328 ± 0.019
0.4HisAsn: 0.4 ± 0.025
1.357HisPro: 1.357 ± 0.041
0.538HisGln: 0.538 ± 0.025
1.383HisArg: 1.383 ± 0.041
1.069HisSer: 1.069 ± 0.035
1.113HisThr: 1.113 ± 0.039
1.407HisVal: 1.407 ± 0.042
0.24HisTrp: 0.24 ± 0.018
0.398HisTyr: 0.398 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.479IleAla: 7.479 ± 0.093
0.218IleCys: 0.218 ± 0.014
3.332IleAsp: 3.332 ± 0.07
3.181IleGlu: 3.181 ± 0.068
1.24IlePhe: 1.24 ± 0.041
4.769IleGly: 4.769 ± 0.079
0.763IleHis: 0.763 ± 0.033
2.111IleIle: 2.111 ± 0.053
0.843IleLys: 0.843 ± 0.039
3.813IleLeu: 3.813 ± 0.075
0.801IleMet: 0.801 ± 0.036
1.016IleAsn: 1.016 ± 0.029
2.498IlePro: 2.498 ± 0.049
1.057IleGln: 1.057 ± 0.033
2.667IleArg: 2.667 ± 0.059
2.7IleSer: 2.7 ± 0.065
3.212IleThr: 3.212 ± 0.065
4.667IleVal: 4.667 ± 0.082
0.463IleTrp: 0.463 ± 0.024
0.748IleTyr: 0.748 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.343LysAla: 2.343 ± 0.049
0.073LysCys: 0.073 ± 0.008
1.167LysAsp: 1.167 ± 0.041
1.088LysGlu: 1.088 ± 0.043
0.65LysPhe: 0.65 ± 0.033
1.623LysGly: 1.623 ± 0.047
0.572LysHis: 0.572 ± 0.027
1.226LysIle: 1.226 ± 0.04
0.867LysLys: 0.867 ± 0.036
2.52LysLeu: 2.52 ± 0.06
0.507LysMet: 0.507 ± 0.023
0.692LysAsn: 0.692 ± 0.036
1.403LysPro: 1.403 ± 0.046
0.922LysGln: 0.922 ± 0.036
1.881LysArg: 1.881 ± 0.05
1.336LysSer: 1.336 ± 0.046
1.442LysThr: 1.442 ± 0.045
1.777LysVal: 1.777 ± 0.056
0.294LysTrp: 0.294 ± 0.017
0.516LysTyr: 0.516 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
14.879LeuAla: 14.879 ± 0.156
0.508LeuCys: 0.508 ± 0.024
6.051LeuAsp: 6.051 ± 0.09
5.587LeuGlu: 5.587 ± 0.092
3.039LeuPhe: 3.039 ± 0.06
9.719LeuGly: 9.719 ± 0.142
1.725LeuHis: 1.725 ± 0.054
4.673LeuIle: 4.673 ± 0.093
2.027LeuLys: 2.027 ± 0.06
10.261LeuLeu: 10.261 ± 0.149
1.733LeuMet: 1.733 ± 0.054
2.05LeuAsn: 2.05 ± 0.049
5.543LeuPro: 5.543 ± 0.084
2.617LeuGln: 2.617 ± 0.055
7.056LeuArg: 7.056 ± 0.12
6.436LeuSer: 6.436 ± 0.096
6.778LeuThr: 6.778 ± 0.099
8.794LeuVal: 8.794 ± 0.125
1.167LeuTrp: 1.167 ± 0.043
1.533LeuTyr: 1.533 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
1.923MetAla: 1.923 ± 0.055
0.1MetCys: 0.1 ± 0.01
0.813MetAsp: 0.813 ± 0.031
0.691MetGlu: 0.691 ± 0.03
0.604MetPhe: 0.604 ± 0.029
1.372MetGly: 1.372 ± 0.038
0.395MetHis: 0.395 ± 0.022
0.895MetIle: 0.895 ± 0.032
0.475MetLys: 0.475 ± 0.022
2.298MetLeu: 2.298 ± 0.055
0.335MetMet: 0.335 ± 0.02
0.623MetAsn: 0.623 ± 0.027
1.083MetPro: 1.083 ± 0.036
0.644MetGln: 0.644 ± 0.024
1.526MetArg: 1.526 ± 0.039
1.528MetSer: 1.528 ± 0.041
1.542MetThr: 1.542 ± 0.04
1.378MetVal: 1.378 ± 0.039
0.196MetTrp: 0.196 ± 0.014
0.303MetTyr: 0.303 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.852AsnAla: 2.852 ± 0.061
0.14AsnCys: 0.14 ± 0.014
1.227AsnAsp: 1.227 ± 0.042
1.25AsnGlu: 1.25 ± 0.034
0.694AsnPhe: 0.694 ± 0.03
2.126AsnGly: 2.126 ± 0.062
0.374AsnHis: 0.374 ± 0.021
1.015AsnIle: 1.015 ± 0.034
0.473AsnLys: 0.473 ± 0.025
2.033AsnLeu: 2.033 ± 0.052
0.389AsnMet: 0.389 ± 0.02
0.551AsnAsn: 0.551 ± 0.028
1.753AsnPro: 1.753 ± 0.057
0.666AsnGln: 0.666 ± 0.03
1.387AsnArg: 1.387 ± 0.037
1.231AsnSer: 1.231 ± 0.045
1.411AsnThr: 1.411 ± 0.048
1.863AsnVal: 1.863 ± 0.057
0.347AsnTrp: 0.347 ± 0.022
0.535AsnTyr: 0.535 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.931ProAla: 6.931 ± 0.12
0.169ProCys: 0.169 ± 0.014
3.129ProAsp: 3.129 ± 0.067
4.38ProGlu: 4.38 ± 0.076
1.678ProPhe: 1.678 ± 0.047
5.208ProGly: 5.208 ± 0.091
1.037ProHis: 1.037 ± 0.033
2.178ProIle: 2.178 ± 0.049
1.307ProLys: 1.307 ± 0.041
4.783ProLeu: 4.783 ± 0.079
0.872ProMet: 0.872 ± 0.031
1.276ProAsn: 1.276 ± 0.045
1.915ProPro: 1.915 ± 0.055
1.553ProGln: 1.553 ± 0.045
2.947ProArg: 2.947 ± 0.067
2.914ProSer: 2.914 ± 0.059
2.988ProThr: 2.988 ± 0.07
4.678ProVal: 4.678 ± 0.073
0.686ProTrp: 0.686 ± 0.031
0.91ProTyr: 0.91 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.722GlnAla: 3.722 ± 0.07
0.12GlnCys: 0.12 ± 0.012
1.214GlnAsp: 1.214 ± 0.033
1.495GlnGlu: 1.495 ± 0.045
0.911GlnPhe: 0.911 ± 0.032
2.184GlnGly: 2.184 ± 0.048
0.702GlnHis: 0.702 ± 0.026
1.479GlnIle: 1.479 ± 0.044
0.643GlnLys: 0.643 ± 0.025
3.772GlnLeu: 3.772 ± 0.084
0.557GlnMet: 0.557 ± 0.028
0.674GlnAsn: 0.674 ± 0.036
1.655GlnPro: 1.655 ± 0.047
1.394GlnGln: 1.394 ± 0.044
2.546GlnArg: 2.546 ± 0.066
1.588GlnSer: 1.588 ± 0.043
1.535GlnThr: 1.535 ± 0.038
2.248GlnVal: 2.248 ± 0.049
0.428GlnTrp: 0.428 ± 0.024
0.61GlnTyr: 0.61 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
8.457ArgAla: 8.457 ± 0.114
0.296ArgCys: 0.296 ± 0.02
3.927ArgAsp: 3.927 ± 0.06
4.762ArgGlu: 4.762 ± 0.078
2.357ArgPhe: 2.357 ± 0.056
5.427ArgGly: 5.427 ± 0.089
1.187ArgHis: 1.187 ± 0.031
3.506ArgIle: 3.506 ± 0.072
1.626ArgLys: 1.626 ± 0.045
6.388ArgLeu: 6.388 ± 0.108
1.514ArgMet: 1.514 ± 0.042
1.395ArgAsn: 1.395 ± 0.046
2.981ArgPro: 2.981 ± 0.069
1.868ArgGln: 1.868 ± 0.045
4.841ArgArg: 4.841 ± 0.092
4.051ArgSer: 4.051 ± 0.077
3.644ArgThr: 3.644 ± 0.061
6.002ArgVal: 6.002 ± 0.083
0.962ArgTrp: 0.962 ± 0.035
1.413ArgTyr: 1.413 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
7.427SerAla: 7.427 ± 0.096
0.296SerCys: 0.296 ± 0.019
3.324SerAsp: 3.324 ± 0.073
3.59SerGlu: 3.59 ± 0.066
2.206SerPhe: 2.206 ± 0.055
6.322SerGly: 6.322 ± 0.095
1.045SerHis: 1.045 ± 0.035
2.752SerIle: 2.752 ± 0.058
1.355SerLys: 1.355 ± 0.042
5.806SerLeu: 5.806 ± 0.085
1.212SerMet: 1.212 ± 0.034
1.273SerAsn: 1.273 ± 0.039
3.159SerPro: 3.159 ± 0.068
1.615SerGln: 1.615 ± 0.048
3.617SerArg: 3.617 ± 0.059
3.438SerSer: 3.438 ± 0.065
3.375SerThr: 3.375 ± 0.076
4.779SerVal: 4.779 ± 0.076
0.934SerTrp: 0.934 ± 0.035
1.258SerTyr: 1.258 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.644ThrAla: 7.644 ± 0.105
0.276ThrCys: 0.276 ± 0.022
3.237ThrAsp: 3.237 ± 0.074
3.636ThrGlu: 3.636 ± 0.067
1.899ThrPhe: 1.899 ± 0.046
6.058ThrGly: 6.058 ± 0.085
1.268ThrHis: 1.268 ± 0.038
2.945ThrIle: 2.945 ± 0.071
1.35ThrLys: 1.35 ± 0.042
6.423ThrLeu: 6.423 ± 0.095
1.028ThrMet: 1.028 ± 0.037
1.348ThrAsn: 1.348 ± 0.047
3.98ThrPro: 3.98 ± 0.075
1.705ThrGln: 1.705 ± 0.043
3.526ThrArg: 3.526 ± 0.076
3.452ThrSer: 3.452 ± 0.061
3.578ThrThr: 3.578 ± 0.081
5.956ThrVal: 5.956 ± 0.14
0.756ThrTrp: 0.756 ± 0.034
1.121ThrTyr: 1.121 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
11.386ValAla: 11.386 ± 0.137
0.48ValCys: 0.48 ± 0.023
4.808ValAsp: 4.808 ± 0.077
4.754ValGlu: 4.754 ± 0.077
2.991ValPhe: 2.991 ± 0.062
6.887ValGly: 6.887 ± 0.1
1.51ValHis: 1.51 ± 0.046
4.362ValIle: 4.362 ± 0.076
1.786ValLys: 1.786 ± 0.058
9.177ValLeu: 9.177 ± 0.132
1.517ValMet: 1.517 ± 0.05
2.029ValAsn: 2.029 ± 0.053
4.353ValPro: 4.353 ± 0.081
2.252ValGln: 2.252 ± 0.055
5.63ValArg: 5.63 ± 0.083
5.492ValSer: 5.492 ± 0.085
5.936ValThr: 5.936 ± 0.136
7.669ValVal: 7.669 ± 0.125
1.027ValTrp: 1.027 ± 0.037
1.486ValTyr: 1.486 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.516TrpAla: 1.516 ± 0.036
0.079TrpCys: 0.079 ± 0.009
0.746TrpAsp: 0.746 ± 0.029
0.714TrpGlu: 0.714 ± 0.028
0.547TrpPhe: 0.547 ± 0.028
1.057TrpGly: 1.057 ± 0.039
0.289TrpHis: 0.289 ± 0.018
0.693TrpIle: 0.693 ± 0.028
0.303TrpLys: 0.303 ± 0.018
1.547TrpLeu: 1.547 ± 0.049
0.288TrpMet: 0.288 ± 0.016
0.413TrpAsn: 0.413 ± 0.022
0.597TrpPro: 0.597 ± 0.028
0.541TrpGln: 0.541 ± 0.027
1.027TrpArg: 1.027 ± 0.038
0.833TrpSer: 0.833 ± 0.033
0.71TrpThr: 0.71 ± 0.028
1.125TrpVal: 1.125 ± 0.04
0.275TrpTrp: 0.275 ± 0.017
0.235TrpTyr: 0.235 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.319TyrAla: 2.319 ± 0.055
0.126TyrCys: 0.126 ± 0.012
1.206TyrAsp: 1.206 ± 0.038
1.196TyrGlu: 1.196 ± 0.043
0.667TyrPhe: 0.667 ± 0.031
1.838TyrGly: 1.838 ± 0.041
0.307TyrHis: 0.307 ± 0.018
0.742TyrIle: 0.742 ± 0.031
0.354TyrLys: 0.354 ± 0.02
2.065TyrLeu: 2.065 ± 0.053
0.288TyrMet: 0.288 ± 0.019
0.422TyrAsn: 0.422 ± 0.02
1.015TyrPro: 1.015 ± 0.035
0.524TyrGln: 0.524 ± 0.024
1.466TyrArg: 1.466 ± 0.041
1.146TyrSer: 1.146 ± 0.036
1.227TyrThr: 1.227 ± 0.051
1.539TyrVal: 1.539 ± 0.041
0.301TyrTrp: 0.301 ± 0.02
0.408TyrTyr: 0.408 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2703 proteins (881507 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski