Amino acid dipepetide frequency for Gordonia phage Zarbodnamra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.747AlaAla: 18.747 ± 1.316
0.807AlaCys: 0.807 ± 0.327
7.946AlaAsp: 7.946 ± 0.805
6.394AlaGlu: 6.394 ± 0.601
3.725AlaPhe: 3.725 ± 0.514
9.436AlaGly: 9.436 ± 0.814
1.924AlaHis: 1.924 ± 0.324
5.711AlaIle: 5.711 ± 0.461
3.787AlaLys: 3.787 ± 0.604
10.243AlaLeu: 10.243 ± 0.907
3.042AlaMet: 3.042 ± 0.659
3.104AlaAsn: 3.104 ± 0.567
4.407AlaPro: 4.407 ± 0.543
4.407AlaGln: 4.407 ± 0.535
7.635AlaArg: 7.635 ± 0.799
5.649AlaSer: 5.649 ± 0.841
7.635AlaThr: 7.635 ± 0.73
7.822AlaVal: 7.822 ± 0.974
2.049AlaTrp: 2.049 ± 0.299
1.986AlaTyr: 1.986 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.497CysAla: 0.497 ± 0.191
0.124CysCys: 0.124 ± 0.125
1.055CysAsp: 1.055 ± 0.324
0.31CysGlu: 0.31 ± 0.129
0.0CysPhe: 0.0 ± 0.0
1.117CysGly: 1.117 ± 0.419
0.683CysHis: 0.683 ± 0.254
0.186CysIle: 0.186 ± 0.113
0.124CysLys: 0.124 ± 0.086
0.621CysLeu: 0.621 ± 0.217
0.372CysMet: 0.372 ± 0.164
0.372CysAsn: 0.372 ± 0.137
0.993CysPro: 0.993 ± 0.263
0.435CysGln: 0.435 ± 0.147
0.497CysArg: 0.497 ± 0.173
0.559CysSer: 0.559 ± 0.223
0.621CysThr: 0.621 ± 0.187
0.372CysVal: 0.372 ± 0.196
0.248CysTrp: 0.248 ± 0.16
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.704AspAla: 6.704 ± 0.718
0.497AspCys: 0.497 ± 0.201
5.152AspAsp: 5.152 ± 0.685
4.78AspGlu: 4.78 ± 0.656
1.738AspPhe: 1.738 ± 0.336
7.201AspGly: 7.201 ± 0.879
2.111AspHis: 2.111 ± 0.346
2.856AspIle: 2.856 ± 0.522
1.552AspLys: 1.552 ± 0.37
5.773AspLeu: 5.773 ± 0.699
1.366AspMet: 1.366 ± 0.275
1.862AspAsn: 1.862 ± 0.352
4.035AspPro: 4.035 ± 0.585
2.483AspGln: 2.483 ± 0.359
4.78AspArg: 4.78 ± 0.747
3.228AspSer: 3.228 ± 0.407
4.532AspThr: 4.532 ± 0.483
5.277AspVal: 5.277 ± 0.637
1.179AspTrp: 1.179 ± 0.277
1.8AspTyr: 1.8 ± 0.375
0.0AspXaa: 0.0 ± 0.0
Glu
5.09GluAla: 5.09 ± 0.53
0.435GluCys: 0.435 ± 0.187
2.918GluAsp: 2.918 ± 0.393
1.862GluGlu: 1.862 ± 0.494
2.111GluPhe: 2.111 ± 0.382
3.911GluGly: 3.911 ± 0.418
1.179GluHis: 1.179 ± 0.247
2.731GluIle: 2.731 ± 0.372
2.049GluLys: 2.049 ± 0.35
4.842GluLeu: 4.842 ± 0.569
1.862GluMet: 1.862 ± 0.319
1.366GluAsn: 1.366 ± 0.33
3.663GluPro: 3.663 ± 0.661
3.414GluGln: 3.414 ± 0.521
4.221GluArg: 4.221 ± 0.603
2.669GluSer: 2.669 ± 0.355
2.669GluThr: 2.669 ± 0.356
5.09GluVal: 5.09 ± 0.593
1.179GluTrp: 1.179 ± 0.359
1.428GluTyr: 1.428 ± 0.38
0.0GluXaa: 0.0 ± 0.0
Phe
2.793PheAla: 2.793 ± 0.374
0.248PheCys: 0.248 ± 0.119
2.359PheAsp: 2.359 ± 0.315
1.862PheGlu: 1.862 ± 0.353
0.869PhePhe: 0.869 ± 0.236
2.235PheGly: 2.235 ± 0.349
0.372PheHis: 0.372 ± 0.171
0.745PheIle: 0.745 ± 0.218
1.055PheLys: 1.055 ± 0.309
1.552PheLeu: 1.552 ± 0.416
0.435PheMet: 0.435 ± 0.137
0.559PheAsn: 0.559 ± 0.211
1.614PhePro: 1.614 ± 0.278
0.621PheGln: 0.621 ± 0.164
1.924PheArg: 1.924 ± 0.308
1.614PheSer: 1.614 ± 0.36
2.111PheThr: 2.111 ± 0.349
3.414PheVal: 3.414 ± 0.506
0.186PheTrp: 0.186 ± 0.092
0.621PheTyr: 0.621 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
9.001GlyAla: 9.001 ± 1.124
0.559GlyCys: 0.559 ± 0.199
5.587GlyAsp: 5.587 ± 0.558
4.78GlyGlu: 4.78 ± 0.687
2.731GlyPhe: 2.731 ± 0.444
6.58GlyGly: 6.58 ± 0.837
1.738GlyHis: 1.738 ± 0.369
3.725GlyIle: 3.725 ± 0.678
3.352GlyLys: 3.352 ± 0.475
8.629GlyLeu: 8.629 ± 1.141
1.428GlyMet: 1.428 ± 0.243
2.421GlyAsn: 2.421 ± 0.359
3.725GlyPro: 3.725 ± 0.572
3.104GlyGln: 3.104 ± 0.422
6.828GlyArg: 6.828 ± 0.653
4.594GlySer: 4.594 ± 0.506
4.966GlyThr: 4.966 ± 0.526
6.021GlyVal: 6.021 ± 0.621
2.607GlyTrp: 2.607 ± 0.396
2.483GlyTyr: 2.483 ± 0.38
0.0GlyXaa: 0.0 ± 0.0
His
2.173HisAla: 2.173 ± 0.31
0.31HisCys: 0.31 ± 0.147
1.676HisAsp: 1.676 ± 0.336
0.869HisGlu: 0.869 ± 0.277
0.497HisPhe: 0.497 ± 0.161
1.614HisGly: 1.614 ± 0.288
0.683HisHis: 0.683 ± 0.181
1.055HisIle: 1.055 ± 0.272
0.497HisLys: 0.497 ± 0.17
1.862HisLeu: 1.862 ± 0.404
0.31HisMet: 0.31 ± 0.116
0.559HisAsn: 0.559 ± 0.195
1.614HisPro: 1.614 ± 0.291
0.869HisGln: 0.869 ± 0.223
1.8HisArg: 1.8 ± 0.265
1.242HisSer: 1.242 ± 0.332
1.117HisThr: 1.117 ± 0.312
1.8HisVal: 1.8 ± 0.356
0.497HisTrp: 0.497 ± 0.163
0.559HisTyr: 0.559 ± 0.178
0.0HisXaa: 0.0 ± 0.0
Ile
5.835IleAla: 5.835 ± 0.53
0.372IleCys: 0.372 ± 0.152
4.035IleAsp: 4.035 ± 0.553
2.297IleGlu: 2.297 ± 0.337
0.869IlePhe: 0.869 ± 0.224
4.532IleGly: 4.532 ± 0.797
0.807IleHis: 0.807 ± 0.227
1.676IleIle: 1.676 ± 0.306
1.8IleLys: 1.8 ± 0.422
2.483IleLeu: 2.483 ± 0.352
0.186IleMet: 0.186 ± 0.112
1.179IleAsn: 1.179 ± 0.264
2.918IlePro: 2.918 ± 0.459
1.179IleGln: 1.179 ± 0.28
4.035IleArg: 4.035 ± 0.493
2.359IleSer: 2.359 ± 0.412
3.6IleThr: 3.6 ± 0.424
4.47IleVal: 4.47 ± 0.582
0.31IleTrp: 0.31 ± 0.132
0.745IleTyr: 0.745 ± 0.205
0.0IleXaa: 0.0 ± 0.0
Lys
3.911LysAla: 3.911 ± 0.582
0.248LysCys: 0.248 ± 0.111
1.676LysAsp: 1.676 ± 0.467
1.428LysGlu: 1.428 ± 0.269
1.366LysPhe: 1.366 ± 0.278
2.235LysGly: 2.235 ± 0.466
0.745LysHis: 0.745 ± 0.281
1.428LysIle: 1.428 ± 0.365
2.049LysLys: 2.049 ± 0.361
3.166LysLeu: 3.166 ± 0.536
0.683LysMet: 0.683 ± 0.204
0.931LysAsn: 0.931 ± 0.268
2.669LysPro: 2.669 ± 0.352
1.117LysGln: 1.117 ± 0.248
2.049LysArg: 2.049 ± 0.359
1.738LysSer: 1.738 ± 0.318
2.483LysThr: 2.483 ± 0.426
2.731LysVal: 2.731 ± 0.336
0.683LysTrp: 0.683 ± 0.172
0.869LysTyr: 0.869 ± 0.249
0.0LysXaa: 0.0 ± 0.0
Leu
11.484LeuAla: 11.484 ± 0.959
0.745LeuCys: 0.745 ± 0.227
5.711LeuAsp: 5.711 ± 0.708
3.6LeuGlu: 3.6 ± 0.56
1.8LeuPhe: 1.8 ± 0.272
7.201LeuGly: 7.201 ± 0.859
0.993LeuHis: 0.993 ± 0.237
3.538LeuIle: 3.538 ± 0.538
1.8LeuLys: 1.8 ± 0.368
4.718LeuLeu: 4.718 ± 0.644
1.428LeuMet: 1.428 ± 0.396
1.986LeuAsn: 1.986 ± 0.327
4.47LeuPro: 4.47 ± 0.551
1.862LeuGln: 1.862 ± 0.358
5.09LeuArg: 5.09 ± 0.581
4.904LeuSer: 4.904 ± 0.717
5.959LeuThr: 5.959 ± 0.559
6.332LeuVal: 6.332 ± 0.608
2.297LeuTrp: 2.297 ± 0.343
1.304LeuTyr: 1.304 ± 0.235
0.0LeuXaa: 0.0 ± 0.0
Met
3.228MetAla: 3.228 ± 0.458
0.248MetCys: 0.248 ± 0.123
0.559MetAsp: 0.559 ± 0.181
0.683MetGlu: 0.683 ± 0.177
0.497MetPhe: 0.497 ± 0.147
1.676MetGly: 1.676 ± 0.338
0.31MetHis: 0.31 ± 0.128
1.179MetIle: 1.179 ± 0.29
0.683MetLys: 0.683 ± 0.211
1.676MetLeu: 1.676 ± 0.34
0.31MetMet: 0.31 ± 0.162
0.372MetAsn: 0.372 ± 0.131
1.924MetPro: 1.924 ± 0.292
0.683MetGln: 0.683 ± 0.209
1.862MetArg: 1.862 ± 0.497
2.235MetSer: 2.235 ± 0.384
2.545MetThr: 2.545 ± 0.374
0.559MetVal: 0.559 ± 0.217
0.683MetTrp: 0.683 ± 0.281
0.248MetTyr: 0.248 ± 0.107
0.0MetXaa: 0.0 ± 0.0
Asn
2.235AsnAla: 2.235 ± 0.383
0.248AsnCys: 0.248 ± 0.136
1.8AsnAsp: 1.8 ± 0.278
1.117AsnGlu: 1.117 ± 0.22
0.31AsnPhe: 0.31 ± 0.129
3.352AsnGly: 3.352 ± 0.518
0.931AsnHis: 0.931 ± 0.26
0.869AsnIle: 0.869 ± 0.264
0.807AsnLys: 0.807 ± 0.227
2.421AsnLeu: 2.421 ± 0.335
0.497AsnMet: 0.497 ± 0.189
0.621AsnAsn: 0.621 ± 0.24
3.042AsnPro: 3.042 ± 0.442
1.055AsnGln: 1.055 ± 0.249
1.862AsnArg: 1.862 ± 0.458
1.8AsnSer: 1.8 ± 0.384
2.049AsnThr: 2.049 ± 0.376
1.676AsnVal: 1.676 ± 0.399
0.435AsnTrp: 0.435 ± 0.133
0.807AsnTyr: 0.807 ± 0.218
0.0AsnXaa: 0.0 ± 0.0
Pro
6.58ProAla: 6.58 ± 0.913
0.807ProCys: 0.807 ± 0.31
4.532ProAsp: 4.532 ± 0.598
4.283ProGlu: 4.283 ± 0.643
1.49ProPhe: 1.49 ± 0.261
5.152ProGly: 5.152 ± 0.624
1.117ProHis: 1.117 ± 0.283
3.042ProIle: 3.042 ± 0.389
2.669ProLys: 2.669 ± 0.36
2.918ProLeu: 2.918 ± 0.433
1.366ProMet: 1.366 ± 0.378
1.924ProAsn: 1.924 ± 0.344
3.166ProPro: 3.166 ± 0.604
1.49ProGln: 1.49 ± 0.245
3.476ProArg: 3.476 ± 0.502
3.166ProSer: 3.166 ± 0.385
4.035ProThr: 4.035 ± 0.655
3.911ProVal: 3.911 ± 0.568
1.242ProTrp: 1.242 ± 0.295
1.304ProTyr: 1.304 ± 0.318
0.0ProXaa: 0.0 ± 0.0
Gln
3.538GlnAla: 3.538 ± 0.494
0.186GlnCys: 0.186 ± 0.112
1.179GlnAsp: 1.179 ± 0.26
1.304GlnGlu: 1.304 ± 0.323
1.055GlnPhe: 1.055 ± 0.263
2.359GlnGly: 2.359 ± 0.421
1.117GlnHis: 1.117 ± 0.323
1.738GlnIle: 1.738 ± 0.354
1.055GlnLys: 1.055 ± 0.241
3.352GlnLeu: 3.352 ± 0.513
0.745GlnMet: 0.745 ± 0.241
0.931GlnAsn: 0.931 ± 0.189
2.111GlnPro: 2.111 ± 0.332
1.676GlnGln: 1.676 ± 0.397
3.29GlnArg: 3.29 ± 0.4
1.8GlnSer: 1.8 ± 0.328
1.986GlnThr: 1.986 ± 0.333
2.545GlnVal: 2.545 ± 0.477
0.993GlnTrp: 0.993 ± 0.305
1.055GlnTyr: 1.055 ± 0.195
0.0GlnXaa: 0.0 ± 0.0
Arg
7.76ArgAla: 7.76 ± 0.79
0.993ArgCys: 0.993 ± 0.305
5.711ArgAsp: 5.711 ± 0.51
4.345ArgGlu: 4.345 ± 0.576
2.111ArgPhe: 2.111 ± 0.35
6.146ArgGly: 6.146 ± 0.658
1.924ArgHis: 1.924 ± 0.365
4.035ArgIle: 4.035 ± 0.542
2.235ArgLys: 2.235 ± 0.333
5.649ArgLeu: 5.649 ± 0.511
2.421ArgMet: 2.421 ± 0.381
2.173ArgAsn: 2.173 ± 0.356
3.6ArgPro: 3.6 ± 0.405
2.545ArgGln: 2.545 ± 0.519
6.828ArgArg: 6.828 ± 1.038
3.849ArgSer: 3.849 ± 0.486
4.407ArgThr: 4.407 ± 0.569
5.214ArgVal: 5.214 ± 0.635
1.428ArgTrp: 1.428 ± 0.36
1.117ArgTyr: 1.117 ± 0.274
0.0ArgXaa: 0.0 ± 0.0
Ser
6.642SerAla: 6.642 ± 0.761
0.062SerCys: 0.062 ± 0.059
3.104SerAsp: 3.104 ± 0.423
3.352SerGlu: 3.352 ± 0.467
1.179SerPhe: 1.179 ± 0.306
5.711SerGly: 5.711 ± 0.768
0.807SerHis: 0.807 ± 0.262
2.669SerIle: 2.669 ± 0.477
1.552SerLys: 1.552 ± 0.27
3.228SerLeu: 3.228 ± 0.485
1.49SerMet: 1.49 ± 0.243
2.235SerAsn: 2.235 ± 0.427
2.98SerPro: 2.98 ± 0.48
1.49SerGln: 1.49 ± 0.341
3.787SerArg: 3.787 ± 0.608
2.235SerSer: 2.235 ± 0.378
4.594SerThr: 4.594 ± 0.473
4.532SerVal: 4.532 ± 0.59
1.366SerTrp: 1.366 ± 0.269
0.745SerTyr: 0.745 ± 0.256
0.0SerXaa: 0.0 ± 0.0
Thr
7.449ThrAla: 7.449 ± 0.646
0.497ThrCys: 0.497 ± 0.196
5.401ThrAsp: 5.401 ± 0.745
3.787ThrGlu: 3.787 ± 0.581
2.173ThrPhe: 2.173 ± 0.532
5.897ThrGly: 5.897 ± 0.688
1.242ThrHis: 1.242 ± 0.286
2.793ThrIle: 2.793 ± 0.413
2.98ThrLys: 2.98 ± 0.469
5.525ThrLeu: 5.525 ± 0.627
1.242ThrMet: 1.242 ± 0.227
2.049ThrAsn: 2.049 ± 0.369
4.407ThrPro: 4.407 ± 0.602
1.862ThrGln: 1.862 ± 0.351
4.656ThrArg: 4.656 ± 0.569
3.663ThrSer: 3.663 ± 0.515
4.097ThrThr: 4.097 ± 0.594
6.146ThrVal: 6.146 ± 0.543
1.49ThrTrp: 1.49 ± 0.253
1.304ThrTyr: 1.304 ± 0.327
0.0ThrXaa: 0.0 ± 0.0
Val
8.877ValAla: 8.877 ± 0.835
1.304ValCys: 1.304 ± 0.358
6.146ValAsp: 6.146 ± 0.625
4.966ValGlu: 4.966 ± 0.513
1.738ValPhe: 1.738 ± 0.334
5.525ValGly: 5.525 ± 0.631
1.49ValHis: 1.49 ± 0.26
4.159ValIle: 4.159 ± 0.468
2.607ValLys: 2.607 ± 0.409
4.904ValLeu: 4.904 ± 0.616
1.862ValMet: 1.862 ± 0.359
1.676ValAsn: 1.676 ± 0.291
3.911ValPro: 3.911 ± 0.51
2.545ValGln: 2.545 ± 0.509
5.835ValArg: 5.835 ± 0.599
3.849ValSer: 3.849 ± 0.521
6.084ValThr: 6.084 ± 0.729
6.953ValVal: 6.953 ± 0.707
1.552ValTrp: 1.552 ± 0.334
2.173ValTyr: 2.173 ± 0.342
0.0ValXaa: 0.0 ± 0.0
Trp
1.924TrpAla: 1.924 ± 0.412
0.372TrpCys: 0.372 ± 0.169
1.366TrpAsp: 1.366 ± 0.32
0.869TrpGlu: 0.869 ± 0.217
0.621TrpPhe: 0.621 ± 0.236
0.807TrpGly: 0.807 ± 0.236
0.683TrpHis: 0.683 ± 0.245
0.683TrpIle: 0.683 ± 0.196
0.807TrpLys: 0.807 ± 0.2
2.173TrpLeu: 2.173 ± 0.371
0.559TrpMet: 0.559 ± 0.218
0.807TrpAsn: 0.807 ± 0.351
1.366TrpPro: 1.366 ± 0.303
0.559TrpGln: 0.559 ± 0.186
1.676TrpArg: 1.676 ± 0.294
1.366TrpSer: 1.366 ± 0.326
1.614TrpThr: 1.614 ± 0.254
1.924TrpVal: 1.924 ± 0.3
0.497TrpTrp: 0.497 ± 0.175
0.683TrpTyr: 0.683 ± 0.197
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.986TyrAla: 1.986 ± 0.308
0.124TyrCys: 0.124 ± 0.092
0.993TyrAsp: 0.993 ± 0.223
1.8TyrGlu: 1.8 ± 0.343
0.31TyrPhe: 0.31 ± 0.158
2.173TyrGly: 2.173 ± 0.362
0.745TyrHis: 0.745 ± 0.205
0.869TyrIle: 0.869 ± 0.294
0.745TyrLys: 0.745 ± 0.249
1.49TyrLeu: 1.49 ± 0.343
0.497TyrMet: 0.497 ± 0.173
0.807TyrAsn: 0.807 ± 0.214
1.117TyrPro: 1.117 ± 0.239
0.621TyrGln: 0.621 ± 0.206
2.359TyrArg: 2.359 ± 0.432
1.242TyrSer: 1.242 ± 0.302
1.552TyrThr: 1.552 ± 0.289
1.366TyrVal: 1.366 ± 0.348
0.435TyrTrp: 0.435 ± 0.145
0.559TyrTyr: 0.559 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 84 proteins (16110 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski