Amino acid dipepetide frequency for Enterovirga rhinocerotis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.283AlaAla: 20.283 ± 0.16
1.112AlaCys: 1.112 ± 0.028
6.927AlaAsp: 6.927 ± 0.076
8.45AlaGlu: 8.45 ± 0.108
4.779AlaPhe: 4.779 ± 0.063
12.443AlaGly: 12.443 ± 0.094
2.108AlaHis: 2.108 ± 0.042
6.755AlaIle: 6.755 ± 0.067
3.922AlaLys: 3.922 ± 0.068
14.45AlaLeu: 14.45 ± 0.124
3.516AlaMet: 3.516 ± 0.053
2.452AlaAsn: 2.452 ± 0.048
6.637AlaPro: 6.637 ± 0.09
3.56AlaGln: 3.56 ± 0.056
10.383AlaArg: 10.383 ± 0.109
7.175AlaSer: 7.175 ± 0.076
6.26AlaThr: 6.26 ± 0.066
9.456AlaVal: 9.456 ± 0.079
1.652AlaTrp: 1.652 ± 0.036
2.635AlaTyr: 2.635 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.893CysAla: 0.893 ± 0.026
0.094CysCys: 0.094 ± 0.008
0.45CysAsp: 0.45 ± 0.018
0.412CysGlu: 0.412 ± 0.015
0.302CysPhe: 0.302 ± 0.014
0.854CysGly: 0.854 ± 0.024
0.2CysHis: 0.2 ± 0.011
0.321CysIle: 0.321 ± 0.014
0.122CysLys: 0.122 ± 0.009
0.785CysLeu: 0.785 ± 0.024
0.155CysMet: 0.155 ± 0.01
0.178CysAsn: 0.178 ± 0.011
0.412CysPro: 0.412 ± 0.017
0.164CysGln: 0.164 ± 0.01
0.728CysArg: 0.728 ± 0.021
0.44CysSer: 0.44 ± 0.017
0.34CysThr: 0.34 ± 0.015
0.576CysVal: 0.576 ± 0.018
0.094CysTrp: 0.094 ± 0.008
0.175CysTyr: 0.175 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.835AspAla: 6.835 ± 0.069
0.407AspCys: 0.407 ± 0.018
2.858AspAsp: 2.858 ± 0.056
3.693AspGlu: 3.693 ± 0.048
1.996AspPhe: 1.996 ± 0.038
5.425AspGly: 5.425 ± 0.068
1.166AspHis: 1.166 ± 0.027
2.666AspIle: 2.666 ± 0.041
1.331AspLys: 1.331 ± 0.032
6.437AspLeu: 6.437 ± 0.075
1.091AspMet: 1.091 ± 0.027
0.96AspAsn: 0.96 ± 0.027
3.858AspPro: 3.858 ± 0.055
1.447AspGln: 1.447 ± 0.032
4.958AspArg: 4.958 ± 0.065
1.865AspSer: 1.865 ± 0.032
2.357AspThr: 2.357 ± 0.045
4.083AspVal: 4.083 ± 0.055
0.912AspTrp: 0.912 ± 0.027
1.305AspTyr: 1.305 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
9.214GluAla: 9.214 ± 0.101
0.309GluCys: 0.309 ± 0.013
2.735GluAsp: 2.735 ± 0.045
3.238GluGlu: 3.238 ± 0.055
1.529GluPhe: 1.529 ± 0.035
4.711GluGly: 4.711 ± 0.053
1.071GluHis: 1.071 ± 0.027
3.379GluIle: 3.379 ± 0.058
1.784GluLys: 1.784 ± 0.043
4.633GluLeu: 4.633 ± 0.055
1.328GluMet: 1.328 ± 0.032
1.164GluAsn: 1.164 ± 0.028
3.224GluPro: 3.224 ± 0.051
1.601GluGln: 1.601 ± 0.038
5.75GluArg: 5.75 ± 0.081
2.25GluSer: 2.25 ± 0.03
3.567GluThr: 3.567 ± 0.056
3.992GluVal: 3.992 ± 0.058
0.582GluTrp: 0.582 ± 0.019
0.835GluTyr: 0.835 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.711PheAla: 4.711 ± 0.063
0.35PheCys: 0.35 ± 0.016
2.49PheAsp: 2.49 ± 0.045
2.011PheGlu: 2.011 ± 0.039
1.279PhePhe: 1.279 ± 0.03
3.973PheGly: 3.973 ± 0.055
0.666PheHis: 0.666 ± 0.02
1.352PheIle: 1.352 ± 0.035
0.866PheLys: 0.866 ± 0.03
3.201PheLeu: 3.201 ± 0.055
0.721PheMet: 0.721 ± 0.024
0.797PheAsn: 0.797 ± 0.025
1.626PhePro: 1.626 ± 0.04
0.902PheGln: 0.902 ± 0.023
2.458PheArg: 2.458 ± 0.038
1.96PheSer: 1.96 ± 0.038
1.781PheThr: 1.781 ± 0.036
2.948PheVal: 2.948 ± 0.043
0.496PheTrp: 0.496 ± 0.017
0.833PheTyr: 0.833 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.539GlyAla: 10.539 ± 0.084
0.844GlyCys: 0.844 ± 0.023
4.409GlyAsp: 4.409 ± 0.059
5.226GlyGlu: 5.226 ± 0.066
3.785GlyPhe: 3.785 ± 0.049
8.591GlyGly: 8.591 ± 0.117
1.976GlyHis: 1.976 ± 0.036
5.042GlyIle: 5.042 ± 0.066
2.677GlyLys: 2.677 ± 0.049
10.003GlyLeu: 10.003 ± 0.079
2.212GlyMet: 2.212 ± 0.04
1.831GlyAsn: 1.831 ± 0.046
4.443GlyPro: 4.443 ± 0.057
2.75GlyGln: 2.75 ± 0.052
8.161GlyArg: 8.161 ± 0.08
5.205GlySer: 5.205 ± 0.061
5.012GlyThr: 5.012 ± 0.058
5.858GlyVal: 5.858 ± 0.067
1.458GlyTrp: 1.458 ± 0.034
2.198GlyTyr: 2.198 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.299HisAla: 2.299 ± 0.047
0.193HisCys: 0.193 ± 0.011
1.15HisAsp: 1.15 ± 0.028
0.979HisGlu: 0.979 ± 0.027
0.713HisPhe: 0.713 ± 0.021
1.938HisGly: 1.938 ± 0.037
0.518HisHis: 0.518 ± 0.022
0.685HisIle: 0.685 ± 0.022
0.342HisLys: 0.342 ± 0.015
2.095HisLeu: 2.095 ± 0.042
0.35HisMet: 0.35 ± 0.017
0.354HisAsn: 0.354 ± 0.017
1.415HisPro: 1.415 ± 0.03
0.474HisGln: 0.474 ± 0.017
1.558HisArg: 1.558 ± 0.039
0.774HisSer: 0.774 ± 0.023
0.638HisThr: 0.638 ± 0.024
1.518HisVal: 1.518 ± 0.029
0.329HisTrp: 0.329 ± 0.017
0.462HisTyr: 0.462 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.44IleAla: 7.44 ± 0.078
0.441IleCys: 0.441 ± 0.016
3.202IleAsp: 3.202 ± 0.046
3.421IleGlu: 3.421 ± 0.048
1.398IlePhe: 1.398 ± 0.037
5.401IleGly: 5.401 ± 0.067
0.84IleHis: 0.84 ± 0.023
1.62IleIle: 1.62 ± 0.039
1.173IleLys: 1.173 ± 0.03
4.607IleLeu: 4.607 ± 0.056
0.848IleMet: 0.848 ± 0.025
1.051IleAsn: 1.051 ± 0.029
2.289IlePro: 2.289 ± 0.045
1.102IleGln: 1.102 ± 0.024
3.611IleArg: 3.611 ± 0.052
2.263IleSer: 2.263 ± 0.047
2.231IleThr: 2.231 ± 0.044
4.561IleVal: 4.561 ± 0.06
0.528IleTrp: 0.528 ± 0.021
0.938IleTyr: 0.938 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
4.134LysAla: 4.134 ± 0.069
0.103LysCys: 0.103 ± 0.009
1.463LysAsp: 1.463 ± 0.038
1.331LysGlu: 1.331 ± 0.037
0.649LysPhe: 0.649 ± 0.025
2.438LysGly: 2.438 ± 0.05
0.444LysHis: 0.444 ± 0.016
1.238LysIle: 1.238 ± 0.034
0.96LysLys: 0.96 ± 0.033
2.689LysLeu: 2.689 ± 0.043
0.536LysMet: 0.536 ± 0.02
0.581LysAsn: 0.581 ± 0.021
1.974LysPro: 1.974 ± 0.045
0.746LysGln: 0.746 ± 0.026
2.173LysArg: 2.173 ± 0.04
1.402LysSer: 1.402 ± 0.033
1.658LysThr: 1.658 ± 0.029
2.105LysVal: 2.105 ± 0.047
0.27LysTrp: 0.27 ± 0.014
0.457LysTyr: 0.457 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.666LeuAla: 15.666 ± 0.119
0.852LeuCys: 0.852 ± 0.025
6.423LeuAsp: 6.423 ± 0.072
4.814LeuGlu: 4.814 ± 0.059
3.433LeuPhe: 3.433 ± 0.053
9.284LeuGly: 9.284 ± 0.084
1.761LeuHis: 1.761 ± 0.036
4.429LeuIle: 4.429 ± 0.058
2.991LeuLys: 2.991 ± 0.044
9.639LeuLeu: 9.639 ± 0.105
1.968LeuMet: 1.968 ± 0.041
2.07LeuAsn: 2.07 ± 0.038
5.915LeuPro: 5.915 ± 0.068
2.259LeuGln: 2.259 ± 0.037
7.623LeuArg: 7.623 ± 0.087
6.167LeuSer: 6.167 ± 0.057
5.33LeuThr: 5.33 ± 0.057
8.352LeuVal: 8.352 ± 0.084
1.18LeuTrp: 1.18 ± 0.027
1.96LeuTyr: 1.96 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.007MetAla: 3.007 ± 0.042
0.124MetCys: 0.124 ± 0.01
0.898MetAsp: 0.898 ± 0.025
0.917MetGlu: 0.917 ± 0.027
0.588MetPhe: 0.588 ± 0.022
1.665MetGly: 1.665 ± 0.037
0.356MetHis: 0.356 ± 0.016
1.181MetIle: 1.181 ± 0.028
0.768MetLys: 0.768 ± 0.022
2.181MetLeu: 2.181 ± 0.038
0.556MetMet: 0.556 ± 0.022
0.6MetAsn: 0.6 ± 0.02
1.457MetPro: 1.457 ± 0.03
0.645MetGln: 0.645 ± 0.019
1.934MetArg: 1.934 ± 0.042
1.578MetSer: 1.578 ± 0.031
1.764MetThr: 1.764 ± 0.037
1.509MetVal: 1.509 ± 0.034
0.199MetTrp: 0.199 ± 0.012
0.271MetTyr: 0.271 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.672AsnAla: 2.672 ± 0.042
0.174AsnCys: 0.174 ± 0.012
1.104AsnAsp: 1.104 ± 0.032
0.974AsnGlu: 0.974 ± 0.029
0.71AsnPhe: 0.71 ± 0.024
1.933AsnGly: 1.933 ± 0.039
0.393AsnHis: 0.393 ± 0.016
0.999AsnIle: 0.999 ± 0.029
0.529AsnLys: 0.529 ± 0.019
2.214AsnLeu: 2.214 ± 0.036
0.431AsnMet: 0.431 ± 0.016
0.492AsnAsn: 0.492 ± 0.02
1.614AsnPro: 1.614 ± 0.036
0.547AsnGln: 0.547 ± 0.019
1.628AsnArg: 1.628 ± 0.037
0.915AsnSer: 0.915 ± 0.026
0.994AsnThr: 0.994 ± 0.027
1.685AsnVal: 1.685 ± 0.036
0.337AsnTrp: 0.337 ± 0.015
0.515AsnTyr: 0.515 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.75ProAla: 7.75 ± 0.082
0.306ProCys: 0.306 ± 0.015
4.119ProAsp: 4.119 ± 0.051
3.8ProGlu: 3.8 ± 0.057
2.064ProPhe: 2.064 ± 0.043
5.419ProGly: 5.419 ± 0.06
1.084ProHis: 1.084 ± 0.027
2.652ProIle: 2.652 ± 0.043
1.656ProLys: 1.656 ± 0.031
5.016ProLeu: 5.016 ± 0.069
1.161ProMet: 1.161 ± 0.031
1.304ProAsn: 1.304 ± 0.031
3.378ProPro: 3.378 ± 0.067
1.459ProGln: 1.459 ± 0.031
3.567ProArg: 3.567 ± 0.057
3.342ProSer: 3.342 ± 0.051
2.688ProThr: 2.688 ± 0.042
4.422ProVal: 4.422 ± 0.066
0.747ProTrp: 0.747 ± 0.025
1.128ProTyr: 1.128 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.789GlnAla: 3.789 ± 0.06
0.149GlnCys: 0.149 ± 0.009
1.359GlnAsp: 1.359 ± 0.032
1.304GlnGlu: 1.304 ± 0.03
0.823GlnPhe: 0.823 ± 0.025
2.206GlnGly: 2.206 ± 0.039
0.518GlnHis: 0.518 ± 0.018
1.516GlnIle: 1.516 ± 0.032
0.788GlnLys: 0.788 ± 0.022
2.274GlnLeu: 2.274 ± 0.043
0.681GlnMet: 0.681 ± 0.021
0.688GlnAsn: 0.688 ± 0.021
1.639GlnPro: 1.639 ± 0.038
0.856GlnGln: 0.856 ± 0.029
2.138GlnArg: 2.138 ± 0.038
1.431GlnSer: 1.431 ± 0.029
1.442GlnThr: 1.442 ± 0.03
1.961GlnVal: 1.961 ± 0.035
0.291GlnTrp: 0.291 ± 0.013
0.454GlnTyr: 0.454 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.253ArgAla: 9.253 ± 0.102
0.507ArgCys: 0.507 ± 0.019
4.708ArgAsp: 4.708 ± 0.065
4.783ArgGlu: 4.783 ± 0.064
3.13ArgPhe: 3.13 ± 0.045
5.909ArgGly: 5.909 ± 0.073
1.804ArgHis: 1.804 ± 0.038
4.571ArgIle: 4.571 ± 0.064
1.908ArgLys: 1.908 ± 0.038
9.127ArgLeu: 9.127 ± 0.098
1.913ArgMet: 1.913 ± 0.034
1.668ArgAsn: 1.668 ± 0.035
4.744ArgPro: 4.744 ± 0.062
2.38ArgGln: 2.38 ± 0.044
7.533ArgArg: 7.533 ± 0.089
4.336ArgSer: 4.336 ± 0.062
3.82ArgThr: 3.82 ± 0.056
5.33ArgVal: 5.33 ± 0.059
1.068ArgTrp: 1.068 ± 0.025
1.778ArgTyr: 1.778 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.421SerAla: 6.421 ± 0.077
0.408SerCys: 0.408 ± 0.017
2.862SerAsp: 2.862 ± 0.044
2.665SerGlu: 2.665 ± 0.047
2.269SerPhe: 2.269 ± 0.047
5.797SerGly: 5.797 ± 0.061
0.974SerHis: 0.974 ± 0.026
2.598SerIle: 2.598 ± 0.041
1.293SerLys: 1.293 ± 0.032
5.561SerLeu: 5.561 ± 0.066
1.163SerMet: 1.163 ± 0.028
1.065SerAsn: 1.065 ± 0.032
3.116SerPro: 3.116 ± 0.047
1.299SerGln: 1.299 ± 0.033
4.11SerArg: 4.11 ± 0.059
2.892SerSer: 2.892 ± 0.05
2.534SerThr: 2.534 ± 0.045
3.989SerVal: 3.989 ± 0.06
0.763SerTrp: 0.763 ± 0.021
1.23SerTyr: 1.23 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
6.194ThrAla: 6.194 ± 0.062
0.387ThrCys: 0.387 ± 0.015
2.552ThrAsp: 2.552 ± 0.041
2.439ThrGlu: 2.439 ± 0.041
1.935ThrPhe: 1.935 ± 0.036
5.293ThrGly: 5.293 ± 0.066
0.884ThrHis: 0.884 ± 0.025
3.027ThrIle: 3.027 ± 0.047
1.388ThrLys: 1.388 ± 0.032
5.673ThrLeu: 5.673 ± 0.066
1.145ThrMet: 1.145 ± 0.029
1.094ThrAsn: 1.094 ± 0.032
3.15ThrPro: 3.15 ± 0.047
1.191ThrGln: 1.191 ± 0.033
3.56ThrArg: 3.56 ± 0.052
2.767ThrSer: 2.767 ± 0.046
2.919ThrThr: 2.919 ± 0.046
4.151ThrVal: 4.151 ± 0.053
0.659ThrTrp: 0.659 ± 0.02
1.117ThrTyr: 1.117 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
10.07ValAla: 10.07 ± 0.094
0.611ValCys: 0.611 ± 0.022
3.966ValAsp: 3.966 ± 0.055
4.776ValGlu: 4.776 ± 0.055
2.782ValPhe: 2.782 ± 0.043
5.873ValGly: 5.873 ± 0.068
1.281ValHis: 1.281 ± 0.028
3.633ValIle: 3.633 ± 0.054
1.983ValLys: 1.983 ± 0.041
7.763ValLeu: 7.763 ± 0.076
1.757ValMet: 1.757 ± 0.033
1.675ValAsn: 1.675 ± 0.037
4.296ValPro: 4.296 ± 0.062
1.925ValGln: 1.925 ± 0.037
5.264ValArg: 5.264 ± 0.065
4.4ValSer: 4.4 ± 0.058
4.42ValThr: 4.42 ± 0.055
6.515ValVal: 6.515 ± 0.069
0.867ValTrp: 0.867 ± 0.022
1.388ValTyr: 1.388 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.303TrpAla: 1.303 ± 0.031
0.122TrpCys: 0.122 ± 0.009
0.635TrpAsp: 0.635 ± 0.019
0.517TrpGlu: 0.517 ± 0.016
0.517TrpPhe: 0.517 ± 0.018
0.956TrpGly: 0.956 ± 0.027
0.324TrpHis: 0.324 ± 0.016
0.629TrpIle: 0.629 ± 0.023
0.368TrpLys: 0.368 ± 0.017
1.599TrpLeu: 1.599 ± 0.035
0.322TrpMet: 0.322 ± 0.013
0.369TrpAsn: 0.369 ± 0.016
0.757TrpPro: 0.757 ± 0.025
0.465TrpGln: 0.465 ± 0.018
1.256TrpArg: 1.256 ± 0.028
0.834TrpSer: 0.834 ± 0.024
0.823TrpThr: 0.823 ± 0.024
0.7TrpVal: 0.7 ± 0.021
0.205TrpTrp: 0.205 ± 0.011
0.277TrpTyr: 0.277 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.481TyrAla: 2.481 ± 0.041
0.202TyrCys: 0.202 ± 0.01
1.341TyrAsp: 1.341 ± 0.028
1.148TyrGlu: 1.148 ± 0.027
0.744TyrPhe: 0.744 ± 0.024
2.112TyrGly: 2.112 ± 0.042
0.415TyrHis: 0.415 ± 0.015
0.673TyrIle: 0.673 ± 0.022
0.504TyrLys: 0.504 ± 0.02
2.169TyrLeu: 2.169 ± 0.04
0.344TyrMet: 0.344 ± 0.016
0.464TyrAsn: 0.464 ± 0.019
1.115TyrPro: 1.115 ± 0.028
0.535TyrGln: 0.535 ± 0.019
1.876TyrArg: 1.876 ± 0.038
1.01TyrSer: 1.01 ± 0.025
0.946TyrThr: 0.946 ± 0.025
1.536TyrVal: 1.536 ± 0.035
0.342TyrTrp: 0.342 ± 0.016
0.53TyrTyr: 0.53 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4822 proteins (1527424 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski