Amino acid dipepetide frequency for Altererythrobacter sp. Root672

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.58AlaAla: 16.58 ± 0.193	0.993AlaCys: 0.993 ± 0.034	6.736AlaAsp: 6.736 ± 0.073	8.206AlaGlu: 8.206 ± 0.119	4.22AlaPhe: 4.22 ± 0.061	10.831AlaGly: 10.831 ± 0.122	1.989AlaHis: 1.989 ± 0.046	6.234AlaIle: 6.234 ± 0.087	4.007AlaLys: 4.007 ± 0.078	13.209AlaLeu: 13.209 ± 0.151	3.495AlaMet: 3.495 ± 0.069	3.321AlaAsn: 3.321 ± 0.062	5.594AlaPro: 5.594 ± 0.092	4.567AlaGln: 4.567 ± 0.07	8.39AlaArg: 8.39 ± 0.099	6.587AlaSer: 6.587 ± 0.082	6.168AlaThr: 6.168 ± 0.091	8.42AlaVal: 8.42 ± 0.115	1.643AlaTrp: 1.643 ± 0.038	2.537AlaTyr: 2.537 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.907CysAla: 0.907 ± 0.031	0.1CysCys: 0.1 ± 0.009	0.544CysAsp: 0.544 ± 0.019	0.47CysGlu: 0.47 ± 0.022	0.286CysPhe: 0.286 ± 0.021	0.862CysGly: 0.862 ± 0.032	0.23CysHis: 0.23 ± 0.022	0.317CysIle: 0.317 ± 0.018	0.169CysLys: 0.169 ± 0.013	0.711CysLeu: 0.711 ± 0.027	0.16CysMet: 0.16 ± 0.013	0.22CysAsn: 0.22 ± 0.014	0.413CysPro: 0.413 ± 0.02	0.201CysGln: 0.201 ± 0.013	0.544CysArg: 0.544 ± 0.026	0.496CysSer: 0.496 ± 0.024	0.407CysThr: 0.407 ± 0.02	0.558CysVal: 0.558 ± 0.027	0.098CysTrp: 0.098 ± 0.01	0.172CysTyr: 0.172 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.749AspAla: 6.749 ± 0.099	0.513AspCys: 0.513 ± 0.022	3.076AspAsp: 3.076 ± 0.057	3.751AspGlu: 3.751 ± 0.073	2.272AspPhe: 2.272 ± 0.048	5.463AspGly: 5.463 ± 0.072	1.194AspHis: 1.194 ± 0.04	2.689AspIle: 2.689 ± 0.052	1.788AspLys: 1.788 ± 0.042	5.763AspLeu: 5.763 ± 0.08	1.25AspMet: 1.25 ± 0.035	1.467AspAsn: 1.467 ± 0.043	3.898AspPro: 3.898 ± 0.056	1.851AspGln: 1.851 ± 0.046	4.452AspArg: 4.452 ± 0.066	2.49AspSer: 2.49 ± 0.053	2.611AspThr: 2.611 ± 0.053	3.911AspVal: 3.911 ± 0.07	1.164AspTrp: 1.164 ± 0.033	1.58AspTyr: 1.58 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.247GluAla: 8.247 ± 0.12	0.357GluCys: 0.357 ± 0.019	3.155GluAsp: 3.155 ± 0.054	3.619GluGlu: 3.619 ± 0.071	2.048GluPhe: 2.048 ± 0.042	5.063GluGly: 5.063 ± 0.074	1.221GluHis: 1.221 ± 0.035	3.184GluIle: 3.184 ± 0.057	2.046GluLys: 2.046 ± 0.043	6.024GluLeu: 6.024 ± 0.087	1.471GluMet: 1.471 ± 0.037	1.58GluAsn: 1.58 ± 0.039	3.009GluPro: 3.009 ± 0.06	2.431GluGln: 2.431 ± 0.049	5.312GluArg: 5.312 ± 0.092	2.495GluSer: 2.495 ± 0.058	3.254GluThr: 3.254 ± 0.049	4.374GluVal: 4.374 ± 0.071	0.988GluTrp: 0.988 ± 0.027	1.179GluTyr: 1.179 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.916PheAla: 4.916 ± 0.074	0.314PheCys: 0.314 ± 0.018	2.798PheAsp: 2.798 ± 0.054	2.331PheGlu: 2.331 ± 0.038	1.3PhePhe: 1.3 ± 0.033	3.865PheGly: 3.865 ± 0.069	0.73PheHis: 0.73 ± 0.027	1.459PheIle: 1.459 ± 0.037	0.93PheLys: 0.93 ± 0.03	3.139PheLeu: 3.139 ± 0.058	0.783PheMet: 0.783 ± 0.027	1.12PheAsn: 1.12 ± 0.036	1.662PhePro: 1.662 ± 0.042	0.997PheGln: 0.997 ± 0.036	2.289PheArg: 2.289 ± 0.047	2.163PheSer: 2.163 ± 0.047	2.138PheThr: 2.138 ± 0.044	2.755PheVal: 2.755 ± 0.047	0.561PheTrp: 0.561 ± 0.024	0.941PheTyr: 0.941 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.341GlyAla: 9.341 ± 0.094	0.798GlyCys: 0.798 ± 0.032	4.785GlyAsp: 4.785 ± 0.064	5.374GlyGlu: 5.374 ± 0.075	3.638GlyPhe: 3.638 ± 0.062	7.915GlyGly: 7.915 ± 0.126	1.819GlyHis: 1.819 ± 0.045	4.37GlyIle: 4.37 ± 0.068	3.549GlyLys: 3.549 ± 0.068	8.862GlyLeu: 8.862 ± 0.092	2.292GlyMet: 2.292 ± 0.039	2.521GlyAsn: 2.521 ± 0.06	3.984GlyPro: 3.984 ± 0.067	3.173GlyGln: 3.173 ± 0.057	6.17GlyArg: 6.17 ± 0.082	5.301GlySer: 5.301 ± 0.09	5.039GlyThr: 5.039 ± 0.097	6.313GlyVal: 6.313 ± 0.09	1.682GlyTrp: 1.682 ± 0.044	2.311GlyTyr: 2.311 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.052HisAla: 2.052 ± 0.051	0.244HisCys: 0.244 ± 0.015	1.128HisAsp: 1.128 ± 0.032	1.119HisGlu: 1.119 ± 0.035	0.824HisPhe: 0.824 ± 0.026	1.84HisGly: 1.84 ± 0.044	0.513HisHis: 0.513 ± 0.024	0.841HisIle: 0.841 ± 0.03	0.461HisLys: 0.461 ± 0.02	1.824HisLeu: 1.824 ± 0.047	0.418HisMet: 0.418 ± 0.021	0.491HisAsn: 0.491 ± 0.023	1.292HisPro: 1.292 ± 0.038	0.577HisGln: 0.577 ± 0.025	1.355HisArg: 1.355 ± 0.035	1.041HisSer: 1.041 ± 0.036	0.802HisThr: 0.802 ± 0.029	1.364HisVal: 1.364 ± 0.035	0.357HisTrp: 0.357 ± 0.02	0.545HisTyr: 0.545 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.908IleAla: 6.908 ± 0.104	0.425IleCys: 0.425 ± 0.021	3.632IleAsp: 3.632 ± 0.059	3.832IleGlu: 3.832 ± 0.06	1.462IlePhe: 1.462 ± 0.038	4.943IleGly: 4.943 ± 0.073	0.857IleHis: 0.857 ± 0.027	1.798IleIle: 1.798 ± 0.047	1.224IleLys: 1.224 ± 0.038	3.794IleLeu: 3.794 ± 0.068	0.846IleMet: 0.846 ± 0.03	1.402IleAsn: 1.402 ± 0.043	2.315IlePro: 2.315 ± 0.047	1.222IleGln: 1.222 ± 0.035	3.015IleArg: 3.015 ± 0.057	2.588IleSer: 2.588 ± 0.052	2.5IleThr: 2.5 ± 0.049	3.957IleVal: 3.957 ± 0.066	0.604IleTrp: 0.604 ± 0.024	1.08IleTyr: 1.08 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.797LysAla: 3.797 ± 0.068	0.166LysCys: 0.166 ± 0.013	1.639LysAsp: 1.639 ± 0.051	1.394LysGlu: 1.394 ± 0.037	0.983LysPhe: 0.983 ± 0.03	2.593LysGly: 2.593 ± 0.05	0.554LysHis: 0.554 ± 0.025	1.514LysIle: 1.514 ± 0.042	1.079LysLys: 1.079 ± 0.037	3.338LysLeu: 3.338 ± 0.059	0.699LysMet: 0.699 ± 0.027	0.752LysAsn: 0.752 ± 0.028	1.969LysPro: 1.969 ± 0.053	0.936LysGln: 0.936 ± 0.031	2.254LysArg: 2.254 ± 0.052	1.553LysSer: 1.553 ± 0.042	1.677LysThr: 1.677 ± 0.037	2.393LysVal: 2.393 ± 0.053	0.416LysTrp: 0.416 ± 0.022	0.639LysTyr: 0.639 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.146LeuAla: 14.146 ± 0.154	0.721LeuCys: 0.721 ± 0.027	6.069LeuAsp: 6.069 ± 0.077	5.691LeuGlu: 5.691 ± 0.098	3.727LeuPhe: 3.727 ± 0.073	8.463LeuGly: 8.463 ± 0.097	1.718LeuHis: 1.718 ± 0.044	4.61LeuIle: 4.61 ± 0.074	3.075LeuLys: 3.075 ± 0.056	9.747LeuLeu: 9.747 ± 0.162	2.092LeuMet: 2.092 ± 0.045	2.499LeuAsn: 2.499 ± 0.057	5.546LeuPro: 5.546 ± 0.072	2.804LeuGln: 2.804 ± 0.05	6.698LeuArg: 6.698 ± 0.086	6.071LeuSer: 6.071 ± 0.08	5.711LeuThr: 5.711 ± 0.083	7.602LeuVal: 7.602 ± 0.101	1.218LeuTrp: 1.218 ± 0.034	1.971LeuTyr: 1.971 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.915MetAla: 2.915 ± 0.058	0.129MetCys: 0.129 ± 0.011	1.105MetAsp: 1.105 ± 0.03	1.081MetGlu: 1.081 ± 0.028	0.694MetPhe: 0.694 ± 0.023	1.871MetGly: 1.871 ± 0.041	0.453MetHis: 0.453 ± 0.019	1.227MetIle: 1.227 ± 0.037	0.895MetLys: 0.895 ± 0.029	2.455MetLeu: 2.455 ± 0.056	0.538MetMet: 0.538 ± 0.026	0.672MetAsn: 0.672 ± 0.025	1.457MetPro: 1.457 ± 0.037	0.735MetGln: 0.735 ± 0.027	1.739MetArg: 1.739 ± 0.04	1.417MetSer: 1.417 ± 0.037	1.614MetThr: 1.614 ± 0.04	1.627MetVal: 1.627 ± 0.035	0.242MetTrp: 0.242 ± 0.016	0.275MetTyr: 0.275 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.109AsnAla: 3.109 ± 0.051	0.262AsnCys: 0.262 ± 0.016	1.435AsnAsp: 1.435 ± 0.042	1.32AsnGlu: 1.32 ± 0.036	1.086AsnPhe: 1.086 ± 0.038	2.716AsnGly: 2.716 ± 0.066	0.493AsnHis: 0.493 ± 0.021	1.226AsnIle: 1.226 ± 0.036	0.643AsnLys: 0.643 ± 0.024	2.7AsnLeu: 2.7 ± 0.057	0.554AsnMet: 0.554 ± 0.021	0.796AsnAsn: 0.796 ± 0.034	1.977AsnPro: 1.977 ± 0.051	0.857AsnGln: 0.857 ± 0.031	1.936AsnArg: 1.936 ± 0.04	1.49AsnSer: 1.49 ± 0.042	1.324AsnThr: 1.324 ± 0.045	1.999AsnVal: 1.999 ± 0.041	0.499AsnTrp: 0.499 ± 0.021	0.764AsnTyr: 0.764 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.574ProAla: 6.574 ± 0.094	0.336ProCys: 0.336 ± 0.02	3.681ProAsp: 3.681 ± 0.059	4.016ProGlu: 4.016 ± 0.071	2.024ProPhe: 2.024 ± 0.048	4.891ProGly: 4.891 ± 0.087	1.005ProHis: 1.005 ± 0.031	2.514ProIle: 2.514 ± 0.043	1.577ProLys: 1.577 ± 0.045	4.956ProLeu: 4.956 ± 0.077	1.163ProMet: 1.163 ± 0.034	1.534ProAsn: 1.534 ± 0.045	2.836ProPro: 2.836 ± 0.079	1.887ProGln: 1.887 ± 0.046	2.888ProArg: 2.888 ± 0.058	2.906ProSer: 2.906 ± 0.05	2.733ProThr: 2.733 ± 0.103	4.24ProVal: 4.24 ± 0.07	0.709ProTrp: 0.709 ± 0.026	1.157ProTyr: 1.157 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.319GlnAla: 4.319 ± 0.068	0.236GlnCys: 0.236 ± 0.016	1.608GlnAsp: 1.608 ± 0.037	1.602GlnGlu: 1.602 ± 0.039	1.281GlnPhe: 1.281 ± 0.043	2.696GlnGly: 2.696 ± 0.052	0.645GlnHis: 0.645 ± 0.022	1.67GlnIle: 1.67 ± 0.045	0.869GlnLys: 0.869 ± 0.027	3.504GlnLeu: 3.504 ± 0.065	0.832GlnMet: 0.832 ± 0.029	0.753GlnAsn: 0.753 ± 0.029	1.9GlnPro: 1.9 ± 0.04	1.363GlnGln: 1.363 ± 0.039	2.5GlnArg: 2.5 ± 0.05	1.711GlnSer: 1.711 ± 0.041	1.639GlnThr: 1.639 ± 0.042	2.674GlnVal: 2.674 ± 0.052	0.489GlnTrp: 0.489 ± 0.021	0.728GlnTyr: 0.728 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.602ArgAla: 7.602 ± 0.089	0.502ArgCys: 0.502 ± 0.022	4.009ArgAsp: 4.009 ± 0.057	4.645ArgGlu: 4.645 ± 0.078	3.006ArgPhe: 3.006 ± 0.056	5.036ArgGly: 5.036 ± 0.078	1.564ArgHis: 1.564 ± 0.041	3.765ArgIle: 3.765 ± 0.048	2.189ArgLys: 2.189 ± 0.052	7.739ArgLeu: 7.739 ± 0.103	1.798ArgMet: 1.798 ± 0.049	1.922ArgAsn: 1.922 ± 0.048	3.493ArgPro: 3.493 ± 0.063	2.519ArgGln: 2.519 ± 0.051	5.144ArgArg: 5.144 ± 0.083	3.72ArgSer: 3.72 ± 0.063	3.365ArgThr: 3.365 ± 0.061	4.741ArgVal: 4.741 ± 0.071	1.202ArgTrp: 1.202 ± 0.034	1.796ArgTyr: 1.796 ± 0.039	0.001ArgXaa: 0.001 ± 0.001
Ser	6.349SerAla: 6.349 ± 0.088	0.435SerCys: 0.435 ± 0.023	3.063SerAsp: 3.063 ± 0.056	3.03SerGlu: 3.03 ± 0.056	2.31SerPhe: 2.31 ± 0.045	5.675SerGly: 5.675 ± 0.077	1.01SerHis: 1.01 ± 0.031	2.671SerIle: 2.671 ± 0.048	1.47SerLys: 1.47 ± 0.04	5.468SerLeu: 5.468 ± 0.081	1.2SerMet: 1.2 ± 0.032	1.524SerAsn: 1.524 ± 0.043	2.958SerPro: 2.958 ± 0.056	1.739SerGln: 1.739 ± 0.039	3.62SerArg: 3.62 ± 0.061	3.007SerSer: 3.007 ± 0.065	2.788SerThr: 2.788 ± 0.053	3.778SerVal: 3.778 ± 0.063	0.88SerTrp: 0.88 ± 0.03	1.386SerTyr: 1.386 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.257ThrAla: 6.257 ± 0.094	0.394ThrCys: 0.394 ± 0.018	2.938ThrAsp: 2.938 ± 0.059	2.762ThrGlu: 2.762 ± 0.05	1.936ThrPhe: 1.936 ± 0.045	5.453ThrGly: 5.453 ± 0.099	0.964ThrHis: 0.964 ± 0.032	2.764ThrIle: 2.764 ± 0.055	1.3ThrLys: 1.3 ± 0.04	5.587ThrLeu: 5.587 ± 0.078	1.182ThrMet: 1.182 ± 0.034	1.441ThrAsn: 1.441 ± 0.037	3.384ThrPro: 3.384 ± 0.1	1.542ThrGln: 1.542 ± 0.042	3.252ThrArg: 3.252 ± 0.048	2.833ThrSer: 2.833 ± 0.048	2.75ThrThr: 2.75 ± 0.06	4.263ThrVal: 4.263 ± 0.079	0.717ThrTrp: 0.717 ± 0.031	1.268ThrTyr: 1.268 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.994ValAla: 8.994 ± 0.113	0.579ValCys: 0.579 ± 0.024	4.217ValAsp: 4.217 ± 0.064	4.847ValGlu: 4.847 ± 0.076	2.551ValPhe: 2.551 ± 0.047	5.883ValGly: 5.883 ± 0.091	1.292ValHis: 1.292 ± 0.036	3.925ValIle: 3.925 ± 0.069	2.038ValLys: 2.038 ± 0.053	7.169ValLeu: 7.169 ± 0.094	1.586ValMet: 1.586 ± 0.039	2.01ValAsn: 2.01 ± 0.046	4.093ValPro: 4.093 ± 0.064	2.211ValGln: 2.211 ± 0.048	4.979ValArg: 4.979 ± 0.068	4.249ValSer: 4.249 ± 0.064	4.547ValThr: 4.547 ± 0.064	5.715ValVal: 5.715 ± 0.076	0.947ValTrp: 0.947 ± 0.027	1.364ValTyr: 1.364 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.455TrpAla: 1.455 ± 0.039	0.128TrpCys: 0.128 ± 0.011	0.765TrpAsp: 0.765 ± 0.026	0.696TrpGlu: 0.696 ± 0.029	0.615TrpPhe: 0.615 ± 0.027	1.035TrpGly: 1.035 ± 0.03	0.36TrpHis: 0.36 ± 0.018	0.726TrpIle: 0.726 ± 0.029	0.47TrpLys: 0.47 ± 0.022	1.907TrpLeu: 1.907 ± 0.049	0.375TrpMet: 0.375 ± 0.018	0.528TrpAsn: 0.528 ± 0.024	0.741TrpPro: 0.741 ± 0.03	0.682TrpGln: 0.682 ± 0.026	1.318TrpArg: 1.318 ± 0.036	0.921TrpSer: 0.921 ± 0.031	0.805TrpThr: 0.805 ± 0.027	0.923TrpVal: 0.923 ± 0.031	0.261TrpTrp: 0.261 ± 0.015	0.333TrpTyr: 0.333 ± 0.019	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.51TyrAla: 2.51 ± 0.046	0.234TyrCys: 0.234 ± 0.013	1.546TyrAsp: 1.546 ± 0.043	1.273TyrGlu: 1.273 ± 0.036	0.927TyrPhe: 0.927 ± 0.034	2.142TyrGly: 2.142 ± 0.045	0.479TyrHis: 0.479 ± 0.02	0.9TyrIle: 0.9 ± 0.028	0.565TyrLys: 0.565 ± 0.02	2.283TyrLeu: 2.283 ± 0.046	0.405TyrMet: 0.405 ± 0.022	0.631TyrAsn: 0.631 ± 0.027	1.103TyrPro: 1.103 ± 0.032	0.723TyrGln: 0.723 ± 0.024	1.907TyrArg: 1.907 ± 0.047	1.323TyrSer: 1.323 ± 0.042	1.116TyrThr: 1.116 ± 0.034	1.591TyrVal: 1.591 ± 0.046	0.369TyrTrp: 0.369 ± 0.019	0.622TyrTyr: 0.622 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3454 proteins (1085735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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