Amino acid dipepetide frequency for Mahlapitsi orthoreovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.748AlaAla: 6.748 ± 1.357
1.35AlaCys: 1.35 ± 0.391
4.049AlaAsp: 4.049 ± 0.583
3.644AlaGlu: 3.644 ± 0.89
2.564AlaPhe: 2.564 ± 0.529
3.779AlaGly: 3.779 ± 0.323
0.945AlaHis: 0.945 ± 0.232
5.533AlaIle: 5.533 ± 0.84
2.969AlaLys: 2.969 ± 0.537
6.748AlaLeu: 6.748 ± 0.784
3.104AlaMet: 3.104 ± 0.887
4.588AlaAsn: 4.588 ± 1.6
3.644AlaPro: 3.644 ± 0.454
3.374AlaGln: 3.374 ± 0.617
4.453AlaArg: 4.453 ± 0.591
4.858AlaSer: 4.858 ± 0.911
5.533AlaThr: 5.533 ± 0.511
4.184AlaVal: 4.184 ± 0.347
1.08AlaTrp: 1.08 ± 0.538
2.834AlaTyr: 2.834 ± 0.579
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.22
0.135CysCys: 0.135 ± 0.141
1.215CysAsp: 1.215 ± 0.279
0.675CysGlu: 0.675 ± 0.355
0.135CysPhe: 0.135 ± 0.122
0.405CysGly: 0.405 ± 0.223
0.27CysHis: 0.27 ± 0.15
0.405CysIle: 0.405 ± 0.181
0.27CysLys: 0.27 ± 0.164
2.024CysLeu: 2.024 ± 0.448
0.675CysMet: 0.675 ± 0.248
0.81CysAsn: 0.81 ± 0.31
0.81CysPro: 0.81 ± 0.232
0.405CysGln: 0.405 ± 0.261
1.215CysArg: 1.215 ± 0.415
0.54CysSer: 0.54 ± 0.268
0.945CysThr: 0.945 ± 0.237
0.675CysVal: 0.675 ± 0.36
0.405CysTrp: 0.405 ± 0.154
0.81CysTyr: 0.81 ± 0.262
0.0CysXaa: 0.0 ± 0.0
Asp
3.104AspAla: 3.104 ± 0.639
0.675AspCys: 0.675 ± 0.253
5.128AspAsp: 5.128 ± 1.012
3.374AspGlu: 3.374 ± 0.534
2.024AspPhe: 2.024 ± 0.518
3.644AspGly: 3.644 ± 0.766
1.889AspHis: 1.889 ± 0.352
3.104AspIle: 3.104 ± 0.459
2.294AspLys: 2.294 ± 0.298
5.803AspLeu: 5.803 ± 1.105
1.215AspMet: 1.215 ± 0.431
2.834AspAsn: 2.834 ± 0.456
2.564AspPro: 2.564 ± 0.546
2.024AspGln: 2.024 ± 0.455
3.104AspArg: 3.104 ± 0.494
4.184AspSer: 4.184 ± 0.573
2.834AspThr: 2.834 ± 0.394
6.208AspVal: 6.208 ± 0.605
0.945AspTrp: 0.945 ± 0.408
2.429AspTyr: 2.429 ± 0.407
0.0AspXaa: 0.0 ± 0.0
Glu
4.049GluAla: 4.049 ± 0.56
0.54GluCys: 0.54 ± 0.21
2.159GluAsp: 2.159 ± 0.677
2.294GluGlu: 2.294 ± 0.354
1.08GluPhe: 1.08 ± 0.372
2.429GluGly: 2.429 ± 0.354
1.754GluHis: 1.754 ± 0.622
2.294GluIle: 2.294 ± 0.426
1.889GluLys: 1.889 ± 0.673
3.779GluLeu: 3.779 ± 0.558
1.619GluMet: 1.619 ± 0.485
2.564GluAsn: 2.564 ± 0.789
1.484GluPro: 1.484 ± 0.392
2.969GluGln: 2.969 ± 0.597
3.509GluArg: 3.509 ± 0.625
3.374GluSer: 3.374 ± 0.508
3.239GluThr: 3.239 ± 0.602
3.374GluVal: 3.374 ± 0.375
1.215GluTrp: 1.215 ± 0.328
1.484GluTyr: 1.484 ± 0.284
0.0GluXaa: 0.0 ± 0.0
Phe
1.08PheAla: 1.08 ± 0.166
0.81PheCys: 0.81 ± 0.229
1.889PheAsp: 1.889 ± 0.398
1.754PheGlu: 1.754 ± 0.487
1.215PhePhe: 1.215 ± 0.417
2.834PheGly: 2.834 ± 0.668
0.675PheHis: 0.675 ± 0.262
1.754PheIle: 1.754 ± 0.508
0.54PheLys: 0.54 ± 0.237
3.914PheLeu: 3.914 ± 0.553
1.215PheMet: 1.215 ± 0.349
2.564PheAsn: 2.564 ± 0.444
2.024PhePro: 2.024 ± 0.482
1.754PheGln: 1.754 ± 0.435
1.484PheArg: 1.484 ± 0.398
2.699PheSer: 2.699 ± 0.67
2.159PheThr: 2.159 ± 0.39
2.969PheVal: 2.969 ± 0.728
0.675PheTrp: 0.675 ± 0.386
1.619PheTyr: 1.619 ± 0.426
0.0PheXaa: 0.0 ± 0.0
Gly
4.723GlyAla: 4.723 ± 0.67
0.405GlyCys: 0.405 ± 0.34
2.564GlyAsp: 2.564 ± 0.413
2.429GlyGlu: 2.429 ± 0.68
1.889GlyPhe: 1.889 ± 0.329
2.294GlyGly: 2.294 ± 0.689
0.945GlyHis: 0.945 ± 0.253
2.294GlyIle: 2.294 ± 0.528
2.429GlyLys: 2.429 ± 0.522
4.453GlyLeu: 4.453 ± 0.899
2.159GlyMet: 2.159 ± 0.409
2.429GlyAsn: 2.429 ± 0.287
2.024GlyPro: 2.024 ± 0.38
1.619GlyGln: 1.619 ± 0.459
2.159GlyArg: 2.159 ± 0.358
3.509GlySer: 3.509 ± 0.579
2.159GlyThr: 2.159 ± 0.662
5.668GlyVal: 5.668 ± 1.089
0.81GlyTrp: 0.81 ± 0.306
1.484GlyTyr: 1.484 ± 0.478
0.0GlyXaa: 0.0 ± 0.0
His
2.159HisAla: 2.159 ± 0.498
0.135HisCys: 0.135 ± 0.128
2.024HisAsp: 2.024 ± 0.432
1.619HisGlu: 1.619 ± 0.346
1.754HisPhe: 1.754 ± 0.294
0.675HisGly: 0.675 ± 0.363
0.54HisHis: 0.54 ± 0.266
0.81HisIle: 0.81 ± 0.316
1.35HisLys: 1.35 ± 0.303
3.104HisLeu: 3.104 ± 0.698
0.135HisMet: 0.135 ± 0.119
1.215HisAsn: 1.215 ± 0.336
1.35HisPro: 1.35 ± 0.332
1.215HisGln: 1.215 ± 0.355
0.675HisArg: 0.675 ± 0.321
1.215HisSer: 1.215 ± 0.386
0.81HisThr: 0.81 ± 0.556
1.619HisVal: 1.619 ± 0.462
0.405HisTrp: 0.405 ± 0.213
0.945HisTyr: 0.945 ± 0.449
0.0HisXaa: 0.0 ± 0.0
Ile
4.453IleAla: 4.453 ± 0.782
0.405IleCys: 0.405 ± 0.175
3.779IleAsp: 3.779 ± 0.738
3.239IleGlu: 3.239 ± 0.743
1.889IlePhe: 1.889 ± 0.503
3.239IleGly: 3.239 ± 0.524
1.35IleHis: 1.35 ± 0.455
2.024IleIle: 2.024 ± 0.456
2.834IleLys: 2.834 ± 0.491
4.858IleLeu: 4.858 ± 0.771
2.024IleMet: 2.024 ± 0.815
3.644IleAsn: 3.644 ± 0.665
3.104IlePro: 3.104 ± 0.604
2.699IleGln: 2.699 ± 0.67
4.184IleArg: 4.184 ± 0.972
3.779IleSer: 3.779 ± 0.672
4.049IleThr: 4.049 ± 0.862
2.834IleVal: 2.834 ± 0.556
0.27IleTrp: 0.27 ± 0.176
2.024IleTyr: 2.024 ± 0.626
0.0IleXaa: 0.0 ± 0.0
Lys
2.834LysAla: 2.834 ± 0.393
0.81LysCys: 0.81 ± 0.401
2.564LysAsp: 2.564 ± 0.473
2.564LysGlu: 2.564 ± 0.711
1.35LysPhe: 1.35 ± 0.376
1.215LysGly: 1.215 ± 0.315
0.675LysHis: 0.675 ± 0.343
2.024LysIle: 2.024 ± 0.485
0.945LysLys: 0.945 ± 0.194
4.049LysLeu: 4.049 ± 0.481
0.675LysMet: 0.675 ± 0.2
1.35LysAsn: 1.35 ± 0.315
2.159LysPro: 2.159 ± 0.586
1.619LysGln: 1.619 ± 0.428
2.564LysArg: 2.564 ± 0.487
3.644LysSer: 3.644 ± 0.605
2.294LysThr: 2.294 ± 0.399
3.104LysVal: 3.104 ± 0.913
0.945LysTrp: 0.945 ± 0.452
2.294LysTyr: 2.294 ± 0.51
0.0LysXaa: 0.0 ± 0.0
Leu
6.613LeuAla: 6.613 ± 0.664
1.215LeuCys: 1.215 ± 0.279
7.018LeuAsp: 7.018 ± 0.775
3.779LeuGlu: 3.779 ± 0.314
3.374LeuPhe: 3.374 ± 0.411
3.644LeuGly: 3.644 ± 0.561
1.754LeuHis: 1.754 ± 0.401
5.938LeuIle: 5.938 ± 0.968
5.668LeuLys: 5.668 ± 1.288
8.772LeuLeu: 8.772 ± 0.705
3.509LeuMet: 3.509 ± 0.589
4.588LeuAsn: 4.588 ± 0.857
7.422LeuPro: 7.422 ± 0.825
3.509LeuGln: 3.509 ± 0.426
5.398LeuArg: 5.398 ± 0.939
8.637LeuSer: 8.637 ± 1.213
7.557LeuThr: 7.557 ± 0.743
4.993LeuVal: 4.993 ± 1.062
1.35LeuTrp: 1.35 ± 0.279
2.294LeuTyr: 2.294 ± 0.363
0.0LeuXaa: 0.0 ± 0.0
Met
2.564MetAla: 2.564 ± 0.464
0.405MetCys: 0.405 ± 0.142
0.945MetAsp: 0.945 ± 0.336
1.484MetGlu: 1.484 ± 0.391
1.215MetPhe: 1.215 ± 0.398
1.889MetGly: 1.889 ± 0.531
0.81MetHis: 0.81 ± 0.142
1.35MetIle: 1.35 ± 0.333
1.619MetLys: 1.619 ± 0.41
2.159MetLeu: 2.159 ± 0.609
1.619MetMet: 1.619 ± 0.301
1.889MetAsn: 1.889 ± 0.388
1.215MetPro: 1.215 ± 0.423
1.484MetGln: 1.484 ± 0.43
1.484MetArg: 1.484 ± 0.335
1.754MetSer: 1.754 ± 0.574
2.024MetThr: 2.024 ± 0.363
2.294MetVal: 2.294 ± 0.36
0.405MetTrp: 0.405 ± 0.253
1.35MetTyr: 1.35 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
4.723AsnAla: 4.723 ± 1.14
0.81AsnCys: 0.81 ± 0.308
2.294AsnAsp: 2.294 ± 0.443
2.699AsnGlu: 2.699 ± 0.554
1.754AsnPhe: 1.754 ± 0.445
1.889AsnGly: 1.889 ± 0.404
0.81AsnHis: 0.81 ± 0.407
3.104AsnIle: 3.104 ± 0.521
1.619AsnLys: 1.619 ± 0.299
5.398AsnLeu: 5.398 ± 0.81
0.945AsnMet: 0.945 ± 0.2
2.294AsnAsn: 2.294 ± 0.62
3.509AsnPro: 3.509 ± 0.823
1.619AsnGln: 1.619 ± 0.294
2.429AsnArg: 2.429 ± 0.49
2.159AsnSer: 2.159 ± 0.366
3.104AsnThr: 3.104 ± 0.802
6.748AsnVal: 6.748 ± 0.964
1.35AsnTrp: 1.35 ± 0.464
1.754AsnTyr: 1.754 ± 0.564
0.0AsnXaa: 0.0 ± 0.0
Pro
3.644ProAla: 3.644 ± 0.755
0.81ProCys: 0.81 ± 0.219
3.509ProAsp: 3.509 ± 0.689
1.889ProGlu: 1.889 ± 0.282
2.834ProPhe: 2.834 ± 0.484
2.834ProGly: 2.834 ± 0.795
0.945ProHis: 0.945 ± 0.337
4.049ProIle: 4.049 ± 0.997
1.484ProLys: 1.484 ± 0.314
7.018ProLeu: 7.018 ± 0.727
1.08ProMet: 1.08 ± 0.294
2.294ProAsn: 2.294 ± 0.545
3.509ProPro: 3.509 ± 0.716
1.35ProGln: 1.35 ± 0.41
2.969ProArg: 2.969 ± 0.521
5.263ProSer: 5.263 ± 0.492
4.318ProThr: 4.318 ± 0.774
4.318ProVal: 4.318 ± 0.744
0.945ProTrp: 0.945 ± 0.345
2.294ProTyr: 2.294 ± 0.417
0.0ProXaa: 0.0 ± 0.0
Gln
3.509GlnAla: 3.509 ± 0.599
0.405GlnCys: 0.405 ± 0.246
1.35GlnAsp: 1.35 ± 0.25
0.81GlnGlu: 0.81 ± 0.326
1.619GlnPhe: 1.619 ± 0.569
1.35GlnGly: 1.35 ± 0.525
1.08GlnHis: 1.08 ± 0.419
1.619GlnIle: 1.619 ± 0.325
0.81GlnLys: 0.81 ± 0.348
6.478GlnLeu: 6.478 ± 1.378
1.484GlnMet: 1.484 ± 0.247
1.889GlnAsn: 1.889 ± 0.417
1.889GlnPro: 1.889 ± 0.487
2.429GlnGln: 2.429 ± 0.364
2.699GlnArg: 2.699 ± 0.537
3.239GlnSer: 3.239 ± 0.841
2.429GlnThr: 2.429 ± 0.539
3.239GlnVal: 3.239 ± 0.216
0.945GlnTrp: 0.945 ± 0.321
1.619GlnTyr: 1.619 ± 0.365
0.0GlnXaa: 0.0 ± 0.0
Arg
5.938ArgAla: 5.938 ± 0.727
1.215ArgCys: 1.215 ± 0.46
2.699ArgAsp: 2.699 ± 0.657
2.564ArgGlu: 2.564 ± 0.526
1.484ArgPhe: 1.484 ± 0.341
3.374ArgGly: 3.374 ± 0.524
1.35ArgHis: 1.35 ± 0.495
3.644ArgIle: 3.644 ± 0.658
2.024ArgLys: 2.024 ± 0.857
3.509ArgLeu: 3.509 ± 0.563
1.619ArgMet: 1.619 ± 0.473
3.374ArgAsn: 3.374 ± 0.473
3.374ArgPro: 3.374 ± 0.377
2.294ArgGln: 2.294 ± 0.402
3.509ArgArg: 3.509 ± 0.447
3.914ArgSer: 3.914 ± 0.582
3.374ArgThr: 3.374 ± 0.71
4.723ArgVal: 4.723 ± 0.796
1.35ArgTrp: 1.35 ± 0.292
2.024ArgTyr: 2.024 ± 0.454
0.0ArgXaa: 0.0 ± 0.0
Ser
4.858SerAla: 4.858 ± 0.845
0.54SerCys: 0.54 ± 0.259
4.858SerAsp: 4.858 ± 0.66
4.184SerGlu: 4.184 ± 1.172
2.024SerPhe: 2.024 ± 0.391
3.644SerGly: 3.644 ± 0.991
1.484SerHis: 1.484 ± 0.439
4.318SerIle: 4.318 ± 0.667
2.969SerLys: 2.969 ± 0.379
6.748SerLeu: 6.748 ± 1.527
1.35SerMet: 1.35 ± 0.48
2.969SerAsn: 2.969 ± 0.637
3.914SerPro: 3.914 ± 0.363
2.294SerGln: 2.294 ± 0.382
5.128SerArg: 5.128 ± 0.42
4.858SerSer: 4.858 ± 1.258
3.779SerThr: 3.779 ± 0.548
5.398SerVal: 5.398 ± 0.815
0.945SerTrp: 0.945 ± 0.291
3.644SerTyr: 3.644 ± 0.769
0.0SerXaa: 0.0 ± 0.0
Thr
5.668ThrAla: 5.668 ± 0.758
0.945ThrCys: 0.945 ± 0.365
3.374ThrAsp: 3.374 ± 0.451
2.969ThrGlu: 2.969 ± 0.771
1.889ThrPhe: 1.889 ± 0.499
2.699ThrGly: 2.699 ± 0.522
1.889ThrHis: 1.889 ± 0.259
3.779ThrIle: 3.779 ± 0.85
1.619ThrLys: 1.619 ± 0.653
7.152ThrLeu: 7.152 ± 0.356
0.81ThrMet: 0.81 ± 0.263
2.834ThrAsn: 2.834 ± 0.77
3.779ThrPro: 3.779 ± 0.702
2.699ThrGln: 2.699 ± 0.467
2.834ThrArg: 2.834 ± 0.533
4.453ThrSer: 4.453 ± 0.813
3.644ThrThr: 3.644 ± 0.665
5.398ThrVal: 5.398 ± 1.02
0.945ThrTrp: 0.945 ± 0.265
2.699ThrTyr: 2.699 ± 0.436
0.0ThrXaa: 0.0 ± 0.0
Val
5.668ValAla: 5.668 ± 0.527
1.08ValCys: 1.08 ± 0.336
4.858ValAsp: 4.858 ± 1.1
4.049ValGlu: 4.049 ± 0.737
2.834ValPhe: 2.834 ± 0.345
3.644ValGly: 3.644 ± 0.608
2.834ValHis: 2.834 ± 0.364
5.398ValIle: 5.398 ± 0.794
2.834ValLys: 2.834 ± 0.668
5.938ValLeu: 5.938 ± 0.512
2.024ValMet: 2.024 ± 0.221
3.104ValAsn: 3.104 ± 0.426
6.208ValPro: 6.208 ± 0.675
3.104ValGln: 3.104 ± 0.555
4.318ValArg: 4.318 ± 0.931
5.128ValSer: 5.128 ± 0.732
4.588ValThr: 4.588 ± 0.897
5.668ValVal: 5.668 ± 0.75
1.619ValTrp: 1.619 ± 0.523
2.969ValTyr: 2.969 ± 0.948
0.0ValXaa: 0.0 ± 0.0
Trp
0.54TrpAla: 0.54 ± 0.359
0.135TrpCys: 0.135 ± 0.119
0.81TrpAsp: 0.81 ± 0.198
0.405TrpGlu: 0.405 ± 0.173
0.675TrpPhe: 0.675 ± 0.335
0.54TrpGly: 0.54 ± 0.187
0.135TrpHis: 0.135 ± 0.12
1.08TrpIle: 1.08 ± 0.306
1.215TrpLys: 1.215 ± 0.494
2.159TrpLeu: 2.159 ± 0.505
1.215TrpMet: 1.215 ± 0.309
0.945TrpAsn: 0.945 ± 0.313
1.35TrpPro: 1.35 ± 0.344
1.08TrpGln: 1.08 ± 0.283
1.35TrpArg: 1.35 ± 0.214
0.945TrpSer: 0.945 ± 0.218
0.675TrpThr: 0.675 ± 0.227
0.945TrpVal: 0.945 ± 0.361
0.27TrpTrp: 0.27 ± 0.226
0.945TrpTyr: 0.945 ± 0.293
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.564TyrAla: 2.564 ± 0.614
0.54TyrCys: 0.54 ± 0.274
2.294TyrAsp: 2.294 ± 0.64
0.81TyrGlu: 0.81 ± 0.456
2.024TyrPhe: 2.024 ± 0.659
2.429TyrGly: 2.429 ± 0.487
1.619TyrHis: 1.619 ± 0.567
2.159TyrIle: 2.159 ± 0.462
2.294TyrLys: 2.294 ± 0.855
2.969TyrLeu: 2.969 ± 0.525
1.35TyrMet: 1.35 ± 0.318
2.834TyrAsn: 2.834 ± 0.457
2.024TyrPro: 2.024 ± 0.585
1.35TyrGln: 1.35 ± 0.268
1.889TyrArg: 1.889 ± 0.226
1.754TyrSer: 1.754 ± 0.647
2.564TyrThr: 2.564 ± 0.405
3.509TyrVal: 3.509 ± 0.395
0.54TyrTrp: 0.54 ± 0.232
1.619TyrTyr: 1.619 ± 0.606
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (7411 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski