Amino acid dipepetide frequency for Roseovarius spongiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.544AlaAla: 18.544 ± 0.198	1.201AlaCys: 1.201 ± 0.033	7.384AlaAsp: 7.384 ± 0.091	8.548AlaGlu: 8.548 ± 0.11	4.327AlaPhe: 4.327 ± 0.069	11.458AlaGly: 11.458 ± 0.135	2.718AlaHis: 2.718 ± 0.05	5.926AlaIle: 5.926 ± 0.069	3.185AlaLys: 3.185 ± 0.056	15.077AlaLeu: 15.077 ± 0.143	3.765AlaMet: 3.765 ± 0.064	2.567AlaAsn: 2.567 ± 0.048	7.094AlaPro: 7.094 ± 0.107	4.545AlaGln: 4.545 ± 0.071	10.861AlaArg: 10.861 ± 0.125	5.409AlaSer: 5.409 ± 0.075	5.903AlaThr: 5.903 ± 0.081	8.221AlaVal: 8.221 ± 0.088	1.637AlaTrp: 1.637 ± 0.035	2.483AlaTyr: 2.483 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.208CysAla: 1.208 ± 0.035	0.119CysCys: 0.119 ± 0.011	0.655CysAsp: 0.655 ± 0.025	0.468CysGlu: 0.468 ± 0.019	0.341CysPhe: 0.341 ± 0.016	0.949CysGly: 0.949 ± 0.035	0.28CysHis: 0.28 ± 0.016	0.429CysIle: 0.429 ± 0.017	0.185CysLys: 0.185 ± 0.013	0.815CysLeu: 0.815 ± 0.025	0.17CysMet: 0.17 ± 0.012	0.218CysAsn: 0.218 ± 0.012	0.502CysPro: 0.502 ± 0.026	0.21CysGln: 0.21 ± 0.013	0.583CysArg: 0.583 ± 0.024	0.416CysSer: 0.416 ± 0.02	0.449CysThr: 0.449 ± 0.02	0.645CysVal: 0.645 ± 0.024	0.121CysTrp: 0.121 ± 0.01	0.225CysTyr: 0.225 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.984AspAla: 8.984 ± 0.108	0.547AspCys: 0.547 ± 0.02	3.828AspAsp: 3.828 ± 0.084	3.761AspGlu: 3.761 ± 0.056	2.296AspPhe: 2.296 ± 0.047	5.88AspGly: 5.88 ± 0.116	1.325AspHis: 1.325 ± 0.039	3.22AspIle: 3.22 ± 0.053	1.484AspLys: 1.484 ± 0.037	6.394AspLeu: 6.394 ± 0.083	1.829AspMet: 1.829 ± 0.04	1.165AspAsn: 1.165 ± 0.039	3.754AspPro: 3.754 ± 0.064	1.568AspGln: 1.568 ± 0.035	4.559AspArg: 4.559 ± 0.067	2.277AspSer: 2.277 ± 0.049	2.891AspThr: 2.891 ± 0.071	4.239AspVal: 4.239 ± 0.069	1.227AspTrp: 1.227 ± 0.037	1.515AspTyr: 1.515 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.173GluAla: 8.173 ± 0.094	0.402GluCys: 0.402 ± 0.017	3.543GluAsp: 3.543 ± 0.068	3.742GluGlu: 3.742 ± 0.074	1.858GluPhe: 1.858 ± 0.039	5.063GluGly: 5.063 ± 0.076	1.196GluHis: 1.196 ± 0.034	3.605GluIle: 3.605 ± 0.053	1.997GluLys: 1.997 ± 0.05	5.003GluLeu: 5.003 ± 0.074	1.922GluMet: 1.922 ± 0.044	1.64GluAsn: 1.64 ± 0.035	2.671GluPro: 2.671 ± 0.041	1.818GluGln: 1.818 ± 0.041	4.994GluArg: 4.994 ± 0.072	2.404GluSer: 2.404 ± 0.05	3.794GluThr: 3.794 ± 0.064	4.403GluVal: 4.403 ± 0.065	0.786GluTrp: 0.786 ± 0.027	1.064GluTyr: 1.064 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.583PheAla: 4.583 ± 0.067	0.406PheCys: 0.406 ± 0.02	2.873PheAsp: 2.873 ± 0.056	2.248PheGlu: 2.248 ± 0.046	1.402PhePhe: 1.402 ± 0.042	3.679PheGly: 3.679 ± 0.059	0.767PheHis: 0.767 ± 0.029	1.54PheIle: 1.54 ± 0.039	0.799PheLys: 0.799 ± 0.03	3.358PheLeu: 3.358 ± 0.068	0.829PheMet: 0.829 ± 0.028	0.955PheAsn: 0.955 ± 0.03	1.488PhePro: 1.488 ± 0.034	0.902PheGln: 0.902 ± 0.028	2.296PheArg: 2.296 ± 0.044	1.966PheSer: 1.966 ± 0.048	2.066PheThr: 2.066 ± 0.049	2.492PheVal: 2.492 ± 0.05	0.551PheTrp: 0.551 ± 0.023	0.937PheTyr: 0.937 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.939GlyAla: 11.939 ± 0.151	0.886GlyCys: 0.886 ± 0.028	5.292GlyAsp: 5.292 ± 0.099	4.962GlyGlu: 4.962 ± 0.078	3.648GlyPhe: 3.648 ± 0.054	8.225GlyGly: 8.225 ± 0.146	1.959GlyHis: 1.959 ± 0.044	4.28GlyIle: 4.28 ± 0.067	2.758GlyLys: 2.758 ± 0.059	9.038GlyLeu: 9.038 ± 0.104	2.796GlyMet: 2.796 ± 0.053	1.931GlyAsn: 1.931 ± 0.047	3.867GlyPro: 3.867 ± 0.062	2.918GlyGln: 2.918 ± 0.051	6.691GlyArg: 6.691 ± 0.08	3.984GlySer: 3.984 ± 0.061	4.025GlyThr: 4.025 ± 0.063	6.706GlyVal: 6.706 ± 0.082	1.557GlyTrp: 1.557 ± 0.036	2.295GlyTyr: 2.295 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.621HisAla: 2.621 ± 0.051	0.251HisCys: 0.251 ± 0.014	1.416HisAsp: 1.416 ± 0.038	1.184HisGlu: 1.184 ± 0.031	0.808HisPhe: 0.808 ± 0.029	2.014HisGly: 2.014 ± 0.044	0.598HisHis: 0.598 ± 0.029	0.886HisIle: 0.886 ± 0.027	0.423HisLys: 0.423 ± 0.02	2.064HisLeu: 2.064 ± 0.041	0.564HisMet: 0.564 ± 0.02	0.431HisAsn: 0.431 ± 0.02	1.418HisPro: 1.418 ± 0.039	0.522HisGln: 0.522 ± 0.021	1.411HisArg: 1.411 ± 0.035	0.881HisSer: 0.881 ± 0.028	0.785HisThr: 0.785 ± 0.025	1.646HisVal: 1.646 ± 0.043	0.372HisTrp: 0.372 ± 0.018	0.593HisTyr: 0.593 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.252IleAla: 7.252 ± 0.078	0.573IleCys: 0.573 ± 0.02	3.577IleAsp: 3.577 ± 0.061	3.655IleGlu: 3.655 ± 0.055	1.685IlePhe: 1.685 ± 0.036	4.825IleGly: 4.825 ± 0.069	0.859IleHis: 0.859 ± 0.03	2.1IleIle: 2.1 ± 0.046	1.228IleLys: 1.228 ± 0.036	4.555IleLeu: 4.555 ± 0.073	1.08IleMet: 1.08 ± 0.03	1.197IleAsn: 1.197 ± 0.038	2.33IlePro: 2.33 ± 0.049	1.008IleGln: 1.008 ± 0.032	3.364IleArg: 3.364 ± 0.056	2.504IleSer: 2.504 ± 0.051	2.723IleThr: 2.723 ± 0.052	3.788IleVal: 3.788 ± 0.066	0.632IleTrp: 0.632 ± 0.022	1.145IleTyr: 1.145 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.356LysAla: 3.356 ± 0.064	0.159LysCys: 0.159 ± 0.011	1.462LysAsp: 1.462 ± 0.036	1.397LysGlu: 1.397 ± 0.04	0.836LysPhe: 0.836 ± 0.025	2.362LysGly: 2.362 ± 0.053	0.577LysHis: 0.577 ± 0.023	1.337LysIle: 1.337 ± 0.04	1.024LysLys: 1.024 ± 0.041	2.608LysLeu: 2.608 ± 0.05	0.745LysMet: 0.745 ± 0.027	0.664LysAsn: 0.664 ± 0.025	1.58LysPro: 1.58 ± 0.041	0.79LysGln: 0.79 ± 0.027	2.188LysArg: 2.188 ± 0.045	1.553LysSer: 1.553 ± 0.043	1.607LysThr: 1.607 ± 0.042	1.879LysVal: 1.879 ± 0.047	0.337LysTrp: 0.337 ± 0.018	0.543LysTyr: 0.543 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.305LeuAla: 13.305 ± 0.148	1.016LeuCys: 1.016 ± 0.035	6.256LeuAsp: 6.256 ± 0.079	5.287LeuGlu: 5.287 ± 0.074	3.46LeuPhe: 3.46 ± 0.07	8.908LeuGly: 8.908 ± 0.113	2.025LeuHis: 2.025 ± 0.043	5.316LeuIle: 5.316 ± 0.075	2.749LeuLys: 2.749 ± 0.053	9.051LeuLeu: 9.051 ± 0.113	2.641LeuMet: 2.641 ± 0.051	2.494LeuAsn: 2.494 ± 0.046	5.627LeuPro: 5.627 ± 0.086	2.359LeuGln: 2.359 ± 0.044	8.025LeuArg: 8.025 ± 0.094	6.138LeuSer: 6.138 ± 0.082	5.753LeuThr: 5.753 ± 0.068	6.479LeuVal: 6.479 ± 0.086	1.411LeuTrp: 1.411 ± 0.038	1.957LeuTyr: 1.957 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.373MetAla: 3.373 ± 0.05	0.187MetCys: 0.187 ± 0.013	1.448MetAsp: 1.448 ± 0.033	1.35MetGlu: 1.35 ± 0.036	0.789MetPhe: 0.789 ± 0.023	2.275MetGly: 2.275 ± 0.048	0.468MetHis: 0.468 ± 0.021	1.562MetIle: 1.562 ± 0.037	0.971MetLys: 0.971 ± 0.031	2.764MetLeu: 2.764 ± 0.046	0.801MetMet: 0.801 ± 0.031	0.834MetAsn: 0.834 ± 0.03	1.512MetPro: 1.512 ± 0.036	1.058MetGln: 1.058 ± 0.027	2.153MetArg: 2.153 ± 0.044	1.66MetSer: 1.66 ± 0.036	2.105MetThr: 2.105 ± 0.044	1.814MetVal: 1.814 ± 0.044	0.246MetTrp: 0.246 ± 0.015	0.316MetTyr: 0.316 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.032AsnAla: 3.032 ± 0.048	0.228AsnCys: 0.228 ± 0.015	1.375AsnAsp: 1.375 ± 0.038	1.169AsnGlu: 1.169 ± 0.031	0.869AsnPhe: 0.869 ± 0.03	2.166AsnGly: 2.166 ± 0.048	0.47AsnHis: 0.47 ± 0.018	1.222AsnIle: 1.222 ± 0.034	0.542AsnLys: 0.542 ± 0.023	2.3AsnLeu: 2.3 ± 0.048	0.603AsnMet: 0.603 ± 0.025	0.575AsnAsn: 0.575 ± 0.028	1.685AsnPro: 1.685 ± 0.042	0.583AsnGln: 0.583 ± 0.021	1.712AsnArg: 1.712 ± 0.038	1.044AsnSer: 1.044 ± 0.03	1.214AsnThr: 1.214 ± 0.032	1.713AsnVal: 1.713 ± 0.04	0.419AsnTrp: 0.419 ± 0.021	0.589AsnTyr: 0.589 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.219ProAla: 6.219 ± 0.085	0.379ProCys: 0.379 ± 0.017	4.327ProAsp: 4.327 ± 0.068	4.347ProGlu: 4.347 ± 0.067	1.964ProPhe: 1.964 ± 0.042	5.011ProGly: 5.011 ± 0.073	1.09ProHis: 1.09 ± 0.03	2.141ProIle: 2.141 ± 0.044	1.416ProLys: 1.416 ± 0.04	4.754ProLeu: 4.754 ± 0.069	1.29ProMet: 1.29 ± 0.034	1.179ProAsn: 1.179 ± 0.033	2.695ProPro: 2.695 ± 0.061	1.458ProGln: 1.458 ± 0.035	3.314ProArg: 3.314 ± 0.061	2.299ProSer: 2.299 ± 0.045	2.193ProThr: 2.193 ± 0.039	4.18ProVal: 4.18 ± 0.057	0.669ProTrp: 0.669 ± 0.025	1.161ProTyr: 1.161 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.747GlnAla: 3.747 ± 0.061	0.199GlnCys: 0.199 ± 0.015	1.606GlnAsp: 1.606 ± 0.042	1.617GlnGlu: 1.617 ± 0.039	0.967GlnPhe: 0.967 ± 0.031	2.374GlnGly: 2.374 ± 0.044	0.551GlnHis: 0.551 ± 0.021	1.666GlnIle: 1.666 ± 0.042	0.892GlnLys: 0.892 ± 0.031	2.534GlnLeu: 2.534 ± 0.055	0.989GlnMet: 0.989 ± 0.032	0.742GlnAsn: 0.742 ± 0.027	1.478GlnPro: 1.478 ± 0.036	0.921GlnGln: 0.921 ± 0.028	2.126GlnArg: 2.126 ± 0.045	1.599GlnSer: 1.599 ± 0.034	1.694GlnThr: 1.694 ± 0.038	2.089GlnVal: 2.089 ± 0.047	0.392GlnTrp: 0.392 ± 0.02	0.532GlnTyr: 0.532 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.128ArgAla: 10.128 ± 0.117	0.546ArgCys: 0.546 ± 0.022	5.1ArgAsp: 5.1 ± 0.068	4.423ArgGlu: 4.423 ± 0.068	2.834ArgPhe: 2.834 ± 0.055	5.351ArgGly: 5.351 ± 0.068	1.71ArgHis: 1.71 ± 0.041	4.216ArgIle: 4.216 ± 0.055	2.201ArgLys: 2.201 ± 0.054	8.066ArgLeu: 8.066 ± 0.11	2.167ArgMet: 2.167 ± 0.045	1.85ArgAsn: 1.85 ± 0.034	3.618ArgPro: 3.618 ± 0.05	2.265ArgGln: 2.265 ± 0.051	6.204ArgArg: 6.204 ± 0.102	3.214ArgSer: 3.214 ± 0.052	3.237ArgThr: 3.237 ± 0.055	5.164ArgVal: 5.164 ± 0.069	1.011ArgTrp: 1.011 ± 0.028	1.743ArgTyr: 1.743 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.744SerAla: 5.744 ± 0.074	0.397SerCys: 0.397 ± 0.016	3.247SerAsp: 3.247 ± 0.057	2.721SerGlu: 2.721 ± 0.049	2.052SerPhe: 2.052 ± 0.042	5.308SerGly: 5.308 ± 0.073	1.0SerHis: 1.0 ± 0.027	2.233SerIle: 2.233 ± 0.049	1.242SerLys: 1.242 ± 0.039	4.585SerLeu: 4.585 ± 0.066	1.249SerMet: 1.249 ± 0.031	1.155SerAsn: 1.155 ± 0.033	2.407SerPro: 2.407 ± 0.044	1.31SerGln: 1.31 ± 0.037	3.166SerArg: 3.166 ± 0.057	2.251SerSer: 2.251 ± 0.058	2.169SerThr: 2.169 ± 0.047	3.595SerVal: 3.595 ± 0.061	0.675SerTrp: 0.675 ± 0.025	1.245SerTyr: 1.245 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.825ThrAla: 5.825 ± 0.071	0.465ThrCys: 0.465 ± 0.021	3.056ThrAsp: 3.056 ± 0.057	2.843ThrGlu: 2.843 ± 0.049	1.815ThrPhe: 1.815 ± 0.045	5.481ThrGly: 5.481 ± 0.076	1.09ThrHis: 1.09 ± 0.031	2.522ThrIle: 2.522 ± 0.046	1.154ThrLys: 1.154 ± 0.036	6.102ThrLeu: 6.102 ± 0.074	1.231ThrMet: 1.231 ± 0.031	1.114ThrAsn: 1.114 ± 0.037	3.316ThrPro: 3.316 ± 0.054	1.404ThrGln: 1.404 ± 0.036	3.687ThrArg: 3.687 ± 0.056	2.396ThrSer: 2.396 ± 0.046	2.56ThrThr: 2.56 ± 0.051	3.872ThrVal: 3.872 ± 0.064	0.661ThrTrp: 0.661 ± 0.023	1.22ThrTyr: 1.22 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.772ValAla: 8.772 ± 0.093	0.635ValCys: 0.635 ± 0.022	3.931ValAsp: 3.931 ± 0.063	4.389ValGlu: 4.389 ± 0.07	2.748ValPhe: 2.748 ± 0.046	5.31ValGly: 5.31 ± 0.069	1.359ValHis: 1.359 ± 0.037	4.214ValIle: 4.214 ± 0.068	1.831ValLys: 1.831 ± 0.05	7.211ValLeu: 7.211 ± 0.089	2.123ValMet: 2.123 ± 0.046	1.853ValAsn: 1.853 ± 0.043	3.245ValPro: 3.245 ± 0.047	1.939ValGln: 1.939 ± 0.038	4.635ValArg: 4.635 ± 0.057	3.946ValSer: 3.946 ± 0.061	4.718ValThr: 4.718 ± 0.074	5.212ValVal: 5.212 ± 0.085	0.958ValTrp: 0.958 ± 0.031	1.443ValTyr: 1.443 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.47TrpAla: 1.47 ± 0.039	0.149TrpCys: 0.149 ± 0.011	0.794TrpAsp: 0.794 ± 0.028	0.66TrpGlu: 0.66 ± 0.023	0.578TrpPhe: 0.578 ± 0.022	1.051TrpGly: 1.051 ± 0.027	0.315TrpHis: 0.315 ± 0.018	0.725TrpIle: 0.725 ± 0.026	0.428TrpLys: 0.428 ± 0.02	1.729TrpLeu: 1.729 ± 0.043	0.414TrpMet: 0.414 ± 0.019	0.41TrpAsn: 0.41 ± 0.018	0.713TrpPro: 0.713 ± 0.021	0.519TrpGln: 0.519 ± 0.021	1.364TrpArg: 1.364 ± 0.035	0.782TrpSer: 0.782 ± 0.028	0.826TrpThr: 0.826 ± 0.031	0.806TrpVal: 0.806 ± 0.03	0.256TrpTrp: 0.256 ± 0.015	0.267TrpTyr: 0.267 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.577TyrAla: 2.577 ± 0.046	0.243TyrCys: 0.243 ± 0.013	1.575TyrAsp: 1.575 ± 0.035	1.305TyrGlu: 1.305 ± 0.039	0.859TyrPhe: 0.859 ± 0.03	2.068TyrGly: 2.068 ± 0.044	0.532TyrHis: 0.532 ± 0.02	0.941TyrIle: 0.941 ± 0.026	0.494TyrLys: 0.494 ± 0.023	2.248TyrLeu: 2.248 ± 0.042	0.478TyrMet: 0.478 ± 0.021	0.537TyrAsn: 0.537 ± 0.021	1.086TyrPro: 1.086 ± 0.032	0.617TyrGln: 0.617 ± 0.022	1.715TyrArg: 1.715 ± 0.042	1.028TyrSer: 1.028 ± 0.03	1.102TyrThr: 1.102 ± 0.031	1.532TyrVal: 1.532 ± 0.039	0.335TyrTrp: 0.335 ± 0.019	0.597TyrTyr: 0.597 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3730 proteins (1211542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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