Amino acid dipepetide frequency for Fulvivirga imtechensis AK7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.067AlaAla: 5.067 ± 0.065
0.678AlaCys: 0.678 ± 0.024
3.869AlaAsp: 3.869 ± 0.051
4.456AlaGlu: 4.456 ± 0.055
3.36AlaPhe: 3.36 ± 0.046
5.276AlaGly: 5.276 ± 0.072
1.299AlaHis: 1.299 ± 0.032
5.238AlaIle: 5.238 ± 0.057
3.951AlaLys: 3.951 ± 0.063
6.813AlaLeu: 6.813 ± 0.078
1.638AlaMet: 1.638 ± 0.03
3.127AlaAsn: 3.127 ± 0.045
2.178AlaPro: 2.178 ± 0.043
2.451AlaGln: 2.451 ± 0.036
2.827AlaArg: 2.827 ± 0.043
4.42AlaSer: 4.42 ± 0.063
3.816AlaThr: 3.816 ± 0.054
4.682AlaVal: 4.682 ± 0.054
0.718AlaTrp: 0.718 ± 0.022
2.701AlaTyr: 2.701 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.435CysAla: 0.435 ± 0.016
0.117CysCys: 0.117 ± 0.009
0.403CysAsp: 0.403 ± 0.017
0.471CysGlu: 0.471 ± 0.018
0.383CysPhe: 0.383 ± 0.014
0.621CysGly: 0.621 ± 0.019
0.18CysHis: 0.18 ± 0.01
0.561CysIle: 0.561 ± 0.018
0.432CysLys: 0.432 ± 0.015
0.703CysLeu: 0.703 ± 0.019
0.191CysMet: 0.191 ± 0.009
0.365CysAsn: 0.365 ± 0.014
0.346CysPro: 0.346 ± 0.016
0.256CysGln: 0.256 ± 0.013
0.318CysArg: 0.318 ± 0.013
0.586CysSer: 0.586 ± 0.024
0.426CysThr: 0.426 ± 0.019
0.403CysVal: 0.403 ± 0.015
0.098CysTrp: 0.098 ± 0.007
0.324CysTyr: 0.324 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.476AspAla: 3.476 ± 0.049
0.408AspCys: 0.408 ± 0.016
3.094AspAsp: 3.094 ± 0.052
3.868AspGlu: 3.868 ± 0.05
3.163AspPhe: 3.163 ± 0.042
3.825AspGly: 3.825 ± 0.071
1.249AspHis: 1.249 ± 0.027
4.602AspIle: 4.602 ± 0.058
3.713AspLys: 3.713 ± 0.053
5.421AspLeu: 5.421 ± 0.055
1.225AspMet: 1.225 ± 0.026
3.032AspAsn: 3.032 ± 0.046
2.421AspPro: 2.421 ± 0.044
2.23AspGln: 2.23 ± 0.033
2.38AspArg: 2.38 ± 0.039
3.06AspSer: 3.06 ± 0.044
2.661AspThr: 2.661 ± 0.044
3.488AspVal: 3.488 ± 0.044
0.699AspTrp: 0.699 ± 0.02
2.638AspTyr: 2.638 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.937GluAla: 4.937 ± 0.066
0.387GluCys: 0.387 ± 0.015
3.617GluAsp: 3.617 ± 0.043
5.351GluGlu: 5.351 ± 0.071
2.782GluPhe: 2.782 ± 0.039
4.295GluGly: 4.295 ± 0.051
1.268GluHis: 1.268 ± 0.025
5.061GluIle: 5.061 ± 0.057
5.535GluLys: 5.535 ± 0.075
6.574GluLeu: 6.574 ± 0.072
1.719GluMet: 1.719 ± 0.035
3.721GluAsn: 3.721 ± 0.044
1.925GluPro: 1.925 ± 0.035
2.651GluGln: 2.651 ± 0.038
3.09GluArg: 3.09 ± 0.046
3.451GluSer: 3.451 ± 0.041
3.042GluThr: 3.042 ± 0.04
5.003GluVal: 5.003 ± 0.055
0.78GluTrp: 0.78 ± 0.026
2.641GluTyr: 2.641 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
2.901PheAla: 2.901 ± 0.042
0.415PheCys: 0.415 ± 0.014
3.172PheAsp: 3.172 ± 0.046
3.161PheGlu: 3.161 ± 0.041
2.52PhePhe: 2.52 ± 0.049
3.311PheGly: 3.311 ± 0.05
0.903PheHis: 0.903 ± 0.021
3.623PheIle: 3.623 ± 0.048
2.971PheLys: 2.971 ± 0.042
4.297PheLeu: 4.297 ± 0.06
1.071PheMet: 1.071 ± 0.028
2.8PheAsn: 2.8 ± 0.04
1.604PhePro: 1.604 ± 0.031
1.478PheGln: 1.478 ± 0.027
2.014PheArg: 2.014 ± 0.038
3.667PheSer: 3.667 ± 0.045
2.914PheThr: 2.914 ± 0.05
2.87PheVal: 2.87 ± 0.042
0.543PheTrp: 0.543 ± 0.018
2.114PheTyr: 2.114 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.667GlyAla: 4.667 ± 0.058
0.627GlyCys: 0.627 ± 0.028
3.631GlyAsp: 3.631 ± 0.05
4.217GlyGlu: 4.217 ± 0.05
3.44GlyPhe: 3.44 ± 0.049
5.045GlyGly: 5.045 ± 0.069
1.329GlyHis: 1.329 ± 0.031
5.301GlyIle: 5.301 ± 0.057
4.76GlyLys: 4.76 ± 0.056
6.229GlyLeu: 6.229 ± 0.068
1.707GlyMet: 1.707 ± 0.034
3.554GlyAsn: 3.554 ± 0.055
1.629GlyPro: 1.629 ± 0.033
2.33GlyGln: 2.33 ± 0.04
2.805GlyArg: 2.805 ± 0.04
4.476GlySer: 4.476 ± 0.079
4.151GlyThr: 4.151 ± 0.077
4.666GlyVal: 4.666 ± 0.057
0.86GlyTrp: 0.86 ± 0.026
3.129GlyTyr: 3.129 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.162HisAla: 1.162 ± 0.028
0.219HisCys: 0.219 ± 0.012
1.0HisAsp: 1.0 ± 0.025
1.256HisGlu: 1.256 ± 0.032
1.221HisPhe: 1.221 ± 0.025
1.304HisGly: 1.304 ± 0.031
0.616HisHis: 0.616 ± 0.018
1.454HisIle: 1.454 ± 0.03
1.082HisLys: 1.082 ± 0.027
2.098HisLeu: 2.098 ± 0.039
0.406HisMet: 0.406 ± 0.015
0.915HisAsn: 0.915 ± 0.023
0.993HisPro: 0.993 ± 0.023
0.844HisGln: 0.844 ± 0.023
0.874HisArg: 0.874 ± 0.021
1.189HisSer: 1.189 ± 0.028
0.984HisThr: 0.984 ± 0.022
1.16HisVal: 1.16 ± 0.026
0.272HisTrp: 0.272 ± 0.013
0.953HisTyr: 0.953 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.351IleAla: 5.351 ± 0.058
0.596IleCys: 0.596 ± 0.017
4.549IleAsp: 4.549 ± 0.048
5.002IleGlu: 5.002 ± 0.065
3.403IlePhe: 3.403 ± 0.05
4.848IleGly: 4.848 ± 0.061
1.444IleHis: 1.444 ± 0.028
5.228IleIle: 5.228 ± 0.066
4.765IleLys: 4.765 ± 0.054
6.273IleLeu: 6.273 ± 0.069
1.386IleMet: 1.386 ± 0.031
4.213IleAsn: 4.213 ± 0.053
3.021IlePro: 3.021 ± 0.045
2.205IleGln: 2.205 ± 0.036
3.244IleArg: 3.244 ± 0.039
5.466IleSer: 5.466 ± 0.051
4.502IleThr: 4.502 ± 0.07
4.31IleVal: 4.31 ± 0.051
0.689IleTrp: 0.689 ± 0.02
2.869IleTyr: 2.869 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.736LysAla: 4.736 ± 0.066
0.359LysCys: 0.359 ± 0.013
3.791LysAsp: 3.791 ± 0.049
5.477LysGlu: 5.477 ± 0.07
2.427LysPhe: 2.427 ± 0.04
4.29LysGly: 4.29 ± 0.048
1.332LysHis: 1.332 ± 0.029
4.869LysIle: 4.869 ± 0.057
5.474LysLys: 5.474 ± 0.071
5.986LysLeu: 5.986 ± 0.072
1.794LysMet: 1.794 ± 0.031
3.75LysAsn: 3.75 ± 0.049
2.334LysPro: 2.334 ± 0.038
2.301LysGln: 2.301 ± 0.041
2.97LysArg: 2.97 ± 0.046
3.838LysSer: 3.838 ± 0.046
3.468LysThr: 3.468 ± 0.052
4.534LysVal: 4.534 ± 0.058
0.7LysTrp: 0.7 ± 0.017
2.854LysTyr: 2.854 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
6.592LeuAla: 6.592 ± 0.074
0.715LeuCys: 0.715 ± 0.02
4.951LeuAsp: 4.951 ± 0.05
6.145LeuGlu: 6.145 ± 0.068
4.446LeuPhe: 4.446 ± 0.062
5.802LeuGly: 5.802 ± 0.061
1.815LeuHis: 1.815 ± 0.035
6.787LeuIle: 6.787 ± 0.08
7.046LeuLys: 7.046 ± 0.077
8.998LeuLeu: 8.998 ± 0.103
2.17LeuMet: 2.17 ± 0.037
5.087LeuAsn: 5.087 ± 0.051
3.748LeuPro: 3.748 ± 0.042
3.492LeuGln: 3.492 ± 0.045
4.012LeuArg: 4.012 ± 0.043
6.954LeuSer: 6.954 ± 0.072
5.292LeuThr: 5.292 ± 0.061
5.65LeuVal: 5.65 ± 0.061
0.922LeuTrp: 0.922 ± 0.026
3.468LeuTyr: 3.468 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.928MetAla: 1.928 ± 0.028
0.136MetCys: 0.136 ± 0.008
1.28MetAsp: 1.28 ± 0.025
1.6MetGlu: 1.6 ± 0.029
0.829MetPhe: 0.829 ± 0.023
1.469MetGly: 1.469 ± 0.031
0.465MetHis: 0.465 ± 0.016
1.573MetIle: 1.573 ± 0.036
1.983MetLys: 1.983 ± 0.036
2.187MetLeu: 2.187 ± 0.038
0.584MetMet: 0.584 ± 0.018
1.237MetAsn: 1.237 ± 0.024
0.902MetPro: 0.902 ± 0.023
0.803MetGln: 0.803 ± 0.02
0.981MetArg: 0.981 ± 0.024
1.384MetSer: 1.384 ± 0.028
1.162MetThr: 1.162 ± 0.024
1.469MetVal: 1.469 ± 0.03
0.176MetTrp: 0.176 ± 0.009
0.669MetTyr: 0.669 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.405AsnAla: 3.405 ± 0.049
0.377AsnCys: 0.377 ± 0.015
2.907AsnAsp: 2.907 ± 0.047
3.41AsnGlu: 3.41 ± 0.049
2.533AsnPhe: 2.533 ± 0.042
3.815AsnGly: 3.815 ± 0.064
0.999AsnHis: 0.999 ± 0.024
4.374AsnIle: 4.374 ± 0.054
3.306AsnLys: 3.306 ± 0.052
4.7AsnLeu: 4.7 ± 0.054
1.161AsnMet: 1.161 ± 0.028
3.141AsnAsn: 3.141 ± 0.057
2.385AsnPro: 2.385 ± 0.042
1.784AsnGln: 1.784 ± 0.028
2.207AsnArg: 2.207 ± 0.038
3.294AsnSer: 3.294 ± 0.051
3.047AsnThr: 3.047 ± 0.056
3.083AsnVal: 3.083 ± 0.053
0.659AsnTrp: 0.659 ± 0.02
2.412AsnTyr: 2.412 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
2.683ProAla: 2.683 ± 0.044
0.23ProCys: 0.23 ± 0.011
2.637ProAsp: 2.637 ± 0.044
3.13ProGlu: 3.13 ± 0.043
1.849ProPhe: 1.849 ± 0.036
2.782ProGly: 2.782 ± 0.045
0.698ProHis: 0.698 ± 0.021
2.097ProIle: 2.097 ± 0.033
1.985ProLys: 1.985 ± 0.037
3.28ProLeu: 3.28 ± 0.041
0.724ProMet: 0.724 ± 0.021
1.698ProAsn: 1.698 ± 0.036
1.117ProPro: 1.117 ± 0.027
1.294ProGln: 1.294 ± 0.03
1.157ProArg: 1.157 ± 0.024
2.124ProSer: 2.124 ± 0.034
1.792ProThr: 1.792 ± 0.037
3.133ProVal: 3.133 ± 0.047
0.378ProTrp: 0.378 ± 0.015
1.461ProTyr: 1.461 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
2.419GlnAla: 2.419 ± 0.038
0.213GlnCys: 0.213 ± 0.011
1.673GlnAsp: 1.673 ± 0.029
2.467GlnGlu: 2.467 ± 0.041
1.593GlnPhe: 1.593 ± 0.031
2.055GlnGly: 2.055 ± 0.037
0.757GlnHis: 0.757 ± 0.018
2.298GlnIle: 2.298 ± 0.036
2.62GlnLys: 2.62 ± 0.041
3.8GlnLeu: 3.8 ± 0.051
0.862GlnMet: 0.862 ± 0.022
1.867GlnAsn: 1.867 ± 0.031
1.348GlnPro: 1.348 ± 0.03
1.7GlnGln: 1.7 ± 0.034
1.615GlnArg: 1.615 ± 0.032
2.072GlnSer: 2.072 ± 0.035
1.686GlnThr: 1.686 ± 0.03
2.431GlnVal: 2.431 ± 0.042
0.48GlnTrp: 0.48 ± 0.014
1.479GlnTyr: 1.479 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
2.544ArgAla: 2.544 ± 0.04
0.248ArgCys: 0.248 ± 0.012
2.207ArgAsp: 2.207 ± 0.038
3.054ArgGlu: 3.054 ± 0.052
2.07ArgPhe: 2.07 ± 0.036
2.383ArgGly: 2.383 ± 0.037
0.911ArgHis: 0.911 ± 0.025
3.154ArgIle: 3.154 ± 0.04
3.304ArgLys: 3.304 ± 0.049
4.252ArgLeu: 4.252 ± 0.055
1.138ArgMet: 1.138 ± 0.029
2.26ArgAsn: 2.26 ± 0.036
1.347ArgPro: 1.347 ± 0.028
1.675ArgGln: 1.675 ± 0.031
1.717ArgArg: 1.717 ± 0.036
2.653ArgSer: 2.653 ± 0.043
2.066ArgThr: 2.066 ± 0.033
2.723ArgVal: 2.723 ± 0.04
0.511ArgTrp: 0.511 ± 0.017
1.889ArgTyr: 1.889 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
4.381SerAla: 4.381 ± 0.05
0.553SerCys: 0.553 ± 0.021
3.663SerAsp: 3.663 ± 0.054
3.981SerGlu: 3.981 ± 0.05
3.6SerPhe: 3.6 ± 0.052
5.468SerGly: 5.468 ± 0.087
1.289SerHis: 1.289 ± 0.028
4.713SerIle: 4.713 ± 0.053
3.844SerLys: 3.844 ± 0.049
6.141SerLeu: 6.141 ± 0.063
1.4SerMet: 1.4 ± 0.026
3.148SerAsn: 3.148 ± 0.048
2.343SerPro: 2.343 ± 0.042
2.117SerGln: 2.117 ± 0.034
2.675SerArg: 2.675 ± 0.041
4.476SerSer: 4.476 ± 0.065
3.459SerThr: 3.459 ± 0.056
4.059SerVal: 4.059 ± 0.056
0.788SerTrp: 0.788 ± 0.022
2.863SerTyr: 2.863 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
3.993ThrAla: 3.993 ± 0.065
0.382ThrCys: 0.382 ± 0.015
3.228ThrAsp: 3.228 ± 0.05
3.211ThrGlu: 3.211 ± 0.039
2.739ThrPhe: 2.739 ± 0.047
4.581ThrGly: 4.581 ± 0.068
1.014ThrHis: 1.014 ± 0.024
4.109ThrIle: 4.109 ± 0.053
2.759ThrLys: 2.759 ± 0.04
5.149ThrLeu: 5.149 ± 0.059
1.008ThrMet: 1.008 ± 0.023
2.581ThrAsn: 2.581 ± 0.053
2.356ThrPro: 2.356 ± 0.042
1.598ThrGln: 1.598 ± 0.029
1.982ThrArg: 1.982 ± 0.035
3.695ThrSer: 3.695 ± 0.058
3.294ThrThr: 3.294 ± 0.072
3.851ThrVal: 3.851 ± 0.07
0.635ThrTrp: 0.635 ± 0.024
2.336ThrTyr: 2.336 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.703ValAla: 4.703 ± 0.056
0.541ValCys: 0.541 ± 0.018
3.757ValAsp: 3.757 ± 0.048
4.261ValGlu: 4.261 ± 0.051
3.14ValPhe: 3.14 ± 0.043
3.935ValGly: 3.935 ± 0.042
1.139ValHis: 1.139 ± 0.024
4.989ValIle: 4.989 ± 0.047
4.408ValLys: 4.408 ± 0.053
5.953ValLeu: 5.953 ± 0.063
1.493ValMet: 1.493 ± 0.03
3.555ValAsn: 3.555 ± 0.052
2.372ValPro: 2.372 ± 0.039
2.026ValGln: 2.026 ± 0.037
2.715ValArg: 2.715 ± 0.043
4.56ValSer: 4.56 ± 0.06
3.779ValThr: 3.779 ± 0.082
4.78ValVal: 4.78 ± 0.056
0.73ValTrp: 0.73 ± 0.02
2.522ValTyr: 2.522 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.66TrpAla: 0.66 ± 0.017
0.096TrpCys: 0.096 ± 0.007
0.656TrpAsp: 0.656 ± 0.02
0.677TrpGlu: 0.677 ± 0.02
0.527TrpPhe: 0.527 ± 0.017
0.724TrpGly: 0.724 ± 0.018
0.286TrpHis: 0.286 ± 0.012
0.756TrpIle: 0.756 ± 0.024
0.785TrpLys: 0.785 ± 0.023
1.188TrpLeu: 1.188 ± 0.024
0.329TrpMet: 0.329 ± 0.014
0.596TrpAsn: 0.596 ± 0.019
0.303TrpPro: 0.303 ± 0.014
0.504TrpGln: 0.504 ± 0.017
0.513TrpArg: 0.513 ± 0.019
0.734TrpSer: 0.734 ± 0.024
0.586TrpThr: 0.586 ± 0.025
0.744TrpVal: 0.744 ± 0.022
0.184TrpTrp: 0.184 ± 0.011
0.491TrpTyr: 0.491 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.525TyrAla: 2.525 ± 0.033
0.32TyrCys: 0.32 ± 0.014
2.568TyrAsp: 2.568 ± 0.045
2.633TyrGlu: 2.633 ± 0.036
2.328TyrPhe: 2.328 ± 0.039
2.726TyrGly: 2.726 ± 0.042
1.011TyrHis: 1.011 ± 0.021
2.571TyrIle: 2.571 ± 0.04
2.562TyrLys: 2.562 ± 0.043
4.048TyrLeu: 4.048 ± 0.05
0.811TyrMet: 0.811 ± 0.021
2.353TyrAsn: 2.353 ± 0.04
1.577TyrPro: 1.577 ± 0.029
1.694TyrGln: 1.694 ± 0.036
2.012TyrArg: 2.012 ± 0.038
2.864TyrSer: 2.864 ± 0.036
2.373TyrThr: 2.373 ± 0.049
2.32TyrVal: 2.32 ± 0.035
0.517TyrTrp: 0.517 ± 0.015
2.105TyrTyr: 2.105 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5952 proteins (1920940 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski