Amino acid dipepetide frequency for Pseudoalteromonas phage PM2 (Bacteriophage PM2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.826AlaAla: 9.826 ± 2.02
0.0AlaCys: 0.0 ± 0.0
4.437AlaAsp: 4.437 ± 0.858
6.973AlaGlu: 6.973 ± 1.358
3.17AlaPhe: 3.17 ± 1.088
6.339AlaGly: 6.339 ± 1.469
0.951AlaHis: 0.951 ± 0.558
3.803AlaIle: 3.803 ± 1.211
8.241AlaLys: 8.241 ± 1.823
9.192AlaLeu: 9.192 ± 1.544
4.754AlaMet: 4.754 ± 1.667
2.536AlaAsn: 2.536 ± 0.867
3.17AlaPro: 3.17 ± 0.973
3.803AlaGln: 3.803 ± 1.019
4.437AlaArg: 4.437 ± 1.29
6.656AlaSer: 6.656 ± 1.589
4.437AlaThr: 4.437 ± 1.404
6.656AlaVal: 6.656 ± 1.202
1.585AlaTrp: 1.585 ± 0.742
1.585AlaTyr: 1.585 ± 0.592
0.0AlaXaa: 0.0 ± 0.0
Cys
0.317CysAla: 0.317 ± 0.328
0.634CysCys: 0.634 ± 0.438
0.317CysAsp: 0.317 ± 0.239
0.634CysGlu: 0.634 ± 0.496
0.0CysPhe: 0.0 ± 0.0
0.951CysGly: 0.951 ± 0.781
0.317CysHis: 0.317 ± 0.351
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.317CysLeu: 0.317 ± 0.396
0.0CysMet: 0.0 ± 0.0
0.634CysAsn: 0.634 ± 0.384
0.634CysPro: 0.634 ± 0.418
0.634CysGln: 0.634 ± 0.384
0.634CysArg: 0.634 ± 0.456
1.585CysSer: 1.585 ± 0.841
0.634CysThr: 0.634 ± 0.704
0.634CysVal: 0.634 ± 0.438
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
7.607AspAla: 7.607 ± 2.27
0.317AspCys: 0.317 ± 0.351
4.437AspAsp: 4.437 ± 2.261
5.071AspGlu: 5.071 ± 1.491
3.487AspPhe: 3.487 ± 1.057
5.071AspGly: 5.071 ± 1.315
0.951AspHis: 0.951 ± 0.526
2.536AspIle: 2.536 ± 0.995
3.487AspLys: 3.487 ± 1.637
5.705AspLeu: 5.705 ± 1.944
1.585AspMet: 1.585 ± 0.637
3.803AspAsn: 3.803 ± 0.951
1.268AspPro: 1.268 ± 0.485
1.268AspGln: 1.268 ± 0.508
1.902AspArg: 1.902 ± 0.879
4.12AspSer: 4.12 ± 1.577
1.585AspThr: 1.585 ± 0.503
2.536AspVal: 2.536 ± 0.956
1.585AspTrp: 1.585 ± 0.56
2.853AspTyr: 2.853 ± 1.235
0.0AspXaa: 0.0 ± 0.0
Glu
2.853GluAla: 2.853 ± 0.992
0.0GluCys: 0.0 ± 0.0
1.902GluAsp: 1.902 ± 0.886
3.803GluGlu: 3.803 ± 1.262
4.12GluPhe: 4.12 ± 0.871
3.803GluGly: 3.803 ± 1.428
1.902GluHis: 1.902 ± 0.6
5.388GluIle: 5.388 ± 1.115
3.487GluLys: 3.487 ± 1.401
8.558GluLeu: 8.558 ± 1.875
0.951GluMet: 0.951 ± 0.439
4.437GluAsn: 4.437 ± 1.024
1.902GluPro: 1.902 ± 0.765
4.437GluGln: 4.437 ± 1.285
3.17GluArg: 3.17 ± 0.902
3.17GluSer: 3.17 ± 0.745
3.803GluThr: 3.803 ± 0.942
2.219GluVal: 2.219 ± 0.994
0.317GluTrp: 0.317 ± 0.351
2.536GluTyr: 2.536 ± 0.962
0.0GluXaa: 0.0 ± 0.0
Phe
3.487PheAla: 3.487 ± 0.7
0.951PheCys: 0.951 ± 0.673
1.902PheAsp: 1.902 ± 0.624
1.902PheGlu: 1.902 ± 0.979
0.634PhePhe: 0.634 ± 0.426
4.12PheGly: 4.12 ± 1.5
0.317PheHis: 0.317 ± 0.314
2.536PheIle: 2.536 ± 0.723
3.803PheLys: 3.803 ± 0.962
4.754PheLeu: 4.754 ± 1.71
1.902PheMet: 1.902 ± 0.838
0.951PheAsn: 0.951 ± 0.511
1.585PhePro: 1.585 ± 0.705
1.585PheGln: 1.585 ± 0.939
0.317PheArg: 0.317 ± 0.288
1.902PheSer: 1.902 ± 0.614
1.902PheThr: 1.902 ± 0.545
1.902PheVal: 1.902 ± 0.759
0.0PheTrp: 0.0 ± 0.0
1.585PheTyr: 1.585 ± 0.529
0.0PheXaa: 0.0 ± 0.0
Gly
8.558GlyAla: 8.558 ± 2.411
0.317GlyCys: 0.317 ± 0.352
2.853GlyAsp: 2.853 ± 0.903
4.437GlyGlu: 4.437 ± 1.505
3.17GlyPhe: 3.17 ± 0.952
6.656GlyGly: 6.656 ± 1.764
0.317GlyHis: 0.317 ± 0.239
3.487GlyIle: 3.487 ± 1.267
2.219GlyLys: 2.219 ± 1.029
6.973GlyLeu: 6.973 ± 1.732
3.487GlyMet: 3.487 ± 1.324
4.754GlyAsn: 4.754 ± 1.453
0.317GlyPro: 0.317 ± 0.314
3.17GlyGln: 3.17 ± 1.288
1.902GlyArg: 1.902 ± 0.728
3.487GlySer: 3.487 ± 1.038
2.536GlyThr: 2.536 ± 1.272
8.558GlyVal: 8.558 ± 1.803
0.317GlyTrp: 0.317 ± 0.397
2.536GlyTyr: 2.536 ± 0.735
0.0GlyXaa: 0.0 ± 0.0
His
0.951HisAla: 0.951 ± 0.55
0.0HisCys: 0.0 ± 0.0
1.268HisAsp: 1.268 ± 0.507
1.268HisGlu: 1.268 ± 0.561
0.317HisPhe: 0.317 ± 0.314
0.634HisGly: 0.634 ± 0.478
0.634HisHis: 0.634 ± 0.384
0.634HisIle: 0.634 ± 0.339
1.902HisLys: 1.902 ± 0.754
1.268HisLeu: 1.268 ± 0.614
0.951HisMet: 0.951 ± 0.448
0.0HisAsn: 0.0 ± 0.0
0.634HisPro: 0.634 ± 0.347
0.0HisGln: 0.0 ± 0.0
0.634HisArg: 0.634 ± 0.451
0.951HisSer: 0.951 ± 0.748
0.317HisThr: 0.317 ± 0.325
0.634HisVal: 0.634 ± 0.407
0.951HisTrp: 0.951 ± 0.502
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.071IleAla: 5.071 ± 1.142
0.634IleCys: 0.634 ± 0.373
6.022IleAsp: 6.022 ± 1.461
4.437IleGlu: 4.437 ± 1.035
0.634IlePhe: 0.634 ± 0.478
3.803IleGly: 3.803 ± 0.634
0.317IleHis: 0.317 ± 0.314
1.902IleIle: 1.902 ± 0.843
6.339IleLys: 6.339 ± 1.643
3.17IleLeu: 3.17 ± 0.976
0.317IleMet: 0.317 ± 0.322
4.437IleAsn: 4.437 ± 1.08
2.536IlePro: 2.536 ± 0.541
1.268IleGln: 1.268 ± 0.54
3.803IleArg: 3.803 ± 1.545
6.022IleSer: 6.022 ± 1.477
3.17IleThr: 3.17 ± 0.949
3.487IleVal: 3.487 ± 0.851
0.317IleTrp: 0.317 ± 0.325
1.268IleTyr: 1.268 ± 0.796
0.0IleXaa: 0.0 ± 0.0
Lys
8.558LysAla: 8.558 ± 1.514
0.0LysCys: 0.0 ± 0.0
2.536LysAsp: 2.536 ± 0.775
2.536LysGlu: 2.536 ± 0.785
1.268LysPhe: 1.268 ± 0.486
5.705LysGly: 5.705 ± 0.953
0.634LysHis: 0.634 ± 0.576
2.219LysIle: 2.219 ± 0.74
7.924LysLys: 7.924 ± 1.87
6.339LysLeu: 6.339 ± 1.17
1.585LysMet: 1.585 ± 0.679
2.219LysAsn: 2.219 ± 0.708
3.487LysPro: 3.487 ± 1.148
4.437LysGln: 4.437 ± 1.603
3.803LysArg: 3.803 ± 1.167
6.656LysSer: 6.656 ± 1.34
4.754LysThr: 4.754 ± 1.171
1.585LysVal: 1.585 ± 0.661
0.951LysTrp: 0.951 ± 0.496
4.12LysTyr: 4.12 ± 1.179
0.0LysXaa: 0.0 ± 0.0
Leu
9.509LeuAla: 9.509 ± 2.429
0.317LeuCys: 0.317 ± 0.352
8.558LeuAsp: 8.558 ± 1.333
5.388LeuGlu: 5.388 ± 1.157
1.585LeuPhe: 1.585 ± 0.675
4.12LeuGly: 4.12 ± 1.109
1.268LeuHis: 1.268 ± 0.714
4.754LeuIle: 4.754 ± 1.318
6.656LeuLys: 6.656 ± 1.474
6.973LeuLeu: 6.973 ± 2.239
4.12LeuMet: 4.12 ± 1.214
7.607LeuAsn: 7.607 ± 1.366
1.902LeuPro: 1.902 ± 0.725
2.536LeuGln: 2.536 ± 1.173
4.754LeuArg: 4.754 ± 1.213
3.803LeuSer: 3.803 ± 1.072
4.754LeuThr: 4.754 ± 1.388
7.29LeuVal: 7.29 ± 1.37
0.634LeuTrp: 0.634 ± 0.439
1.268LeuTyr: 1.268 ± 0.549
0.0LeuXaa: 0.0 ± 0.0
Met
3.803MetAla: 3.803 ± 1.589
0.317MetCys: 0.317 ± 0.351
0.951MetAsp: 0.951 ± 0.652
0.951MetGlu: 0.951 ± 0.521
1.902MetPhe: 1.902 ± 1.061
2.536MetGly: 2.536 ± 0.935
0.0MetHis: 0.0 ± 0.0
1.585MetIle: 1.585 ± 0.666
2.219MetLys: 2.219 ± 0.643
4.12MetLeu: 4.12 ± 0.913
0.0MetMet: 0.0 ± 0.0
1.585MetAsn: 1.585 ± 0.667
0.634MetPro: 0.634 ± 0.443
1.585MetGln: 1.585 ± 0.73
2.536MetArg: 2.536 ± 0.851
1.268MetSer: 1.268 ± 0.683
3.17MetThr: 3.17 ± 0.857
1.585MetVal: 1.585 ± 0.555
0.0MetTrp: 0.0 ± 0.0
0.317MetTyr: 0.317 ± 0.341
0.0MetXaa: 0.0 ± 0.0
Asn
1.902AsnAla: 1.902 ± 0.854
0.317AsnCys: 0.317 ± 0.239
3.17AsnAsp: 3.17 ± 1.146
3.17AsnGlu: 3.17 ± 0.863
3.487AsnPhe: 3.487 ± 1.207
4.12AsnGly: 4.12 ± 0.961
0.634AsnHis: 0.634 ± 0.478
3.487AsnIle: 3.487 ± 1.045
4.12AsnLys: 4.12 ± 1.137
1.268AsnLeu: 1.268 ± 0.446
1.902AsnMet: 1.902 ± 0.964
5.705AsnAsn: 5.705 ± 1.278
2.219AsnPro: 2.219 ± 1.052
3.17AsnGln: 3.17 ± 1.068
2.219AsnArg: 2.219 ± 0.71
3.803AsnSer: 3.803 ± 0.735
2.219AsnThr: 2.219 ± 0.932
3.803AsnVal: 3.803 ± 1.152
0.0AsnTrp: 0.0 ± 0.0
2.219AsnTyr: 2.219 ± 0.893
0.0AsnXaa: 0.0 ± 0.0
Pro
2.219ProAla: 2.219 ± 0.929
0.951ProCys: 0.951 ± 0.541
0.634ProAsp: 0.634 ± 0.724
4.12ProGlu: 4.12 ± 1.05
1.585ProPhe: 1.585 ± 0.725
0.0ProGly: 0.0 ± 0.0
0.951ProHis: 0.951 ± 0.55
1.902ProIle: 1.902 ± 0.922
2.536ProLys: 2.536 ± 0.717
2.536ProLeu: 2.536 ± 0.972
0.951ProMet: 0.951 ± 0.619
1.268ProAsn: 1.268 ± 0.602
0.317ProPro: 0.317 ± 0.325
0.634ProGln: 0.634 ± 0.528
1.902ProArg: 1.902 ± 0.77
2.219ProSer: 2.219 ± 0.77
2.853ProThr: 2.853 ± 1.536
2.219ProVal: 2.219 ± 0.645
0.317ProTrp: 0.317 ± 0.239
0.634ProTyr: 0.634 ± 0.367
0.0ProXaa: 0.0 ± 0.0
Gln
3.487GlnAla: 3.487 ± 0.888
0.634GlnCys: 0.634 ± 0.485
1.268GlnAsp: 1.268 ± 0.572
2.536GlnGlu: 2.536 ± 1.232
2.219GlnPhe: 2.219 ± 0.956
1.268GlnGly: 1.268 ± 0.459
0.317GlnHis: 0.317 ± 0.325
5.705GlnIle: 5.705 ± 1.172
2.853GlnLys: 2.853 ± 0.84
5.071GlnLeu: 5.071 ± 1.592
0.634GlnMet: 0.634 ± 0.339
0.951GlnAsn: 0.951 ± 0.551
0.317GlnPro: 0.317 ± 0.397
2.219GlnGln: 2.219 ± 0.774
2.536GlnArg: 2.536 ± 0.878
2.536GlnSer: 2.536 ± 1.049
1.585GlnThr: 1.585 ± 0.599
1.585GlnVal: 1.585 ± 0.78
0.634GlnTrp: 0.634 ± 0.367
1.902GlnTyr: 1.902 ± 0.991
0.0GlnXaa: 0.0 ± 0.0
Arg
4.12ArgAla: 4.12 ± 1.468
0.634ArgCys: 0.634 ± 0.485
4.12ArgAsp: 4.12 ± 1.192
1.902ArgGlu: 1.902 ± 0.668
1.268ArgPhe: 1.268 ± 0.755
2.853ArgGly: 2.853 ± 0.978
1.268ArgHis: 1.268 ± 0.451
2.536ArgIle: 2.536 ± 0.581
4.12ArgLys: 4.12 ± 0.848
3.17ArgLeu: 3.17 ± 0.899
0.951ArgMet: 0.951 ± 0.427
2.536ArgAsn: 2.536 ± 0.976
1.585ArgPro: 1.585 ± 0.668
1.268ArgGln: 1.268 ± 0.499
3.487ArgArg: 3.487 ± 1.209
3.17ArgSer: 3.17 ± 1.007
3.17ArgThr: 3.17 ± 1.219
5.388ArgVal: 5.388 ± 1.112
1.268ArgTrp: 1.268 ± 0.54
0.634ArgTyr: 0.634 ± 0.419
0.0ArgXaa: 0.0 ± 0.0
Ser
5.388SerAla: 5.388 ± 1.326
0.634SerCys: 0.634 ± 0.339
5.071SerAsp: 5.071 ± 1.207
2.219SerGlu: 2.219 ± 0.909
2.536SerPhe: 2.536 ± 1.182
3.17SerGly: 3.17 ± 1.072
0.951SerHis: 0.951 ± 0.452
4.12SerIle: 4.12 ± 0.877
4.12SerLys: 4.12 ± 1.086
3.17SerLeu: 3.17 ± 1.123
1.902SerMet: 1.902 ± 0.765
3.487SerAsn: 3.487 ± 1.513
3.17SerPro: 3.17 ± 0.928
1.268SerGln: 1.268 ± 0.594
2.219SerArg: 2.219 ± 0.576
1.902SerSer: 1.902 ± 0.959
6.339SerThr: 6.339 ± 1.354
8.241SerVal: 8.241 ± 2.165
0.634SerTrp: 0.634 ± 0.473
1.585SerTyr: 1.585 ± 0.678
0.0SerXaa: 0.0 ± 0.0
Thr
4.12ThrAla: 4.12 ± 0.907
0.951ThrCys: 0.951 ± 0.45
3.803ThrAsp: 3.803 ± 1.111
4.437ThrGlu: 4.437 ± 0.904
2.853ThrPhe: 2.853 ± 1.029
4.437ThrGly: 4.437 ± 1.405
0.317ThrHis: 0.317 ± 0.36
4.12ThrIle: 4.12 ± 0.964
2.536ThrLys: 2.536 ± 0.767
6.973ThrLeu: 6.973 ± 1.274
1.585ThrMet: 1.585 ± 0.84
0.951ThrAsn: 0.951 ± 0.711
1.902ThrPro: 1.902 ± 0.642
3.487ThrGln: 3.487 ± 1.262
1.902ThrArg: 1.902 ± 0.706
2.536ThrSer: 2.536 ± 1.273
4.754ThrThr: 4.754 ± 1.001
3.17ThrVal: 3.17 ± 1.048
0.0ThrTrp: 0.0 ± 0.0
2.853ThrTyr: 2.853 ± 1.234
0.0ThrXaa: 0.0 ± 0.0
Val
5.071ValAla: 5.071 ± 1.238
0.951ValCys: 0.951 ± 0.856
5.071ValAsp: 5.071 ± 0.963
5.388ValGlu: 5.388 ± 1.546
2.853ValPhe: 2.853 ± 0.958
6.339ValGly: 6.339 ± 1.408
1.268ValHis: 1.268 ± 0.635
3.803ValIle: 3.803 ± 1.046
3.803ValLys: 3.803 ± 1.124
5.071ValLeu: 5.071 ± 1.188
1.902ValMet: 1.902 ± 0.765
4.12ValAsn: 4.12 ± 0.736
2.853ValPro: 2.853 ± 1.338
1.585ValGln: 1.585 ± 0.804
4.12ValArg: 4.12 ± 1.012
3.487ValSer: 3.487 ± 1.104
2.853ValThr: 2.853 ± 0.747
4.437ValVal: 4.437 ± 1.534
1.902ValTrp: 1.902 ± 0.932
0.951ValTyr: 0.951 ± 0.498
0.0ValXaa: 0.0 ± 0.0
Trp
1.585TrpAla: 1.585 ± 0.64
0.317TrpCys: 0.317 ± 0.351
0.317TrpAsp: 0.317 ± 0.328
0.317TrpGlu: 0.317 ± 0.351
0.634TrpPhe: 0.634 ± 0.457
1.268TrpGly: 1.268 ± 0.69
0.317TrpHis: 0.317 ± 0.239
0.951TrpIle: 0.951 ± 0.511
0.0TrpLys: 0.0 ± 0.0
1.585TrpLeu: 1.585 ± 0.579
0.317TrpMet: 0.317 ± 0.337
0.317TrpAsn: 0.317 ± 0.362
0.0TrpPro: 0.0 ± 0.0
0.634TrpGln: 0.634 ± 0.478
1.585TrpArg: 1.585 ± 0.528
0.634TrpSer: 0.634 ± 0.339
0.317TrpThr: 0.317 ± 0.288
0.951TrpVal: 0.951 ± 0.712
0.317TrpTrp: 0.317 ± 0.239
0.317TrpTyr: 0.317 ± 0.325
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.12TyrAla: 4.12 ± 1.302
0.0TyrCys: 0.0 ± 0.0
2.536TyrAsp: 2.536 ± 1.061
1.268TyrGlu: 1.268 ± 0.701
0.317TyrPhe: 0.317 ± 0.337
2.853TyrGly: 2.853 ± 0.854
0.317TyrHis: 0.317 ± 0.239
3.487TyrIle: 3.487 ± 1.019
0.951TyrLys: 0.951 ± 0.555
1.902TyrLeu: 1.902 ± 0.811
0.951TyrMet: 0.951 ± 0.521
0.634TyrAsn: 0.634 ± 0.373
0.317TyrPro: 0.317 ± 0.351
1.268TyrGln: 1.268 ± 0.49
1.585TyrArg: 1.585 ± 0.725
2.219TyrSer: 2.219 ± 0.946
2.536TyrThr: 2.536 ± 1.05
0.951TyrVal: 0.951 ± 0.663
0.951TyrTrp: 0.951 ± 0.667
0.634TyrTyr: 0.634 ± 0.395
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (3156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski