Amino acid dipepetide frequency for Cytobacillus kochii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.262AlaAla: 5.262 ± 0.081
0.602AlaCys: 0.602 ± 0.025
3.38AlaAsp: 3.38 ± 0.06
4.717AlaGlu: 4.717 ± 0.073
3.211AlaPhe: 3.211 ± 0.047
5.009AlaGly: 5.009 ± 0.071
1.45AlaHis: 1.45 ± 0.037
6.337AlaIle: 6.337 ± 0.089
5.0AlaLys: 5.0 ± 0.083
7.082AlaLeu: 7.082 ± 0.082
2.039AlaMet: 2.039 ± 0.043
2.91AlaAsn: 2.91 ± 0.054
1.918AlaPro: 1.918 ± 0.04
2.263AlaGln: 2.263 ± 0.051
2.45AlaArg: 2.45 ± 0.057
4.281AlaSer: 4.281 ± 0.093
3.665AlaThr: 3.665 ± 0.095
5.016AlaVal: 5.016 ± 0.069
0.563AlaTrp: 0.563 ± 0.025
2.369AlaTyr: 2.369 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.49CysAla: 0.49 ± 0.027
0.099CysCys: 0.099 ± 0.01
0.391CysAsp: 0.391 ± 0.018
0.472CysGlu: 0.472 ± 0.021
0.323CysPhe: 0.323 ± 0.018
0.651CysGly: 0.651 ± 0.024
0.212CysHis: 0.212 ± 0.013
0.59CysIle: 0.59 ± 0.022
0.362CysLys: 0.362 ± 0.018
0.739CysLeu: 0.739 ± 0.028
0.196CysMet: 0.196 ± 0.012
0.291CysAsn: 0.291 ± 0.015
0.313CysPro: 0.313 ± 0.017
0.267CysGln: 0.267 ± 0.016
0.28CysArg: 0.28 ± 0.015
0.484CysSer: 0.484 ± 0.019
0.375CysThr: 0.375 ± 0.018
0.406CysVal: 0.406 ± 0.019
0.07CysTrp: 0.07 ± 0.008
0.264CysTyr: 0.264 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.1AspAla: 3.1 ± 0.05
0.384AspCys: 0.384 ± 0.018
2.435AspAsp: 2.435 ± 0.05
4.485AspGlu: 4.485 ± 0.072
2.281AspPhe: 2.281 ± 0.047
3.251AspGly: 3.251 ± 0.057
1.201AspHis: 1.201 ± 0.032
4.424AspIle: 4.424 ± 0.06
2.91AspLys: 2.91 ± 0.052
4.772AspLeu: 4.772 ± 0.066
1.327AspMet: 1.327 ± 0.033
1.736AspAsn: 1.736 ± 0.037
1.739AspPro: 1.739 ± 0.036
2.039AspGln: 2.039 ± 0.042
2.119AspArg: 2.119 ± 0.04
2.523AspSer: 2.523 ± 0.05
2.372AspThr: 2.372 ± 0.047
3.568AspVal: 3.568 ± 0.05
0.659AspTrp: 0.659 ± 0.022
2.196AspTyr: 2.196 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.353GluAla: 5.353 ± 0.075
0.383GluCys: 0.383 ± 0.02
3.858GluAsp: 3.858 ± 0.063
7.769GluGlu: 7.769 ± 0.107
2.307GluPhe: 2.307 ± 0.042
4.581GluGly: 4.581 ± 0.083
1.425GluHis: 1.425 ± 0.034
5.79GluIle: 5.79 ± 0.068
6.766GluLys: 6.766 ± 0.088
7.004GluLeu: 7.004 ± 0.094
2.534GluMet: 2.534 ± 0.041
3.794GluAsn: 3.794 ± 0.054
1.942GluPro: 1.942 ± 0.044
3.418GluGln: 3.418 ± 0.059
3.47GluArg: 3.47 ± 0.063
3.732GluSer: 3.732 ± 0.062
3.756GluThr: 3.756 ± 0.055
5.472GluVal: 5.472 ± 0.074
0.848GluTrp: 0.848 ± 0.028
2.226GluTyr: 2.226 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.217PheAla: 3.217 ± 0.054
0.356PheCys: 0.356 ± 0.018
2.225PheAsp: 2.225 ± 0.037
2.633PheGlu: 2.633 ± 0.048
2.298PhePhe: 2.298 ± 0.055
3.122PheGly: 3.122 ± 0.057
1.028PheHis: 1.028 ± 0.032
4.203PheIle: 4.203 ± 0.073
2.388PheLys: 2.388 ± 0.045
4.661PheLeu: 4.661 ± 0.073
1.12PheMet: 1.12 ± 0.034
1.958PheAsn: 1.958 ± 0.04
1.573PhePro: 1.573 ± 0.042
1.691PheGln: 1.691 ± 0.039
1.413PheArg: 1.413 ± 0.035
3.199PheSer: 3.199 ± 0.063
2.603PheThr: 2.603 ± 0.05
2.901PheVal: 2.901 ± 0.052
0.457PheTrp: 0.457 ± 0.02
1.692PheTyr: 1.692 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.767GlyAla: 4.767 ± 0.084
0.606GlyCys: 0.606 ± 0.023
3.123GlyAsp: 3.123 ± 0.055
4.813GlyGlu: 4.813 ± 0.07
3.306GlyPhe: 3.306 ± 0.063
4.88GlyGly: 4.88 ± 0.083
1.385GlyHis: 1.385 ± 0.042
5.754GlyIle: 5.754 ± 0.101
4.934GlyLys: 4.934 ± 0.068
6.731GlyLeu: 6.731 ± 0.078
2.108GlyMet: 2.108 ± 0.045
2.654GlyAsn: 2.654 ± 0.049
1.728GlyPro: 1.728 ± 0.05
2.201GlyGln: 2.201 ± 0.042
2.494GlyArg: 2.494 ± 0.052
3.915GlySer: 3.915 ± 0.059
3.762GlyThr: 3.762 ± 0.088
5.1GlyVal: 5.1 ± 0.088
0.777GlyTrp: 0.777 ± 0.025
2.781GlyTyr: 2.781 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.397HisAla: 1.397 ± 0.047
0.229HisCys: 0.229 ± 0.015
1.007HisAsp: 1.007 ± 0.032
1.434HisGlu: 1.434 ± 0.034
1.143HisPhe: 1.143 ± 0.032
1.266HisGly: 1.266 ± 0.03
0.751HisHis: 0.751 ± 0.028
1.761HisIle: 1.761 ± 0.038
1.11HisLys: 1.11 ± 0.032
2.381HisLeu: 2.381 ± 0.046
0.581HisMet: 0.581 ± 0.021
0.762HisAsn: 0.762 ± 0.028
1.177HisPro: 1.177 ± 0.033
1.003HisGln: 1.003 ± 0.03
0.865HisArg: 0.865 ± 0.027
1.425HisSer: 1.425 ± 0.048
1.15HisThr: 1.15 ± 0.031
1.332HisVal: 1.332 ± 0.037
0.235HisTrp: 0.235 ± 0.016
0.956HisTyr: 0.956 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.513IleAla: 6.513 ± 0.081
0.713IleCys: 0.713 ± 0.026
4.594IleAsp: 4.594 ± 0.065
6.06IleGlu: 6.06 ± 0.082
3.572IlePhe: 3.572 ± 0.066
6.264IleGly: 6.264 ± 0.087
1.896IleHis: 1.896 ± 0.04
6.668IleIle: 6.668 ± 0.091
4.741IleLys: 4.741 ± 0.065
7.485IleLeu: 7.485 ± 0.107
1.907IleMet: 1.907 ± 0.038
3.528IleAsn: 3.528 ± 0.056
3.452IlePro: 3.452 ± 0.056
3.135IleGln: 3.135 ± 0.056
2.998IleArg: 2.998 ± 0.055
5.213IleSer: 5.213 ± 0.074
4.62IleThr: 4.62 ± 0.084
5.607IleVal: 5.607 ± 0.074
0.639IleTrp: 0.639 ± 0.021
2.591IleTyr: 2.591 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.468LysAla: 4.468 ± 0.068
0.325LysCys: 0.325 ± 0.018
3.744LysAsp: 3.744 ± 0.062
7.402LysGlu: 7.402 ± 0.088
1.743LysPhe: 1.743 ± 0.04
4.636LysGly: 4.636 ± 0.062
1.294LysHis: 1.294 ± 0.03
4.608LysIle: 4.608 ± 0.06
5.887LysLys: 5.887 ± 0.08
5.687LysLeu: 5.687 ± 0.075
2.248LysMet: 2.248 ± 0.046
3.329LysAsn: 3.329 ± 0.055
2.111LysPro: 2.111 ± 0.054
3.326LysGln: 3.326 ± 0.057
3.287LysArg: 3.287 ± 0.063
3.498LysSer: 3.498 ± 0.061
3.383LysThr: 3.383 ± 0.046
4.801LysVal: 4.801 ± 0.066
0.885LysTrp: 0.885 ± 0.026
2.267LysTyr: 2.267 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
7.215LeuAla: 7.215 ± 0.075
0.7LeuCys: 0.7 ± 0.023
4.615LeuAsp: 4.615 ± 0.067
6.264LeuGlu: 6.264 ± 0.079
4.994LeuPhe: 4.994 ± 0.08
6.28LeuGly: 6.28 ± 0.076
2.11LeuHis: 2.11 ± 0.047
7.77LeuIle: 7.77 ± 0.104
6.407LeuLys: 6.407 ± 0.079
10.499LeuLeu: 10.499 ± 0.127
2.548LeuMet: 2.548 ± 0.05
4.406LeuAsn: 4.406 ± 0.061
3.937LeuPro: 3.937 ± 0.055
3.923LeuGln: 3.923 ± 0.062
3.508LeuArg: 3.508 ± 0.068
7.194LeuSer: 7.194 ± 0.086
5.785LeuThr: 5.785 ± 0.071
6.004LeuVal: 6.004 ± 0.072
0.792LeuTrp: 0.792 ± 0.026
3.15LeuTyr: 3.15 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.016MetAla: 2.016 ± 0.042
0.147MetCys: 0.147 ± 0.01
1.387MetAsp: 1.387 ± 0.033
1.985MetGlu: 1.985 ± 0.043
1.017MetPhe: 1.017 ± 0.028
1.759MetGly: 1.759 ± 0.04
0.469MetHis: 0.469 ± 0.019
2.423MetIle: 2.423 ± 0.038
2.7MetLys: 2.7 ± 0.046
2.509MetLeu: 2.509 ± 0.042
0.899MetMet: 0.899 ± 0.027
1.72MetAsn: 1.72 ± 0.035
0.954MetPro: 0.954 ± 0.028
0.953MetGln: 0.953 ± 0.025
1.127MetArg: 1.127 ± 0.034
1.785MetSer: 1.785 ± 0.038
1.744MetThr: 1.744 ± 0.033
1.868MetVal: 1.868 ± 0.044
0.177MetTrp: 0.177 ± 0.011
0.755MetTyr: 0.755 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.693AsnAla: 2.693 ± 0.044
0.301AsnCys: 0.301 ± 0.018
2.376AsnAsp: 2.376 ± 0.052
3.933AsnGlu: 3.933 ± 0.069
1.557AsnPhe: 1.557 ± 0.04
3.324AsnGly: 3.324 ± 0.063
1.258AsnHis: 1.258 ± 0.032
3.612AsnIle: 3.612 ± 0.052
3.049AsnLys: 3.049 ± 0.053
3.609AsnLeu: 3.609 ± 0.062
1.187AsnMet: 1.187 ± 0.029
2.117AsnAsn: 2.117 ± 0.043
1.949AsnPro: 1.949 ± 0.042
2.217AsnGln: 2.217 ± 0.044
2.077AsnArg: 2.077 ± 0.04
2.136AsnSer: 2.136 ± 0.043
2.108AsnThr: 2.108 ± 0.044
2.8AsnVal: 2.8 ± 0.046
0.503AsnTrp: 0.503 ± 0.025
1.552AsnTyr: 1.552 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
2.097ProAla: 2.097 ± 0.045
0.187ProCys: 0.187 ± 0.014
1.79ProAsp: 1.79 ± 0.042
2.663ProGlu: 2.663 ± 0.048
2.012ProPhe: 2.012 ± 0.047
2.136ProGly: 2.136 ± 0.049
0.88ProHis: 0.88 ± 0.024
3.048ProIle: 3.048 ± 0.06
2.043ProLys: 2.043 ± 0.045
3.59ProLeu: 3.59 ± 0.056
0.83ProMet: 0.83 ± 0.026
1.553ProAsn: 1.553 ± 0.034
0.974ProPro: 0.974 ± 0.03
1.171ProGln: 1.171 ± 0.032
1.063ProArg: 1.063 ± 0.032
2.26ProSer: 2.26 ± 0.041
2.027ProThr: 2.027 ± 0.04
2.554ProVal: 2.554 ± 0.047
0.306ProTrp: 0.306 ± 0.015
1.436ProTyr: 1.436 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.915GlnAla: 2.915 ± 0.051
0.22GlnCys: 0.22 ± 0.013
1.56GlnAsp: 1.56 ± 0.037
2.801GlnGlu: 2.801 ± 0.057
1.75GlnPhe: 1.75 ± 0.04
2.102GlnGly: 2.102 ± 0.042
0.816GlnHis: 0.816 ± 0.023
2.716GlnIle: 2.716 ± 0.049
2.859GlnLys: 2.859 ± 0.058
4.58GlnLeu: 4.58 ± 0.065
1.222GlnMet: 1.222 ± 0.035
1.584GlnAsn: 1.584 ± 0.04
1.318GlnPro: 1.318 ± 0.035
1.986GlnGln: 1.986 ± 0.05
1.479GlnArg: 1.479 ± 0.039
2.673GlnSer: 2.673 ± 0.051
2.302GlnThr: 2.302 ± 0.045
2.478GlnVal: 2.478 ± 0.045
0.447GlnTrp: 0.447 ± 0.02
1.48GlnTyr: 1.48 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.497ArgAla: 2.497 ± 0.061
0.262ArgCys: 0.262 ± 0.015
1.829ArgAsp: 1.829 ± 0.035
3.15ArgGlu: 3.15 ± 0.064
1.771ArgPhe: 1.771 ± 0.036
2.249ArgGly: 2.249 ± 0.048
0.749ArgHis: 0.749 ± 0.026
3.042ArgIle: 3.042 ± 0.055
3.319ArgLys: 3.319 ± 0.064
3.817ArgLeu: 3.817 ± 0.06
1.344ArgMet: 1.344 ± 0.037
1.859ArgAsn: 1.859 ± 0.04
1.208ArgPro: 1.208 ± 0.037
1.528ArgGln: 1.528 ± 0.034
1.708ArgArg: 1.708 ± 0.042
2.099ArgSer: 2.099 ± 0.039
1.942ArgThr: 1.942 ± 0.043
2.587ArgVal: 2.587 ± 0.05
0.378ArgTrp: 0.378 ± 0.017
1.417ArgTyr: 1.417 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
3.837SerAla: 3.837 ± 0.067
0.423SerCys: 0.423 ± 0.019
2.706SerAsp: 2.706 ± 0.049
4.058SerGlu: 4.058 ± 0.066
3.393SerPhe: 3.393 ± 0.055
4.358SerGly: 4.358 ± 0.069
1.467SerHis: 1.467 ± 0.051
5.277SerIle: 5.277 ± 0.075
3.777SerLys: 3.777 ± 0.058
6.435SerLeu: 6.435 ± 0.075
1.837SerMet: 1.837 ± 0.038
2.538SerAsn: 2.538 ± 0.05
2.14SerPro: 2.14 ± 0.038
2.218SerGln: 2.218 ± 0.055
2.206SerArg: 2.206 ± 0.043
3.931SerSer: 3.931 ± 0.069
3.25SerThr: 3.25 ± 0.056
3.961SerVal: 3.961 ± 0.049
0.628SerTrp: 0.628 ± 0.023
2.326SerTyr: 2.326 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
3.984ThrAla: 3.984 ± 0.069
0.356ThrCys: 0.356 ± 0.018
2.624ThrAsp: 2.624 ± 0.045
3.608ThrGlu: 3.608 ± 0.056
2.583ThrPhe: 2.583 ± 0.047
4.248ThrGly: 4.248 ± 0.271
1.078ThrHis: 1.078 ± 0.028
4.86ThrIle: 4.86 ± 0.063
3.458ThrLys: 3.458 ± 0.052
5.188ThrLeu: 5.188 ± 0.071
1.366ThrMet: 1.366 ± 0.036
2.535ThrAsn: 2.535 ± 0.042
2.131ThrPro: 2.131 ± 0.035
1.49ThrGln: 1.49 ± 0.035
1.768ThrArg: 1.768 ± 0.043
3.357ThrSer: 3.357 ± 0.051
3.023ThrThr: 3.023 ± 0.073
4.075ThrVal: 4.075 ± 0.063
0.481ThrTrp: 0.481 ± 0.02
1.942ThrTyr: 1.942 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
5.021ValAla: 5.021 ± 0.076
0.604ValCys: 0.604 ± 0.027
3.453ValAsp: 3.453 ± 0.06
4.814ValGlu: 4.814 ± 0.065
3.137ValPhe: 3.137 ± 0.051
4.608ValGly: 4.608 ± 0.063
1.324ValHis: 1.324 ± 0.034
5.852ValIle: 5.852 ± 0.078
4.596ValLys: 4.596 ± 0.066
6.539ValLeu: 6.539 ± 0.072
1.824ValMet: 1.824 ± 0.041
3.147ValAsn: 3.147 ± 0.057
2.405ValPro: 2.405 ± 0.044
2.295ValGln: 2.295 ± 0.043
2.404ValArg: 2.404 ± 0.053
4.387ValSer: 4.387 ± 0.06
3.928ValThr: 3.928 ± 0.074
4.636ValVal: 4.636 ± 0.079
0.586ValTrp: 0.586 ± 0.021
2.25ValTyr: 2.25 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.02
0.075TrpCys: 0.075 ± 0.007
0.472TrpAsp: 0.472 ± 0.018
0.659TrpGlu: 0.659 ± 0.021
0.5TrpPhe: 0.5 ± 0.021
0.675TrpGly: 0.675 ± 0.027
0.239TrpHis: 0.239 ± 0.013
0.834TrpIle: 0.834 ± 0.029
0.661TrpLys: 0.661 ± 0.022
1.156TrpLeu: 1.156 ± 0.031
0.372TrpMet: 0.372 ± 0.017
0.484TrpAsn: 0.484 ± 0.018
0.264TrpPro: 0.264 ± 0.016
0.438TrpGln: 0.438 ± 0.017
0.402TrpArg: 0.402 ± 0.02
0.593TrpSer: 0.593 ± 0.022
0.497TrpThr: 0.497 ± 0.022
0.636TrpVal: 0.636 ± 0.025
0.114TrpTrp: 0.114 ± 0.009
0.328TrpTyr: 0.328 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.139TyrAla: 2.139 ± 0.049
0.301TyrCys: 0.301 ± 0.016
1.953TyrAsp: 1.953 ± 0.042
2.71TyrGlu: 2.71 ± 0.046
1.841TyrPhe: 1.841 ± 0.041
2.418TyrGly: 2.418 ± 0.045
0.933TyrHis: 0.933 ± 0.029
2.631TyrIle: 2.631 ± 0.051
1.961TyrLys: 1.961 ± 0.04
3.636TyrLeu: 3.636 ± 0.054
0.906TyrMet: 0.906 ± 0.025
1.452TyrAsn: 1.452 ± 0.036
1.386TyrPro: 1.386 ± 0.034
1.728TyrGln: 1.728 ± 0.041
1.638TyrArg: 1.638 ± 0.038
2.083TyrSer: 2.083 ± 0.045
1.861TyrThr: 1.861 ± 0.041
2.008TyrVal: 2.008 ± 0.047
0.393TyrTrp: 0.393 ± 0.019
1.444TyrTyr: 1.444 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4424 proteins (1257253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski