Amino acid dipepetide frequency for Armatimonadetes bacterium DC

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.569AlaAla: 6.569 ± 0.109	1.172AlaCys: 1.172 ± 0.041	4.233AlaAsp: 4.233 ± 0.081	6.967AlaGlu: 6.967 ± 0.106	3.911AlaPhe: 3.911 ± 0.073	7.125AlaGly: 7.125 ± 0.107	2.278AlaHis: 2.278 ± 0.055	5.801AlaIle: 5.801 ± 0.095	2.432AlaLys: 2.432 ± 0.062	13.009AlaLeu: 13.009 ± 0.18	2.211AlaMet: 2.211 ± 0.054	2.482AlaAsn: 2.482 ± 0.059	5.424AlaPro: 5.424 ± 0.096	5.173AlaGln: 5.173 ± 0.096	7.795AlaArg: 7.795 ± 0.115	4.703AlaSer: 4.703 ± 0.077	4.847AlaThr: 4.847 ± 0.077	7.065AlaVal: 7.065 ± 0.098	1.646AlaTrp: 1.646 ± 0.043	3.26AlaTyr: 3.26 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.986CysAla: 0.986 ± 0.032	0.112CysCys: 0.112 ± 0.013	0.399CysAsp: 0.399 ± 0.02	0.651CysGlu: 0.651 ± 0.027	0.356CysPhe: 0.356 ± 0.02	0.875CysGly: 0.875 ± 0.036	0.253CysHis: 0.253 ± 0.017	0.394CysIle: 0.394 ± 0.02	0.228CysLys: 0.228 ± 0.017	0.924CysLeu: 0.924 ± 0.033	0.215CysMet: 0.215 ± 0.017	0.213CysAsn: 0.213 ± 0.016	0.671CysPro: 0.671 ± 0.031	0.351CysGln: 0.351 ± 0.019	0.636CysArg: 0.636 ± 0.027	0.399CysSer: 0.399 ± 0.023	0.473CysThr: 0.473 ± 0.035	0.807CysVal: 0.807 ± 0.034	0.202CysTrp: 0.202 ± 0.016	0.304CysTyr: 0.304 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.868AspAla: 4.868 ± 0.084	0.399AspCys: 0.399 ± 0.024	2.045AspAsp: 2.045 ± 0.063	2.952AspGlu: 2.952 ± 0.065	1.681AspPhe: 1.681 ± 0.041	3.8AspGly: 3.8 ± 0.088	0.74AspHis: 0.74 ± 0.031	2.152AspIle: 2.152 ± 0.056	1.126AspLys: 1.126 ± 0.039	4.716AspLeu: 4.716 ± 0.079	0.833AspMet: 0.833 ± 0.029	1.004AspAsn: 1.004 ± 0.043	3.566AspPro: 3.566 ± 0.071	1.19AspGln: 1.19 ± 0.036	2.562AspArg: 2.562 ± 0.058	2.201AspSer: 2.201 ± 0.051	2.452AspThr: 2.452 ± 0.047	2.705AspVal: 2.705 ± 0.062	1.062AspTrp: 1.062 ± 0.037	1.815AspTyr: 1.815 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.58GluAla: 7.58 ± 0.132	0.548GluCys: 0.548 ± 0.028	2.296GluAsp: 2.296 ± 0.055	4.423GluGlu: 4.423 ± 0.097	2.125GluPhe: 2.125 ± 0.044	4.969GluGly: 4.969 ± 0.082	1.4GluHis: 1.4 ± 0.046	3.67GluIle: 3.67 ± 0.077	2.265GluLys: 2.265 ± 0.058	6.023GluLeu: 6.023 ± 0.101	1.648GluMet: 1.648 ± 0.045	1.851GluAsn: 1.851 ± 0.048	3.782GluPro: 3.782 ± 0.081	3.813GluGln: 3.813 ± 0.088	6.558GluArg: 6.558 ± 0.115	3.386GluSer: 3.386 ± 0.068	3.785GluThr: 3.785 ± 0.065	5.356GluVal: 5.356 ± 0.082	1.484GluTrp: 1.484 ± 0.042	1.837GluTyr: 1.837 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.604PheAla: 3.604 ± 0.063	0.452PheCys: 0.452 ± 0.022	1.697PheAsp: 1.697 ± 0.052	2.477PheGlu: 2.477 ± 0.061	1.299PhePhe: 1.299 ± 0.043	3.221PheGly: 3.221 ± 0.078	0.755PheHis: 0.755 ± 0.029	1.43PheIle: 1.43 ± 0.045	0.816PheLys: 0.816 ± 0.03	3.458PheLeu: 3.458 ± 0.075	0.592PheMet: 0.592 ± 0.025	1.067PheAsn: 1.067 ± 0.036	1.911PhePro: 1.911 ± 0.05	1.372PheGln: 1.372 ± 0.042	2.58PheArg: 2.58 ± 0.05	1.908PheSer: 1.908 ± 0.061	2.154PheThr: 2.154 ± 0.058	2.814PheVal: 2.814 ± 0.062	0.884PheTrp: 0.884 ± 0.034	1.336PheTyr: 1.336 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	7.373GlyAla: 7.373 ± 0.116	0.906GlyCys: 0.906 ± 0.035	3.632GlyAsp: 3.632 ± 0.069	4.849GlyGlu: 4.849 ± 0.08	3.213GlyPhe: 3.213 ± 0.069	6.186GlyGly: 6.186 ± 0.137	1.387GlyHis: 1.387 ± 0.04	4.181GlyIle: 4.181 ± 0.076	3.05GlyLys: 3.05 ± 0.067	7.233GlyLeu: 7.233 ± 0.125	2.001GlyMet: 2.001 ± 0.05	2.383GlyAsn: 2.383 ± 0.072	1.558GlyPro: 1.558 ± 0.047	2.701GlyGln: 2.701 ± 0.063	5.094GlyArg: 5.094 ± 0.087	3.92GlySer: 3.92 ± 0.085	4.614GlyThr: 4.614 ± 0.096	7.233GlyVal: 7.233 ± 0.093	1.772GlyTrp: 1.772 ± 0.049	3.115GlyTyr: 3.115 ± 0.076	0.0GlyXaa: 0.0 ± 0.0
His	2.415HisAla: 2.415 ± 0.062	0.236HisCys: 0.236 ± 0.019	0.887HisAsp: 0.887 ± 0.032	1.312HisGlu: 1.312 ± 0.041	0.839HisPhe: 0.839 ± 0.032	1.493HisGly: 1.493 ± 0.04	0.637HisHis: 0.637 ± 0.03	1.001HisIle: 1.001 ± 0.029	0.522HisLys: 0.522 ± 0.027	2.498HisLeu: 2.498 ± 0.055	0.351HisMet: 0.351 ± 0.02	0.533HisAsn: 0.533 ± 0.024	1.706HisPro: 1.706 ± 0.044	0.865HisGln: 0.865 ± 0.035	1.527HisArg: 1.527 ± 0.041	0.861HisSer: 0.861 ± 0.034	1.23HisThr: 1.23 ± 0.037	1.107HisVal: 1.107 ± 0.036	0.432HisTrp: 0.432 ± 0.021	0.784HisTyr: 0.784 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.998IleAla: 5.998 ± 0.085	0.396IleCys: 0.396 ± 0.023	2.653IleAsp: 2.653 ± 0.057	4.059IleGlu: 4.059 ± 0.074	1.41IlePhe: 1.41 ± 0.046	4.214IleGly: 4.214 ± 0.077	1.042IleHis: 1.042 ± 0.036	1.944IleIle: 1.944 ± 0.058	1.18IleLys: 1.18 ± 0.036	4.98IleLeu: 4.98 ± 0.081	0.687IleMet: 0.687 ± 0.028	1.201IleAsn: 1.201 ± 0.044	3.126IlePro: 3.126 ± 0.059	2.095IleGln: 2.095 ± 0.057	3.831IleArg: 3.831 ± 0.064	2.117IleSer: 2.117 ± 0.051	3.051IleThr: 3.051 ± 0.056	4.053IleVal: 4.053 ± 0.075	0.674IleTrp: 0.674 ± 0.028	1.362IleTyr: 1.362 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	2.86LysAla: 2.86 ± 0.059	0.171LysCys: 0.171 ± 0.016	1.077LysAsp: 1.077 ± 0.04	1.929LysGlu: 1.929 ± 0.052	0.721LysPhe: 0.721 ± 0.028	2.174LysGly: 2.174 ± 0.052	0.629LysHis: 0.629 ± 0.029	1.476LysIle: 1.476 ± 0.04	0.891LysLys: 0.891 ± 0.039	2.633LysLeu: 2.633 ± 0.06	0.654LysMet: 0.654 ± 0.027	0.699LysAsn: 0.699 ± 0.029	2.372LysPro: 2.372 ± 0.054	1.393LysGln: 1.393 ± 0.044	2.658LysArg: 2.658 ± 0.057	1.198LysSer: 1.198 ± 0.038	1.573LysThr: 1.573 ± 0.045	2.404LysVal: 2.404 ± 0.06	0.471LysTrp: 0.471 ± 0.023	0.674LysTyr: 0.674 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.692LeuAla: 10.692 ± 0.147	1.128LeuCys: 1.128 ± 0.033	4.118LeuAsp: 4.118 ± 0.057	7.381LeuGlu: 7.381 ± 0.104	3.982LeuPhe: 3.982 ± 0.084	8.038LeuGly: 8.038 ± 0.117	2.274LeuHis: 2.274 ± 0.061	5.594LeuIle: 5.594 ± 0.098	3.759LeuLys: 3.759 ± 0.071	11.504LeuLeu: 11.504 ± 0.167	2.707LeuMet: 2.707 ± 0.064	3.205LeuAsn: 3.205 ± 0.059	6.388LeuPro: 6.388 ± 0.09	5.343LeuGln: 5.343 ± 0.103	8.459LeuArg: 8.459 ± 0.103	5.733LeuSer: 5.733 ± 0.087	6.434LeuThr: 6.434 ± 0.09	7.36LeuVal: 7.36 ± 0.111	2.186LeuTrp: 2.186 ± 0.058	3.463LeuTyr: 3.463 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	2.15MetAla: 2.15 ± 0.056	0.148MetCys: 0.148 ± 0.013	0.804MetAsp: 0.804 ± 0.033	1.587MetGlu: 1.587 ± 0.043	0.625MetPhe: 0.625 ± 0.029	1.753MetGly: 1.753 ± 0.049	0.406MetHis: 0.406 ± 0.021	0.903MetIle: 0.903 ± 0.039	0.726MetLys: 0.726 ± 0.033	2.395MetLeu: 2.395 ± 0.054	0.562MetMet: 0.562 ± 0.03	0.627MetAsn: 0.627 ± 0.027	1.476MetPro: 1.476 ± 0.045	0.889MetGln: 0.889 ± 0.034	2.379MetArg: 2.379 ± 0.053	0.997MetSer: 0.997 ± 0.034	1.051MetThr: 1.051 ± 0.038	1.53MetVal: 1.53 ± 0.043	0.291MetTrp: 0.291 ± 0.018	0.425MetTyr: 0.425 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.159AsnAla: 3.159 ± 0.069	0.266AsnCys: 0.266 ± 0.02	1.168AsnAsp: 1.168 ± 0.04	1.497AsnGlu: 1.497 ± 0.042	1.019AsnPhe: 1.019 ± 0.038	2.498AsnGly: 2.498 ± 0.085	0.511AsnHis: 0.511 ± 0.027	1.228AsnIle: 1.228 ± 0.04	0.649AsnLys: 0.649 ± 0.026	3.482AsnLeu: 3.482 ± 0.062	0.455AsnMet: 0.455 ± 0.022	0.874AsnAsn: 0.874 ± 0.039	2.827AsnPro: 2.827 ± 0.08	1.06AsnGln: 1.06 ± 0.043	2.162AsnArg: 2.162 ± 0.051	1.171AsnSer: 1.171 ± 0.042	1.736AsnThr: 1.736 ± 0.055	1.363AsnVal: 1.363 ± 0.041	0.531AsnTrp: 0.531 ± 0.022	0.821AsnTyr: 0.821 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.299ProAla: 5.299 ± 0.092	0.483ProCys: 0.483 ± 0.028	3.854ProAsp: 3.854 ± 0.072	5.142ProGlu: 5.142 ± 0.076	2.208ProPhe: 2.208 ± 0.056	3.183ProGly: 3.183 ± 0.078	1.416ProHis: 1.416 ± 0.039	2.957ProIle: 2.957 ± 0.056	1.649ProLys: 1.649 ± 0.051	5.976ProLeu: 5.976 ± 0.094	1.289ProMet: 1.289 ± 0.039	2.412ProAsn: 2.412 ± 0.077	4.064ProPro: 4.064 ± 0.094	2.372ProGln: 2.372 ± 0.053	3.383ProArg: 3.383 ± 0.07	2.884ProSer: 2.884 ± 0.068	3.212ProThr: 3.212 ± 0.069	4.337ProVal: 4.337 ± 0.083	0.582ProTrp: 0.582 ± 0.026	1.991ProTyr: 1.991 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	4.816GlnAla: 4.816 ± 0.087	0.247GlnCys: 0.247 ± 0.019	1.304GlnAsp: 1.304 ± 0.039	2.759GlnGlu: 2.759 ± 0.068	1.435GlnPhe: 1.435 ± 0.043	3.105GlnGly: 3.105 ± 0.065	0.975GlnHis: 0.975 ± 0.036	2.91GlnIle: 2.91 ± 0.061	1.615GlnLys: 1.615 ± 0.056	4.292GlnLeu: 4.292 ± 0.082	1.196GlnMet: 1.196 ± 0.04	1.351GlnAsn: 1.351 ± 0.037	2.617GlnPro: 2.617 ± 0.063	2.591GlnGln: 2.591 ± 0.073	3.681GlnArg: 3.681 ± 0.076	2.106GlnSer: 2.106 ± 0.05	2.408GlnThr: 2.408 ± 0.06	3.532GlnVal: 3.532 ± 0.069	0.74GlnTrp: 0.74 ± 0.031	1.168GlnTyr: 1.168 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	7.784ArgAla: 7.784 ± 0.107	0.635ArgCys: 0.635 ± 0.027	3.068ArgAsp: 3.068 ± 0.058	5.845ArgGlu: 5.845 ± 0.089	3.057ArgPhe: 3.057 ± 0.056	4.666ArgGly: 4.666 ± 0.068	1.656ArgHis: 1.656 ± 0.057	4.154ArgIle: 4.154 ± 0.074	2.359ArgLys: 2.359 ± 0.054	8.984ArgLeu: 8.984 ± 0.115	1.869ArgMet: 1.869 ± 0.049	2.155ArgAsn: 2.155 ± 0.055	3.37ArgPro: 3.37 ± 0.07	3.67ArgGln: 3.67 ± 0.081	5.463ArgArg: 5.463 ± 0.077	3.042ArgSer: 3.042 ± 0.067	4.038ArgThr: 4.038 ± 0.07	6.089ArgVal: 6.089 ± 0.081	2.037ArgTrp: 2.037 ± 0.056	2.957ArgTyr: 2.957 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.017SerAla: 5.017 ± 0.083	0.357SerCys: 0.357 ± 0.02	2.266SerAsp: 2.266 ± 0.054	3.256SerGlu: 3.256 ± 0.066	1.632SerPhe: 1.632 ± 0.05	4.486SerGly: 4.486 ± 0.102	0.963SerHis: 0.963 ± 0.036	1.96SerIle: 1.96 ± 0.047	1.098SerLys: 1.098 ± 0.044	5.574SerLeu: 5.574 ± 0.092	0.905SerMet: 0.905 ± 0.03	1.242SerAsn: 1.242 ± 0.05	3.05SerPro: 3.05 ± 0.065	2.065SerGln: 2.065 ± 0.054	3.187SerArg: 3.187 ± 0.068	2.133SerSer: 2.133 ± 0.059	2.311SerThr: 2.311 ± 0.05	3.73SerVal: 3.73 ± 0.07	0.79SerTrp: 0.79 ± 0.033	1.214SerTyr: 1.214 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.769ThrAla: 4.769 ± 0.07	0.433ThrCys: 0.433 ± 0.023	2.408ThrAsp: 2.408 ± 0.064	3.178ThrGlu: 3.178 ± 0.065	1.711ThrPhe: 1.711 ± 0.051	4.68ThrGly: 4.68 ± 0.09	1.163ThrHis: 1.163 ± 0.04	2.501ThrIle: 2.501 ± 0.06	0.984ThrLys: 0.984 ± 0.034	7.235ThrLeu: 7.235 ± 0.091	0.961ThrMet: 0.961 ± 0.042	1.373ThrAsn: 1.373 ± 0.052	4.478ThrPro: 4.478 ± 0.079	2.109ThrGln: 2.109 ± 0.056	3.738ThrArg: 3.738 ± 0.063	1.991ThrSer: 1.991 ± 0.055	2.693ThrThr: 2.693 ± 0.071	4.307ThrVal: 4.307 ± 0.072	0.623ThrTrp: 0.623 ± 0.031	1.587ThrTyr: 1.587 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.452ValAla: 7.452 ± 0.105	0.799ValCys: 0.799 ± 0.03	3.382ValAsp: 3.382 ± 0.065	5.171ValGlu: 5.171 ± 0.081	2.774ValPhe: 2.774 ± 0.061	5.852ValGly: 5.852 ± 0.105	1.514ValHis: 1.514 ± 0.046	3.735ValIle: 3.735 ± 0.074	2.153ValLys: 2.153 ± 0.063	8.44ValLeu: 8.44 ± 0.112	1.654ValMet: 1.654 ± 0.049	2.204ValAsn: 2.204 ± 0.057	4.242ValPro: 4.242 ± 0.079	3.35ValGln: 3.35 ± 0.065	6.508ValArg: 6.508 ± 0.088	4.132ValSer: 4.132 ± 0.071	2.131ValThr: 2.131 ± 0.065	6.569ValVal: 6.569 ± 0.121	1.391ValTrp: 1.391 ± 0.042	2.407ValTyr: 2.407 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.487TrpAla: 1.487 ± 0.042	0.209TrpCys: 0.209 ± 0.016	0.814TrpAsp: 0.814 ± 0.032	1.188TrpGlu: 1.188 ± 0.037	0.644TrpPhe: 0.644 ± 0.029	1.495TrpGly: 1.495 ± 0.046	0.467TrpHis: 0.467 ± 0.023	0.813TrpIle: 0.813 ± 0.031	0.465TrpLys: 0.465 ± 0.02	2.789TrpLeu: 2.789 ± 0.067	0.47TrpMet: 0.47 ± 0.024	0.664TrpAsn: 0.664 ± 0.03	0.202TrpPro: 0.202 ± 0.016	1.059TrpGln: 1.059 ± 0.037	1.792TrpArg: 1.792 ± 0.058	1.006TrpSer: 1.006 ± 0.04	0.778TrpThr: 0.778 ± 0.035	1.649TrpVal: 1.649 ± 0.046	0.46TrpTrp: 0.46 ± 0.026	0.508TrpTyr: 0.508 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.229TyrAla: 3.229 ± 0.062	0.353TyrCys: 0.353 ± 0.021	1.764TyrAsp: 1.764 ± 0.056	2.177TyrGlu: 2.177 ± 0.048	1.188TyrPhe: 1.188 ± 0.042	2.588TyrGly: 2.588 ± 0.061	0.773TyrHis: 0.773 ± 0.029	1.267TyrIle: 1.267 ± 0.041	0.688TyrLys: 0.688 ± 0.031	3.605TyrLeu: 3.605 ± 0.068	0.459TyrMet: 0.459 ± 0.025	0.932TyrAsn: 0.932 ± 0.039	1.859TyrPro: 1.859 ± 0.05	1.387TyrGln: 1.387 ± 0.041	2.904TyrArg: 2.904 ± 0.058	1.351TyrSer: 1.351 ± 0.044	1.949TyrThr: 1.949 ± 0.055	1.85TyrVal: 1.85 ± 0.05	0.702TyrTrp: 0.702 ± 0.032	1.197TyrTyr: 1.197 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2575 proteins (877366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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