Amino acid dipepetide frequency for Mycobacterium phage Papez

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.611AlaAla: 12.611 ± 1.223
0.546AlaCys: 0.546 ± 0.166
6.002AlaAsp: 6.002 ± 0.59
6.487AlaGlu: 6.487 ± 0.756
3.274AlaPhe: 3.274 ± 0.537
7.882AlaGly: 7.882 ± 0.725
1.455AlaHis: 1.455 ± 0.347
3.88AlaIle: 3.88 ± 0.47
4.123AlaLys: 4.123 ± 0.563
9.276AlaLeu: 9.276 ± 0.953
1.879AlaMet: 1.879 ± 0.402
2.425AlaAsn: 2.425 ± 0.432
5.032AlaPro: 5.032 ± 0.773
2.91AlaGln: 2.91 ± 0.41
5.942AlaArg: 5.942 ± 0.572
4.729AlaSer: 4.729 ± 0.51
5.76AlaThr: 5.76 ± 0.626
8.367AlaVal: 8.367 ± 0.804
1.758AlaTrp: 1.758 ± 0.325
2.607AlaTyr: 2.607 ± 0.36
0.0AlaXaa: 0.0 ± 0.0
Cys
0.788CysAla: 0.788 ± 0.244
0.061CysCys: 0.061 ± 0.065
0.424CysAsp: 0.424 ± 0.17
0.788CysGlu: 0.788 ± 0.274
0.121CysPhe: 0.121 ± 0.084
0.546CysGly: 0.546 ± 0.212
0.121CysHis: 0.121 ± 0.078
0.182CysIle: 0.182 ± 0.107
0.243CysLys: 0.243 ± 0.144
0.364CysLeu: 0.364 ± 0.213
0.182CysMet: 0.182 ± 0.097
0.364CysAsn: 0.364 ± 0.149
0.243CysPro: 0.243 ± 0.124
0.303CysGln: 0.303 ± 0.121
0.485CysArg: 0.485 ± 0.169
0.424CysSer: 0.424 ± 0.172
0.364CysThr: 0.364 ± 0.146
0.243CysVal: 0.243 ± 0.113
0.121CysTrp: 0.121 ± 0.107
0.121CysTyr: 0.121 ± 0.075
0.0CysXaa: 0.0 ± 0.0
Asp
5.881AspAla: 5.881 ± 0.641
0.424AspCys: 0.424 ± 0.142
4.001AspAsp: 4.001 ± 0.396
4.365AspGlu: 4.365 ± 0.507
2.486AspPhe: 2.486 ± 0.337
5.881AspGly: 5.881 ± 0.628
1.273AspHis: 1.273 ± 0.285
2.91AspIle: 2.91 ± 0.481
2.91AspLys: 2.91 ± 0.461
6.73AspLeu: 6.73 ± 0.678
0.97AspMet: 0.97 ± 0.234
1.94AspAsn: 1.94 ± 0.375
4.85AspPro: 4.85 ± 0.638
1.576AspGln: 1.576 ± 0.366
3.577AspArg: 3.577 ± 0.374
3.456AspSer: 3.456 ± 0.487
3.698AspThr: 3.698 ± 0.416
4.972AspVal: 4.972 ± 0.566
1.758AspTrp: 1.758 ± 0.377
1.819AspTyr: 1.819 ± 0.354
0.0AspXaa: 0.0 ± 0.0
Glu
6.123GluAla: 6.123 ± 0.7
0.303GluCys: 0.303 ± 0.169
4.365GluAsp: 4.365 ± 0.57
5.396GluGlu: 5.396 ± 0.607
2.304GluPhe: 2.304 ± 0.38
4.365GluGly: 4.365 ± 0.53
1.334GluHis: 1.334 ± 0.302
3.88GluIle: 3.88 ± 0.483
2.789GluLys: 2.789 ± 0.405
6.851GluLeu: 6.851 ± 0.531
1.698GluMet: 1.698 ± 0.278
1.94GluAsn: 1.94 ± 0.418
2.971GluPro: 2.971 ± 0.465
2.486GluGln: 2.486 ± 0.356
4.123GluArg: 4.123 ± 0.64
3.456GluSer: 3.456 ± 0.351
3.516GluThr: 3.516 ± 0.462
5.093GluVal: 5.093 ± 0.658
1.516GluTrp: 1.516 ± 0.371
2.486GluTyr: 2.486 ± 0.47
0.0GluXaa: 0.0 ± 0.0
Phe
2.486PheAla: 2.486 ± 0.447
0.182PheCys: 0.182 ± 0.118
2.728PheAsp: 2.728 ± 0.372
2.061PheGlu: 2.061 ± 0.357
0.667PhePhe: 0.667 ± 0.209
3.395PheGly: 3.395 ± 0.52
0.849PheHis: 0.849 ± 0.266
1.334PheIle: 1.334 ± 0.298
1.213PheLys: 1.213 ± 0.289
2.607PheLeu: 2.607 ± 0.48
0.667PheMet: 0.667 ± 0.231
1.455PheAsn: 1.455 ± 0.31
1.698PhePro: 1.698 ± 0.302
0.788PheGln: 0.788 ± 0.166
1.94PheArg: 1.94 ± 0.357
2.243PheSer: 2.243 ± 0.327
2.122PheThr: 2.122 ± 0.366
1.94PheVal: 1.94 ± 0.405
0.788PheTrp: 0.788 ± 0.215
0.788PheTyr: 0.788 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
7.093GlyAla: 7.093 ± 0.951
0.606GlyCys: 0.606 ± 0.177
5.942GlyAsp: 5.942 ± 0.441
4.305GlyGlu: 4.305 ± 0.457
2.85GlyPhe: 2.85 ± 0.496
9.397GlyGly: 9.397 ± 2.257
2.364GlyHis: 2.364 ± 0.484
4.547GlyIle: 4.547 ± 0.753
3.577GlyLys: 3.577 ± 0.503
7.518GlyLeu: 7.518 ± 0.88
1.698GlyMet: 1.698 ± 0.29
3.516GlyAsn: 3.516 ± 0.41
3.82GlyPro: 3.82 ± 0.538
2.486GlyGln: 2.486 ± 0.392
4.729GlyArg: 4.729 ± 0.573
6.487GlySer: 6.487 ± 0.845
5.093GlyThr: 5.093 ± 0.564
5.517GlyVal: 5.517 ± 0.555
2.425GlyTrp: 2.425 ± 0.358
3.092GlyTyr: 3.092 ± 0.465
0.0GlyXaa: 0.0 ± 0.0
His
1.576HisAla: 1.576 ± 0.351
0.182HisCys: 0.182 ± 0.101
1.091HisAsp: 1.091 ± 0.231
1.758HisGlu: 1.758 ± 0.338
0.849HisPhe: 0.849 ± 0.244
1.455HisGly: 1.455 ± 0.308
0.788HisHis: 0.788 ± 0.225
1.031HisIle: 1.031 ± 0.207
0.97HisLys: 0.97 ± 0.296
1.516HisLeu: 1.516 ± 0.356
0.121HisMet: 0.121 ± 0.092
0.243HisAsn: 0.243 ± 0.118
1.273HisPro: 1.273 ± 0.226
0.97HisGln: 0.97 ± 0.26
1.698HisArg: 1.698 ± 0.353
0.606HisSer: 0.606 ± 0.177
1.273HisThr: 1.273 ± 0.291
1.698HisVal: 1.698 ± 0.267
0.546HisTrp: 0.546 ± 0.172
0.788HisTyr: 0.788 ± 0.214
0.0HisXaa: 0.0 ± 0.0
Ile
5.396IleAla: 5.396 ± 0.632
0.243IleCys: 0.243 ± 0.107
3.335IleAsp: 3.335 ± 0.373
3.941IleGlu: 3.941 ± 0.469
0.849IlePhe: 0.849 ± 0.201
4.123IleGly: 4.123 ± 0.512
0.849IleHis: 0.849 ± 0.188
1.879IleIle: 1.879 ± 0.311
2.061IleLys: 2.061 ± 0.36
3.577IleLeu: 3.577 ± 0.441
0.728IleMet: 0.728 ± 0.22
1.698IleAsn: 1.698 ± 0.318
2.971IlePro: 2.971 ± 0.4
1.516IleGln: 1.516 ± 0.312
3.335IleArg: 3.335 ± 0.488
3.213IleSer: 3.213 ± 0.469
3.456IleThr: 3.456 ± 0.489
3.395IleVal: 3.395 ± 0.518
0.788IleTrp: 0.788 ± 0.179
1.698IleTyr: 1.698 ± 0.305
0.0IleXaa: 0.0 ± 0.0
Lys
4.001LysAla: 4.001 ± 0.581
0.182LysCys: 0.182 ± 0.104
2.668LysAsp: 2.668 ± 0.462
1.758LysGlu: 1.758 ± 0.314
1.334LysPhe: 1.334 ± 0.309
2.546LysGly: 2.546 ± 0.373
1.273LysHis: 1.273 ± 0.323
2.183LysIle: 2.183 ± 0.399
2.304LysLys: 2.304 ± 0.424
3.698LysLeu: 3.698 ± 0.426
0.97LysMet: 0.97 ± 0.212
1.273LysAsn: 1.273 ± 0.247
2.728LysPro: 2.728 ± 0.391
1.698LysGln: 1.698 ± 0.38
2.91LysArg: 2.91 ± 0.41
2.425LysSer: 2.425 ± 0.4
2.183LysThr: 2.183 ± 0.34
3.395LysVal: 3.395 ± 0.374
0.667LysTrp: 0.667 ± 0.252
1.091LysTyr: 1.091 ± 0.335
0.0LysXaa: 0.0 ± 0.0
Leu
8.791LeuAla: 8.791 ± 0.826
0.485LeuCys: 0.485 ± 0.177
6.427LeuAsp: 6.427 ± 0.562
5.396LeuGlu: 5.396 ± 0.61
2.243LeuPhe: 2.243 ± 0.351
8.245LeuGly: 8.245 ± 0.749
1.394LeuHis: 1.394 ± 0.359
4.486LeuIle: 4.486 ± 0.558
3.759LeuLys: 3.759 ± 0.525
6.245LeuLeu: 6.245 ± 0.535
1.637LeuMet: 1.637 ± 0.276
3.213LeuAsn: 3.213 ± 0.383
5.578LeuPro: 5.578 ± 0.525
2.971LeuGln: 2.971 ± 0.519
5.76LeuArg: 5.76 ± 0.621
6.063LeuSer: 6.063 ± 0.555
5.942LeuThr: 5.942 ± 0.524
4.547LeuVal: 4.547 ± 0.55
1.152LeuTrp: 1.152 ± 0.329
2.364LeuTyr: 2.364 ± 0.419
0.0LeuXaa: 0.0 ± 0.0
Met
2.304MetAla: 2.304 ± 0.339
0.0MetCys: 0.0 ± 0.0
1.031MetAsp: 1.031 ± 0.268
1.273MetGlu: 1.273 ± 0.346
0.667MetPhe: 0.667 ± 0.18
1.455MetGly: 1.455 ± 0.257
0.364MetHis: 0.364 ± 0.159
0.606MetIle: 0.606 ± 0.192
1.031MetLys: 1.031 ± 0.258
1.213MetLeu: 1.213 ± 0.256
0.182MetMet: 0.182 ± 0.108
0.97MetAsn: 0.97 ± 0.192
0.849MetPro: 0.849 ± 0.241
0.546MetGln: 0.546 ± 0.195
1.031MetArg: 1.031 ± 0.255
2.122MetSer: 2.122 ± 0.408
1.819MetThr: 1.819 ± 0.333
1.152MetVal: 1.152 ± 0.247
0.243MetTrp: 0.243 ± 0.115
0.485MetTyr: 0.485 ± 0.18
0.0MetXaa: 0.0 ± 0.0
Asn
3.638AsnAla: 3.638 ± 0.59
0.121AsnCys: 0.121 ± 0.102
2.183AsnAsp: 2.183 ± 0.383
1.94AsnGlu: 1.94 ± 0.326
0.97AsnPhe: 0.97 ± 0.245
3.88AsnGly: 3.88 ± 0.544
0.788AsnHis: 0.788 ± 0.19
1.637AsnIle: 1.637 ± 0.326
0.546AsnLys: 0.546 ± 0.203
2.425AsnLeu: 2.425 ± 0.371
0.546AsnMet: 0.546 ± 0.143
0.909AsnAsn: 0.909 ± 0.257
2.668AsnPro: 2.668 ± 0.37
1.091AsnGln: 1.091 ± 0.238
1.576AsnArg: 1.576 ± 0.381
1.394AsnSer: 1.394 ± 0.337
2.122AsnThr: 2.122 ± 0.372
2.789AsnVal: 2.789 ± 0.414
0.728AsnTrp: 0.728 ± 0.21
1.334AsnTyr: 1.334 ± 0.309
0.0AsnXaa: 0.0 ± 0.0
Pro
4.85ProAla: 4.85 ± 0.602
0.546ProCys: 0.546 ± 0.18
4.79ProAsp: 4.79 ± 0.524
4.547ProGlu: 4.547 ± 0.518
2.425ProPhe: 2.425 ± 0.383
4.668ProGly: 4.668 ± 0.554
0.97ProHis: 0.97 ± 0.266
2.425ProIle: 2.425 ± 0.42
2.001ProLys: 2.001 ± 0.357
4.365ProLeu: 4.365 ± 0.548
0.849ProMet: 0.849 ± 0.22
1.637ProAsn: 1.637 ± 0.305
2.728ProPro: 2.728 ± 0.381
1.394ProGln: 1.394 ± 0.311
2.789ProArg: 2.789 ± 0.507
3.82ProSer: 3.82 ± 0.497
4.183ProThr: 4.183 ± 0.62
3.698ProVal: 3.698 ± 0.383
0.909ProTrp: 0.909 ± 0.311
1.455ProTyr: 1.455 ± 0.322
0.0ProXaa: 0.0 ± 0.0
Gln
2.971GlnAla: 2.971 ± 0.502
0.121GlnCys: 0.121 ± 0.09
1.516GlnAsp: 1.516 ± 0.356
1.637GlnGlu: 1.637 ± 0.281
1.273GlnPhe: 1.273 ± 0.266
2.425GlnGly: 2.425 ± 0.32
0.728GlnHis: 0.728 ± 0.164
2.91GlnIle: 2.91 ± 0.472
1.213GlnLys: 1.213 ± 0.28
3.698GlnLeu: 3.698 ± 0.521
0.788GlnMet: 0.788 ± 0.265
0.485GlnAsn: 0.485 ± 0.194
1.879GlnPro: 1.879 ± 0.347
1.758GlnGln: 1.758 ± 0.417
1.698GlnArg: 1.698 ± 0.314
1.516GlnSer: 1.516 ± 0.341
1.819GlnThr: 1.819 ± 0.35
2.546GlnVal: 2.546 ± 0.337
0.606GlnTrp: 0.606 ± 0.172
0.606GlnTyr: 0.606 ± 0.203
0.0GlnXaa: 0.0 ± 0.0
Arg
5.699ArgAla: 5.699 ± 0.573
0.849ArgCys: 0.849 ± 0.227
2.971ArgAsp: 2.971 ± 0.371
4.911ArgGlu: 4.911 ± 0.614
1.819ArgPhe: 1.819 ± 0.353
4.911ArgGly: 4.911 ± 0.795
1.031ArgHis: 1.031 ± 0.272
3.031ArgIle: 3.031 ± 0.495
3.092ArgLys: 3.092 ± 0.484
5.578ArgLeu: 5.578 ± 0.735
1.637ArgMet: 1.637 ± 0.298
2.304ArgAsn: 2.304 ± 0.414
2.546ArgPro: 2.546 ± 0.46
2.001ArgGln: 2.001 ± 0.432
4.972ArgArg: 4.972 ± 0.707
3.638ArgSer: 3.638 ± 0.463
2.91ArgThr: 2.91 ± 0.501
5.093ArgVal: 5.093 ± 0.532
1.273ArgTrp: 1.273 ± 0.302
1.819ArgTyr: 1.819 ± 0.257
0.0ArgXaa: 0.0 ± 0.0
Ser
6.123SerAla: 6.123 ± 0.711
0.546SerCys: 0.546 ± 0.181
3.577SerAsp: 3.577 ± 0.395
3.698SerGlu: 3.698 ± 0.505
2.061SerPhe: 2.061 ± 0.357
6.427SerGly: 6.427 ± 0.963
1.213SerHis: 1.213 ± 0.254
2.728SerIle: 2.728 ± 0.418
2.183SerLys: 2.183 ± 0.376
4.85SerLeu: 4.85 ± 0.512
1.516SerMet: 1.516 ± 0.263
2.789SerAsn: 2.789 ± 0.472
3.031SerPro: 3.031 ± 0.533
2.061SerGln: 2.061 ± 0.291
3.213SerArg: 3.213 ± 0.435
3.82SerSer: 3.82 ± 0.77
3.213SerThr: 3.213 ± 0.481
4.001SerVal: 4.001 ± 0.549
1.758SerTrp: 1.758 ± 0.351
1.334SerTyr: 1.334 ± 0.338
0.0SerXaa: 0.0 ± 0.0
Thr
5.638ThrAla: 5.638 ± 0.752
0.303ThrCys: 0.303 ± 0.119
4.547ThrAsp: 4.547 ± 0.564
4.547ThrGlu: 4.547 ± 0.547
2.122ThrPhe: 2.122 ± 0.389
6.123ThrGly: 6.123 ± 0.659
1.091ThrHis: 1.091 ± 0.298
2.728ThrIle: 2.728 ± 0.506
2.728ThrLys: 2.728 ± 0.351
5.457ThrLeu: 5.457 ± 0.804
0.97ThrMet: 0.97 ± 0.226
1.758ThrAsn: 1.758 ± 0.341
4.001ThrPro: 4.001 ± 0.544
1.698ThrGln: 1.698 ± 0.259
3.092ThrArg: 3.092 ± 0.538
3.456ThrSer: 3.456 ± 0.508
4.001ThrThr: 4.001 ± 0.614
5.396ThrVal: 5.396 ± 0.673
1.091ThrTrp: 1.091 ± 0.26
1.758ThrTyr: 1.758 ± 0.369
0.0ThrXaa: 0.0 ± 0.0
Val
6.972ValAla: 6.972 ± 0.744
0.243ValCys: 0.243 ± 0.115
5.093ValAsp: 5.093 ± 0.534
4.729ValGlu: 4.729 ± 0.524
2.243ValPhe: 2.243 ± 0.347
5.093ValGly: 5.093 ± 0.622
1.273ValHis: 1.273 ± 0.212
4.062ValIle: 4.062 ± 0.565
2.91ValLys: 2.91 ± 0.443
5.881ValLeu: 5.881 ± 0.58
1.213ValMet: 1.213 ± 0.314
2.789ValAsn: 2.789 ± 0.375
3.88ValPro: 3.88 ± 0.505
2.243ValGln: 2.243 ± 0.387
5.214ValArg: 5.214 ± 0.578
4.79ValSer: 4.79 ± 0.612
5.396ValThr: 5.396 ± 0.619
5.153ValVal: 5.153 ± 0.726
1.637ValTrp: 1.637 ± 0.302
2.364ValTyr: 2.364 ± 0.364
0.0ValXaa: 0.0 ± 0.0
Trp
1.576TrpAla: 1.576 ± 0.3
0.243TrpCys: 0.243 ± 0.104
1.516TrpAsp: 1.516 ± 0.311
1.152TrpGlu: 1.152 ± 0.196
0.909TrpPhe: 0.909 ± 0.245
1.758TrpGly: 1.758 ± 0.363
0.667TrpHis: 0.667 ± 0.21
1.031TrpIle: 1.031 ± 0.222
0.364TrpLys: 0.364 ± 0.169
2.183TrpLeu: 2.183 ± 0.399
0.546TrpMet: 0.546 ± 0.189
0.424TrpAsn: 0.424 ± 0.149
0.667TrpPro: 0.667 ± 0.209
0.667TrpGln: 0.667 ± 0.182
1.455TrpArg: 1.455 ± 0.307
1.152TrpSer: 1.152 ± 0.288
1.455TrpThr: 1.455 ± 0.361
2.183TrpVal: 2.183 ± 0.359
0.728TrpTrp: 0.728 ± 0.289
0.303TrpTyr: 0.303 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.425TyrAla: 2.425 ± 0.381
0.303TyrCys: 0.303 ± 0.124
1.273TyrAsp: 1.273 ± 0.324
2.304TyrGlu: 2.304 ± 0.404
0.485TyrPhe: 0.485 ± 0.159
2.486TyrGly: 2.486 ± 0.393
0.606TyrHis: 0.606 ± 0.163
1.576TyrIle: 1.576 ± 0.362
1.273TyrLys: 1.273 ± 0.28
2.668TyrLeu: 2.668 ± 0.376
0.485TyrMet: 0.485 ± 0.148
1.152TyrAsn: 1.152 ± 0.252
1.698TyrPro: 1.698 ± 0.29
1.031TyrGln: 1.031 ± 0.284
2.546TyrArg: 2.546 ± 0.408
1.334TyrSer: 1.334 ± 0.309
2.183TyrThr: 2.183 ± 0.408
2.001TyrVal: 2.001 ± 0.371
0.485TyrTrp: 0.485 ± 0.197
0.546TyrTyr: 0.546 ± 0.202
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 94 proteins (16495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski