Amino acid dipepetide frequency for Esox lucius (Northern pike)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.26AlaAla: 5.26 ± 0.017	1.351AlaCys: 1.351 ± 0.007	3.044AlaAsp: 3.044 ± 0.009	4.31AlaGlu: 4.31 ± 0.013	2.398AlaPhe: 2.398 ± 0.008	4.237AlaGly: 4.237 ± 0.014	1.468AlaHis: 1.468 ± 0.005	2.808AlaIle: 2.808 ± 0.009	3.304AlaLys: 3.304 ± 0.011	6.46AlaLeu: 6.46 ± 0.016	1.649AlaMet: 1.649 ± 0.006	2.194AlaAsn: 2.194 ± 0.007	3.365AlaPro: 3.365 ± 0.013	2.801AlaGln: 2.801 ± 0.009	3.135AlaArg: 3.135 ± 0.008	5.065AlaSer: 5.065 ± 0.013	3.46AlaThr: 3.46 ± 0.014	4.846AlaVal: 4.846 ± 0.014	0.697AlaTrp: 0.697 ± 0.004	1.569AlaTyr: 1.569 ± 0.006	0.0AlaXaa: 0.0 ± 0.0
Cys	1.194CysAla: 1.194 ± 0.006	0.639CysCys: 0.639 ± 0.005	1.177CysAsp: 1.177 ± 0.009	1.237CysGlu: 1.237 ± 0.008	0.961CysPhe: 0.961 ± 0.006	1.644CysGly: 1.644 ± 0.009	0.678CysHis: 0.678 ± 0.004	1.043CysIle: 1.043 ± 0.006	1.119CysLys: 1.119 ± 0.006	2.347CysLeu: 2.347 ± 0.008	0.486CysMet: 0.486 ± 0.004	0.868CysAsn: 0.868 ± 0.006	1.372CysPro: 1.372 ± 0.009	1.082CysGln: 1.082 ± 0.007	1.308CysArg: 1.308 ± 0.006	2.134CysSer: 2.134 ± 0.011	1.214CysThr: 1.214 ± 0.007	1.781CysVal: 1.781 ± 0.011	0.298CysTrp: 0.298 ± 0.002	0.638CysTyr: 0.638 ± 0.004	0.0CysXaa: 0.0 ± 0.0
Asp	2.775AspAla: 2.775 ± 0.009	1.25AspCys: 1.25 ± 0.008	2.982AspAsp: 2.982 ± 0.011	3.546AspGlu: 3.546 ± 0.013	2.153AspPhe: 2.153 ± 0.008	3.67AspGly: 3.67 ± 0.013	1.257AspHis: 1.257 ± 0.006	2.843AspIle: 2.843 ± 0.01	2.717AspLys: 2.717 ± 0.01	5.184AspLeu: 5.184 ± 0.011	1.372AspMet: 1.372 ± 0.005	2.07AspAsn: 2.07 ± 0.008	3.025AspPro: 3.025 ± 0.01	2.032AspGln: 2.032 ± 0.006	2.815AspArg: 2.815 ± 0.01	4.203AspSer: 4.203 ± 0.011	2.75AspThr: 2.75 ± 0.009	3.319AspVal: 3.319 ± 0.01	0.728AspTrp: 0.728 ± 0.004	1.632AspTyr: 1.632 ± 0.006	0.0AspXaa: 0.0 ± 0.0
Glu	4.547GluAla: 4.547 ± 0.015	1.319GluCys: 1.319 ± 0.009	4.294GluAsp: 4.294 ± 0.012	7.174GluGlu: 7.174 ± 0.029	2.002GluPhe: 2.002 ± 0.007	4.367GluGly: 4.367 ± 0.013	1.45GluHis: 1.45 ± 0.006	2.862GluIle: 2.862 ± 0.008	4.493GluLys: 4.493 ± 0.018	6.036GluLeu: 6.036 ± 0.017	1.798GluMet: 1.798 ± 0.008	2.671GluAsn: 2.671 ± 0.01	2.676GluPro: 2.676 ± 0.01	2.872GluGln: 2.872 ± 0.01	4.282GluArg: 4.282 ± 0.017	3.997GluSer: 3.997 ± 0.011	3.324GluThr: 3.324 ± 0.011	4.454GluVal: 4.454 ± 0.012	0.715GluTrp: 0.715 ± 0.004	1.713GluTyr: 1.713 ± 0.006	0.0GluXaa: 0.0 ± 0.0
Phe	1.917PheAla: 1.917 ± 0.007	0.96PheCys: 0.96 ± 0.004	1.849PheAsp: 1.849 ± 0.007	1.916PheGlu: 1.916 ± 0.006	1.636PhePhe: 1.636 ± 0.007	2.291PheGly: 2.291 ± 0.008	1.048PheHis: 1.048 ± 0.005	1.97PheIle: 1.97 ± 0.008	1.829PheLys: 1.829 ± 0.007	3.985PheLeu: 3.985 ± 0.012	0.843PheMet: 0.843 ± 0.004	1.581PheAsn: 1.581 ± 0.006	1.859PhePro: 1.859 ± 0.007	1.717PheGln: 1.717 ± 0.006	1.932PheArg: 1.932 ± 0.007	3.417PheSer: 3.417 ± 0.01	2.333PheThr: 2.333 ± 0.008	2.294PheVal: 2.294 ± 0.008	0.492PheTrp: 0.492 ± 0.003	1.277PheTyr: 1.277 ± 0.005	0.0PheXaa: 0.0 ± 0.0
Gly	4.01GlyAla: 4.01 ± 0.015	1.34GlyCys: 1.34 ± 0.007	3.389GlyAsp: 3.389 ± 0.01	4.257GlyGlu: 4.257 ± 0.013	2.5GlyPhe: 2.5 ± 0.01	5.551GlyGly: 5.551 ± 0.023	1.776GlyHis: 1.776 ± 0.008	2.695GlyIle: 2.695 ± 0.009	3.675GlyLys: 3.675 ± 0.012	5.734GlyLeu: 5.734 ± 0.014	1.613GlyMet: 1.613 ± 0.008	2.558GlyAsn: 2.558 ± 0.009	3.461GlyPro: 3.461 ± 0.021	2.886GlyGln: 2.886 ± 0.01	3.78GlyArg: 3.78 ± 0.013	5.612GlySer: 5.612 ± 0.015	3.589GlyThr: 3.589 ± 0.012	4.307GlyVal: 4.307 ± 0.014	0.833GlyTrp: 0.833 ± 0.005	1.985GlyTyr: 1.985 ± 0.008	0.0GlyXaa: 0.0 ± 0.0
His	1.378HisAla: 1.378 ± 0.007	0.807HisCys: 0.807 ± 0.005	1.012HisAsp: 1.012 ± 0.005	1.2HisGlu: 1.2 ± 0.006	1.077HisPhe: 1.077 ± 0.005	1.629HisGly: 1.629 ± 0.007	1.013HisHis: 1.013 ± 0.008	1.357HisIle: 1.357 ± 0.006	1.244HisLys: 1.244 ± 0.006	2.73HisLeu: 2.73 ± 0.009	0.639HisMet: 0.639 ± 0.004	1.047HisAsn: 1.047 ± 0.005	1.681HisPro: 1.681 ± 0.009	1.308HisGln: 1.308 ± 0.008	1.632HisArg: 1.632 ± 0.006	2.38HisSer: 2.38 ± 0.009	1.8HisThr: 1.8 ± 0.013	1.494HisVal: 1.494 ± 0.006	0.344HisTrp: 0.344 ± 0.003	0.896HisTyr: 0.896 ± 0.005	0.0HisXaa: 0.0 ± 0.0
Ile	2.617IleAla: 2.617 ± 0.008	1.051IleCys: 1.051 ± 0.006	2.231IleAsp: 2.231 ± 0.008	2.481IleGlu: 2.481 ± 0.009	1.875IlePhe: 1.875 ± 0.008	2.445IleGly: 2.445 ± 0.008	1.357IleHis: 1.357 ± 0.007	2.451IleIle: 2.451 ± 0.01	2.566IleLys: 2.566 ± 0.009	4.424IleLeu: 4.424 ± 0.013	1.123IleMet: 1.123 ± 0.005	2.019IleAsn: 2.019 ± 0.007	2.49IlePro: 2.49 ± 0.01	2.239IleGln: 2.239 ± 0.007	2.523IleArg: 2.523 ± 0.008	3.688IleSer: 3.688 ± 0.008	2.887IleThr: 2.887 ± 0.01	2.705IleVal: 2.705 ± 0.01	0.494IleTrp: 0.494 ± 0.003	1.433IleTyr: 1.433 ± 0.006	0.0IleXaa: 0.0 ± 0.0
Lys	3.675LysAla: 3.675 ± 0.015	1.06LysCys: 1.06 ± 0.006	3.24LysAsp: 3.24 ± 0.01	4.538LysGlu: 4.538 ± 0.015	1.614LysPhe: 1.614 ± 0.006	3.278LysGly: 3.278 ± 0.011	1.407LysHis: 1.407 ± 0.005	2.502LysIle: 2.502 ± 0.008	4.118LysLys: 4.118 ± 0.014	4.902LysLeu: 4.902 ± 0.014	1.468LysMet: 1.468 ± 0.007	2.242LysAsn: 2.242 ± 0.008	2.787LysPro: 2.787 ± 0.011	2.431LysGln: 2.431 ± 0.009	3.273LysArg: 3.273 ± 0.011	3.566LysSer: 3.566 ± 0.013	3.176LysThr: 3.176 ± 0.012	3.578LysVal: 3.578 ± 0.012	0.584LysTrp: 0.584 ± 0.004	1.512LysTyr: 1.512 ± 0.006	0.0LysXaa: 0.0 ± 0.0
Leu	6.206LeuAla: 6.206 ± 0.015	2.288LeuCys: 2.288 ± 0.01	5.025LeuAsp: 5.025 ± 0.013	6.567LeuGlu: 6.567 ± 0.018	3.589LeuPhe: 3.589 ± 0.01	5.525LeuGly: 5.525 ± 0.014	2.726LeuHis: 2.726 ± 0.011	3.899LeuIle: 3.899 ± 0.011	5.63LeuLys: 5.63 ± 0.015	10.031LeuLeu: 10.031 ± 0.026	2.17LeuMet: 2.17 ± 0.007	3.712LeuAsn: 3.712 ± 0.009	5.268LeuPro: 5.268 ± 0.015	5.202LeuGln: 5.202 ± 0.015	5.68LeuArg: 5.68 ± 0.015	8.187LeuSer: 8.187 ± 0.017	5.452LeuThr: 5.452 ± 0.013	5.716LeuVal: 5.716 ± 0.015	1.083LeuTrp: 1.083 ± 0.005	2.775LeuTyr: 2.775 ± 0.009	0.0LeuXaa: 0.0 ± 0.0
Met	1.934MetAla: 1.934 ± 0.007	0.516MetCys: 0.516 ± 0.004	1.519MetAsp: 1.519 ± 0.005	2.061MetGlu: 2.061 ± 0.008	0.933MetPhe: 0.933 ± 0.005	1.558MetGly: 1.558 ± 0.007	0.509MetHis: 0.509 ± 0.003	0.913MetIle: 0.913 ± 0.004	1.477MetLys: 1.477 ± 0.006	2.136MetLeu: 2.136 ± 0.007	0.705MetMet: 0.705 ± 0.005	0.948MetAsn: 0.948 ± 0.005	1.099MetPro: 1.099 ± 0.006	0.997MetGln: 0.997 ± 0.005	1.203MetArg: 1.203 ± 0.006	1.85MetSer: 1.85 ± 0.007	1.331MetThr: 1.331 ± 0.006	1.674MetVal: 1.674 ± 0.007	0.272MetTrp: 0.272 ± 0.002	0.686MetTyr: 0.686 ± 0.004	0.0MetXaa: 0.0 ± 0.0
Asn	2.176AsnAla: 2.176 ± 0.007	0.901AsnCys: 0.901 ± 0.006	1.774AsnAsp: 1.774 ± 0.008	2.086AsnGlu: 2.086 ± 0.007	1.417AsnPhe: 1.417 ± 0.006	2.869AsnGly: 2.869 ± 0.012	1.025AsnHis: 1.025 ± 0.005	2.246AsnIle: 2.246 ± 0.008	2.178AsnLys: 2.178 ± 0.008	3.69AsnLeu: 3.69 ± 0.009	1.089AsnMet: 1.089 ± 0.005	1.829AsnAsn: 1.829 ± 0.008	2.357AsnPro: 2.357 ± 0.009	1.761AsnGln: 1.761 ± 0.007	2.031AsnArg: 2.031 ± 0.009	3.118AsnSer: 3.118 ± 0.009	2.374AsnThr: 2.374 ± 0.01	2.43AsnVal: 2.43 ± 0.009	0.471AsnTrp: 0.471 ± 0.003	1.205AsnTyr: 1.205 ± 0.005	0.0AsnXaa: 0.0 ± 0.0
Pro	3.832ProAla: 3.832 ± 0.013	1.152ProCys: 1.152 ± 0.009	2.96ProAsp: 2.96 ± 0.011	3.707ProGlu: 3.707 ± 0.012	1.823ProPhe: 1.823 ± 0.006	4.313ProGly: 4.313 ± 0.02	1.547ProHis: 1.547 ± 0.007	1.969ProIle: 1.969 ± 0.007	2.481ProLys: 2.481 ± 0.011	4.954ProLeu: 4.954 ± 0.014	1.097ProMet: 1.097 ± 0.006	1.965ProAsn: 1.965 ± 0.008	5.238ProPro: 5.238 ± 0.023	2.553ProGln: 2.553 ± 0.012	2.782ProArg: 2.782 ± 0.01	5.344ProSer: 5.344 ± 0.019	3.11ProThr: 3.11 ± 0.015	3.814ProVal: 3.814 ± 0.012	0.58ProTrp: 0.58 ± 0.004	1.502ProTyr: 1.502 ± 0.007	0.0ProXaa: 0.0 ± 0.0
Gln	3.191GlnAla: 3.191 ± 0.01	1.065GlnCys: 1.065 ± 0.008	2.31GlnAsp: 2.31 ± 0.007	3.309GlnGlu: 3.309 ± 0.011	1.417GlnPhe: 1.417 ± 0.006	2.929GlnGly: 2.929 ± 0.009	1.319GlnHis: 1.319 ± 0.006	1.923GlnIle: 1.923 ± 0.006	2.425GlnLys: 2.425 ± 0.009	4.421GlnLeu: 4.421 ± 0.012	1.13GlnMet: 1.13 ± 0.005	1.739GlnAsn: 1.739 ± 0.007	2.473GlnPro: 2.473 ± 0.011	2.93GlnGln: 2.93 ± 0.022	2.986GlnArg: 2.986 ± 0.011	3.253GlnSer: 3.253 ± 0.011	2.494GlnThr: 2.494 ± 0.01	2.865GlnVal: 2.865 ± 0.009	0.56GlnTrp: 0.56 ± 0.004	1.316GlnTyr: 1.316 ± 0.006	0.0GlnXaa: 0.0 ± 0.0
Arg	3.353ArgAla: 3.353 ± 0.01	1.289ArgCys: 1.289 ± 0.008	2.974ArgAsp: 2.974 ± 0.009	3.873ArgGlu: 3.873 ± 0.014	2.018ArgPhe: 2.018 ± 0.006	3.552ArgGly: 3.552 ± 0.015	1.559ArgHis: 1.559 ± 0.007	2.473ArgIle: 2.473 ± 0.007	3.4ArgLys: 3.4 ± 0.008	5.433ArgLeu: 5.433 ± 0.012	1.349ArgMet: 1.349 ± 0.006	2.185ArgAsn: 2.185 ± 0.008	2.976ArgPro: 2.976 ± 0.01	2.667ArgGln: 2.667 ± 0.01	4.112ArgArg: 4.112 ± 0.014	4.278ArgSer: 4.278 ± 0.014	2.98ArgThr: 2.98 ± 0.009	3.478ArgVal: 3.478 ± 0.011	0.693ArgTrp: 0.693 ± 0.005	1.605ArgTyr: 1.605 ± 0.006	0.0ArgXaa: 0.0 ± 0.0
Ser	5.057SerAla: 5.057 ± 0.012	1.912SerCys: 1.912 ± 0.01	4.148SerAsp: 4.148 ± 0.012	4.551SerGlu: 4.551 ± 0.012	3.055SerPhe: 3.055 ± 0.009	5.536SerGly: 5.536 ± 0.018	2.19SerHis: 2.19 ± 0.009	3.37SerIle: 3.37 ± 0.009	3.72SerLys: 3.72 ± 0.012	8.254SerLeu: 8.254 ± 0.017	1.835SerMet: 1.835 ± 0.006	2.951SerAsn: 2.951 ± 0.009	5.687SerPro: 5.687 ± 0.021	3.677SerGln: 3.677 ± 0.01	4.234SerArg: 4.234 ± 0.012	8.702SerSer: 8.702 ± 0.03	4.674SerThr: 4.674 ± 0.016	5.427SerVal: 5.427 ± 0.013	0.965SerTrp: 0.965 ± 0.005	2.177SerTyr: 2.177 ± 0.007	0.0SerXaa: 0.0 ± 0.0
Thr	3.891ThrAla: 3.891 ± 0.011	1.37ThrCys: 1.37 ± 0.009	2.937ThrAsp: 2.937 ± 0.01	3.669ThrGlu: 3.669 ± 0.011	2.158ThrPhe: 2.158 ± 0.008	3.942ThrGly: 3.942 ± 0.013	1.602ThrHis: 1.602 ± 0.01	2.525ThrIle: 2.525 ± 0.008	2.703ThrLys: 2.703 ± 0.019	5.608ThrLeu: 5.608 ± 0.013	1.298ThrMet: 1.298 ± 0.006	1.98ThrAsn: 1.98 ± 0.009	3.715ThrPro: 3.715 ± 0.016	2.374ThrGln: 2.374 ± 0.008	2.591ThrArg: 2.591 ± 0.008	4.638ThrSer: 4.638 ± 0.016	3.517ThrThr: 3.517 ± 0.046	4.321ThrVal: 4.321 ± 0.013	0.7ThrTrp: 0.7 ± 0.004	1.526ThrTyr: 1.526 ± 0.007	0.0ThrXaa: 0.0 ± 0.0
Val	4.198ValAla: 4.198 ± 0.012	1.915ValCys: 1.915 ± 0.012	3.344ValAsp: 3.344 ± 0.011	4.162ValGlu: 4.162 ± 0.011	2.782ValPhe: 2.782 ± 0.01	3.743ValGly: 3.743 ± 0.012	1.629ValHis: 1.629 ± 0.007	3.129ValIle: 3.129 ± 0.01	3.637ValLys: 3.637 ± 0.011	6.441ValLeu: 6.441 ± 0.016	1.595ValMet: 1.595 ± 0.007	2.628ValAsn: 2.628 ± 0.009	3.392ValPro: 3.392 ± 0.012	2.714ValGln: 2.714 ± 0.009	3.441ValArg: 3.441 ± 0.01	5.32ValSer: 5.32 ± 0.012	4.119ValThr: 4.119 ± 0.013	4.608ValVal: 4.608 ± 0.016	0.827ValTrp: 0.827 ± 0.004	1.925ValTyr: 1.925 ± 0.007	0.0ValXaa: 0.0 ± 0.0
Trp	0.719TrpAla: 0.719 ± 0.005	0.271TrpCys: 0.271 ± 0.003	0.671TrpAsp: 0.671 ± 0.004	0.773TrpGlu: 0.773 ± 0.004	0.468TrpPhe: 0.468 ± 0.003	0.674TrpGly: 0.674 ± 0.005	0.286TrpHis: 0.286 ± 0.003	0.561TrpIle: 0.561 ± 0.004	0.724TrpLys: 0.724 ± 0.005	1.178TrpLeu: 1.178 ± 0.006	0.351TrpMet: 0.351 ± 0.003	0.553TrpAsn: 0.553 ± 0.005	0.459TrpPro: 0.459 ± 0.003	0.5TrpGln: 0.5 ± 0.004	0.763TrpArg: 0.763 ± 0.004	0.969TrpSer: 0.969 ± 0.005	0.729TrpThr: 0.729 ± 0.005	0.745TrpVal: 0.745 ± 0.004	0.214TrpTrp: 0.214 ± 0.002	0.357TrpTyr: 0.357 ± 0.003	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.49TyrAla: 1.49 ± 0.006	0.763TyrCys: 0.763 ± 0.004	1.445TyrAsp: 1.445 ± 0.006	1.632TyrGlu: 1.632 ± 0.006	1.269TyrPhe: 1.269 ± 0.006	1.797TyrGly: 1.797 ± 0.006	0.826TyrHis: 0.826 ± 0.004	1.56TyrIle: 1.56 ± 0.006	1.514TyrLys: 1.514 ± 0.007	2.782TyrLeu: 2.782 ± 0.009	0.709TyrMet: 0.709 ± 0.004	1.287TyrAsn: 1.287 ± 0.007	1.343TyrPro: 1.343 ± 0.007	1.31TyrGln: 1.31 ± 0.006	1.744TyrArg: 1.744 ± 0.006	2.402TyrSer: 2.402 ± 0.009	1.751TyrThr: 1.751 ± 0.007	1.693TyrVal: 1.693 ± 0.007	0.415TyrTrp: 0.415 ± 0.004	1.025TyrTyr: 1.025 ± 0.006	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.002

Statistics based on 71519 proteins (50391987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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