Amino acid dipepetide frequency for Sphingopyxis sp. Root1497

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.465AlaAla: 21.465 ± 0.237	1.035AlaCys: 1.035 ± 0.028	8.544AlaAsp: 8.544 ± 0.086	7.617AlaGlu: 7.617 ± 0.095	4.519AlaPhe: 4.519 ± 0.068	12.2AlaGly: 12.2 ± 0.114	2.318AlaHis: 2.318 ± 0.045	7.136AlaIle: 7.136 ± 0.087	4.435AlaLys: 4.435 ± 0.062	13.828AlaLeu: 13.828 ± 0.129	4.159AlaMet: 4.159 ± 0.054	3.353AlaAsn: 3.353 ± 0.062	6.871AlaPro: 6.871 ± 0.087	4.176AlaGln: 4.176 ± 0.057	9.414AlaArg: 9.414 ± 0.1	6.815AlaSer: 6.815 ± 0.09	7.131AlaThr: 7.131 ± 0.089	8.86AlaVal: 8.86 ± 0.09	1.755AlaTrp: 1.755 ± 0.037	2.606AlaTyr: 2.606 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.947CysAla: 0.947 ± 0.026	0.078CysCys: 0.078 ± 0.008	0.548CysAsp: 0.548 ± 0.02	0.361CysGlu: 0.361 ± 0.017	0.28CysPhe: 0.28 ± 0.014	0.839CysGly: 0.839 ± 0.029	0.198CysHis: 0.198 ± 0.015	0.341CysIle: 0.341 ± 0.014	0.152CysLys: 0.152 ± 0.01	0.667CysLeu: 0.667 ± 0.026	0.125CysMet: 0.125 ± 0.01	0.229CysAsn: 0.229 ± 0.016	0.446CysPro: 0.446 ± 0.021	0.211CysGln: 0.211 ± 0.012	0.543CysArg: 0.543 ± 0.021	0.418CysSer: 0.418 ± 0.017	0.392CysThr: 0.392 ± 0.017	0.515CysVal: 0.515 ± 0.018	0.103CysTrp: 0.103 ± 0.008	0.176CysTyr: 0.176 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.756AspAla: 8.756 ± 0.09	0.485AspCys: 0.485 ± 0.021	3.736AspAsp: 3.736 ± 0.056	3.382AspGlu: 3.382 ± 0.051	2.34AspPhe: 2.34 ± 0.046	6.081AspGly: 6.081 ± 0.077	1.414AspHis: 1.414 ± 0.033	3.244AspIle: 3.244 ± 0.055	1.902AspLys: 1.902 ± 0.04	5.83AspLeu: 5.83 ± 0.07	1.447AspMet: 1.447 ± 0.035	1.453AspAsn: 1.453 ± 0.04	3.843AspPro: 3.843 ± 0.055	1.701AspGln: 1.701 ± 0.038	5.019AspArg: 5.019 ± 0.067	2.454AspSer: 2.454 ± 0.044	2.819AspThr: 2.819 ± 0.048	4.133AspVal: 4.133 ± 0.058	1.192AspTrp: 1.192 ± 0.031	1.822AspTyr: 1.822 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.55GluAla: 7.55 ± 0.087	0.306GluCys: 0.306 ± 0.016	2.58GluAsp: 2.58 ± 0.042	2.626GluGlu: 2.626 ± 0.05	1.496GluPhe: 1.496 ± 0.034	4.329GluGly: 4.329 ± 0.06	0.968GluHis: 0.968 ± 0.023	2.879GluIle: 2.879 ± 0.048	1.961GluLys: 1.961 ± 0.045	4.78GluLeu: 4.78 ± 0.056	1.365GluMet: 1.365 ± 0.03	1.329GluAsn: 1.329 ± 0.03	2.44GluPro: 2.44 ± 0.04	1.83GluGln: 1.83 ± 0.038	4.42GluArg: 4.42 ± 0.062	2.165GluSer: 2.165 ± 0.044	3.003GluThr: 3.003 ± 0.048	3.407GluVal: 3.407 ± 0.058	0.777GluTrp: 0.777 ± 0.024	1.002GluTyr: 1.002 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	5.26PheAla: 5.26 ± 0.059	0.314PheCys: 0.314 ± 0.016	2.876PheAsp: 2.876 ± 0.048	1.943PheGlu: 1.943 ± 0.039	1.284PhePhe: 1.284 ± 0.034	3.903PheGly: 3.903 ± 0.059	0.694PheHis: 0.694 ± 0.024	1.434PheIle: 1.434 ± 0.038	0.838PheLys: 0.838 ± 0.027	3.196PheLeu: 3.196 ± 0.05	0.688PheMet: 0.688 ± 0.022	1.038PheAsn: 1.038 ± 0.028	1.549PhePro: 1.549 ± 0.033	0.909PheGln: 0.909 ± 0.026	2.15PheArg: 2.15 ± 0.038	1.982PheSer: 1.982 ± 0.041	1.957PheThr: 1.957 ± 0.041	2.662PheVal: 2.662 ± 0.046	0.52PheTrp: 0.52 ± 0.02	0.943PheTyr: 0.943 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.787GlyAla: 10.787 ± 0.094	0.802GlyCys: 0.802 ± 0.026	5.702GlyAsp: 5.702 ± 0.08	5.075GlyGlu: 5.075 ± 0.068	3.686GlyPhe: 3.686 ± 0.056	9.094GlyGly: 9.094 ± 0.167	1.874GlyHis: 1.874 ± 0.033	4.596GlyIle: 4.596 ± 0.067	3.393GlyLys: 3.393 ± 0.057	8.569GlyLeu: 8.569 ± 0.092	2.283GlyMet: 2.283 ± 0.041	2.515GlyAsn: 2.515 ± 0.075	3.816GlyPro: 3.816 ± 0.053	3.052GlyGln: 3.052 ± 0.05	6.346GlyArg: 6.346 ± 0.071	4.93GlySer: 4.93 ± 0.072	5.011GlyThr: 5.011 ± 0.087	6.311GlyVal: 6.311 ± 0.073	1.809GlyTrp: 1.809 ± 0.034	2.401GlyTyr: 2.401 ± 0.047	0.004GlyXaa: 0.004 ± 0.002
His	2.383HisAla: 2.383 ± 0.047	0.236HisCys: 0.236 ± 0.012	1.219HisAsp: 1.219 ± 0.028	0.876HisGlu: 0.876 ± 0.025	0.852HisPhe: 0.852 ± 0.027	1.969HisGly: 1.969 ± 0.044	0.531HisHis: 0.531 ± 0.02	1.002HisIle: 1.002 ± 0.028	0.478HisLys: 0.478 ± 0.019	1.783HisLeu: 1.783 ± 0.034	0.485HisMet: 0.485 ± 0.018	0.456HisAsn: 0.456 ± 0.018	1.288HisPro: 1.288 ± 0.03	0.507HisGln: 0.507 ± 0.018	1.45HisArg: 1.45 ± 0.034	0.98HisSer: 0.98 ± 0.027	0.599HisThr: 0.599 ± 0.02	1.433HisVal: 1.433 ± 0.035	0.392HisTrp: 0.392 ± 0.018	0.576HisTyr: 0.576 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.218IleAla: 8.218 ± 0.094	0.43IleCys: 0.43 ± 0.018	4.183IleAsp: 4.183 ± 0.066	3.314IleGlu: 3.314 ± 0.047	1.733IlePhe: 1.733 ± 0.038	5.189IleGly: 5.189 ± 0.058	0.883IleHis: 0.883 ± 0.025	2.093IleIle: 2.093 ± 0.044	1.19IleLys: 1.19 ± 0.029	4.219IleLeu: 4.219 ± 0.063	0.878IleMet: 0.878 ± 0.025	1.363IleAsn: 1.363 ± 0.039	2.29IlePro: 2.29 ± 0.037	1.068IleGln: 1.068 ± 0.027	3.129IleArg: 3.129 ± 0.041	2.482IleSer: 2.482 ± 0.045	2.368IleThr: 2.368 ± 0.053	4.276IleVal: 4.276 ± 0.052	0.686IleTrp: 0.686 ± 0.024	1.066IleTyr: 1.066 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.238LysAla: 4.238 ± 0.062	0.168LysCys: 0.168 ± 0.01	1.716LysAsp: 1.716 ± 0.037	1.183LysGlu: 1.183 ± 0.033	0.88LysPhe: 0.88 ± 0.03	2.675LysGly: 2.675 ± 0.048	0.527LysHis: 0.527 ± 0.021	1.532LysIle: 1.532 ± 0.034	1.155LysLys: 1.155 ± 0.033	3.183LysLeu: 3.183 ± 0.05	0.735LysMet: 0.735 ± 0.021	0.681LysAsn: 0.681 ± 0.023	1.939LysPro: 1.939 ± 0.044	0.936LysGln: 0.936 ± 0.026	2.14LysArg: 2.14 ± 0.044	1.61LysSer: 1.61 ± 0.034	1.698LysThr: 1.698 ± 0.033	2.045LysVal: 2.045 ± 0.041	0.436LysTrp: 0.436 ± 0.017	0.661LysTyr: 0.661 ± 0.025	0.001LysXaa: 0.001 ± 0.001
Leu	14.44LeuAla: 14.44 ± 0.138	0.707LeuCys: 0.707 ± 0.021	6.051LeuAsp: 6.051 ± 0.079	4.104LeuGlu: 4.104 ± 0.057	3.782LeuPhe: 3.782 ± 0.059	8.309LeuGly: 8.309 ± 0.089	1.787LeuHis: 1.787 ± 0.039	4.885LeuIle: 4.885 ± 0.066	2.819LeuLys: 2.819 ± 0.048	9.492LeuLeu: 9.492 ± 0.117	2.109LeuMet: 2.109 ± 0.037	2.273LeuAsn: 2.273 ± 0.046	5.524LeuPro: 5.524 ± 0.065	2.293LeuGln: 2.293 ± 0.045	6.341LeuArg: 6.341 ± 0.072	5.698LeuSer: 5.698 ± 0.07	5.722LeuThr: 5.722 ± 0.073	7.134LeuVal: 7.134 ± 0.074	1.303LeuTrp: 1.303 ± 0.033	2.014LeuTyr: 2.014 ± 0.045	0.001LeuXaa: 0.001 ± 0.001
Met	3.358MetAla: 3.358 ± 0.054	0.142MetCys: 0.142 ± 0.01	1.103MetAsp: 1.103 ± 0.027	1.014MetGlu: 1.014 ± 0.026	0.703MetPhe: 0.703 ± 0.026	1.838MetGly: 1.838 ± 0.039	0.421MetHis: 0.421 ± 0.015	1.378MetIle: 1.378 ± 0.032	0.885MetLys: 0.885 ± 0.023	2.737MetLeu: 2.737 ± 0.053	0.672MetMet: 0.672 ± 0.024	0.634MetAsn: 0.634 ± 0.021	1.446MetPro: 1.446 ± 0.032	0.687MetGln: 0.687 ± 0.023	1.72MetArg: 1.72 ± 0.035	1.391MetSer: 1.391 ± 0.032	1.875MetThr: 1.875 ± 0.039	1.584MetVal: 1.584 ± 0.032	0.24MetTrp: 0.24 ± 0.014	0.265MetTyr: 0.265 ± 0.014	0.001MetXaa: 0.001 ± 0.001
Asn	3.209AsnAla: 3.209 ± 0.069	0.241AsnCys: 0.241 ± 0.013	1.51AsnAsp: 1.51 ± 0.047	1.055AsnGlu: 1.055 ± 0.03	1.058AsnPhe: 1.058 ± 0.026	2.507AsnGly: 2.507 ± 0.062	0.46AsnHis: 0.46 ± 0.018	1.469AsnIle: 1.469 ± 0.037	0.67AsnLys: 0.67 ± 0.027	2.435AsnLeu: 2.435 ± 0.047	0.552AsnMet: 0.552 ± 0.023	0.712AsnAsn: 0.712 ± 0.026	1.785AsnPro: 1.785 ± 0.038	0.695AsnGln: 0.695 ± 0.023	1.857AsnArg: 1.857 ± 0.037	1.344AsnSer: 1.344 ± 0.037	1.026AsnThr: 1.026 ± 0.034	1.761AsnVal: 1.761 ± 0.042	0.465AsnTrp: 0.465 ± 0.017	0.757AsnTyr: 0.757 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.607ProAla: 7.607 ± 0.096	0.318ProCys: 0.318 ± 0.016	3.949ProAsp: 3.949 ± 0.057	3.199ProGlu: 3.199 ± 0.048	1.893ProPhe: 1.893 ± 0.033	5.032ProGly: 5.032 ± 0.061	1.075ProHis: 1.075 ± 0.032	2.381ProIle: 2.381 ± 0.04	1.535ProLys: 1.535 ± 0.039	5.027ProLeu: 5.027 ± 0.076	1.203ProMet: 1.203 ± 0.026	1.275ProAsn: 1.275 ± 0.029	2.825ProPro: 2.825 ± 0.074	1.546ProGln: 1.546 ± 0.034	2.967ProArg: 2.967 ± 0.044	2.54ProSer: 2.54 ± 0.045	2.665ProThr: 2.665 ± 0.051	4.424ProVal: 4.424 ± 0.063	0.668ProTrp: 0.668 ± 0.024	1.132ProTyr: 1.132 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.844GlnAla: 3.844 ± 0.049	0.209GlnCys: 0.209 ± 0.014	1.407GlnAsp: 1.407 ± 0.033	1.092GlnGlu: 1.092 ± 0.03	1.075GlnPhe: 1.075 ± 0.027	2.341GlnGly: 2.341 ± 0.043	0.584GlnHis: 0.584 ± 0.018	1.664GlnIle: 1.664 ± 0.031	0.889GlnLys: 0.889 ± 0.026	3.009GlnLeu: 3.009 ± 0.052	0.797GlnMet: 0.797 ± 0.023	0.739GlnAsn: 0.739 ± 0.026	1.77GlnPro: 1.77 ± 0.034	1.109GlnGln: 1.109 ± 0.027	2.3GlnArg: 2.3 ± 0.04	1.623GlnSer: 1.623 ± 0.033	1.422GlnThr: 1.422 ± 0.031	2.054GlnVal: 2.054 ± 0.038	0.447GlnTrp: 0.447 ± 0.018	0.686GlnTyr: 0.686 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.647ArgAla: 8.647 ± 0.097	0.483ArgCys: 0.483 ± 0.021	4.433ArgAsp: 4.433 ± 0.064	3.64ArgGlu: 3.64 ± 0.056	3.052ArgPhe: 3.052 ± 0.045	5.217ArgGly: 5.217 ± 0.065	1.601ArgHis: 1.601 ± 0.03	4.067ArgIle: 4.067 ± 0.061	1.977ArgLys: 1.977 ± 0.038	7.664ArgLeu: 7.664 ± 0.088	1.853ArgMet: 1.853 ± 0.035	1.72ArgAsn: 1.72 ± 0.032	3.533ArgPro: 3.533 ± 0.054	2.226ArgGln: 2.226 ± 0.044	5.263ArgArg: 5.263 ± 0.075	3.483ArgSer: 3.483 ± 0.046	3.415ArgThr: 3.415 ± 0.048	4.698ArgVal: 4.698 ± 0.059	1.234ArgTrp: 1.234 ± 0.037	1.832ArgTyr: 1.832 ± 0.042	0.001ArgXaa: 0.001 ± 0.001
Ser	6.356SerAla: 6.356 ± 0.069	0.39SerCys: 0.39 ± 0.018	3.331SerAsp: 3.331 ± 0.044	2.56SerGlu: 2.56 ± 0.05	2.297SerPhe: 2.297 ± 0.042	5.492SerGly: 5.492 ± 0.077	0.923SerHis: 0.923 ± 0.024	2.721SerIle: 2.721 ± 0.048	1.364SerLys: 1.364 ± 0.033	5.003SerLeu: 5.003 ± 0.05	1.095SerMet: 1.095 ± 0.025	1.363SerAsn: 1.363 ± 0.036	2.756SerPro: 2.756 ± 0.044	1.38SerGln: 1.38 ± 0.027	3.239SerArg: 3.239 ± 0.051	2.633SerSer: 2.633 ± 0.056	2.47SerThr: 2.47 ± 0.048	3.633SerVal: 3.633 ± 0.054	0.829SerTrp: 0.829 ± 0.024	1.376SerTyr: 1.376 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.716ThrAla: 6.716 ± 0.104	0.384ThrCys: 0.384 ± 0.017	3.047ThrAsp: 3.047 ± 0.056	2.254ThrGlu: 2.254 ± 0.036	1.661ThrPhe: 1.661 ± 0.037	5.628ThrGly: 5.628 ± 0.088	1.028ThrHis: 1.028 ± 0.026	3.106ThrIle: 3.106 ± 0.055	1.361ThrLys: 1.361 ± 0.034	5.678ThrLeu: 5.678 ± 0.064	1.215ThrMet: 1.215 ± 0.029	1.349ThrAsn: 1.349 ± 0.035	3.434ThrPro: 3.434 ± 0.048	1.341ThrGln: 1.341 ± 0.031	3.432ThrArg: 3.432 ± 0.052	2.664ThrSer: 2.664 ± 0.045	2.786ThrThr: 2.786 ± 0.062	3.904ThrVal: 3.904 ± 0.054	0.599ThrTrp: 0.599 ± 0.024	1.138ThrTyr: 1.138 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.163ValAla: 10.163 ± 0.095	0.494ValCys: 0.494 ± 0.018	4.618ValAsp: 4.618 ± 0.06	4.243ValGlu: 4.243 ± 0.053	2.068ValPhe: 2.068 ± 0.044	6.078ValGly: 6.078 ± 0.071	1.337ValHis: 1.337 ± 0.032	3.538ValIle: 3.538 ± 0.056	2.013ValLys: 2.013 ± 0.045	5.814ValLeu: 5.814 ± 0.068	1.63ValMet: 1.63 ± 0.037	1.929ValAsn: 1.929 ± 0.043	3.9ValPro: 3.9 ± 0.062	2.022ValGln: 2.022 ± 0.039	4.993ValArg: 4.993 ± 0.06	3.795ValSer: 3.795 ± 0.058	4.448ValThr: 4.448 ± 0.055	5.195ValVal: 5.195 ± 0.068	0.859ValTrp: 0.859 ± 0.025	1.379ValTyr: 1.379 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.509TrpAla: 1.509 ± 0.039	0.118TrpCys: 0.118 ± 0.01	0.826TrpAsp: 0.826 ± 0.026	0.593TrpGlu: 0.593 ± 0.02	0.598TrpPhe: 0.598 ± 0.022	1.02TrpGly: 1.02 ± 0.028	0.358TrpHis: 0.358 ± 0.016	0.714TrpIle: 0.714 ± 0.024	0.479TrpLys: 0.479 ± 0.019	1.784TrpLeu: 1.784 ± 0.039	0.372TrpMet: 0.372 ± 0.014	0.477TrpAsn: 0.477 ± 0.016	0.745TrpPro: 0.745 ± 0.023	0.662TrpGln: 0.662 ± 0.021	1.372TrpArg: 1.372 ± 0.032	0.951TrpSer: 0.951 ± 0.025	0.921TrpThr: 0.921 ± 0.028	0.905TrpVal: 0.905 ± 0.03	0.264TrpTrp: 0.264 ± 0.015	0.303TrpTyr: 0.303 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.784TyrAla: 2.784 ± 0.041	0.227TyrCys: 0.227 ± 0.012	1.676TyrAsp: 1.676 ± 0.041	1.082TyrGlu: 1.082 ± 0.029	0.883TyrPhe: 0.883 ± 0.024	2.314TyrGly: 2.314 ± 0.044	0.514TyrHis: 0.514 ± 0.018	0.877TyrIle: 0.877 ± 0.026	0.642TyrLys: 0.642 ± 0.024	2.09TyrLeu: 2.09 ± 0.042	0.428TyrMet: 0.428 ± 0.019	0.679TyrAsn: 0.679 ± 0.025	1.062TyrPro: 1.062 ± 0.031	0.707TyrGln: 0.707 ± 0.022	1.944TyrArg: 1.944 ± 0.038	1.254TyrSer: 1.254 ± 0.031	1.0TyrThr: 1.0 ± 0.029	1.578TyrVal: 1.578 ± 0.038	0.393TyrTrp: 0.393 ± 0.018	0.66TyrTyr: 0.66 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 4384 proteins (1426498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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