Amino acid dipepetide frequency for Gordonia phage Lysidious

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.946AlaAla: 15.946 ± 1.368
0.849AlaCys: 0.849 ± 0.299
7.761AlaAsp: 7.761 ± 0.805
6.245AlaGlu: 6.245 ± 0.665
3.335AlaPhe: 3.335 ± 0.638
9.277AlaGly: 9.277 ± 1.049
1.88AlaHis: 1.88 ± 0.44
5.76AlaIle: 5.76 ± 0.537
4.002AlaLys: 4.002 ± 0.619
9.459AlaLeu: 9.459 ± 0.989
2.547AlaMet: 2.547 ± 0.535
3.153AlaAsn: 3.153 ± 0.515
5.275AlaPro: 5.275 ± 0.658
4.365AlaGln: 4.365 ± 0.564
8.549AlaArg: 8.549 ± 0.879
5.699AlaSer: 5.699 ± 0.741
7.276AlaThr: 7.276 ± 0.8
8.064AlaVal: 8.064 ± 0.858
1.758AlaTrp: 1.758 ± 0.352
2.304AlaTyr: 2.304 ± 0.366
0.0AlaXaa: 0.0 ± 0.0
Cys
0.788CysAla: 0.788 ± 0.261
0.243CysCys: 0.243 ± 0.144
1.213CysAsp: 1.213 ± 0.318
0.303CysGlu: 0.303 ± 0.137
0.061CysPhe: 0.061 ± 0.058
0.788CysGly: 0.788 ± 0.287
0.485CysHis: 0.485 ± 0.179
0.243CysIle: 0.243 ± 0.13
0.182CysLys: 0.182 ± 0.14
0.667CysLeu: 0.667 ± 0.193
0.364CysMet: 0.364 ± 0.161
0.424CysAsn: 0.424 ± 0.175
0.788CysPro: 0.788 ± 0.27
0.424CysGln: 0.424 ± 0.134
0.97CysArg: 0.97 ± 0.261
0.364CysSer: 0.364 ± 0.142
0.667CysThr: 0.667 ± 0.211
0.424CysVal: 0.424 ± 0.193
0.243CysTrp: 0.243 ± 0.143
0.061CysTyr: 0.061 ± 0.053
0.0CysXaa: 0.0 ± 0.0
Asp
7.518AspAla: 7.518 ± 0.825
0.485AspCys: 0.485 ± 0.163
4.911AspAsp: 4.911 ± 0.574
4.244AspGlu: 4.244 ± 0.647
1.637AspPhe: 1.637 ± 0.287
6.912AspGly: 6.912 ± 0.854
2.061AspHis: 2.061 ± 0.367
2.789AspIle: 2.789 ± 0.381
1.516AspLys: 1.516 ± 0.347
6.124AspLeu: 6.124 ± 0.796
1.516AspMet: 1.516 ± 0.264
2.122AspAsn: 2.122 ± 0.353
3.82AspPro: 3.82 ± 0.508
2.789AspGln: 2.789 ± 0.334
5.336AspArg: 5.336 ± 0.881
3.517AspSer: 3.517 ± 0.378
4.426AspThr: 4.426 ± 0.59
5.942AspVal: 5.942 ± 0.644
1.152AspTrp: 1.152 ± 0.294
1.576AspTyr: 1.576 ± 0.268
0.0AspXaa: 0.0 ± 0.0
Glu
5.396GluAla: 5.396 ± 0.656
0.606GluCys: 0.606 ± 0.205
3.213GluAsp: 3.213 ± 0.449
2.425GluGlu: 2.425 ± 0.497
2.425GluPhe: 2.425 ± 0.364
3.577GluGly: 3.577 ± 0.374
1.273GluHis: 1.273 ± 0.258
2.789GluIle: 2.789 ± 0.39
2.243GluLys: 2.243 ± 0.287
4.911GluLeu: 4.911 ± 0.779
1.395GluMet: 1.395 ± 0.315
1.758GluAsn: 1.758 ± 0.328
3.335GluPro: 3.335 ± 0.581
3.032GluGln: 3.032 ± 0.501
5.032GluArg: 5.032 ± 0.562
2.547GluSer: 2.547 ± 0.34
3.032GluThr: 3.032 ± 0.446
4.851GluVal: 4.851 ± 0.621
1.091GluTrp: 1.091 ± 0.301
1.334GluTyr: 1.334 ± 0.322
0.0GluXaa: 0.0 ± 0.0
Phe
2.607PheAla: 2.607 ± 0.367
0.424PheCys: 0.424 ± 0.165
2.122PheAsp: 2.122 ± 0.294
1.819PheGlu: 1.819 ± 0.291
0.667PhePhe: 0.667 ± 0.237
2.183PheGly: 2.183 ± 0.368
0.303PheHis: 0.303 ± 0.161
0.728PheIle: 0.728 ± 0.272
0.97PheLys: 0.97 ± 0.304
1.516PheLeu: 1.516 ± 0.381
0.485PheMet: 0.485 ± 0.149
0.728PheAsn: 0.728 ± 0.205
1.516PhePro: 1.516 ± 0.242
0.606PheGln: 0.606 ± 0.166
2.304PheArg: 2.304 ± 0.284
1.698PheSer: 1.698 ± 0.382
2.365PheThr: 2.365 ± 0.385
2.789PheVal: 2.789 ± 0.36
0.364PheTrp: 0.364 ± 0.177
0.667PheTyr: 0.667 ± 0.204
0.0PheXaa: 0.0 ± 0.0
Gly
8.003GlyAla: 8.003 ± 1.237
0.546GlyCys: 0.546 ± 0.192
5.639GlyAsp: 5.639 ± 0.526
4.729GlyGlu: 4.729 ± 0.556
2.789GlyPhe: 2.789 ± 0.451
5.942GlyGly: 5.942 ± 0.855
1.94GlyHis: 1.94 ± 0.403
3.517GlyIle: 3.517 ± 0.602
3.395GlyLys: 3.395 ± 0.491
7.64GlyLeu: 7.64 ± 1.214
1.637GlyMet: 1.637 ± 0.277
2.789GlyAsn: 2.789 ± 0.514
3.759GlyPro: 3.759 ± 0.523
2.85GlyGln: 2.85 ± 0.432
6.184GlyArg: 6.184 ± 0.649
3.759GlySer: 3.759 ± 0.51
4.365GlyThr: 4.365 ± 0.569
6.366GlyVal: 6.366 ± 0.701
2.607GlyTrp: 2.607 ± 0.365
2.607GlyTyr: 2.607 ± 0.428
0.0GlyXaa: 0.0 ± 0.0
His
2.122HisAla: 2.122 ± 0.32
0.364HisCys: 0.364 ± 0.158
1.758HisAsp: 1.758 ± 0.279
0.909HisGlu: 0.909 ± 0.216
0.303HisPhe: 0.303 ± 0.151
2.183HisGly: 2.183 ± 0.369
0.364HisHis: 0.364 ± 0.151
1.213HisIle: 1.213 ± 0.319
0.546HisLys: 0.546 ± 0.175
1.94HisLeu: 1.94 ± 0.389
0.303HisMet: 0.303 ± 0.13
0.728HisAsn: 0.728 ± 0.207
1.455HisPro: 1.455 ± 0.311
0.728HisGln: 0.728 ± 0.207
1.94HisArg: 1.94 ± 0.418
1.213HisSer: 1.213 ± 0.271
1.637HisThr: 1.637 ± 0.366
1.576HisVal: 1.576 ± 0.318
0.485HisTrp: 0.485 ± 0.164
0.364HisTyr: 0.364 ± 0.141
0.0HisXaa: 0.0 ± 0.0
Ile
5.336IleAla: 5.336 ± 0.538
0.243IleCys: 0.243 ± 0.113
3.395IleAsp: 3.395 ± 0.488
2.971IleGlu: 2.971 ± 0.438
0.909IlePhe: 0.909 ± 0.204
4.911IleGly: 4.911 ± 0.734
0.667IleHis: 0.667 ± 0.232
1.516IleIle: 1.516 ± 0.362
1.455IleLys: 1.455 ± 0.45
2.304IleLeu: 2.304 ± 0.347
0.182IleMet: 0.182 ± 0.092
1.395IleAsn: 1.395 ± 0.287
2.971IlePro: 2.971 ± 0.408
0.788IleGln: 0.788 ± 0.219
4.244IleArg: 4.244 ± 0.573
2.425IleSer: 2.425 ± 0.427
3.638IleThr: 3.638 ± 0.459
4.244IleVal: 4.244 ± 0.456
0.243IleTrp: 0.243 ± 0.121
0.728IleTyr: 0.728 ± 0.215
0.0IleXaa: 0.0 ± 0.0
Lys
3.456LysAla: 3.456 ± 0.499
0.182LysCys: 0.182 ± 0.111
2.001LysAsp: 2.001 ± 0.464
1.213LysGlu: 1.213 ± 0.272
1.091LysPhe: 1.091 ± 0.275
2.486LysGly: 2.486 ± 0.473
0.546LysHis: 0.546 ± 0.246
1.758LysIle: 1.758 ± 0.316
1.758LysLys: 1.758 ± 0.326
2.971LysLeu: 2.971 ± 0.445
0.606LysMet: 0.606 ± 0.239
0.788LysAsn: 0.788 ± 0.223
2.486LysPro: 2.486 ± 0.382
0.728LysGln: 0.728 ± 0.201
2.243LysArg: 2.243 ± 0.341
1.88LysSer: 1.88 ± 0.332
2.365LysThr: 2.365 ± 0.335
2.971LysVal: 2.971 ± 0.473
0.546LysTrp: 0.546 ± 0.154
0.728LysTyr: 0.728 ± 0.24
0.0LysXaa: 0.0 ± 0.0
Leu
11.399LeuAla: 11.399 ± 1.084
0.728LeuCys: 0.728 ± 0.237
5.457LeuAsp: 5.457 ± 0.77
3.456LeuGlu: 3.456 ± 0.497
2.001LeuPhe: 2.001 ± 0.273
5.578LeuGly: 5.578 ± 0.895
1.334LeuHis: 1.334 ± 0.28
3.213LeuIle: 3.213 ± 0.493
1.819LeuLys: 1.819 ± 0.317
4.79LeuLeu: 4.79 ± 0.767
1.819LeuMet: 1.819 ± 0.36
2.243LeuAsn: 2.243 ± 0.35
4.547LeuPro: 4.547 ± 0.538
1.88LeuGln: 1.88 ± 0.324
5.154LeuArg: 5.154 ± 0.579
4.487LeuSer: 4.487 ± 0.613
5.517LeuThr: 5.517 ± 0.607
6.488LeuVal: 6.488 ± 0.63
2.365LeuTrp: 2.365 ± 0.35
1.576LeuTyr: 1.576 ± 0.297
0.0LeuXaa: 0.0 ± 0.0
Met
3.456MetAla: 3.456 ± 0.447
0.303MetCys: 0.303 ± 0.138
0.667MetAsp: 0.667 ± 0.186
0.788MetGlu: 0.788 ± 0.214
0.485MetPhe: 0.485 ± 0.141
1.516MetGly: 1.516 ± 0.326
0.364MetHis: 0.364 ± 0.165
0.788MetIle: 0.788 ± 0.216
0.667MetLys: 0.667 ± 0.193
1.637MetLeu: 1.637 ± 0.339
0.303MetMet: 0.303 ± 0.164
0.485MetAsn: 0.485 ± 0.157
1.698MetPro: 1.698 ± 0.321
0.667MetGln: 0.667 ± 0.225
1.819MetArg: 1.819 ± 0.517
1.576MetSer: 1.576 ± 0.311
2.607MetThr: 2.607 ± 0.416
0.909MetVal: 0.909 ± 0.236
0.546MetTrp: 0.546 ± 0.264
0.243MetTyr: 0.243 ± 0.121
0.0MetXaa: 0.0 ± 0.0
Asn
2.607AsnAla: 2.607 ± 0.413
0.182AsnCys: 0.182 ± 0.111
1.94AsnAsp: 1.94 ± 0.296
1.213AsnGlu: 1.213 ± 0.29
0.606AsnPhe: 0.606 ± 0.202
3.759AsnGly: 3.759 ± 0.555
0.788AsnHis: 0.788 ± 0.231
0.909AsnIle: 0.909 ± 0.279
0.849AsnLys: 0.849 ± 0.217
2.243AsnLeu: 2.243 ± 0.334
0.667AsnMet: 0.667 ± 0.193
0.97AsnAsn: 0.97 ± 0.244
3.395AsnPro: 3.395 ± 0.363
0.97AsnGln: 0.97 ± 0.228
2.061AsnArg: 2.061 ± 0.45
1.88AsnSer: 1.88 ± 0.304
2.183AsnThr: 2.183 ± 0.353
1.94AsnVal: 1.94 ± 0.357
0.424AsnTrp: 0.424 ± 0.144
0.849AsnTyr: 0.849 ± 0.237
0.0AsnXaa: 0.0 ± 0.0
Pro
6.669ProAla: 6.669 ± 0.876
0.728ProCys: 0.728 ± 0.246
4.729ProAsp: 4.729 ± 0.628
3.88ProGlu: 3.88 ± 0.481
1.576ProPhe: 1.576 ± 0.279
5.032ProGly: 5.032 ± 0.659
1.455ProHis: 1.455 ± 0.316
2.728ProIle: 2.728 ± 0.401
2.547ProLys: 2.547 ± 0.34
3.456ProLeu: 3.456 ± 0.426
1.576ProMet: 1.576 ± 0.461
1.88ProAsn: 1.88 ± 0.362
3.335ProPro: 3.335 ± 0.673
2.122ProGln: 2.122 ± 0.289
3.517ProArg: 3.517 ± 0.476
2.971ProSer: 2.971 ± 0.369
4.062ProThr: 4.062 ± 0.575
3.88ProVal: 3.88 ± 0.481
1.152ProTrp: 1.152 ± 0.267
1.152ProTyr: 1.152 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
3.456GlnAla: 3.456 ± 0.594
0.0GlnCys: 0.0 ± 0.0
1.213GlnAsp: 1.213 ± 0.262
1.273GlnGlu: 1.273 ± 0.317
1.091GlnPhe: 1.091 ± 0.268
2.425GlnGly: 2.425 ± 0.358
0.788GlnHis: 0.788 ± 0.221
1.576GlnIle: 1.576 ± 0.309
1.031GlnLys: 1.031 ± 0.178
3.335GlnLeu: 3.335 ± 0.414
0.909GlnMet: 0.909 ± 0.225
0.909GlnAsn: 0.909 ± 0.198
2.183GlnPro: 2.183 ± 0.451
1.758GlnGln: 1.758 ± 0.404
3.274GlnArg: 3.274 ± 0.479
1.698GlnSer: 1.698 ± 0.359
1.758GlnThr: 1.758 ± 0.349
3.032GlnVal: 3.032 ± 0.499
0.909GlnTrp: 0.909 ± 0.259
1.213GlnTyr: 1.213 ± 0.245
0.0GlnXaa: 0.0 ± 0.0
Arg
8.185ArgAla: 8.185 ± 0.823
1.152ArgCys: 1.152 ± 0.302
5.942ArgAsp: 5.942 ± 0.61
4.972ArgGlu: 4.972 ± 0.697
2.061ArgPhe: 2.061 ± 0.351
6.306ArgGly: 6.306 ± 0.603
2.243ArgHis: 2.243 ± 0.382
4.062ArgIle: 4.062 ± 0.532
2.061ArgLys: 2.061 ± 0.306
6.003ArgLeu: 6.003 ± 0.622
1.88ArgMet: 1.88 ± 0.323
2.789ArgAsn: 2.789 ± 0.382
3.517ArgPro: 3.517 ± 0.415
2.425ArgGln: 2.425 ± 0.467
7.761ArgArg: 7.761 ± 1.227
4.729ArgSer: 4.729 ± 0.52
4.79ArgThr: 4.79 ± 0.565
5.457ArgVal: 5.457 ± 0.717
1.637ArgTrp: 1.637 ± 0.397
1.516ArgTyr: 1.516 ± 0.332
0.0ArgXaa: 0.0 ± 0.0
Ser
6.427SerAla: 6.427 ± 0.796
0.121SerCys: 0.121 ± 0.093
3.395SerAsp: 3.395 ± 0.457
3.82SerGlu: 3.82 ± 0.536
1.516SerPhe: 1.516 ± 0.31
4.79SerGly: 4.79 ± 0.723
0.849SerHis: 0.849 ± 0.237
2.304SerIle: 2.304 ± 0.543
1.637SerLys: 1.637 ± 0.251
3.456SerLeu: 3.456 ± 0.544
1.334SerMet: 1.334 ± 0.246
1.819SerAsn: 1.819 ± 0.467
2.91SerPro: 2.91 ± 0.393
1.395SerGln: 1.395 ± 0.326
4.305SerArg: 4.305 ± 0.754
2.607SerSer: 2.607 ± 0.621
3.82SerThr: 3.82 ± 0.454
4.123SerVal: 4.123 ± 0.472
1.455SerTrp: 1.455 ± 0.271
0.728SerTyr: 0.728 ± 0.2
0.0SerXaa: 0.0 ± 0.0
Thr
7.458ThrAla: 7.458 ± 0.688
0.546ThrCys: 0.546 ± 0.188
5.517ThrAsp: 5.517 ± 0.696
4.123ThrGlu: 4.123 ± 0.486
2.183ThrPhe: 2.183 ± 0.485
4.911ThrGly: 4.911 ± 0.58
1.698ThrHis: 1.698 ± 0.31
3.577ThrIle: 3.577 ± 0.422
2.304ThrLys: 2.304 ± 0.343
5.154ThrLeu: 5.154 ± 0.668
0.909ThrMet: 0.909 ± 0.201
2.122ThrAsn: 2.122 ± 0.427
4.487ThrPro: 4.487 ± 0.53
1.94ThrGln: 1.94 ± 0.35
4.365ThrArg: 4.365 ± 0.48
3.153ThrSer: 3.153 ± 0.462
4.002ThrThr: 4.002 ± 0.53
6.063ThrVal: 6.063 ± 0.508
1.516ThrTrp: 1.516 ± 0.377
1.758ThrTyr: 1.758 ± 0.48
0.0ThrXaa: 0.0 ± 0.0
Val
8.61ValAla: 8.61 ± 0.951
1.395ValCys: 1.395 ± 0.405
6.366ValAsp: 6.366 ± 0.702
5.214ValGlu: 5.214 ± 0.579
1.273ValPhe: 1.273 ± 0.267
5.639ValGly: 5.639 ± 0.562
1.94ValHis: 1.94 ± 0.37
3.213ValIle: 3.213 ± 0.389
2.183ValLys: 2.183 ± 0.408
4.669ValLeu: 4.669 ± 0.437
2.001ValMet: 2.001 ± 0.355
1.698ValAsn: 1.698 ± 0.334
4.669ValPro: 4.669 ± 0.587
2.85ValGln: 2.85 ± 0.437
6.912ValArg: 6.912 ± 0.689
4.002ValSer: 4.002 ± 0.601
6.488ValThr: 6.488 ± 0.791
6.73ValVal: 6.73 ± 0.689
1.091ValTrp: 1.091 ± 0.421
2.243ValTyr: 2.243 ± 0.343
0.0ValXaa: 0.0 ± 0.0
Trp
1.637TrpAla: 1.637 ± 0.347
0.303TrpCys: 0.303 ± 0.149
1.698TrpAsp: 1.698 ± 0.355
1.031TrpGlu: 1.031 ± 0.259
0.243TrpPhe: 0.243 ± 0.131
0.788TrpGly: 0.788 ± 0.224
0.424TrpHis: 0.424 ± 0.196
0.849TrpIle: 0.849 ± 0.164
0.788TrpLys: 0.788 ± 0.161
2.122TrpLeu: 2.122 ± 0.35
0.546TrpMet: 0.546 ± 0.174
0.788TrpAsn: 0.788 ± 0.362
1.273TrpPro: 1.273 ± 0.247
0.667TrpGln: 0.667 ± 0.163
1.637TrpArg: 1.637 ± 0.31
1.455TrpSer: 1.455 ± 0.302
1.213TrpThr: 1.213 ± 0.266
1.819TrpVal: 1.819 ± 0.287
0.424TrpTrp: 0.424 ± 0.148
0.606TrpTyr: 0.606 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.425TyrAla: 2.425 ± 0.391
0.364TyrCys: 0.364 ± 0.163
1.455TyrAsp: 1.455 ± 0.258
1.637TyrGlu: 1.637 ± 0.364
0.606TyrPhe: 0.606 ± 0.224
2.061TyrGly: 2.061 ± 0.31
0.728TyrHis: 0.728 ± 0.219
1.031TyrIle: 1.031 ± 0.3
0.849TyrLys: 0.849 ± 0.204
1.455TyrLeu: 1.455 ± 0.26
0.485TyrMet: 0.485 ± 0.159
0.849TyrAsn: 0.849 ± 0.224
1.031TyrPro: 1.031 ± 0.201
0.849TyrGln: 0.849 ± 0.226
1.88TyrArg: 1.88 ± 0.361
1.152TyrSer: 1.152 ± 0.292
1.576TyrThr: 1.576 ± 0.344
1.516TyrVal: 1.516 ± 0.327
0.303TyrTrp: 0.303 ± 0.121
0.788TyrTyr: 0.788 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (16494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski