Amino acid dipepetide frequency for Paenibacillus thalictri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.432AlaAla: 10.432 ± 0.105	0.764AlaCys: 0.764 ± 0.016	4.734AlaAsp: 4.734 ± 0.056	5.747AlaGlu: 5.747 ± 0.064	3.355AlaPhe: 3.355 ± 0.04	7.422AlaGly: 7.422 ± 0.073	1.473AlaHis: 1.473 ± 0.027	5.214AlaIle: 5.214 ± 0.053	4.506AlaLys: 4.506 ± 0.043	8.387AlaLeu: 8.387 ± 0.07	2.269AlaMet: 2.269 ± 0.029	2.766AlaAsn: 2.766 ± 0.036	3.059AlaPro: 3.059 ± 0.044	3.02AlaGln: 3.02 ± 0.041	3.477AlaArg: 3.477 ± 0.04	5.337AlaSer: 5.337 ± 0.051	3.738AlaThr: 3.738 ± 0.063	7.005AlaVal: 7.005 ± 0.061	0.945AlaTrp: 0.945 ± 0.021	2.769AlaTyr: 2.769 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.607CysAla: 0.607 ± 0.017	0.131CysCys: 0.131 ± 0.008	0.427CysAsp: 0.427 ± 0.012	0.464CysGlu: 0.464 ± 0.014	0.346CysPhe: 0.346 ± 0.011	0.844CysGly: 0.844 ± 0.019	0.203CysHis: 0.203 ± 0.008	0.531CysIle: 0.531 ± 0.014	0.328CysLys: 0.328 ± 0.012	0.785CysLeu: 0.785 ± 0.017	0.228CysMet: 0.228 ± 0.009	0.244CysAsn: 0.244 ± 0.01	0.33CysPro: 0.33 ± 0.013	0.219CysGln: 0.219 ± 0.01	0.492CysArg: 0.492 ± 0.014	0.645CysSer: 0.645 ± 0.016	0.41CysThr: 0.41 ± 0.012	0.507CysVal: 0.507 ± 0.012	0.105CysTrp: 0.105 ± 0.007	0.279CysTyr: 0.279 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.075AspAla: 4.075 ± 0.041	0.392AspCys: 0.392 ± 0.012	2.406AspAsp: 2.406 ± 0.031	3.58AspGlu: 3.58 ± 0.043	2.108AspPhe: 2.108 ± 0.03	4.157AspGly: 4.157 ± 0.058	1.126AspHis: 1.126 ± 0.02	3.458AspIle: 3.458 ± 0.039	2.911AspLys: 2.911 ± 0.039	4.548AspLeu: 4.548 ± 0.043	1.447AspMet: 1.447 ± 0.026	1.886AspAsn: 1.886 ± 0.032	2.532AspPro: 2.532 ± 0.031	1.864AspGln: 1.864 ± 0.025	2.624AspArg: 2.624 ± 0.033	2.701AspSer: 2.701 ± 0.036	2.566AspThr: 2.566 ± 0.033	3.497AspVal: 3.497 ± 0.042	0.877AspTrp: 0.877 ± 0.018	2.073AspTyr: 2.073 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.808GluAla: 5.808 ± 0.058	0.398GluCys: 0.398 ± 0.013	2.692GluAsp: 2.692 ± 0.034	4.304GluGlu: 4.304 ± 0.054	2.073GluPhe: 2.073 ± 0.029	3.894GluGly: 3.894 ± 0.045	1.589GluHis: 1.589 ± 0.029	3.788GluIle: 3.788 ± 0.046	3.686GluLys: 3.686 ± 0.046	7.023GluLeu: 7.023 ± 0.073	1.878GluMet: 1.878 ± 0.025	2.257GluAsn: 2.257 ± 0.032	2.357GluPro: 2.357 ± 0.036	3.704GluGln: 3.704 ± 0.054	3.818GluArg: 3.818 ± 0.053	3.209GluSer: 3.209 ± 0.04	3.393GluThr: 3.393 ± 0.036	3.892GluVal: 3.892 ± 0.041	0.956GluTrp: 0.956 ± 0.017	1.958GluTyr: 1.958 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.469PheAla: 3.469 ± 0.04	0.377PheCys: 0.377 ± 0.012	2.273PheAsp: 2.273 ± 0.03	2.313PheGlu: 2.313 ± 0.033	1.902PhePhe: 1.902 ± 0.032	3.16PheGly: 3.16 ± 0.042	0.954PheHis: 0.954 ± 0.019	2.885PheIle: 2.885 ± 0.04	2.107PheLys: 2.107 ± 0.03	3.863PheLeu: 3.863 ± 0.052	1.127PheMet: 1.127 ± 0.02	1.62PheAsn: 1.62 ± 0.028	1.7PhePro: 1.7 ± 0.026	1.54PheGln: 1.54 ± 0.023	2.01PheArg: 2.01 ± 0.028	2.877PheSer: 2.877 ± 0.036	2.551PheThr: 2.551 ± 0.035	2.962PheVal: 2.962 ± 0.035	0.539PheTrp: 0.539 ± 0.015	1.567PheTyr: 1.567 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	6.073GlyAla: 6.073 ± 0.1	0.821GlyCys: 0.821 ± 0.02	3.522GlyAsp: 3.522 ± 0.04	4.373GlyGlu: 4.373 ± 0.049	3.217GlyPhe: 3.217 ± 0.038	5.884GlyGly: 5.884 ± 0.08	1.497GlyHis: 1.497 ± 0.024	5.566GlyIle: 5.566 ± 0.057	4.687GlyLys: 4.687 ± 0.046	7.185GlyLeu: 7.185 ± 0.055	2.333GlyMet: 2.333 ± 0.029	2.768GlyAsn: 2.768 ± 0.037	2.096GlyPro: 2.096 ± 0.032	2.771GlyGln: 2.771 ± 0.039	3.469GlyArg: 3.469 ± 0.046	4.934GlySer: 4.934 ± 0.056	4.552GlyThr: 4.552 ± 0.062	5.277GlyVal: 5.277 ± 0.049	1.121GlyTrp: 1.121 ± 0.023	2.937GlyTyr: 2.937 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	1.593HisAla: 1.593 ± 0.027	0.2HisCys: 0.2 ± 0.009	0.979HisAsp: 0.979 ± 0.024	1.26HisGlu: 1.26 ± 0.02	1.127HisPhe: 1.127 ± 0.02	1.543HisGly: 1.543 ± 0.025	0.629HisHis: 0.629 ± 0.018	1.527HisIle: 1.527 ± 0.023	0.88HisLys: 0.88 ± 0.017	2.035HisLeu: 2.035 ± 0.029	0.646HisMet: 0.646 ± 0.016	0.703HisAsn: 0.703 ± 0.018	1.195HisPro: 1.195 ± 0.023	0.786HisGln: 0.786 ± 0.018	1.104HisArg: 1.104 ± 0.022	1.15HisSer: 1.15 ± 0.022	1.079HisThr: 1.079 ± 0.023	1.495HisVal: 1.495 ± 0.023	0.357HisTrp: 0.357 ± 0.012	0.902HisTyr: 0.902 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.94IleAla: 5.94 ± 0.045	0.631IleCys: 0.631 ± 0.018	3.63IleAsp: 3.63 ± 0.035	3.937IleGlu: 3.937 ± 0.041	2.343IlePhe: 2.343 ± 0.031	5.257IleGly: 5.257 ± 0.054	1.417IleHis: 1.417 ± 0.024	3.838IleIle: 3.838 ± 0.043	2.884IleLys: 2.884 ± 0.037	5.284IleLeu: 5.284 ± 0.051	1.62IleMet: 1.62 ± 0.026	2.377IleAsn: 2.377 ± 0.031	3.182IlePro: 3.182 ± 0.041	2.394IleGln: 2.394 ± 0.03	3.768IleArg: 3.768 ± 0.038	4.45IleSer: 4.45 ± 0.05	3.67IleThr: 3.67 ± 0.042	5.35IleVal: 5.35 ± 0.048	0.769IleTrp: 0.769 ± 0.017	2.096IleTyr: 2.096 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.38LysAla: 4.38 ± 0.045	0.236LysCys: 0.236 ± 0.01	2.9LysAsp: 2.9 ± 0.041	3.927LysGlu: 3.927 ± 0.048	1.64LysPhe: 1.64 ± 0.027	3.467LysGly: 3.467 ± 0.042	1.13LysHis: 1.13 ± 0.021	3.092LysIle: 3.092 ± 0.035	3.294LysLys: 3.294 ± 0.046	5.721LysLeu: 5.721 ± 0.055	1.799LysMet: 1.799 ± 0.031	2.136LysAsn: 2.136 ± 0.033	2.387LysPro: 2.387 ± 0.035	2.71LysGln: 2.71 ± 0.033	2.647LysArg: 2.647 ± 0.037	3.072LysSer: 3.072 ± 0.037	3.022LysThr: 3.022 ± 0.036	3.547LysVal: 3.547 ± 0.038	0.78LysTrp: 0.78 ± 0.018	1.869LysTyr: 1.869 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	8.574LeuAla: 8.574 ± 0.076	0.865LeuCys: 0.865 ± 0.019	5.02LeuAsp: 5.02 ± 0.046	5.901LeuGlu: 5.901 ± 0.062	4.554LeuPhe: 4.554 ± 0.051	6.618LeuGly: 6.618 ± 0.06	2.184LeuHis: 2.184 ± 0.034	6.355LeuIle: 6.355 ± 0.058	5.419LeuLys: 5.419 ± 0.049	11.048LeuLeu: 11.048 ± 0.111	2.577LeuMet: 2.577 ± 0.033	3.865LeuAsn: 3.865 ± 0.042	4.625LeuPro: 4.625 ± 0.046	4.438LeuGln: 4.438 ± 0.046	4.808LeuArg: 4.808 ± 0.048	6.911LeuSer: 6.911 ± 0.058	5.515LeuThr: 5.515 ± 0.043	6.235LeuVal: 6.235 ± 0.049	1.028LeuTrp: 1.028 ± 0.022	3.307LeuTyr: 3.307 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.331MetAla: 2.331 ± 0.027	0.172MetCys: 0.172 ± 0.008	1.515MetAsp: 1.515 ± 0.024	1.832MetGlu: 1.832 ± 0.026	1.145MetPhe: 1.145 ± 0.022	1.698MetGly: 1.698 ± 0.025	0.454MetHis: 0.454 ± 0.015	1.977MetIle: 1.977 ± 0.033	1.985MetLys: 1.985 ± 0.025	3.039MetLeu: 3.039 ± 0.037	0.937MetMet: 0.937 ± 0.021	1.46MetAsn: 1.46 ± 0.023	1.25MetPro: 1.25 ± 0.017	1.038MetGln: 1.038 ± 0.019	1.343MetArg: 1.343 ± 0.02	1.81MetSer: 1.81 ± 0.028	1.658MetThr: 1.658 ± 0.028	1.764MetVal: 1.764 ± 0.028	0.269MetTrp: 0.269 ± 0.01	0.888MetTyr: 0.888 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.915AsnAla: 2.915 ± 0.039	0.261AsnCys: 0.261 ± 0.01	1.863AsnAsp: 1.863 ± 0.03	2.359AsnGlu: 2.359 ± 0.032	1.34AsnPhe: 1.34 ± 0.023	3.424AsnGly: 3.424 ± 0.044	0.766AsnHis: 0.766 ± 0.017	2.375AsnIle: 2.375 ± 0.03	2.104AsnLys: 2.104 ± 0.036	3.2AsnLeu: 3.2 ± 0.034	1.134AsnMet: 1.134 ± 0.02	1.608AsnAsn: 1.608 ± 0.031	2.091AsnPro: 2.091 ± 0.031	1.411AsnGln: 1.411 ± 0.027	2.049AsnArg: 2.049 ± 0.029	2.194AsnSer: 2.194 ± 0.035	2.126AsnThr: 2.126 ± 0.032	2.752AsnVal: 2.752 ± 0.039	0.555AsnTrp: 0.555 ± 0.016	1.423AsnTyr: 1.423 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.912ProAla: 3.912 ± 0.05	0.259ProCys: 0.259 ± 0.012	2.703ProAsp: 2.703 ± 0.033	3.219ProGlu: 3.219 ± 0.043	1.999ProPhe: 1.999 ± 0.027	3.237ProGly: 3.237 ± 0.038	1.06ProHis: 1.06 ± 0.022	2.426ProIle: 2.426 ± 0.032	1.859ProLys: 1.859 ± 0.031	4.305ProLeu: 4.305 ± 0.049	1.015ProMet: 1.015 ± 0.02	1.601ProAsn: 1.601 ± 0.028	1.452ProPro: 1.452 ± 0.029	1.705ProGln: 1.705 ± 0.029	1.424ProArg: 1.424 ± 0.024	2.587ProSer: 2.587 ± 0.032	1.943ProThr: 1.943 ± 0.031	3.411ProVal: 3.411 ± 0.04	0.551ProTrp: 0.551 ± 0.016	1.643ProTyr: 1.643 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.628GlnAla: 3.628 ± 0.044	0.232GlnCys: 0.232 ± 0.009	1.741GlnAsp: 1.741 ± 0.027	2.464GlnGlu: 2.464 ± 0.041	1.689GlnPhe: 1.689 ± 0.025	2.602GlnGly: 2.602 ± 0.037	0.824GlnHis: 0.824 ± 0.018	2.558GlnIle: 2.558 ± 0.037	2.091GlnLys: 2.091 ± 0.03	4.533GlnLeu: 4.533 ± 0.05	1.282GlnMet: 1.282 ± 0.023	1.443GlnAsn: 1.443 ± 0.023	1.718GlnPro: 1.718 ± 0.025	1.983GlnGln: 1.983 ± 0.033	1.927GlnArg: 1.927 ± 0.033	2.353GlnSer: 2.353 ± 0.03	2.29GlnThr: 2.29 ± 0.032	2.578GlnVal: 2.578 ± 0.033	0.543GlnTrp: 0.543 ± 0.014	1.438GlnTyr: 1.438 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.19ArgAla: 3.19 ± 0.04	0.412ArgCys: 0.412 ± 0.013	2.33ArgAsp: 2.33 ± 0.03	3.422ArgGlu: 3.422 ± 0.049	2.29ArgPhe: 2.29 ± 0.031	2.915ArgGly: 2.915 ± 0.042	1.135ArgHis: 1.135 ± 0.021	3.569ArgIle: 3.569 ± 0.041	2.917ArgLys: 2.917 ± 0.034	5.467ArgLeu: 5.467 ± 0.057	1.646ArgMet: 1.646 ± 0.025	1.945ArgAsn: 1.945 ± 0.032	1.749ArgPro: 1.749 ± 0.033	2.163ArgGln: 2.163 ± 0.034	2.566ArgArg: 2.566 ± 0.044	3.155ArgSer: 3.155 ± 0.038	2.594ArgThr: 2.594 ± 0.03	2.959ArgVal: 2.959 ± 0.042	0.755ArgTrp: 0.755 ± 0.017	1.862ArgTyr: 1.862 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	5.299SerAla: 5.299 ± 0.052	0.48SerCys: 0.48 ± 0.015	3.113SerAsp: 3.113 ± 0.038	3.642SerGlu: 3.642 ± 0.043	3.044SerPhe: 3.044 ± 0.034	5.916SerGly: 5.916 ± 0.054	1.221SerHis: 1.221 ± 0.023	4.061SerIle: 4.061 ± 0.045	3.156SerLys: 3.156 ± 0.038	6.337SerLeu: 6.337 ± 0.058	1.744SerMet: 1.744 ± 0.027	2.193SerAsn: 2.193 ± 0.037	2.557SerPro: 2.557 ± 0.033	2.128SerGln: 2.128 ± 0.028	3.081SerArg: 3.081 ± 0.037	4.361SerSer: 4.361 ± 0.055	3.052SerThr: 3.052 ± 0.035	4.625SerVal: 4.625 ± 0.043	0.886SerTrp: 0.886 ± 0.02	2.338SerTyr: 2.338 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.079ThrAla: 5.079 ± 0.064	0.39ThrCys: 0.39 ± 0.012	2.848ThrAsp: 2.848 ± 0.038	2.957ThrGlu: 2.957 ± 0.034	2.408ThrPhe: 2.408 ± 0.039	4.827ThrGly: 4.827 ± 0.114	0.978ThrHis: 0.978 ± 0.02	3.706ThrIle: 3.706 ± 0.053	2.36ThrLys: 2.36 ± 0.033	5.413ThrLeu: 5.413 ± 0.047	1.43ThrMet: 1.43 ± 0.021	1.954ThrAsn: 1.954 ± 0.028	2.65ThrPro: 2.65 ± 0.032	1.611ThrGln: 1.611 ± 0.028	2.197ThrArg: 2.197 ± 0.032	3.33ThrSer: 3.33 ± 0.041	2.794ThrThr: 2.794 ± 0.05	4.711ThrVal: 4.711 ± 0.06	0.68ThrTrp: 0.68 ± 0.018	1.96ThrTyr: 1.96 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	5.332ValAla: 5.332 ± 0.052	0.686ValCys: 0.686 ± 0.017	3.512ValAsp: 3.512 ± 0.041	4.019ValGlu: 4.019 ± 0.041	3.012ValPhe: 3.012 ± 0.037	4.607ValGly: 4.607 ± 0.046	1.49ValHis: 1.49 ± 0.026	4.849ValIle: 4.849 ± 0.047	4.053ValLys: 4.053 ± 0.046	6.975ValLeu: 6.975 ± 0.057	1.985ValMet: 1.985 ± 0.029	2.831ValAsn: 2.831 ± 0.038	3.258ValPro: 3.258 ± 0.043	2.764ValGln: 2.764 ± 0.03	3.495ValArg: 3.495 ± 0.04	5.053ValSer: 5.053 ± 0.047	4.538ValThr: 4.538 ± 0.07	5.069ValVal: 5.069 ± 0.049	0.896ValTrp: 0.896 ± 0.022	2.62ValTyr: 2.62 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.889TrpAla: 0.889 ± 0.02	0.093TrpCys: 0.093 ± 0.007	0.707TrpAsp: 0.707 ± 0.019	0.729TrpGlu: 0.729 ± 0.017	0.577TrpPhe: 0.577 ± 0.015	0.894TrpGly: 0.894 ± 0.021	0.346TrpHis: 0.346 ± 0.011	0.868TrpIle: 0.868 ± 0.019	0.795TrpLys: 0.795 ± 0.018	1.456TrpLeu: 1.456 ± 0.026	0.463TrpMet: 0.463 ± 0.011	0.747TrpAsn: 0.747 ± 0.017	0.408TrpPro: 0.408 ± 0.012	0.52TrpGln: 0.52 ± 0.012	0.641TrpArg: 0.641 ± 0.014	0.882TrpSer: 0.882 ± 0.021	0.741TrpThr: 0.741 ± 0.019	0.894TrpVal: 0.894 ± 0.02	0.167TrpTrp: 0.167 ± 0.008	0.46TrpTyr: 0.46 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.895TyrAla: 2.895 ± 0.035	0.324TyrCys: 0.324 ± 0.01	1.91TyrAsp: 1.91 ± 0.039	2.229TyrGlu: 2.229 ± 0.032	1.627TyrPhe: 1.627 ± 0.024	2.715TyrGly: 2.715 ± 0.034	0.714TyrHis: 0.714 ± 0.016	2.195TyrIle: 2.195 ± 0.028	1.734TyrLys: 1.734 ± 0.023	3.245TyrLeu: 3.245 ± 0.044	1.005TyrMet: 1.005 ± 0.02	1.547TyrAsn: 1.547 ± 0.027	1.713TyrPro: 1.713 ± 0.027	1.151TyrGln: 1.151 ± 0.023	2.102TyrArg: 2.102 ± 0.029	2.225TyrSer: 2.225 ± 0.027	2.048TyrThr: 2.048 ± 0.032	2.511TyrVal: 2.511 ± 0.027	0.499TyrTrp: 0.499 ± 0.014	1.436TyrTyr: 1.436 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7735 proteins (2731292 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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